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Elucidation of spinal mechanism of chronic myalgia using novel in vivo patch clamp method and search for therapeutic agents.

Research Project

Project/Area Number 19K09323
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 55050:Anesthesiology-related
Research InstitutionUniversity of Toyama

Principal Investigator

Uta Daiuek  富山大学, 学術研究部薬学・和漢系, 准教授 (70598416)

Co-Investigator(Kenkyū-buntansha) 田口 徹  新潟医療福祉大学, リハビリテーション学部, 教授 (90464156)
Project Period (FY) 2019-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2021: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords線維筋痛症 / 電気生理学 / 痛み / 脊髄後角 / in vivoパッチクランプ / シナプス伝達 / in vivo記録 / ニューロン / 筋膜性疼痛 / in vivo patch clamp / fibromyalgia / spinal dorsal horn / 筋 / pain / electrophysiology / 慢性疼痛 / chronic myalgia / spinal cord
Outline of Research at the Start

本研究では、線維筋痛症(FM)や筋・筋膜性疼痛(MPS)などの「慢性難治性筋痛疾患」の脊髄機構の全容解明とその有効薬物の同定を目的とする。その為に、①筋痛の脊髄情報伝達機構を可能にする新規in vivoパッチクランプ法の開発、②電気生理・行動薬理・生化学的解析法を駆使した治療薬の探索を行う。本研究により、慢性難治性筋痛疾患の脊髄機構の全容を明らかにし、新規治療薬開発への道筋を切り開く。

Outline of Final Research Achievements

We examined the activities of superficial dorsal horn (SDH) neurons, as well as excitatory and inhibitory postsynaptic inputs to SDH neurons, using a putative rat model of fibromyalgia that was established by injecting reserpine. Extracellular recordings in vivo revealed that SDH neurons were sensitized to mechanical stimulation applied to the neurons' receptive fields, and the mechanically sensitized neurons were spontaneously more active. Using patch-clamp recordings in vivo, spontaneous excitatory synaptic responses to SDH neurons were found to increase in the pain model. These results demonstrate that the SDH neurons were strongly sensitized in response to the reserpine treatment, and that increased excitatory postsynaptic inputs could be responsible for the spinal nociceptive hypersensitivity in the putative FM model.

Academic Significance and Societal Importance of the Research Achievements

本研究により、これまで国内外で全く行われていなかった筋痛時における脊髄後角での神経機構の変容の一端を解明することが出来た。また本研究で用いた技術は世界初のものであり、今後の生理学的意義も非常に大きい。また、得られた成果をもとに、今後筋痛覚過敏に対する治療薬開発のための分子ターゲットの発見に期待が持てるとともに、まだ不明点の多い線維筋痛症の病態メカニズム解明に貢献できるものと思われる。

Report

(6 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (171 results)

All 2024 2023 2022 2021 2020 2019 Other

All Journal Article (45 results) (of which Int'l Joint Research: 8 results,  Peer Reviewed: 45 results,  Open Access: 34 results) Presentation (118 results) (of which Int'l Joint Research: 21 results,  Invited: 6 results) Book (1 results) Remarks (7 results)

  • [Journal Article] Combined Experiments with <i>in Vivo</i> Fiber Photometry and Behavior Tests Can Facilitate the Measurement of Neuronal Activity in the Primary Somatosensory Cortex and Hyperalgesia in an Inflammatory Pain Mice Model2024

    • Author(s)
      Ishikawa Tatsuya、Uta Daisuke、Okuda Hiroaki、Potapenko Ilia、Hori Kiyomi、Kume Toshiaki、Ozaki Noriyuki
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 47 Issue: 3 Pages: 591-599

    • DOI

      10.1248/bpb.b23-00700

    • ISSN
      0918-6158, 1347-5215
    • Year and Date
      2024-03-05
    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Study of Analgesic Effects of Laser Irradiation in Rats2024

    • Author(s)
      Ishibashi Naoya、Uta Daisuke
    • Journal Title

      The Journal of Japan Society for Laser Surgery and Medicine

      Volume: 44 Issue: 4 Pages: 350-359

    • DOI

      10.2530/jslsm.jslsm-44_0045

    • ISSN
      0288-6200, 1881-1639
    • Year and Date
      2024-01-15
    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of a Single Dose of Oxaliplatin on the Induction of Peripheral Neuropathy in a Rat Model: An <i>in Vivo</i> Electrophysiological Study2023

    • Author(s)
      Uta Daisuke、Takeuchi Keita、Fukano Keigo、Kawamura Hinata、Ito Akitoshi
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 46 Issue: 8 Pages: 1128-1132

    • DOI

      10.1248/bpb.b23-00263

    • ISSN
      0918-6158, 1347-5215
    • Year and Date
      2023-08-01
    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Chronic Treatment with Aβ42 with a Toxic Conformer and LPS Induces Inflammatory Responses in BV-2 Microglia with Dysregulation of Hypoxia-Inducible Factor Expression2023

    • Author(s)
      Maki Takahito、Sawahata Masahito、Uta Daisuke、Irie Kazuhiro、Kume Toshiaki
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 46 Issue: 2 Pages: 359-363

    • DOI

      10.1248/bpb.b22-00855

    • ISSN
      0918-6158, 1347-5215
    • Year and Date
      2023-02-01
    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] An electrophysiological method for evaluation of topical antipruritic drugs on itch-related neuronal activities in the spinal cord in hairless mice2023

    • Author(s)
      Yuhki Ueda, Daisuke Uta, Hidemasa Furue, Yoshitaka Ohtubo
    • Journal Title

      European Journal of Pharmacology

      Volume: 952:175798. Pages: 1-11

    • DOI

      10.1016/j.ejphar.2023.175798

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Relationship between Laser Intensity at the Peripheral Nerve and Inhibitory Effect of Percutaneous Photobiomodulation on Neuronal Firing in a Rat Spinal Dorsal Horn2023

    • Author(s)
      Uta Daisuke、Ishibashi Naoya、Kawase Yuki、Tao Shinichi、Sawahata Masahito、Kume Toshiaki
    • Journal Title

      Journal of Clinical Medicine

      Volume: 12 Issue: 15 Pages: 5126-5126

    • DOI

      10.3390/jcm12155126

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Periostin activates distinct modules of inflammation and itching downstream of the type 2 inflammation pathway2023

    • Author(s)
      Nunomura Satoshi、Uta Daisuke、Kitajima Isao、Nanri Yasuhiro、Matsuda Kosuke、Ejiri Naoko、Kitajima Midori、Ikemitsu Hitoshi、Koga Misaki、Yamamoto Sayaka、Honda Yuko、Takedomi Hironobu、Andoh Tsugunobu、Conway Simon J.、Izuhara Kenji
    • Journal Title

