A novel diagnostic approach for chronic lung allograft dysfunction after lung transplantation

• Project/Area Number: 19K09305
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 55040:Respiratory surgery-related
• Research Institution: Okayama University
• Principal Investigator: Sugimoto Seiichiro 岡山大学, 大学病院, 准教授 (40570148)
• Co-Investigator(Kenkyū-buntansha): 豊岡 伸一 岡山大学, 医歯薬学域, 教授 (30397880) ; 大藤 剛宏 岡山大学, 大学病院, 教授 (40452578)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2021: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 肺移植 / 慢性移植肺機能不全（CLAD） / 慢性腎臓病（CKD） / バイオマーカー / 個別化医療 / マイクロRNA / 一塩基多型（SNP） / ジャポニカアレイ / 慢性移植肺機能不全 / 一塩基多型 / 血中遊離DNA / リキッドバイオプシー / 拒絶反応 / 呼吸機能 / DNA

Outline of Research at the Start

肺移植後の慢性拒絶反応（CLAD）は肺移植後の長期生存を低下させる主な原因である。CLADは早期治療により増悪を防止できる場合があり、新しい早期診断法が必要とされている。我々は生体肺移植のドナーとレシピエントのDNAの違いから、レシピエント血中のドナー由来DNAを検出し、急性拒絶反応が診断できることを発見した。しかし、限られたDNAの解析では、DNAの類似性から診断が困難な場合があった。一方、ジャポニカアレイは多量のDNAを微量の検体から安価に解析できるため、本研究ではジャポニカアレイを用いて、レシピエント血中のドナー由来DNAを測定し、CLADの新しい早期診断法の開発を目指す。

Outline of Final Research Achievements

First, we investigated the role of circulating microRNAs in the diagnosis of chronic lung allograft dysfunction (CLAD) after bilateral lung transplantation (LT). Plasma levels of miR-21 were significantly higher in the CLAD group than in the non-CLAD group. The miR-21 levels were significantly correlated with the percent baseline value of the forced expiratory volume in 1 second, the forced vital capacity, and the total lung capacity at one year before and onset of CLAD. Circulating miR-21 were associated with the development of CLAD and appears to have the potential to detect CLAD after bilateral LT.
Next, we investigated single-nucleotide polymorphism (SNP) associated with renal dysfunction after LT using the SNP array for the Japanese population, Japonica Array NEO, comprising a total of 66,883 markers. Three SNPs, rs10277115, rs4690095 and rs792064 were associated with significant differences in the postoperative change of ΔeGFR and the development of renal dysfunction after LT.

Academic Significance and Societal Importance of the Research Achievements

肺移植後5年生存率は他の臓器移植よりも低く国際平均で約60％であり、肺移植の予後を改善するためには慢性期合併症の克服が鍵となる。慢性移植肺機能不全は肺移植後5年で約50％の肺移植患者に発症するが、本研究成果が新たな慢性移植肺機能不全の診断方法となる可能性がある。また、慢性腎臓病は肺移植後10年で約25％の肺移植患者に発症するが、本研究成果により、その発症を予測し個別化医療に応用できる可能性がある。

Research Products

• [Journal Article] Lung Transplantation for Bronchiectasis Due to Hyperimmunoglobulin E Syndrome (2022)
  • Author(s): Shimizu Dai、Otani Shinji、Sugimoto Seiichiro、Yamamoto Haruchika、Tomioka Yasuaki、Shiotani Toshio、Miyoshi Kentaroh、Okazaki Mikio、Yamane Masaomi、Toyooka Shinichi
  • Journal Title: The Annals of Thoracic Surgery Volume: 113 Issue: 4 Pages: e251-e253
  • DOI: 10.1016/j.athoracsur.2021.05.088
  • Peer Reviewed
• [Journal Article] Acute Pulmonary Edema Due to Arteriovenous Shunt Placement after Lung Transplant (2022)
  • Author(s): Shimizu Dai、Miyoshi Kentaroh、Sugimoto Seiichiro、Toma Tomoko、Matsuda Yusuke、Tomioka Yasuaki、Shiotani Toshio、Otani Shinji、Yamane Masaomi、Toyooka Shinichi
  • Journal Title: The Annals of Thoracic Surgery Volume: - Issue: 4 Pages: e245-e247
  • DOI: 10.1016/j.athoracsur.2021.12.017
  • Peer Reviewed
• [Journal Article] Paediatric lung transplantation: the impact of age on the survival (2022)
  • Author(s): Otani Shinji、Yamamoto Haruchika、Tanaka Shin、Tomioka Yasuaki、Matsubara Kei、Shimizu Dai、Shiotani Toshio、Suzawa Ken、Miyoshi Kentaroh、Yamamoto Hiromasa、Okazaki Mikio、Sugimoto Seiichiro、Yamane Masaomi、Toyooka Shinichi
  • Journal Title: Surgery Today Volume: - Issue: 11 Pages: 1540-1550
  • DOI: 10.1007/s00595-022-02492-w
  • Peer Reviewed
