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Elucidation of novel metastatic process via regulation of non-coding RNA in CRC

Research Project

Project/Area Number 19K09143
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 55020:Digestive surgery-related
Research InstitutionMie University

Principal Investigator

Imaoka Hiroki  三重大学, 医学系研究科, 寄附講座助教 (70762938)

Co-Investigator(Kenkyū-buntansha) 問山 裕二  三重大学, 医学系研究科, 教授 (00422824)
奥川 喜永  三重大学, 医学部附属病院, 教授 (30555545)
楠 正人  三重大学, 医学系研究科, 寄附講座大学教員 (50192026)
井出 正造  三重大学, 医学系研究科, リサーチアソシエイト (90616088)
Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2021: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords大腸癌 / 転移 / Circular RNA / バイオマーカー / CircRNA / biomarker / 非翻訳RNA / 遠隔転移 / 大腸がん / ノンコーディングRNA / Non-coding RNA
Outline of Research at the Start

本研究は、同時性肝転移、リンパ節転移を認めた患者群の正常大腸粘膜、原発巣、転移リンパ節、肝転移の4群間のprofilingから大腸癌進展・転移に関与するCircRNAを同定し、新たなNon-invasive biomarkerの確立と、癌進展機序解明からの新規治療法開発を目的とするTwo way approachを行い、現在極めて予後不良な経過をたどる大腸癌患者の予後・QOLの向上をめざすことを目的とする。

Outline of Final Research Achievements

In this study, we identified the expression level of FLANC was significantly high in CRC tissues compared with adjacent normal mucosa. Furthermore, the high expression group of FLANC showed significantly poor overall survival and disease free survival compared with low expression group.

Academic Significance and Societal Importance of the Research Achievements

大腸癌進展・転移に関与するCircRNAのバイオマーカーとしての有用性には大きな期待が寄せられると考えられる。本研究ではFLANCが大腸癌の腫瘍進展・転移に関与しており、予後予測マーカーとして有用となり得る可能性について証明した。今後はCirc RNAの網羅的プロファイリングを行い、大腸癌転移に関するバイオマーカーとしての意義を検証していく予定であり、本研究成果はその試金石となりうる役割を果たしていると考える。

Report

(4 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (9 results)

All 2021 2020 2019

All Journal Article (7 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 7 results,  Open Access: 1 results) Presentation (2 results)

  • [Journal Article] High platelet?×?C-reactive protein level multiplier is a negative prognostic marker in rectal cancer treated by neoadjuvant chemoradiotherapy2021

    • Author(s)
      Ide Shozo、Toiyama Yuji、Okugawa Yoshinaga、Shimura Tadanobu、Fujikawa Hiroyuki、Hiro Junichiro、Ohi Masaki、Kusunoki Masato
    • Journal Title

      International Journal of Clinical Oncology

      Volume: 26 Issue: 4 Pages: 708-716

    • DOI

      10.1007/s10147-020-01857-w

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cumulative perioperative lymphocyte/C-reactive protein ratio as a predictor of the long-term outcomes of patients with colorectal cancer2021

    • Author(s)
      Okugawa Yoshinaga、Toiyama Yuji、Fujikawa Hiroyuki、Kawamura Mikio、Yasuda Hiromi、Yokoe Takeshi、Mochiki Ikuyo、Okita Yoshiki、Ohi Masaki、Nakatani Kaname
    • Journal Title

      Surgery Today

      Volume: 51 Issue: 12 Pages: 1906-1917

    • DOI

      10.1007/s00595-021-02291-9

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Geriatric nutritional risk index predicts cancer prognosis in patients with local advanced rectal cancer undergoing chemoradiotherapy followed by curative surgery2021

    • Author(s)
      Ide Shozo、Okugawa Yoshinaga、Omura Yusuke、Yamamoto Akira、Ichikawa Takashi、Kitajima Takahito、Shimura Tadanobu、Imaoka Hiroki、Fujikawa Hiroyuki、Yasuda Hiromi、Yokoe Takeshi、Okita Yoshiki、Ohi Masaki、Toiyama Yuji
    • Journal Title