      Cell Reports

      Volume: 42 Issue: 1 Pages: 111933-111933

    • DOI

      10.1016/j.celrep.2022.111933

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Developing a Novel Method for the Analysis of Spinal Cord?Penile Neurotransmission Mechanisms2023

    • Author(s)
      Uta Daisuke、Kiyohara Kazuhiro、Nagaoka Yuuya、Kino Yurika、Fujita Takuya
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 24 Issue: 2 Pages: 1434-1434

    • DOI

      10.3390/ijms24021434

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Near-Infrared Photobiomodulation of the Peripheral Nerve Inhibits the Neuronal Firing in a Rat Spinal Dorsal Horn Evoked by Mechanical Stimulation2023

    • Author(s)
      Uta Daisuke、Ishibashi Naoya、Konno Takahiro、Okada Yuki、Kawase Yuki、Tao Shinichi、Kume Toshiaki
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 24 Issue: 3 Pages: 2352-2352

    • DOI

      10.3390/ijms24032352

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Light-Touch-Induced Afterdischarge Firing in the Superficial Spinal Dorsal Horn Neurons in Hairless Mice with Irritant Contact Dermatitis2022

    • Author(s)
      Uta Daisuke、Inami Yoshihiro、Fukushima Miki、Kume Toshiaki
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 45 Issue: 11 Pages: 1678-1683

    • DOI

      10.1248/bpb.b22-00507

    • ISSN
      0918-6158, 1347-5215
    • Year and Date
      2022-11-01
    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Involvement of Histamine H3 Receptor Agonism in Premature Ejaculation Found by Studies in Rats2022

    • Author(s)
      Kiyohara Kazuhiro、Uta Daisuke、Nagaoka Yuuya、Kino Yurika、Nonaka Hideki、Ninomiya-Baba Midori、Fujita Takuya
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 23 Issue: 4 Pages: 2291-2291

    • DOI

      10.3390/ijms23042291

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Nociceptive chemical hypersensitivity in the spinal cord of a rat reserpine-induced fibromyalgia model2022

    • Author(s)
      Ejiri Yuto、Uta Daisuke、Ota Hiroki、Mizumura Kazue、Taguchi Toru
    • Journal Title

      Neuroscience Research

      Volume: - Pages: 87-94

    • DOI

      10.1016/j.neures.2022.03.005

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Norepinephrine Restores Inhibitory Tone of Spinal Lamina X Circuitry, thus Contributing to Analgesia Against Inflammatory Pain2022

    • Author(s)
      Nobuko Ohashi, Daisuke Uta, Masayuki Ohashi, Hiroshi Baba
    • Journal Title

      Neuroscience

      Volume: 490 Pages: 224-235

    • DOI

      10.1016/j.neuroscience.2022.03.023

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Analgesic effect of ivabradine against inflammatory pain mediated by hyperpolarization-activated cyclic nucleotide?gated cation channels expressed on primary afferent terminals in the spinal dorsal horn2022

    • Author(s)
      Ohashi Nobuko、Uta Daisuke、Ohashi Masayuki、Baba Hiroshi
    • Journal Title

      Pain

      Volume: 163 Issue: 7 Pages: 1356-1369

    • DOI

      10.1097/j.pain.0000000000002523

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of naftopidil on the postsynaptic sensitivity in substantia gelatinosa neurons from lumbosacral spinal cord in rats.2022

    • Author(s)
      Uta D, Hattori T, Yamada K, Sawahata M, Kume T, Yoshimura M.
    • Journal Title

      The Journal of Functional Diagnosis of the Spinal Cord

      Volume: -

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effects of various gabapentinoids on paclitaxel-induced peripheral neuropathic pain.2022

    • Author(s)
      Yamada K, Uta D, Matsuda K, Sawahata M, Kume T.
    • Journal Title

      The Journal of Functional Diagnosis of the Spinal Cord

      Volume: -

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] APP Knock-In Mice Produce E22P-Aβ Exhibiting an Alzheimer’s Disease-like Phenotype with Dysregulation of Hypoxia-Inducible Factor Expression2022

    • Author(s)
      Maki Takahito、Sawahata Masahito、Akutsu Ichiro、Amaike Shohei、Hiramatsu Genki、Uta Daisuke、Izuo Naotaka、Shimizu Takahiko、Irie Kazuhiro、Kume Toshiaki
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 23 Issue: 21 Pages: 13259-13259

    • DOI

      10.3390/ijms232113259

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Histamine enhances ATP-induced itching and responsiveness to ATP in keratinocytes2022

    • Author(s)
      Inami Yoshihiro、Fukushima Miki、Kume Toshiaki、Uta Daisuke
    • Journal Title

      Journal of Pharmacological Sciences

      Volume: 148 Issue: 2 Pages: 255-261

    • DOI

      10.1016/j.jphs.2021.12.004

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Chemogenetic activation of central gastrin-releasing peptide-expressing neurons elicits itch-related scratching behavior in male and female mice Pharmacology Research and Perspective2021

    • Author(s)
      Norikazu Kiguchi, Yohji Fukazawa, Ayano Saika, Daisuke Uta, Fumihiro Saika, Tomoe Y. Nakamura, Mei-Chuan Ko, Shiroh Kishioka
    • Journal Title

      Pharmacology Research and Perspective

      Volume: - Issue: 3 Pages: 1-11

    • DOI

      10.1002/prp2.790

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Estrogens influence female itch sensitivity via the spinal gastrin-releasing peptide receptor neurons2021

    • Author(s)
      Keiko Takanami, Daisuke Uta, Ken Ichi Matsuda, Mitsuhiro Kawata, Earl Carstens, Tatsuya Sakamoto, Hirotaka Sakamoto
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 118 Issue: 31

    • DOI

      10.1073/pnas.2103536118

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Analyses of the Mode of Action of an Alpha-Adrenoceptor Blocker in Substantia Gelatinosa Neurons in Rats2021

    • Author(s)
      Uta Daisuke、Hattori Tsuyoshi、Yoshimura Megumu
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 22 Issue: 17 Pages: 9636-9636

    • DOI

      10.3390/ijms22179636

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Actions of local anesthetics in rat spinal dorsal horn neurons by using in vivo patch clamp recording.2021

    • Author(s)
      Uta D, Yamada K, Matsuda K, Kume T, Imoto K, Furue H.
    • Journal Title

      The Journal of Functional Diagnosis of the Spinal Cord

      Volume: 42 Pages: 3-8

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Behavior and electrophysiology studies of the peripheral neuropathy induced by paclitaxel in mouse.2021

    • Author(s)
      Yamada K, Uta D, Matsuda K, Kume T.
    • Journal Title

      The Journal of Functional Diagnosis of the Spinal Cord

      Volume: 42 Pages: 9-14

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Electrophysiological and behavioral analysis of a mouse model of atopic dermatitis.2021