• [Journal Article] 生体肺移植後の慢性移植肺機能不全（CLAD） (2022)
  • Author(s): 杉本誠一郎、田中 真、三好健太郎、豊岡伸一
  • Journal Title: 胸部外科 Volume: 75 Pages: 297-301
• [Journal Article] “Hybrid Lung Transplantation” Combining Living Donor and Cadaveric Lung Transplants: Report of 2 Cases (2021)
  • Author(s): Kurosaki Takeshi、Oto Takahiro、Otani Shinji、Miyoshi Kentaroh、Sugimoto Seiichiro、Yamane Masaomi、Toyooka Shinichi
  • Journal Title: Transplantation Proceedings Volume: 53 Issue: 6 Pages: 2004-2007
  • DOI: 10.1016/j.transproceed.2021.04.019
  • Peer Reviewed
• [Journal Article] Emphysematous changes and lower levels of plasma irisin are associated with bronchiolitis obliterans syndrome after bilateral living-donor lobar lung transplantation (2021)
  • Author(s): Shiotani Toshio、Sugimoto Seiichiro、Yamamoto Haruchika、Miyoshi Kentaroh、Otani Shinji、Suzawa Ken、Yamamoto Hiromasa、Okazaki Mikio、Yamane Masaomi、Toyooka Shinichi
  • Journal Title: Surgery Today Volume: 52 Issue: 2 Pages: 294-305
  • DOI: 10.1007/s00595-021-02339-w
  • Peer Reviewed
• [Journal Article] Protective effects of anti-HMGB1 monoclonal antibody on lung ischemia reperfusion injury in mice (2021)
  • Author(s): Nakata Kentaro、Okazaki Mikio、Shimizu Dai、Suzawa Ken、Shien Kazuhiko、Miyoshi Kentaroh、Otani Shinji、Yamamoto Hiromasa、Sugimoto Seiichiro、Yamane Masaomi、Ousaka Daiki、Ohara Toshiaki、Matsukawa Akihiro、Nishibori Masahiro、Toyooka Shinichi
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 573 Pages: 164-170
  • DOI: 10.1016/j.bbrc.2021.08.015
  • Peer Reviewed / Open Access
• [Journal Article] Lung transplantation for idiopathic multicentric Castleman disease: potential efficacy and tolerability of a humanized anti-interleukin-6 receptor monoclonal antibody (2021)
  • Author(s): Tomioka Yasuaki、Otani Shinji、Tanaka Shin、Shien Kazuhiko、Suzawa Ken、Miyoshi Kentaroh、Yamamoto Hiromasa、Okazaki Mikio、Sugimoto Seiichiro、Yamane Masaomi、Toyooka Shinichi
  • Journal Title: Surgical Case Reports Volume: 7 Issue: 1
  • DOI: 10.1186/s40792-021-01297-2
  • Peer Reviewed / Open Access
• [Journal Article] Effect of preoperative long-term use of corticosteroids on the development of post-transplant lymphoproliferative disorders after lung transplantation: a single-center experience in Japan (2021)
  • Author(s): Shimizu Dai、Otani Shinji、Sugimoto Seiichiro、Yamamoto Haruchika、Tomioka Yasuaki、Shiotani Toshio、Miyoshi Kentaroh、Okazaki Mikio、Yamane Masaomi、Toyooka Shinichi
  • Journal Title: Surgery Today Volume: 52 Issue: 4 Pages: 697-704
  • DOI: 10.1007/s00595-021-02390-7
  • Peer Reviewed
• [Journal Article] Meticulous closure of collateral vessels in the perihilar mediastinal pleura to control intraoperative bleeding during lung transplantation for pulmonary hypertension (2021)
  • Author(s): Yamamoto Haruchika、Sugimoto Seiichiro、Imanishi Kentaro、Hashimoto Kohei、Miyoshi Kentaroh、Otani Shinji、Yamane Masaomi、Toyooka Shinichi
  • Journal Title: Journal of Thoracic Disease Volume: 13 Issue: 10 Pages: 5658-5669
  • DOI: 10.21037/jtd-21-1119
  • NAID: 120007175402
  • Peer Reviewed / Open Access
• [Journal Article] Long-term outcomes of living-donor lobar lung transplantation (2021)
  • Author(s): Sugimoto Seiichiro、Date Hiroshi、Miyoshi Kentaroh、Otani Shinji、Ishihara Megumi、Yamane Masaomi、Toyooka Shinichi
  • Journal Title: The Journal of Thoracic and Cardiovascular Surgery Volume: - Issue: 2 Pages: 440-448
  • DOI: 10.1016/j.jtcvs.2021.08.090
  • Peer Reviewed
• [Journal Article] Lung transplantation for Kartagener syndrome: technical aspects and morphological adaptation of the transplanted lungs (2021)
  • Author(s): Yamamoto H, Sugimoto S, Miyoshi K, Otani S, Yamane M, Toyooka S.