      World Journal of Surgical Oncology

      Volume: 19 Issue: 1 Pages: 34-34

    • DOI

      10.1186/s12957-021-02139-z

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Preoperative heat shock protein 47 levels identify colorectal cancer patients with lymph node metastasis and poor prognosis2020

    • Author(s)
      Mori Koichiro、Toiyama Yuji、Okugawa Yoshinaga、Ichikawa Takashi、Nagano Yuka、Oki Satoshi、Shimura Tadanobu、Fujikawa Hiroyuki、Hiro Junichiro、Kobayash Minako、Araki Toshimitsu、Inoue Yasuhiro、Mohri Yasuhiko、Kusunoki Masato
    • Journal Title

      Oncology Letters

      Volume: 20 Issue: 6 Pages: 333-333

    • DOI

      10.3892/ol.2020.12196

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Fusobacterium nucleatum infection correlates with two types of microsatellite alterations in colorectal cancer and triggers DNA damage2020

    • Author(s)
      Okita Yoshiki、Koi Minoru、Takeda Koki、Ross Ryan、Mukherjee Bhramar、Koeppe Erika、Stoffel Elena M.、Galanko Joseph A.、McCoy Amber N.、Keku Temitope O.、Okugawa Yoshinaga、Kitajima Takahito、Toiyama Yuji、Martens Eric、Carethers John M.
    • Journal Title

      Gut Pathogens

      Volume: 12 Issue: 1 Pages: 46-46

    • DOI

      10.1186/s13099-020-00384-3

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Therapeutic potential of FLANC, a novel primate-specific long non-coding RNA in colorectal cancer2020

    • Author(s)
      Pichler Martin、Rodriguez-Aguayo Cristian、Nam Su Youn、Dragomir Mihnea Paul、Bayraktar Recep、Anfossi Simone、Knutsen Erik、Ivan Cristina、Fuentes-Mattei Enrique、Lee Sang Kil、Ling Hui、Catela Ivkovic Tina、Huang Guoliang、Huang Li、Okugawa Yoshinaga
    • Journal Title

      Gut

      Volume: - Issue: 10 Pages: 2019-318903

    • DOI

      10.1136/gutjnl-2019-318903

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Activation of AZIN1 RNA editing is a novel mechanism that promotes invasive potential of cancer-associated fibroblasts in colorectal cancer2019

    • Author(s)
      Takeda S, Shigeyasu K, Okugawa Y, Yoshida K, Mori Y, Yano S, Noma K, Umeda Y, Kondo Y, Kishimoto H, Teraishi F, Nagasaka T, Tazawa H, Kagawa S, Fujiwara T, Goel A.
    • Journal Title

      Cancer Lett

      Volume: 444 Pages: 127-135

    • DOI

      10.1016/j.canlet.2018.12.009

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 臨床実装を視野に入れた大腸癌外科診療におけるあらたなmultiple-outcome prediction biomarkerの確立2019

    • Author(s)
      奥川喜永、問山裕二、山本 晃、大村悠介、浦谷 亮、井出正造、近藤 哲、志村匡信、安田裕美、藤川裕之、大北喜基、白井由美子、横江 毅、三枝 晋、廣 純一郎、大井正貴、荒木俊光、田中光司、三木誓雄、楠 正人
    • Organizer
      第74回日本大腸肛門病学会学術集会、東京
    • Related Report
      2019 Research-status Report
  • [Presentation] 網羅的DNAメチル化解析から抽出した潰瘍性大腸炎合併大腸癌診断マーカー2019

    • Author(s)
      問山裕二、山本 晃、奥川喜永、楠 蔵人、大村悠介、藤川裕之、大北喜基、廣 純一郎、大井正貴、内田恵一、楠 正人
    • Organizer
      第74回日本消化器外科学会総会、東京
    • Related Report
      2019 Research-status Report

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Published: 2019-04-18   Modified: 2023-01-30  

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