    • Author(s)
      Matsuda K, Uta D, Yamada K, Kume T.
    • Journal Title

      The Journal of Functional Diagnosis of the Spinal Cord

      Volume: 42 Pages: 15-19

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Inhibition of transient receptor potential vanilloid 1 and transient receptor potential ankyrin 1 by mosquito and mouse saliva2021

    • Author(s)
      Derouiche Sandra、Li Tianbang、Sakai Yuya、Uta Daisuke、Aoyagi Seiji、Tominaga Makoto
    • Journal Title

      Pain

      Volume: 163 Issue: 2 Pages: 299-307

    • DOI

      10.1097/j.pain.0000000000002337

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Oxytocin Influences Male Sexual Activity via Non-synaptic Axonal Release in the Spinal Cord2021

    • Author(s)
      Oti Takumi、Satoh Keita、Uta Daisuke、Nagafuchi Junta、Tateishi Sayaka、Ueda Ryota、Takanami Keiko、Young Larry J.、Galione Antony、Morris John F.、Sakamoto Tatsuya、Sakamoto Hirotaka
    • Journal Title

      Current Biology

      Volume: 31 Issue: 1 Pages: 103-114

    • DOI

      10.1016/j.cub.2020.09.089

    • NAID

      120007168224

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Inhibitory effect of panaxytriol on BV-2 microglial cell activation2021

    • Author(s)
      Hiramatsu Genki、Uta Daisuke、Mihara Kenichi、Andoh Tsugunobu、Kume Toshiaki
    • Journal Title

      Journal of Pharmacological Sciences

      Volume: 145 Issue: 3 Pages: 273-278

    • DOI

      10.1016/j.jphs.2021.01.001

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Neuronal hyperexcitability and astrocyte activation in spinal dorsal horn of a dermatitis mouse model with cutaneous hypersensitivity2020

    • Author(s)
      Inami Yoshihiro、Uta Daisuke、Andoh Tsugunobu
    • Journal Title

      Neuroscience Letters

      Volume: 720 Pages: 134784-134784

    • DOI

      10.1016/j.neulet.2020.134784

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] GRP receptor and AMPA receptor cooperatively regulate itch-responsive neurons in the spinal dorsal horn2020

    • Author(s)
      Kiguchi Norikazu、Uta Daisuke、Ding Huiping、Uchida Hitoshi、Saika Fumihiro、Matsuzaki Shinsuke、Fukazawa Yohji、Abe Manabu、Sakimura Kenji、Ko Mei-Chuan、Kishioka Shiroh
    • Journal Title

      Neuropharmacology

      Volume: 170 Pages: 108025-108025

    • DOI

      10.1016/j.neuropharm.2020.108025

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Inhibitory effect of amenamevir on acute herpetic pain and postherpetic neuralgia in mice infected with herpes simplex virus-12020

    • Author(s)
      Ueda Yuhki、Uta Daisuke、Tanbo Soichiro、Kawabata Akiko、Kanayama Shoji、Osaki Miho、Nozawa Naoki、Matsumoto Tatsumi、Andoh Tsugunobu
    • Journal Title

      Journal of Dermatological Science

      Volume: 98 Issue: 1 Pages: 50-57

    • DOI

      10.1016/j.jdermsci.2020.03.004

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Differential Effects of Alpha 1-Adrenoceptor Antagonists on the Postsynaptic Sensitivity: Using Slice Patch-Clamp Technique for Inhibitory Postsynaptic Current in Substantia Gelatinosa Neurons From Lumbosacral Spinal Cord in Rats2020

    • Author(s)
      Uta Daisuke、Hattori Tsuyoshi、Yoshimura Megumu
    • Journal Title

      International Neurourology Journal

      Volume: 24 Issue: 2 Pages: 127-134

    • DOI

      10.5213/inj.1938248.124

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of Alpha 1-Adrnoceptor Antagonists on Postsynaptic Sensitivity in Substantia Gelatinosa Neurons From Lumbosacral Spinal Cord in Rats Using Slice Patch-Clamp Technique for mEPSC2020

    • Author(s)
      Uta Daisuke、Hattori Tsuyoshi、Yoshimura Megumu
    • Journal Title

      International Neurourology Journal

      Volume: 24 Issue: 2 Pages: 135-143

    • DOI

      10.5213/inj.1938250.125

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Excessive exercise induces cardiac arrhythmia in a young fibromyalgia mouse model2020

    • Author(s)
      Nakata Taiki、Doi Atsushi、Uta Daisuke、Yoshimura Megumu、Shin Min-Chul
    • Journal Title

      PLOS ONE

      Volume: 15 Issue: 9 Pages: 0239473-0239473

    • DOI

      10.1371/journal.pone.0239473

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development of Artificial Skin Using Keratin Film for Evaluation of Puncture Performance of Microneedle.2020

    • Author(s)
      Nishino R, Aoyagi S, Suzuki M, Ueda A, Okumura Y, Takahashi T, Hosomi R, Fukunaga K, Uta D, Takazawa T, and Fujii T.
    • Journal Title

      Journal of Robotics and Mechatronics

      Volume: 32 Pages: 351-361

    • NAID

      130007833341

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Chronic pain rat models enhance spontaneous glutamatergic transmission on spinal dorsal horn.2020

    • Author(s)
      Uta D, Andoh T, Kume T, Yoshimura M, Koga K.
    • Journal Title

      The Journal of Functional Diagnosis of the Spinal Cord

      Volume: 41

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] L-bupivacaine Inhibition of Nociceptive Transmission in Rat Peripheral and Dorsal Horn Neurons2020

    • Author(s)
      Uta Daisuke、Koga Kohei、Furue Hidemasa、Imoto Keiji、Yoshimura Megumu
    • Journal Title

      Anesthesiology

      Volume: 134 Issue: 1 Pages: 88-102

    • DOI

      10.1097/aln.0000000000003596

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Free gait in a shallow pool accelerates recovery after exercise in model mice with fibromyalgia2020

    • Author(s)
      Nakata Taiki、Doi Atsushi、Uta Daisuke、Shin Min-Chul、Yoshimura Megumu
    • Journal Title

      Journal of Exercise Rehabilitation

      Volume: 16 Issue: 5 Pages: 398-409

    • DOI

      10.12965/jer.2040672.336

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A puncturing device that mimics the mechanism of mosquito's proboscis and labium -Verification of the effect of skin deformation/needle buckling prevention mechanism and puncture experiment on artificial skin and experimental animals-2020

    • Author(s)
      Yamamoto S, Aoyagi S, Yamada M, Takahashi T, Suzuki M, Nagashima T, Kunugi A, Chiyonobu M, Kuroiwa T, Hosomi R, Fukunaga K, Uta D, Takazawa T, Hikitsuchi T, Kawajiri Y, Nakayama K
    • Journal Title

      Int. J. Automation Technology.