  • Journal Title: Gen Thorac Cardiovasc Surg Volume: 69 Issue: 3 Pages: 588-592
  • DOI: 10.1007/s11748-020-01509-w
  • NAID: 120007161127
  • Peer Reviewed
• [Journal Article] Long-term clinical follow-up after lung transplantation in patient with scoliosis: a case report. (2021)
  • Author(s): Yamamoto H, Otani S, Miyoshi K, Sugimoto S, Yamane M, Toyooka S.
  • Journal Title: Gen Thorac Cardiovasc Surg Volume: 69 Issue: 4 Pages: 752-755
  • DOI: 10.1007/s11748-020-01539-4
  • Peer Reviewed
• [Journal Article] The prognostic nutritional index is correlated negatively with the lung allocation score and predicts survival after both cadaveric and living-donor lobar lung transplantation. (2021)
  • Author(s): Yamamoto H, Sugimoto S, Soh J, Shiotani T, Miyoshi K, Otani S, Okazaki M, Yamane M, Toyooka S.
  • Journal Title: Surg Today Volume: ー Issue: 10 Pages: 1610-1618
  • DOI: 10.1007/s00595-021-02244-2
  • NAID: 120007192331
  • Peer Reviewed
• [Journal Article] Long-term Follow-up of Living-Donor Kidney Transplantation after Cadaveric Lung Transplantation (2021)
  • Author(s): Shiotani T, Sugimoto S, Araki K, Tomioka Y, Miyoshi K, Otani S, Yamane M, Toyooka S.
  • Journal Title: Acta Medica Okayama Volume: 75 Issue: 1 Pages: 87-89
  • DOI: 10.18926/AMO/61439
  • NAID: 120006980487
  • URL: https://ousar.lib.okayama-u.ac.jp/61439
  • Peer Reviewed / Open Access
• [Journal Article] Circulating anti-human leukocyte antigen IgM antibodies as a potential early predictor of allograft rejection and a negative clinical outcome after lung transplantation. (2021)
  • Author(s): Miyahara K, Miyoshi K, Kurosaki T, Otani S, Sugimoto S, Yamane M, Toyooka S.
  • Journal Title: Surg Today Volume: ー Issue: 1 Pages: 52-60
  • DOI: 10.1007/s00595-021-02293-7
  • Peer Reviewed
• [Journal Article] Lung perfusion scintigraphy to detect chronic lung allograft dysfunction after living-donor lobar lung transplantation (2020)
  • Author(s): Yamamoto H, Sugimoto S, Kurosaki T, Miyoshi K, Otani S, Okazaki M, Yamane M, Oto T, Toyooka S.
  • Journal Title: Sci Rep Volume: 10 Issue: 1 Pages: 10595-10595
  • DOI: 10.1038/s41598-020-67433-4
  • NAID: 120006872422
  • Peer Reviewed / Open Access
• [Journal Article] Right single lung transplantation using an inverted left donor lung: interposition of pericardial conduit for pulmonary venous anastomosis - a case report (2020)
  • Author(s): Yamamoto Haruchika、Miyoshi Kentaroh、Otani Shinji、Kurosaki Takeshi、Sugimoto Seiichiro、Yamane Masaomi、Toyooka Shinichi、Kobayashi Motomu、Oto Takahiro
  • Journal Title: BMC Pulmonary Medicine Volume: 20 Issue: 1 Pages: 46-46
  • DOI: 10.1186/s12890-020-1075-4
  • NAID: 120006826003
  • Peer Reviewed / Open Access
• [Journal Article] Pulmonary aspergillosis as a late complication after surgery for locally advanced non-small cell lung cancer treated with induction chemoradiotherapy (2020)
