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Preservation of Pelvic Autonomic Nerve and Improvement of Postoperative Function Using 1064nm Near-Infrared Raman Spectroscopy

Research Project

Project/Area Number 19K09228
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 55020:Digestive surgery-related
Research InstitutionShowa University

Principal Investigator

Sato Sumito  昭和大学, 医学部, 兼任講師 (80769315)

Project Period (FY) 2019-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2021: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2020: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywordsラマン分光法 / 大腸癌 / 術後機能 / 自律神経 / ラマン分光 / 骨盤内腫瘍
Outline of Research at the Start

自律神経は、骨盤内に複雑に分布しており、悪性腫瘍等の手術において自律神経を確実に温存することは未だ困難である。自律神経を正確に視認し把握することは難しく、現在自律神経を正確に客観的に認識する技術が必要とされている。ラマン分光法は、物質に光を照射することで得られるスペクトルを分析し、非侵襲的に物質を迅速に同定する手法である。本研究の目的は、ラマン分光法を用いて、骨盤内の自律神経分布を客観的に把握し、神経損傷を回避することで、術後機能の改善につながる新しい手技を構築することにある。

Outline of Final Research Achievements

The objective of this research is to establish a technique to accurately and objectively recognize autonomic nerves, which are intricately distributed in the pelvic region, using Raman spectroscopy techniques. In this study, Raman spectroscopy, which can noninvasively and rapidly identify substances, was validated using fresh tissue samples of autonomic tissue and surrounding organs (cancer tissue, colon, bladder, prostate, uterus, ovary, and ureter) collected from surgical specimens, and the Raman spectra of autonomic tissue at 1309 cm-1, 1442 cm-1, and 1658 cm-1, and by using principal component analysis to compare the principal components extracted from the spectra of each tissue, we successfully discriminated the nerve tissue from the other organs.

Academic Significance and Societal Importance of the Research Achievements

手術の際に損傷するリスクがあり、骨盤内に複雑に分布したために、悪性腫瘍等の手術において確実に温存することが難しい自律神経は、個々により複雑に分布し、視認のみで把握は困難で神経染色などの試みが報告されるも臨床応用には至っていない。ラマン分光法を用いて骨盤内神経を迅速かつ非侵襲的に認識することができれば、臨床的に強力な手術支援ツールになり、その結果手術後に起こりうる術後の排尿障害、性機能障害のリスクを軽減できると考えている。

Report

(6 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (7 results)

All 2024 2023 2021

All Journal Article (4 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 4 results,  Open Access: 2 results) Presentation (3 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Clinical impact of a new method using a clear proctoscope to evaluate the therapeutic effect of sclerotherapy with aluminum potassium sulfate and tannic acid (ALTA) for internal hemorrhoids: a prospective cohort study2023

    • Author(s)
      Sato Sumito、Oga Junichi、Shirahata Atsushi、Ishida Yasuo
    • Journal Title

      Quantitative Imaging in Medicine and Surgery

      Volume: 13 Issue: 1 Pages: 441-448

    • DOI

      10.21037/qims-22-471

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Automated non-invasive identification of pelvic autonomic nerves with a handheld Raman spectrometer and potential application to nerve-sparing colorectal surgery: a preliminary study in surgical specimens2021

    • Author(s)
      Sato Sumito、Kagoshima Hirotada、Shiozawa Manabu、Nukada Suguru、Iguchi Kenta、Mikayama Yo、Oshima Takashi、Numata Masakatsu、Tamagawa Hiroshi、Rino Yasushi、Masuda Munetaka、Tanaka Kuniya
    • Journal Title

      Translational Cancer Research

      Volume: 10 Issue: 9 Pages: 3921-3929

    • DOI

      10.21037/tcr-21-587

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Preoperative Pre-albumin Concentration as a Predictor of Short-term Outcomes in Elderly Patients With Colorectal Cancer2021

    • Author(s)
      SATO SUMITO、SHIOZAWA MANABU、NUKADA SUGURU、IGUCHI KENTA、KAZAMA KEISUKE、ATSUMI YOSUKE、NUMATA MASAKATSU、TAMAGAWA HIROSHI、TANAKA KUNIYA、OSHIMA TAKASHI、RINO YASUSHI
    • Journal Title

      Anticancer Research

      Volume: 41 Issue: 10 Pages: 5195-5202

    • DOI

      10.21873/anticanres.15338

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Application and outcomes of a standardized lymphadenectomy in laparoscopic right hemicolectomy requiring ligation of the middle colic artery2021

    • Author(s)
      S Sato, N Sugano, M Shiozawa, M Uchiyama, K Kazama, A Kato, T Oshima, Y Rino, M Masuda
    • Journal Title

      Tech Coloproctol

      Volume: 25(2) Issue: 2 Pages: 223-227

    • DOI

      10.1007/s10151-020-02388-2

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] Laparoscopic Low Anterior Resection - Procedure, Tip, and Education2024

    • Author(s)
      Sumito Sato
    • Organizer
      THE MEDICAL SCIENTIFIC CONFERENCE UPDATE ON COLORECTAL CANCER TREATMENT
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ラマン分光法を用いた直腸周囲の自律神経同定と 新しい術後機能温存への試み2021

    • Author(s)
      佐藤純人 篭島宏匡 塩澤学 額田卓 井口健太 三箇山洋 大賀純一 白畑敦 沼田正勝 玉川洋 利野靖 田中邦哉
    • Organizer
      第76回 日本大腸肛門病学会学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] Automated non-invasive identification of pelvic autonomic nerves with a handheld Raman spectrometer and potential application to nerve-sparing colorectal surgery2021

    • Author(s)
      Sumito Sato, Hirotada Kagoshima, Manabu Shiozawa, Suguru Nukada, Kenta Iguchi, Yo Mikayama, Takashi Oshima, Masakatsu Numata, Hiroshi Tamagawa, Yasushi Rino, Munetaka Masuda, Kuniya Tanaka
    • Organizer
      APDW 2021
    • Related Report
      2021 Research-status Report

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Published: 2019-04-18   Modified: 2025-01-30  

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