      Volume: 14 Pages: 117-127

    • NAID

      130007782579

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] β2-Microglobulin, interleukin-31, and arachidonic acid metabolites (leukotriene B4 and thromboxane A2) are involved in chronic renal failure-associated itch-associated responses in mice2019

    • Author(s)
      Li Sikai、Andoh Tsugunobu、Zhang Qun、Uta Daisuke、Kuraishi Yasushi
    • Journal Title

      European Journal of Pharmacology

      Volume: 847 Pages: 19-25

    • DOI

      10.1016/j.ejphar.2019.01.017

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Noradrenaline modulates mechanically evoked responses in the rat spinal dorsal horn: an in vivo patch-clamp study2019

    • Author(s)
      Motoki Sonohata, Atsushi Doi, Toshiharu Yasaka, Daisuke Uta, Masaaki Mawatari, Megumu Yoshimura
    • Journal Title

      Journal of Pain Research

      Volume: 12 Pages: 1269-1278

    • DOI

      10.2147/jpr.s181210

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Animal models of chronic pain increase spontaneous glutamatergic transmission in adult rat spinal dorsal horn in?vitro and in?vivo2019

    • Author(s)
      Uta Daisuke、Kato Go、Doi Atsushi、Andoh Tsugunobu、Kume Toshiaki、Yoshimura Megumu、Koga Kohei
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 512 Issue: 2 Pages: 352-359

    • DOI

      10.1016/j.bbrc.2019.03.051

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Characterization on Responsiveness of Excitatory Synaptic Transmissions to α1-Adrenoceptor Blockers in Substantia Gelatinosa Neurons Isolated From Lumbo-Sacral Level in Rat Spinal Cords2019

    • Author(s)
      Uta Daisuke、Hattori Tsuyoshi、Yoshimura Megumu
    • Journal Title

      International Neurourology Journal

      Volume: 23 Issue: 1 Pages: 13-21

    • DOI

      10.5213/inj.1938056.028

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prophylactic Repetitive Treatment with the Herbal Medicine Kei-kyoh-zoh-soh-oh-shin-bu-toh Attenuates Oxaliplatin-Induced Mechanical Allodynia by Decreasing Spinal Astrocytes2019

    • Author(s)
      Andoh Tsugunobu、Fukutomi Daisuke、Uta Daisuke、Kuraishi Yasushi
    • Journal Title

      Evidence-Based Complementary and Alternative Medicine

      Volume: 2019 Pages: 1-11

    • DOI

      10.1155/2019/4029694

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effects of Naftopidil on primary afferent fiber evoked excitatory postsynaptic transmission in adult rat substantia geratinosa neuron.2019

    • Author(s)
      Uta D, Hattori T, Andoh T, Kume T, Yoshimura M.
    • Journal Title

      The Journal of Functional Diagnosis of the Spinal Cord

      Volume: 40 Pages: 1-7

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Chronic pain models amplify transient receptor potential vanilloid 1 (TRPV1) receptor responses in adult rat spinal dorsal horn2019

    • Author(s)
      Uta Daisuke、Yoshimura Megumu、Koga Kohei
    • Journal Title

      Neuropharmacology

      Volume: 160 Pages: 107753-107753

    • DOI

      10.1016/j.neuropharm.2019.107753

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Photobiomodulationによる疼痛緩和のメカニズム解明ー動物を用いた電気生理学的解析法の確立ー2024

    • Author(s)
      歌大介
    • Organizer
      レーザー学会学術講演会第44回年次大会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] 成熟ラットを用いた低出力レーザー照射の鎮痛効果の解析.2024

    • Author(s)
      歌大介、石橋直也、川瀨悠樹、峠真一、澤幡雅仁、久米利明.
    • Organizer
      第45回脊髄機能診断学会
    • Related Report
      2023 Annual Research Report
  • [Presentation] What is “Pain”? -No pain, no gain-.2024

    • Author(s)
      Uta D
    • Organizer
      The 101st Annual Meeting of the Physiological Society of Japan
    • Related Report
      2023 Annual Research Report
  • [Presentation] Optogenetic gamma-band entrainment of parvalbumin-positive neurons in the primary sensory cortex facilitates the activity of spinal dorsal horn neurons and withdrawal response in mice.2024

    • Author(s)
      Otsuki T, Uta D, Yamada K, Tateno M, Koide Y, Matsumoto J, Setogawa T, Nishimaru H.
    • Organizer
      The 101st Annual Meeting of the Physiological Society of Japan
    • Related Report
      2023 Annual Research Report
  • [Presentation] 自閉スペクトラム症モデルマウスの痛覚異常と社会性行動障害におけるTRPV1の役割.2024

    • Author(s)
      田原孟、今戸瑛二、歌大介、川瀬啓生、樋口桃子、山川英訓、小川公一、浅野智志、田熊一敞、橋本均、久米利明、古武弥一郎、吾郷由希夫.
    • Organizer
      日本薬学会第144年会
    • Related Report
      2023 Annual Research Report
  • [Presentation] Behavioral analysis of effects of a novel antipruritic drug using a mouse model of atopic dermatitis.2023

    • Author(s)
      Matsuda K, Sawahata M, Kume T, Uta D.
    • Organizer
      The 7th Toyama-Basel Joint Symposium.
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Optogenetic gamma stimulation of primary somatosensory cortex modulate neuronal activity in the spinal dorsal horn and induce allodynia-like behavior in mice.2023

    • Author(s)
      Otsuki T, Uta D, Yamada K, Tateno M, Matsumoto J, Setogawa T, Nishimaru H.
    • Organizer
      The 10th Federation of the Asian and Oceanian Physiological Societies Congress.
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Analysis of antipruritic effect of a novel gabapentinoid by NC/Nga mice.2023

    • Author(s)
      Matsuda K, Sawahata M, Kume T, Uta D.
    • Organizer
      12th World Congress on Itch (WCI).
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Neuronal hyperexcitability in spinal dorsal horn of irritant contact dermatitis mouse model.2023

    • Author(s)
      Uta D, Inami Y, Fukushima M, Matsuda K, Sawahata M, Kume T.
    • Organizer
      12th World Congress on Itch (WCI).
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 抗がん薬により誘発される感覚異常のモデル動物の作製と病態解明.2023

    • Author(s)
      歌大介
    • Organizer
      第16回日本緩和医療薬学会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] ラット末梢神経へのレーザー照射は機械刺激により誘発された脊髄後角表層ニューロンの活動を抑制する.2023

    • Author(s)
      石橋直也、今野孝浩、岡田祐樹、川瀨悠樹、峠真一、澤幡雅仁、久米利明、歌大介.
    • Organizer
      第34回日本レーザー治療学会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 脊髄損傷後疼痛における脊髄のN型電位依存性Ca2+チャネルの役割.2023