  • Author(s): Sugimoto S, Soh J, Suzawa K, Miyoshi K, Otani S, Yamamoto H, Okazaki M, Yamane M, Oto T, Kanazawa S, Kiura K, Toyooka S
  • Journal Title: Surg Today Volume: － Issue: 8 Pages: 863-871
  • DOI: 10.1007/s00595-020-01960-5
  • NAID: 120007004787
  • Peer Reviewed
• [Journal Article] Warm retrograde perfusion can remove more fat from lung grafts with fat embolism in a porcine model (2020)
  • Author(s): Irie M, Otani S, Kurosaki T, Tanaka S, Ohki T, Miyoshi K, Sugimoto S, Yamane M, Oto T, Toyooka S
  • Journal Title: Gen Thorac Cardiovasc Surg Volume: 68 Issue: 4 Pages: 363-369
  • DOI: 10.1007/s11748-019-01245-w
  • Peer Reviewed
• [Journal Article] Prolonged warm ischemia exacerbated acute rejection after lung transplantation from donation after cardiac death in a mouse (2020)
  • Author(s): Hirano Y, Sugimoto S, Yamamoto S, Okada M, Otani S, Ohara T, Yamane M, Matsukawa A, Oto T, Toyooka S
  • Journal Title: Gen Thorac Cardiovasc Surg Volume: 68 Issue: 1 Pages: 57-62
  • DOI: 10.1007/s11748-019-01181-9
  • NAID: 120006875375
  • Peer Reviewed
• [Journal Article] Airway bacteria of the recipient but not the donor are relevant to post-lung transplant pneumonia (2019)
  • Author(s): Konishi Y, Miyoshi K, Kurosaki T, Otani S, Sugimoto S, Yamane M, Oto T, Toyooka S
  • Journal Title: Gen Thorac Cardiovasc Surg Volume: － Issue: 8 Pages: 833-840
  • DOI: 10.1007/s11748-019-01273-6
  • Peer Reviewed
• [Journal Article] Favorable survival even with high disease‐specific complication rates in lymphangioleiomyomatosis after lung transplantation?long‐term follow‐up of a Japanese center (2019)
  • Author(s): Kurosaki Takeshi、Otani Shinji、Miyoshi Kentaroh、Okazaki Mikio、Sugimoto Seiichiro、Suno Manabu、Yamane Masaomi、Kobayashi Motomu、Oto Takahiro、Toyooka Shinichi
  • Journal Title: The Clinical Respiratory Journal Volume: 14 Issue: 2 Pages: 116-123
  • DOI: 10.1111/crj.13108
  • Peer Reviewed
• [Journal Article] Negative impact of recipient SPRED2 deficiency on transplanted lung in a mouse model (2019)
  • Author(s): Hashimoto Kohei、Yamane Masaomi、Sugimoto Seiichiro、Hirano Yutaka、Kurosaki Takeshi、Otani Shinji、Miyoshi Kentaroh、Ohara Toshiaki、Okazaki Mikio、Yoshimura Teizo、Oto Takahiro、Matsukawa Akihiro、Toyooka Shinichi
  • Journal Title: Transplant Immunology Volume: 57 Pages: 101242-101242
  • DOI: 10.1016/j.trim.2019.101242
  • Peer Reviewed
• [Journal Article] Impact of chronic lung allograft dysfunction, especially restrictive allograft syndrome, on the survival after living-donor lobar lung transplantation compared with cadaveric lung transplantation in adults: a single-center experience (2019)
  • Author(s): Sugimoto S, Yamamoto H, Kurosaki T, Otani S, Okazaki M, Yamane M, Toyooka S, Oto T
  • Journal Title: Surg Today Volume: 49 Issue: 8 Pages: 686-693
  • DOI: 10.1007/s00595-019-01782-0
  • NAID: 120006797356
  • Peer Reviewed
