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A novel cancer immunotherapy focused on organ specific immune memory generation

Research Project

Project/Area Number 19K09147
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 55020:Digestive surgery-related
Research InstitutionKobe University

Principal Investigator

Yamashita Kimihiro  神戸大学, 医学部附属病院, 特命准教授 (80535427)

Co-Investigator(Kenkyū-buntansha) 井上 茂亮  神戸大学, 医学研究科, 特命教授 (30582209)
藤田 貢  近畿大学, 医学部, 准教授 (40609997)
眞庭 謙昌  神戸大学, 医学研究科, 教授 (50362778)
掛地 吉弘  神戸大学, 医学研究科, 教授 (80284488)
高村 史記  近畿大学, 医学部, 講師 (90528564)
Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2021: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2020: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsがんワクチン / NKT細胞 / 腫瘍微小環境 / 大腸癌 / レジデントメモリーT細胞 / AIイメージサイトメトリー / 腫瘍浸潤リンパ球 / 肺転移 / CD8+細胞 / インフルエンザワクチン / CD8+T細胞 / レジデントメモリ-T細胞 / CD8 T細胞 / 組織滞在型メモリーT細胞 / 腫瘍浸潤T細胞
Outline of Research at the Start

本研究は、皮下接種型腫瘍に対し著効するNKT細胞ワクチンベクター免疫療法に抵抗 性を示す難治性転移性肺腫瘍に対し、レジデントメモリーT細胞の誘導環境を利用して有効な腫瘍反応性メモリーT細胞を成立させ、肺の臓器全体の転移制御を行う新規癌免疫療法のモデルを確立する。又、この際に機能する、レジデントメモリー様腫瘍浸潤T細胞の誘導機構を明らかにし、臓器別に制御する免疫療法の開発に応用する。

Outline of Final Research Achievements

This study shows the potential of a novel dendritic cell vaccine therapy in antitumor immunity, in which bone marrow-derived dendritic cells are electroporated with an exogenous ovalbumin protein and simultaneously pulsed with α-galactosylceramide. This strategy enhances the induction of cytotoxic CD8+ T cells specific for tumor-associated antigens through the activation of invariant natural killer T cells, natural killer cells, and intrinsic dendritic cells. Moreover, this strategy sustains antigen-specific antitumor T cell responses over time.

Academic Significance and Societal Importance of the Research Achievements

免疫チェックポイント阻害剤の台頭と共に、奏功症例の解析が進み、がんの発症に伴う遺伝子変異に起因する新生変異抗原(neoantigen)の存在が必要条件であることが示された。ただ、neoantigenの同定は煩雑であり、共通性の極めて低いものであり、困難となる。 本研究は、neoantigenを同定せずとも免疫療法の機会を失しない、効果的なオーダーメイド治療の確立に貢献するものである。

Report

(4 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (7 results)

All 2022 2021

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 1 results) Presentation (4 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Vaccine Based on Dendritic Cells Electroporated with an Exogenous Ovalbumin Protein and Pulsed with Invariant Natural Killer T Cell Ligands Effectively Induces Antigen-Specific Antitumor Immunity2022

    • Author(s)
      Watanabe Akihiro
    • Journal Title

      Cancers

      Volume: 14(1) Issue: 1 Pages: 171-188

    • DOI

      10.3390/cancers14010171

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] CD244+ polymorphonuclear myeloid?derived suppressor cells reflect the status of peritoneal dissemination in a colon cancer mouse model2021

    • Author(s)
      Sugita Yutaka、Yamashita Kimihiro、Fujita Mitsugu、Saito Masafumi、Yamada Kota、Agawa Kyosuke、Watanabe Akihiro、Fukuoka Eiji、Hasegawa Hiroshi、Kanaji Shingo、Oshikiri Taro、Matsuda Takeru、Nakamura Tetsu、Suzuki Satoshi、Kakeji Yoshihiro
    • Journal Title

      Oncology Reports

      Volume: 45 Issue: 6 Pages: 196-196

    • DOI

      10.3892/or.2021.8057

    • NAID

      120007035636

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Simple Cancer Stem Cell Markers Predict Neoadjuvant Chemotherapy Resistance of Esophageal Squamous Cell Carcinoma2021

    • Author(s)
      AGAWA KYOSUKE、YAMASHITA KIMIHIRO、NAKAGAWA AKIO、YAMADA KOUTA、WATANABE AKIHIRO、MUKOHYAMA JUNKO、SAITO MASAFUMI、FUJITA MITSUGU、TAKIGUCHI GOSUKE、URAKAWA NAOKI、HASEGAWA HIROSHI、KANAJI SHINGO、MATSUDA TAKERU、OSHIKIRI TARO、NAKAMURA TETSU、SUZUKI SATOSHI、KAKEJI YOSHIHIRO
    • Journal Title

      Anticancer Research

      Volume: 41 Issue: 8 Pages: 4117-4126

    • DOI

      10.21873/anticanres.15214

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Presentation] Antigen specific antitumor effect induced by antigen-electroporated, natural killer T cell ligandloaded dendritic cells2021

    • Author(s)
      Watanabe Akihiro
    • Organizer
      American Association for Cancer Research(AACR) ANNUAL MEETING
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Antitumor effects of vaccine vectors generated by loading α-galactosylceramide to tumor antigenelectroporated dendritic cells2021

    • Author(s)
      渡部晃大
    • Organizer
      第32回日本消化器癌発生学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 直腸癌術前化学放射線療法におけるCD8+T細胞の誘導とその予後2021

    • Author(s)
      山下 公大
    • Organizer
      第75回日本消化器外科学会総会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 大腸癌腹膜播種モデルにおけるPD-1耐性とその克服2021

    • Author(s)
      山下 公大
    • Organizer
      第121回日本外科学会定期学術集会
    • Related Report
      2021 Annual Research Report

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Published: 2019-04-18   Modified: 2024-12-25  

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