    • Author(s)
      大橋宣子、歌大介、大橋正幸、清水大喜、渡部達範、馬場洋.
    • Organizer
      日本ペインクリニック学会第57回学術集会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 慢性掻痒の病態メカニズム-神経感作と痒み-.2023

    • Author(s)
      歌大介
    • Organizer
      第53回日本神経精神薬理学会年会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] 抗てんかん薬バルプロ酸の胎生期曝露は中枢性感作に伴う持続的な痛覚過敏とアロディニアを引き起こす.2023

    • Author(s)
      田原孟、今戸瑛二、歌大介、浅野智志、田熊一敞、久米利明、吾郷由希夫、古武弥一郎.
    • Organizer
      フォーラム2023:衛生薬学・環境トキシコロジー
    • Related Report
      2023 Annual Research Report
  • [Presentation] ゼブラフィッシュ稚魚を用いた薬効評価可能なAdenosine deaminase 2欠損症モデルの作出.2023

    • Author(s)
      石坂光、澤幡雅仁、歌大介、久米利明.
    • Organizer
      第74回日本薬理学会北部会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 抗がん薬Vincristine誘発末梢神経障害性疼痛に対する新規電位依存性Ca2+リガンドの鎮痛作用の解析.2023

    • Author(s)
      上田悠希、澤幡雅仁、久米利明、歌大介.
    • Organizer
      第74回日本薬理学会北部会
    • Related Report
      2023 Annual Research Report
  • [Presentation] マウス一次体性感覚野におけるガンマ帯域律動活動の誘発によるアロディニア様行動の機能解析.2023

    • Author(s)
      大槻智史、歌大介、山田果琳、立野繭香、松本惇平、瀬戸川剛、西丸広史.
    • Organizer
      第29回脳機能とリハビリテーション研究会学術集会
    • Related Report
      2023 Annual Research Report
  • [Presentation] アルカリ化剤(クエン酸塩)のドラッグリポジショニングを目指した研究.2023

    • Author(s)
      歌大介
    • Organizer
      2023年度富山大学杉谷地区研究発表会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 薬効評価可能なAdenosine deaminase 2欠損症モデルゼブラフィッシュの作出.2023

    • Author(s)
      石坂光、澤幡雅仁、歌大介、久米利明.
    • Organizer
      第9回ゼブラフィッシュ・メダカ創薬研究会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 脳,脊髄ニューロン計測に向けたフレキシブル基板マイクロニードル電極の製作.2023

    • Author(s)
      清水快季、中村翼、山下幸司、歌大介、大澤匡弘、久米利明、沼野利佳、鯉田孝和、河野剛士.
    • Organizer
      第40回「センサ・マイクロマシンと応用システム」シンポジウム
    • Related Report
      2023 Annual Research Report
  • [Presentation] 抗がん薬Vincristine誘発末梢神経障害性疼痛に対する新規ガバペンチノイドの鎮痛作用の行動薬理学的解析.2023

    • Author(s)
      上田悠希、澤幡雅仁、久米利明、歌大介.
    • Organizer
      日本薬学会北陸支部第135回例会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 成熟ラットを用いた低出力レーザ照射による疼痛抑制効果の評価法の確立―in vivo電気生理学的解析法を用いた解析―.2023

    • Author(s)
      歌大介、石橋直也、川瀨悠樹、峠真一、澤幡雅仁、久米利明.
    • Organizer
      Laser Week IV in Tokyo第44回日本レーザー医学会総会
    • Related Report
      2023 Annual Research Report
  • [Presentation] モデル動物を用いた痛覚変調性疼痛の脊髄機構の探索.2023

    • Author(s)
      田口徹,歌大介
    • Organizer
      第45回日本疼痛学会
    • Related Report
      2023 Annual Research Report
  • [Presentation] バルプロ酸の胎内曝露は中枢性感作と痛覚感受性の増大を引き起こす2023

    • Author(s)
      吾郷由希夫、田原孟、今戸瑛二、歌大介、田熊一敞、久米利明、古武弥一郎、浅野智志.
    • Organizer
      The 44th Annual Scientific Meeting of the Japanese Society of Clinical Pharmacological and Therapeutics
    • Related Report
      2023 Annual Research Report
  • [Presentation] Mirogabalin shows preventive effect against Vincristine-induced mechanical allodynia.2023

    • Author(s)
      Ueda Y, Sawahata M, Kume T, Uta D.
    • Organizer
      The 97th Annual Meeting of the Japan Pharmacological Society
    • Related Report
      2023 Annual Research Report
  • [Presentation] Exploration of novel therapeutic agents for adenosine deaminase 2 deficiency using a larval zebrafish.2023

    • Author(s)
      Ishisaka H, Sawahata M, Uta D, Kume T.
    • Organizer
      The 97th Annual Meeting of the Japan Pharmacological Society
    • Related Report
      2023 Annual Research Report
  • [Presentation] Analysis of antipruritic effects of SSRIs using various atopic dermatitis model mice.2023

    • Author(s)
      Matsuda K, Ishisaka H, Sawahata M, Kume T, Uta D.
    • Organizer
      The 97th Annual Meeting of the Japan Pharmacological Society
    • Related Report
      2023 Annual Research Report
  • [Presentation] Animal models of neuropathic and inflammatory pain enhance glutamatergic transmission in adult rat spinal dorsal horn in vitro and in vivo.2023

    • Author(s)
      Uta D, Sawahata M, Matsuda K, Ueda Y, Ishisaka H, Yoshimura M, Koga K, Kume T.
    • Organizer
      The 97th Annual Meeting of the Japan Pharmacological Society
    • Related Report
      2023 Annual Research Report
  • [Presentation] 線維筋痛症モデルラットを用いた脊髄シナプス機構変容の電気生理学的解析.2023

    • Author(s)
      歌大介.
    • Organizer
      生理学研究所 痛み研究会2022「痛みの統合的理解とその制御に向けて」
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] アミロイドβの毒性コンホマーによるアルツハイマー病発症機構と低酸素誘導因子(HIF)経路の関与.2023

    • Author(s)
      牧俊人、天池将平、澤幡雅仁、歌大介、泉尾直孝、清水孝彦、入江一浩、久米利明.
    • Organizer
      日本薬学会第143年会
    • Related Report
      2022 Research-status Report
  • [Presentation] 新規アトピー性皮膚炎モデルマウスを用いた延髄における電気生理学的解析.2023

    • Author(s)
      松田康佑、堀圭汰、北島緑、江尻直子、山田果琳、澤幡雅仁、久米利明、布村聡、出原賢治、北島勲、歌大介.
    • Organizer
      日本薬学会第143年会
    • Related Report
      2022 Research-status Report
  • [Presentation] 線維筋痛症モデルラットにおける脊髄後角表層細胞の機械感受性増大.2023