• [Journal Article] Lung transplantation via cardiopulmonary bypass: excellent survival outcomes from extended criteria donors (2019)
  • Author(s): Taka H, Miyoshi K, Kurosaki T, Douguchi T, Itoh H, Sugimoto S, Yamane M, Kobayashi M, Kasahara S, Oto T
  • Journal Title: Gen Thorac Cardiovasc Surg Volume: 67 Issue: 7 Pages: 624-632
  • DOI: 10.1007/s11748-019-01067-w
  • Peer Reviewed
• [Journal Article] SOCS3 overexpression in T cells ameliorates chronic airway obstruction in a murine heterotopic tracheal transplantation model. (2019)
  • Author(s): Mesaki K, Yamane M, Sugimoto S, Fujisawa M, Yoshimura T, Kurosaki T, Otani S, Oto S, Matsukawa A, Toyooka S
  • Journal Title: Surgery Today Volume: 49(5) Issue: 5 Pages: 443-450
  • DOI: 10.1007/s00595-018-1753-5
  • Peer Reviewed
• [Journal Article] Lung transplant candidates with idiopathic pulmonary fibrosis and long-term pirfenidone therapy: Treatment feasibility influences waitlist survival (2019)
  • Author(s): Tanaka Shin、Miyoshi Kentaroh、Higo Hisao、Kurosaki Takeshi、Otani Shinji、Sugimoto Seiichiro、Yamane Masaomi、Kiura Katsuyuki、Toyooka Shinichi、Oto Takahiro
  • Journal Title: Respiratory Investigation Volume: 57 Issue: 2 Pages: 165-171
  • DOI: 10.1016/j.resinv.2018.12.002
  • Peer Reviewed
• [Presentation] Pediatric Lung Transplantation－Intermediate Outcomes of a Japanese Center (2021)
  • Author(s): S. Otani, Y. Tomioka, K. Matsubara, D. Shimizu, H. Yamamoto, T. Shiotani, K. Suzawa, K. Miyoshi, H. Yamamoto, M. Okazaki, S. Sugimoto, M. Yamane, S. Toyooka
  • Organizer: The International Society for Heart and Lung Transplantation 41st Annual Meeting and Scientific Sessions
  • Int'l Joint Research
• [Presentation] Post-Transplant Lymphoproliferative Disorder in Lung Transplantation: A Single-Center Experience in Japan (2021)
  • Author(s): D. Shimizu, S. Otani, Y. Tomioka, T. Shiotani, H. Yamamoto, K. Miyoshi, M. Okazaki, S. Sugimoto, M. Yamane, S. Toyooka
  • Organizer: The International Society for Heart and Lung Transplantation 41st Annual Meeting and Scientific Sessions
  • Int'l Joint Research
• [Presentation] Risk Assessment of Chronic Lung Allograft Dysfunction Phenotypes after Living-Donor Lobar Lung Transplantation According to the 2019 ISHLT Classification System (2021)
  • Author(s): K. Matsubara, S. Otani, D. Shimizu, Y. Tomioka, T. Shiotani, H. Yamamoto, K. Miyoshi, M. Okazaki, S. Sugimoto, M. Yamane, S. Toyooka
  • Organizer: The International Society for Heart and Lung Transplantation 41st Annual Meeting and Scientific Sessions
  • Int'l Joint Research
• [Presentation] Anti-HMGB1 Monoclonal Antibody Ameliorates Lung Ischemia Reperfusion Injury in Mice (2021)
  • Author(s): K. Nakata, M. Okazaki, S. Sugimoto, M. Yamane, S. Toyooka
  • Organizer: The International Society for Heart and Lung Transplantation 41st Annual Meeting and Scientific Sessions
  • Int'l Joint Research
• [Presentation] The UNCX Polymorphism is Associated with the Development of Renal Dysfunction after Lung Transplantation (2021)
