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Development of Breast Cancer Surgery Support System for MRI non mass enhancement Using Virtual Reality Technology

Research Project

Project/Area Number 19K09059
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 55010:General surgery and pediatric surgery-related
Research InstitutionAichi Medical University

Principal Investigator

Nakano Shogo  愛知医科大学, 医学部, 教授 (20351108)

Co-Investigator(Kenkyū-buntansha) 藤井 公人  愛知医科大学, 医学部, 准教授 (00524331)
高阪 絢子  愛知医科大学, 医学部, 助教 (50440748)
塩見 有佳子 (毛利有佳子)  愛知医科大学, 医学部, 講師 (90465576)
安藤 孝人  愛知医科大学, 医学部, 助教 (40634134)
井戸 美来  愛知医科大学, 医学部, 助教 (70740968)
伊藤 由季絵  愛知医科大学, 医学部, 助教 (10805469)
Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2021: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
KeywordsBreast cancer / MRI / Non mass enhancement / RVS / 乳房温存手術 / 乳房MRI / non mass enhancement / 超音波fusion技術 / 乳癌 / non-mass enhancement / 埋込型病変識別マーカー / 植込み型病変識別マーカー
Outline of Research at the Start

近年、磁気位置追尾システムを用いて超音波(US)とMRIを同一モニター上で対比することができるバーチャルリアリティ技術[Real-time virtual sonography(RVS)]が開発された。本研究においては、RVSを用いて、MRI non-mass enhancement(NME:非腫瘤性病変)のUS下での検出法を確立する。さらにRVS下に植込み型病変識別マーカーを留置し、これをランドマークとして乳房温存手術を安全に行うことができる手術支援システムの開発をめざす。

Outline of Final Research Achievements

We evaluated the usefulness of second-look US combined with ultrasound fusion technology (real-time virtual sonography: RVS) in defining the extent of breast cancer in breast-conserving surgery for breast cancer with Non-mass enhancement (NME). 6 cases were included in the study. After additional supine MRI, second-look US was performed using RVS. After tracing the contrast-enhanced area on the skin with RVS, implantable lesion identification markers were placed and surgery was performed. MRI showed a median diameter of 30.0 mm (23-36), with a distribution of 4 NME and 2 NME+mass. US showed a median diameter of 14.5mm (11-32), with a distribution of 2 NME and 4 NME+mass. All patients underwent breast-conserving surgery. The final pathological diagnosis was DCIS in 4 cases and IDC in 2. All were negative for resection margins, and there were no cases of reoperation. RVS may contribute to improved surgical outcomes in breast-conserving surgery for breast cancer with NME.

Academic Significance and Societal Importance of the Research Achievements

RVSはMRI-NMEの多くを検出できる革新的な画像診断法であり、世界に発信しうる独創的な新技術であることをfeasibility試験で検証できた。今後症例を増やしNMEの広がり診断においてRVSを用いて乳房温存手術のsurgical outcomeが改善されることが証明できれば、RVSによって必要のない乳房全摘術を回避することが可能となる。またMRIガイド下生検が必要な症例をより厳選することが可能となり、医師、患者の負担を軽減することができる。

Report

(4 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (6 results)

All 2022 2020 2019

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (5 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Evaluation of an MRI/US fusion technique for the detection of non-mass enhancement of breast lesions detected by MRI yet occult on conventional B-mode second-look US2022

    • Author(s)
      Manami Goto , Shogo Nakano , Masayuki Saito , Hirona Banno , Yukie Ito , Mirai Ido , Takahito Ando , Junko Kousaka , Kimihito Fujii , Kojiro Suzuki
    • Journal Title

      J Med Ultrason

      Volume: 49 Issue: 2 Pages: 269-278

    • DOI

      10.1007/s10396-021-01175-2

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 乳房MRI-detected non mass enhancement検出における超音波fusion技術を用いたsecond-look USの有用性2022

    • Author(s)
      中野正吾、藤井公人、高阪絢子、毛利有佳子、井戸美来、 後藤真奈美、伊藤由季絵、坂野福奈、西塔誠幸、鈴木耕次郎
    • Organizer
      日本外科学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Second-look US with an MRI/US fusion technique for the identification of non-mass enhancement lesions detected by breast MRI yet occult on conventional B-mode2022

    • Author(s)
      S. Nakano, M. Goto, K. Fujii, J. Kousaka, T. Ando, M. Ido, Y. Ito, H. Banno, M. Saito
    • Organizer
      ECR 2022
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 乳腺画像診断における超音波fusion技術の応用-開発秘話および当院における工夫の実際-2020

    • Author(s)
      中野正吾
    • Organizer
      第45回 日本乳腺甲状腺超音波医学会学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] MRI-detected lesionに対するSecond-look USとしてのReal-time Virtual Sonographyの臨床データ2019

    • Author(s)
      中野正吾
    • Organizer
      第27回日本乳癌学会学術総会
    • Related Report
      2019 Research-status Report
  • [Presentation] 超音波fusion技術を用いた乳房温存手術の断端陽性率改善への取り組み(多施設共同試験 FUSION 02 study)2019

    • Author(s)
      中野正吾
    • Organizer
      第42回日本乳腺甲状腺超音波医学会学術集会
    • Related Report
      2019 Research-status Report

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Published: 2019-04-18   Modified: 2023-01-30  

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