    • Author(s)
      歌大介、坪島功幸、西条寿夫、松田康佑、澤幡雅仁、久米利明、水村和枝、田口徹.
    • Organizer
      日本薬学会第143年会
    • Related Report
      2022 Research-status Report
  • [Presentation] ヒスタミンおよびクロロキン誘発性掻痒に対する新規ガバペンチノイドの鎮痒効果の行動薬理学的解析.2022

    • Author(s)
      堀圭汰、澤幡雅仁、久米利明、歌大介
    • Organizer
      生体機能と創薬シンポジウム2022
    • Related Report
      2022 Research-status Report
  • [Presentation] ヒスタミンおよびクロロキン誘発性掻痒に対する新規ガバペンチノイドの鎮痒効果の行動薬理学的解析.2022

    • Author(s)
      堀圭汰、澤幡雅仁、久米利明、歌大介
    • Organizer
      次世代を担う若手のための創薬・医療薬理シンポジウム2022
    • Related Report
      2022 Research-status Report
  • [Presentation] 行動薬理学的手法を用いた各種起痒物質誘発性掻痒に対する新規ガバペンチノイドの鎮痒効果検討.2022

    • Author(s)
      堀圭汰、澤幡雅仁、久米利明、歌大介
    • Organizer
      第73回日本薬理学会北部会
    • Related Report
      2022 Research-status Report
  • [Presentation] 204.清水快季、中村翼、山下幸司、歌大介、大澤匡弘、久米利明、沼野利佳、鯉田孝和、河野剛士. Siマイクロニードル電極のマウス脊髄後角ニューロン計測への応用. A Si-microneedle electrode device for recording from dorsal horn neurons in the mouse spinal cord.2022

    • Author(s)
      清水快季、中村翼、山下幸司、歌大介、大澤匡弘、久米利明、沼野利佳、鯉田孝和、河野剛士.
    • Organizer
      第82回 応用物理学会 秋季学術講演会
    • Related Report
      2022 Research-status Report
  • [Presentation] FADSマウスを基盤としたアトピー性皮膚炎の病態におけるペリオスチンの機能解析.2022

    • Author(s)
      布村聡、歌大介、南里康弘、松田康佑、北島緑、江尻直子、安東嗣修、北島勲、出原賢治.
    • Organizer
      第71回日本アレルギー学会
    • Related Report
      2022 Research-status Report
  • [Presentation] 成熟ラットを用いたレーザー照射の鎮痛効果の検討.2022

    • Author(s)
      石橋直也、今野孝浩、岡田祐樹、川瀨悠樹、峠真一、久米利明、歌大介.
    • Organizer
      第43回日本レーザー医学会総会
    • Related Report
      2022 Research-status Report
  • [Presentation] NMDAの脳内投与はゼブラフィッシュ稚魚の興奮毒性を惹起し、脳血流を低下させる.2022

    • Author(s)
      高橋祐太、青山佳樹、澤幡雅仁、歌大介、久米利明.
    • Organizer
      第8回ゼブラフィッシュ・メダカ創薬研究会
    • Related Report
      2022 Research-status Report
  • [Presentation] 接触性皮膚炎モデルマウスに対する和漢薬エキスの抗炎症作用の検討.2022

    • Author(s)
      酒井麻衣、水谷玲那、澤幡雅仁、歌大介、當銘一文、小松かつ子、久米利明.
    • Organizer
      日本薬学会北陸支部第134回例会
    • Related Report
      2022 Research-status Report
  • [Presentation] 新規ガバペンチノイドの各種起痒誘発性掻痒に対する作用解析.2022

    • Author(s)
      堀圭汰、澤幡雅仁、久米利明、歌大介
    • Organizer
      日本薬学会北陸支部第134回例会
    • Related Report
      2022 Research-status Report
  • [Presentation] 神経感作と痒み-ケラチノサイトにおけるヒスタミンとATPの関連性-.2022

    • Author(s)
      歌大介.
    • Organizer
      環境医学研究所・順天堂大学かゆみ研究センター 第8回学術シンポジウム
    • Related Report
      2022 Research-status Report
    • Invited
  • [Presentation] アトピー性皮膚炎モデルマウスを用いた脊髄後角における痒み情報伝達機構の解明2022

    • Author(s)
      松田康佑、山田果琳、澤幡雅仁、久米利明、歌大介
    • Organizer
      第32回神経行動薬理若手研究者の集い
    • Related Report
      2022 Research-status Report
  • [Presentation] Inhibitory effect of mirogabalin for various pruritogens-induced acute itch.2022

    • Author(s)
      Hori K, Sawahata M, Kume T, Uta D.
    • Organizer
      Japan Basic and Clinical Pharmacology Week 2022 (The 96th Annual Meeting of the Japan Pharmacological Society)
    • Related Report
      2022 Research-status Report
  • [Presentation] Paclitaxel-induced peripheral neuropathic pain formation contributes to synaptic plasticity in the spinal dorsal horn.2022

    • Author(s)
      Yamada K, Sawahata M, Kume T, Uta D.
    • Organizer
      Japan Basic and Clinical Pharmacology Week 2022 (The 96th Annual Meeting of the Japan Pharmacological Society)
    • Related Report
      2022 Research-status Report
  • [Presentation] Studying nociceptive information pathways in spinal dorsal horn -Problems and new opportunities for the in vivo electrophysiological recording-.2022

    • Author(s)
      Uta D.
    • Organizer
      Japan Basic and Clinical Pharmacology Week 2022 (The 96th Annual Meeting of the Japan Pharmacological Society)
    • Related Report
      2022 Research-status Report
  • [Presentation] Augmented mechanical response of spinal dorsal horn neurons in a rat model of fibromyalgia.2022

    • Author(s)
      Uta D, Tsuboshima K, Nishijo H, Mizumura K, Taguchi T.
    • Organizer
      Japan Basic and Clinical Pharmacology Week 2022 (The 96th Annual Meeting of the Japan Pharmacological Society)
    • Related Report
      2022 Research-status Report
  • [Presentation] 抗がん薬パクリタキセル誘発末梢神経障害性疼痛に対する各種鎮痛薬の作用解析2022

    • Author(s)
      山田果琳, 松田康佑, 澤幡雅仁, 久米利明, 歌大介
    • Organizer
      第43回脊髄機能診断学会
    • Related Report
      2021 Research-status Report
  • [Presentation] ラット脊髄膠様質細胞における抑制性シナプス後電流の解析によるナフトピジルのシナプス後感受性に対する影響2022

    • Author(s)
      歌大介, 服部剛, 山田果琳, 松田康佑, 久米利明, 吉村惠
    • Organizer
      第43回脊髄機能診断学会
    • Related Report
      2021 Research-status Report
  • [Presentation] ミロガバリンは脊髄後角のa2d-1を介してパクリタキセル誘発機械的アロディニアを抑制する2022