  • Author(s): Y. Tomioka, S. Sugimoto, K. Matsubara, D. Shimizu, H. Yamamoto, T. Shiotani, K. Miyoshi, S. Ohtani, M. Okazaki, M. Yamane, S. Toyooka
  • Organizer: The International Society for Heart and Lung Transplantation 41st Annual Meeting and Scientific Sessions
  • Int'l Joint Research
• [Presentation] Plasma Levels of Histidine-Rich Glycoprotein are Associated with the Development of Primary Graft Dysfunction after Lung Transplantation (2021)
  • Author(s): T. Shiotani, S. Sugimoto, H. Yamamoto, K. Matsubara, D. Shimizu, K. Nakata, Y. Tomioka, K. Miyoshi, S. Otani, M. Okazaki, M. Yamane, S. Toyooka
  • Organizer: The International Society for Heart and Lung Transplantation 41st Annual Meeting and Scientific Sessions
  • Int'l Joint Research
• [Presentation] Combination of Neutrophil to Lymphocyte Ratio and Glasgow Prognostic Score Improves Prognostic Accuracy in Lung Transplantation: Validation of 9 Preoperative Prognostic Scoring Methods (2021)
  • Author(s): H. Yamamoto, S. Sugimoto, E. Suzuki, Y. Tomioka, T. Shiotani, D. Shimizu, K. Matsubara, K. Miyoshi, S. Otani, M. Okazaki, M. Yamane, S. Toyooka
  • Organizer: The International Society for Heart and Lung Transplantation 41st Annual Meeting and Scientific Sessions
  • Int'l Joint Research
• [Presentation] 当院における小児肺移植の成績 (2021)
  • Author(s): 大谷 真二, 富岡 泰章, 松原 慧, 清水 大, 山本 治慎, 塩谷 俊雄, 諏澤 憲, 三好 健太郎, 山本 寛斉, 岡崎 幹生, 杉本 誠一郎, 山根 正修, 豊岡 伸一
  • Organizer: 第121回日本外科学会定期学術集会
• [Presentation] 肺移植における予後改善に向けての取組 生体肺移植と脳死肺移植の違いに着目した慢性移植肺機能不全(CLAD)の早期診断を目指した取り組み (2021)
  • Author(s): 杉本 誠一郎, 塩谷 俊雄, 山本 治慎, 富岡 泰章, 諏澤 憲, 三好 健太郎, 大谷 真二, 山本 寛斉, 岡崎 幹生, 山根 正修, 豊岡 伸一
  • Organizer: 第38回日本呼吸器外科学会学術集会
• [Presentation] UNCX遺伝子多型と肺移植後の腎機能障害との関係 (2021)
  • Author(s): 富岡 泰章, 杉本 誠一郎, 山本 治慎, 清水 大, 松原 慧, 塩谷 俊雄, 諏澤 憲, 三好 健太郎, 大谷 真二, 山本 寛斉, 岡崎 幹生, 山根 正修, 豊岡 伸一
  • Organizer: 第38回日本呼吸器外科学会学術集会
• [Presentation] 肺移植患者の周術期におけるClostridioides difficile感染症の検討 (2021)
  • Author(s): 坂田 龍平, 大谷 真二, 石上 恵美, 石原 恵, 土生 智大, 岩田 一馬, 久保 友次郎, 松田 直樹, 清水 大, 松原 慧, 富岡 泰章, 山本 治慎, 塩谷 俊雄, 三好 健太郎, 岡崎 幹生, 杉本 誠一郎, 山根 正修, 豊岡 伸一
  • Organizer: 第38回日本呼吸器外科学会学術集会
• [Presentation] 肺移植後移植片慢性機能不全におけるGoddard scoreの検討 (2021)
  • Author(s): 塩谷 俊雄, 杉本 誠一郎, 山本 治慎, 富岡 泰章, 諏澤 憲, 三好 健太郎, 大谷 真二, 山本 寛斉, 岡崎 幹生, 山根 正修, 豊岡 伸一
  • Organizer: 第38回日本呼吸器外科学会学術集会
• [Presentation] 肺移植における最適な術前予後予測スコアリング法 9つの術前予後予測スコアリング法の検証から (2021)
  • Author(s): 山本 治慎, 杉本 誠一郎, 富岡 泰章, 塩谷 俊雄, 清水 大, 松原 慧, 三好 健太郎, 大谷 真二, 岡崎 幹生, 山根 正修, 豊岡 伸一
  • Organizer: 第38回日本呼吸器外科学会学術集会
• [Presentation] 生体肺移植後と脳死肺移植後の慢性移植肺機能不全（CLAD）の比較 (2021)
  • Author(s): 杉本誠一郎, 三好健太郎, 田中 真, 富岡 泰章, 枝園 和彦, 諏澤 憲, 山本 寛斉, 岡崎 幹生, 山根 正修, 豊岡 伸一
  • Organizer: 第59回日本肺癌学会 中国・四国支部学術集会
• [Presentation] びまん性汎細気管支炎に対する肺移植後の慢性期管理と長期成績 (2021)
  • Author(s): 杉本 誠一郎, 三好 健太郎, 田中 真, 富岡 泰章, 石原 恵, 石上 恵美, 諏澤 憲, 枝園 和彦, 山本 寛斉, 岡崎 幹生, 山根 正修, 豊岡 伸一
  • Organizer: 第57回日本移植学会総会
• [Presentation] 肺移植後の慢性腎臓病に対して血液透析を導入した症例の検討 (2021)
  • Author(s): 富岡 泰章, 杉本 誠一郎, 川名 伸一, 久保 友次郎, 清水 大, 松原 慧, 田中 真, 枝園 和彦, 諏澤 憲, 三好 健太郎, 山本 寛斉, 岡崎 幹生, 山根 正, 豊岡 伸一
  • Organizer: 第57回日本移植学会総会
• [Presentation] 生体肺移植後CLADにおける2019年ISHLT新基準にもとづく予後評価 (2021)
  • Author(s): 松原 慧, 三好 健太郎, 大谷 真二, 川名 伸一, 久保 友次郎, 清水 大, 富岡 泰章, 田中 真, 岡崎 幹生, 杉本 誠一郎, 山根 正修, 豊岡 伸一
  • Organizer: 第57回日本移植学会総会
• [Presentation] マウス異所性気管移植モデルを用いたS100A8/A9抗体の慢性移植肺機能不全に対する効果の検討 (2021)
  • Author(s): 清水 大, 岡崎 幹生, 木下 理恵, 中田 憲太郎, 三好 健太郎, 大谷 真二, 杉本 誠一郎, 山根 正修, 阪口 政清, 豊岡 伸一
  • Organizer: 第57回日本移植学会総会
• [Presentation] Clostridioides difficile感染症診療ガイドライン作成に伴う当院での肺移植周術期の検討 (2021)
  • Author(s): 久保 友次郎, 田中 真, 石上 恵美, 石原 恵, 坂田 龍平, 富岡 泰章, 枝園 和彦, 諏澤 憲, 大谷 真二, 山本 寛斉, 三好 健太郎, 岡崎 幹生, 杉本 誠一郎, 山根 正修, 豊岡 伸一
  • Organizer: 第57回日本移植学会総会
• [Presentation] 血漿Histidine-rich glycoprotein 濃度と肺移植後一時移植機能不全との関係 (2021)
  • Author(s): 塩谷俊雄, 杉本誠一郎, 富岡泰章, 田中真, 諏澤憲, 枝園和彦, 三好健太郎, 山本寛斉, 岡崎幹生, 山根正修, 豊岡伸一
  • Organizer: 第74回日本胸部外科学会定期学術集会
• [Presentation] 片肺移植における二次性肺高血圧の影響～当院 の片側脳死肺移植症例の検討から～ (2021)
  • Author(s): 清水大, 三好健太郎, 杉本誠一郎, 久保友次郎, 川名伸一, 富岡泰章, 松原慧, 田中真, 岡崎幹生, 山根正修, 豊岡伸一
  • Organizer: 第74回日本胸部外科学会定期学術集会
• [Presentation] 肺移植から学ぶゲノム医療 (2020)
  • Author(s): 杉本誠一郎、塩谷俊雄、山本治慎、田中 真、諏澤 憲、三好健太郎、大谷真二、山本寛斉、岡崎幹生、山根正修、大藤剛宏、豊岡伸一
  • Organizer: 第37回日本呼吸器外科学会学術集会
• [Presentation] 肺移植におけるLiquid biopsy：ドナー由来血中遊離DNAとマイクロRNA (2020)
  • Author(s): 杉本誠一郎、塩谷俊雄、富岡泰章、諏澤 憲、三好健太郎、大谷真二、山本寛斉、岡崎幹生、山根正修、豊岡伸一
  • Organizer: 第56回日本移植学会総会
• [Presentation] 高度無気肺を合併したドナー肺による移植成績 (2020)
  • Author(s): 塩谷俊雄、杉本誠一郎、山本治慎、諏澤憲、三好健太郎、大谷真二、山本寛斉、岡崎幹生、山根正修、大藤剛宏、豊岡伸一
  • Organizer: 第37回日本呼吸器外科学会学術集会
• [Presentation] 当院の肺移植後リンパ増殖性疾患7例の検討～治療後のCLAD 発症と日和見感染症による死亡をどう防ぐか～ (2020)
  • Author(s): 清水 大、大谷真二、富岡泰章、松原 慧、塩谷俊雄、山本治慎、三好健太郎、岡崎幹生、杉本誠一郎、山根正修、豊岡伸一
  • Organizer: 第56回日本移植学会総会
• [Presentation] 当院における高齢者レシピエント症例の検討 (2020)
  • Author(s): 富岡泰章、大谷真二、清水 大、松原 慧、山本治慎、塩谷俊雄、三好健太郎、岡崎幹生、杉本誠一郎、山根正修、豊岡伸一
  • Organizer: 第56回日本移植学会総会
• [Presentation] 肺移植待機患者の予後予測におけるPrognostic Nutrition Index(PNI)の有用性 (2020)
  • Author(s): 松原 慧、大谷真二、清水 大、富岡泰章、山本治慎、塩谷俊雄、三好健太郎、岡崎幹生、杉本誠一郎、山根正修、豊岡伸一
  • Organizer: 第56回日本移植学会総会
• [Presentation] 肺移植における無気肺ドナーからの臓器保護的肺摘出法 (2020)
  • Author(s): 二萬英斗、三好健太郎、塩谷俊雄、山本治慎、黒崎毅史、大谷真二、岡崎幹生、杉本誠一郎、山根正修、豊岡伸一
  • Organizer: 第73回日本胸部外科学会定期学術集会
• [Presentation] 抗胸腺細胞グロブリンをfirst lineとした肺移植後急性期抗体関連拒絶反応の治療成績 (2020)
  • Author(s): 三好健太郎、大谷真二、杉本誠一郎、富岡泰章、塩谷俊雄、黒崎毅史、諏澤 憲、山本寛斎、岡崎幹生、山根正修、豊岡伸一
  • Organizer: 第73回日本胸部外科学会定期学術集会
• [Presentation] 抗HMGB1抗体による肺虚血再灌流障害の抑制 (2020)
  • Author(s): 中田憲太郎、岡崎幹生、清水 大、宮内俊作、荒木恒太、三浦章博、塩谷俊雄、諏澤 憲、三好健太郎、大谷真二、山本寛斉、杉本誠一郎、山根正修、大藤剛弘、豊岡伸一
  • Organizer: 第37回日本呼吸器外科学会学術集会
• [Presentation] Plasma micro-RNA Levels are Associated with the Development of Chronic Lung Allograft Dysfunction after Bilateral Living-Donor and Cadaveric Lung Transplantation (2020)
  • Author(s): Shiotani T, Sugimoto S, Yamamoto H, Shimizu D, Miyoshi K, Otani S, Okazaki M, Yamane M, Oto T, Toyooka S