    • Author(s)
      山田果琳, 澤幡雅仁, 久米利明, 歌大介
    • Organizer
      第31回神経行動薬理若手研究者の集い
    • Related Report
      2021 Research-status Report
  • [Presentation] アトピー性皮膚炎モデルマウスに対するミロガバリンの有効性及び作用機序の解明2022

    • Author(s)
      松田康佑, 澤幡雅仁, 久米利明, 歌大介
    • Organizer
      第31回神経行動薬理若手研究者の集い
    • Related Report
      2021 Research-status Report
  • [Presentation] Inhibitory effect of mirogabalin for chronic itch in atopic dermatitis model mice2022

    • Author(s)
      Matsuda K, Sawahata M, Kume T, Uta D
    • Organizer
      The 95th Annual Meeting of the Japan Pharmacological Society
    • Related Report
      2021 Research-status Report
  • [Presentation] Mirogabalin inhibits paclitaxel-induced mechanical allodynia in mice by acting on α2δ-1 subunit in the spinal dorsal horn2022

    • Author(s)
      Yamada K, Sawahata M, Kume T, Uta D
    • Organizer
      The 95th Annual Meeting of the Japan Pharmacological Society
    • Related Report
      2021 Research-status Report
  • [Presentation] Effects of naftopidil on dorsal root evoked excitatory synaptic transmissions in substantia gelatinosa neurons in vitro2022

    • Author(s)
      Uta D, Hattori T, Yamada K, Matsuda K, Sawahata M, Kume T, Yoshimura M
    • Organizer
      The 95th Annual Meeting of the Japan Pharmacological Society
    • Related Report
      2021 Research-status Report
  • [Presentation] ラット脊髄後角におけるTRPA1発現求心性線維の入力を受ける膠様質細胞の電気生理学及び形態学的解析2022

    • Author(s)
      歌大介, 山田果琳, 松田康佑, 古江秀昌, 澤幡雅仁, 久米利明
    • Organizer
      日本薬学会第142年会
    • Related Report
      2021 Research-status Report
  • [Presentation] 抗がん薬誘発末梢性神経障害性疼痛に対する新規電位依存性Ca2+チャネルα2δ-1リガンドの作用解析2022

    • Author(s)
      山田果琳, 澤幡雅仁, 久米利明, 歌大介
    • Organizer
      日本薬学会第142年会
    • Related Report
      2021 Research-status Report
  • [Presentation] 自然発症アトピー性皮膚炎モデルマウスに対するミロガバリンの有効性2022

    • Author(s)
      松田康佑, 澤幡雅仁, 久米利明, 歌大介
    • Organizer
      日本薬学会第142年会
    • Related Report
      2021 Research-status Report
  • [Presentation] Evaluation of itch by in vivo patch clamp method.2021

    • Author(s)
      歌大介
    • Organizer
      遺伝研セミナー
    • Related Report
      2021 Research-status Report
  • [Presentation] アトピー性皮膚炎モデルマウスを用いた新規ガバペンチノイドの鎮痒作用の解析2021

    • Author(s)
      松田康佑, 澤幡雅仁, 久米利明, 歌大介.
    • Organizer
      生体機能と創薬シンポジウム2021
    • Related Report
      2021 Research-status Report
  • [Presentation] 抗がん薬paclitaxel誘発末梢神経障害性疼痛モデルマウスに対する新規ガバペンチノイドの作用検討2021

    • Author(s)
      山田果琳, 澤幡雅仁, 久米利明, 歌大介.
    • Organizer
      生体機能と創薬シンポジウム2021
    • Related Report
      2021 Research-status Report
  • [Presentation] 成熟ラット脊髄後角におけるTRPA1発現求心性線維の入力を受ける膠様質細胞の電気生理学及び形態学的解析2021

    • Author(s)
      歌大介, 古江秀昌, 松田康佑, 山田果琳, 澤幡雅仁, 久米利明
    • Organizer
      生体機能と創薬シンポジウム2021
    • Related Report
      2021 Research-status Report
  • [Presentation] アトピー性皮膚炎モデルマウスを用いた新規ガバペンチノイドの鎮痒作用の解析2021

    • Author(s)
      松田康佑, 澤幡雅仁, 久米利明, 歌大介
    • Organizer
      次世代を担う若手のための創薬・医療薬理シンポジウム2021
    • Related Report
      2021 Research-status Report
  • [Presentation] 抗がん薬paclitaxel誘発末梢神経障害性疼痛モデルマウスに対する新規ガバペンチノイドの作用検討2021

    • Author(s)
      山田果琳, 澤幡雅仁, 久米利明, 歌大介
    • Organizer
      次世代を担う若手のための創薬・医療薬理シンポジウム2021
    • Related Report
      2021 Research-status Report
  • [Presentation] 慢性掻痒モデルマウスに対するミロガバリンの鎮痒作用の解析2021

    • Author(s)
      松田康佑, 澤幡雅仁, 久米利明, 歌大介
    • Organizer
      第40回鎮痛薬・オピオイドペプチドシンポジウム
    • Related Report
      2021 Research-status Report
  • [Presentation] 抗がん薬パクリタキセル誘発末梢神経障害性疼痛モデルマウスに対するミロガバリンの作用検討2021

    • Author(s)
      山田果琳, 澤幡雅仁, 久米利明, 歌大介
    • Organizer
      第40回鎮痛薬・オピオイドペプチドシンポジウム
    • Related Report
      2021 Research-status Report
  • [Presentation] 17β-エストラジオールによる痒み閾値調節2021

    • Author(s)
      高浪景子、歌大介、松田賢一、河田光博、Earl Carstens、坂本竜哉、坂本浩隆
    • Organizer
      第47回日本神経内分泌学会学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] Panaxytriol inhibits lipopolysaccharide-induced microglia activation in brain inflammation mouse model2021

    • Author(s)
      Hiramatsu G, Matsuda K, Uta D, Mihara K, Sawahata M, Kume K
    • Organizer
      6th Toyama-Basel Meeting 2021
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Electrophysiological and behavioral analysis of a mouse model of atopic dermatitis2021

    • Author(s)
      Matsuda K, Yamada K, Sawahata M, Kume K, Uta D
    • Organizer
      6th Toyama-Basel Meeting 2021
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Behavioral and electrophysiological studies of the peripheral neuropathy induced by paclitaxel in mouse2021

    • Author(s)
      Yamada K, Matsuda K, Sawahata M, Kume K, Uta D
    • Organizer
      6th Toyama-Basel Meeting 2021
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] 自然発症アトピー性皮膚炎モデルマウスを用いた新規電位依存性Ca2+チャネル拮抗薬の鎮痒作用の解析2021

    • Author(s)
      松田康佑, 澤幡雅仁, 久米利明, 歌大介
    • Organizer
      第72回日本薬理学会北部会
    • Related Report
      2021 Research-status Report
  • [Presentation] Mechanism of itch transduction in spinal dorsal horn2021