  • Organizer: The International Society for Heart and Lung Transplantation 40th Annual Meeting and Scientific Sessions
  • Int'l Joint Research
• [Presentation] Prognostic Nutritional Index Negatively Correlates with Lung Allocation Score and Predicts Survival after Both Cadaveric and Living-Donor Lobar Lung Transplantation (2020)
  • Author(s): Yamamoto H, Sugimoto S, Shiotani T, Miyoshi K, Otani S, Okazaki M, Yamane M, Oto T, Toyooka S
  • Organizer: The International Society for Heart and Lung Transplantation 40th Annual Meeting and Scientific Sessions
  • Int'l Joint Research
• [Presentation] Differences in onset of chronic lung allograft dysfunction between living donor and cadaveric lung transplantation (2019)
  • Author(s): Sugimoto S, Yamamoto H, Kurosaki T, Otani S, Okazaki M, Yamane M, Toyooka S, Oto T
  • Organizer: The International Society for Heart and Lung Transplantation 39th Annual Meeting and Scientific Sessions
  • Int'l Joint Research
• [Presentation] 高度の胸膜癒着を認めたレシピエントに対する肺移植 (2019)
  • Author(s): 杉本誠一郎、塩谷俊雄、山本治慎、大河知世、三好健太郎、大谷真二、岡崎幹生、山根正修、大藤剛宏、豊岡伸一
  • Organizer: 第35回日本移植学会総会
• [Presentation] 感染性肺疾患に対する肺移植の長期成績 (2019)
  • Author(s): 杉本誠一郎，黒崎毅史，大谷真二，枝園和彦，山本寛斉，岡崎幹生，宗 淳一，山根正修，豊岡伸一，大藤剛宏
  • Organizer: 第36回日本呼吸器外科学会学術集会
• [Presentation] 肺移植に対するゲノム医療の応用 (2019)
  • Author(s): 杉本誠一郎，山本治慎，田中 真，諏澤 憲，黒崎毅史，枝園和彦，大谷真二，山本寛斉，岡崎幹生，宗 淳一，山根正修，大藤剛宏，豊岡伸一
  • Organizer: 第119回日本外科学会定期学術集会
• [Presentation] 生体・脳死肺移植における予後予測因子としてのPrognostic Nutrition Index (PNI)の有用性 (2019)
  • Author(s): 山本治慎、杉本誠一郎、塩谷俊雄、三好健太郎、大谷真二、岡崎幹生、山根正修、大藤剛宏、豊岡伸一
  • Organizer: 第35回日本移植学会総会
• [Presentation] 肺移植後移植片慢性機能不全(CLAD)における血中micro-RNA発現量の検討 (2019)
  • Author(s): 塩谷俊雄，杉本誠一郎，山本治慎，二萬英斗，三好健太郎，大谷真二，岡崎幹生，山根正修，大藤剛宏，豊岡伸一
  • Organizer: 第35回日本移植学会総会
• [Presentation] 生体肺移植後慢性拒絶反応と血中Irisin濃度の関係 (2019)
  • Author(s): 塩谷俊雄，杉本誠一郎，山本治慎，黒崎毅史，枝園和彦，大谷真二，山本寛斉，岡崎幹生，宗 淳一，山根正修，大藤剛宏，豊岡伸一
  • Organizer: 第36回日本呼吸器外科学会学術集会
• [Presentation] 両側生体肺移植後のChronic Lung Allograft Dysfunction の早期診断：肺血流シンチグラフィーの可能性 (2019)
  • Author(s): 山本治慎、杉本誠一郎、黒崎毅史、大谷真二、岡崎幹生、山根正修、豊岡伸一、大藤剛宏
  • Organizer: 第36回日本呼吸器外科学会学術集会
• [Presentation] Early Shift of Lung Perfusion to the Unilateral Lung Predicts the Development of Unilateral Chronic Lung Allograft Dysfunction after Bilateral Living-Donor Lobar Lung Transplantation (2019)
  • Author(s): Yamamoto H, Sugimoto S, Kurosaki T, Otani S, Okazaki M, Yamane M, Toyooka S, Oto T
  • Organizer: The International Society for Heart and Lung Transplantation 39th Annual Meeting and Scientific Sessions
  • Int'l Joint Research
• [Presentation] Decreased Serum Levels of Irisin are Associated with the Development of Chronic Lung Allograft Dysfunction after Bilateral Living-Donor Lobar Lung Transplantation (2019)
  • Author(s): Shiotani T, Sugimoto S, Yamamoto H, Kurosaki T, Otani S, Okazaki M, Yamane M, Toyooka S, Oto T
  • Organizer: The International Society for Heart and Lung Transplantation 39th Annual Meeting and Scientific Sessions
  • Int'l Joint Research