    • Author(s)
      Matsuda K, Sawahata M, Kume K, Uta D
    • Organizer
      The 30th International Symposium of Itch
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Panaxytriol, which is an active Panax ginseng component, inhibits LPS-induced microglia activation in vitro and in vivo2021

    • Author(s)
      Hiramatsu G, Sawahata M, Uta D, Mihara K, Kume T
    • Organizer
      Natural Products or Healthy Aging 2021
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Panaxytriol inhibits lipopolysaccharide induced microglia activation2021

    • Author(s)
      Hiramatsu G, Matsuda K, Uta D, Mihara K, Kume T
    • Organizer
      The 51th Annual Meeting of the Society for Neuroscience
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] 慢性掻痒モデルマウスを用いたmirogabalinの行動薬理学的作用解析2021

    • Author(s)
      松田康佑, 澤幡雅仁, 久米利明, 歌大介
    • Organizer
      日本薬学会北陸支部第133回例会
    • Related Report
      2021 Research-status Report
  • [Presentation] 抗がん薬誘発機械的アロディニアに対するミロガバリンの有用性の検討2021

    • Author(s)
      山田果琳, 澤幡雅仁, 久米利明, 歌大介
    • Organizer
      日本薬学会北陸支部第133回例会
    • Related Report
      2021 Research-status Report
  • [Presentation] Involvement of histamine H3 receptor agonism in premature ejaculation revealed by a novel evaluation system2021

    • Author(s)
      Kiyohara K, Uta D, Nagaoka Y, Kino Y, Nonaka H, Ninomiya M, Fujita T, Okuyama M
    • Organizer
      The 22nd World Meeting on Sexual Medicine (WMSM 2021)
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] NMDAの脳内投与がゼブラフィッシュ稚魚の脳循環及び神経細胞に与える影響2021

    • Author(s)
      澤幡雅仁, 青山佳樹, 歌大介, 久米利明
    • Organizer
      第7回ゼブラフィッシュ・メダカ創薬研究会
    • Related Report
      2021 Research-status Report
  • [Presentation] Study of analgesic effects of low level laser therapy (photobiomodulation) in rats2021

    • Author(s)
      歌大介、石橋直也,今野孝浩,川瀨悠樹,峠真一
    • Organizer
      第43回日本疼痛学会
    • Related Report
      2021 Research-status Report
  • [Presentation] Antipruritic effect of alpha2delta ligands in a mouse model of atopic dermatitis2021

    • Author(s)
      松田康佑, 澤幡雅仁, 久米利明, 歌大介
    • Organizer
      第43回日本疼痛学会
    • Related Report
      2021 Research-status Report
  • [Presentation] Panaxytriolのミクログリア活性化抑制作用機序の解析2020

    • Author(s)
      平松元気、歌大介、三原憲一、安東嗣修、久米利明
    • Organizer
      第71回日本薬理学会北部会
    • Related Report
      2020 Research-status Report
  • [Presentation] PanaxytriolによるLPS誘発ミクログリアの活性化抑制作用2020

    • Author(s)
      平松元気、歌大介、三原憲一、安東嗣修、久米利明
    • Organizer
      富山薬学研究会2020
    • Related Report
      2020 Research-status Report
  • [Presentation] In vivoパッチクランプ法を用いたラット脊髄後角ニューロンに対する局所麻酔薬の作用解析2020

    • Author(s)
      170.歌大介、山田果琳、松田康佑、久米利明、井本敬二、古江秀昌
    • Organizer
      第42回脊髄機能診断研究会
    • Related Report
      2020 Research-status Report
  • [Presentation] Paclitaxel 誘発末梢神経障害性疼痛モデルマウスにおける行動薬理学的及び電気生理学的解析2020

    • Author(s)
      山田果琳、歌大介、松田康佑、久米利明
    • Organizer
      第42回脊髄機能診断研究会
    • Related Report
      2020 Research-status Report
  • [Presentation] アトピー性皮膚炎モデルマウスを用いた脊髄への痒み伝達機構の解析2020

    • Author(s)
      松田康佑、歌大介、山田果琳、久米利明
    • Organizer
      第42回脊髄機能診断研究会
    • Related Report
      2020 Research-status Report
  • [Presentation] Involvement in serotonin receptor subtypes on spontaneous itch-related behavior in mice with atopy-like dermatitis2020

    • Author(s)
      安東嗣修、大崎 岳史、歌大介、倉石泰、久米利明
    • Organizer
      The 94th Annual Meeting of the Japan Pharmacological Society
    • Related Report
      2020 Research-status Report
  • [Presentation] Inhibitory effect of panaxytriol on the lipopolysaccharide-induced microglial activation2020

    • Author(s)
      平松元気、松田康佑、歌大介、三原憲一、安東嗣修、久米利明
    • Organizer
      The 94th Annual Meeting of the Japan Pharmacological Society
    • Related Report
      2020 Research-status Report
  • [Presentation] PanaxytriolはLPS誘発脳内炎症マウスモデルにおける活性化ミクログリアを抑制する2020

    • Author(s)
      平松元気、松田康佑、歌大介、三原憲一、安東嗣修、久米利明
    • Organizer
      日本薬学会第141年会
    • Related Report
      2020 Research-status Report
  • [Presentation] Suppressive effects of amitriptyline and duloxetine on spinal dorsal horn neurons sensitized in a rat model of fibromyalgia.2020

    • Author(s)
      Uta D, Tsuboshima K, Wakatsuki K, Taguchi T.
    • Organizer
      National Institute of Physiological Sciences International Workshop on Frontiers in Defensive Survival Circuit Research “Pain and Survival Strategy (The 2nd Pain and Amygdala Symposium)”
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Prophylactic repetitive administration of aucubin attenuates oxaliplatin-induced mechanical allodynia through the inhibition of spinal astrocyte activation.2020

    • Author(s)
      Maesaka M, Uta D, Kume T, Andoh T.
    • Organizer
      National Institute of Physiological Sciences International Workshop on Frontiers in Defensive Survival Circuit Research “Pain and Survival Strategy (The 2nd Pain and Amygdala Symposium)”
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] nvolvement of macrophages in herpetic pain in herpes simplex virus type-I infected mice.2020

    • Author(s)
      Tanbo S, Uta D, Kume T, Andoh T.
    • Organizer
      National Institute of Physiological Sciences International Workshop on Frontiers in Defensive Survival Circuit Research “Pain and Survival Strategy (The 2nd Pain and Amygdala Symposium)”
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Study on analgesic effect of mosquito saliva -Examination of action on TRPV1 receptor by patch-clamp method-2020

    • Author(s)
      Aoyagi S, Sakai Y, Suzuki M, Hosomi R, Fukunaga K, Uta D, Takazawa T, Hikitsuchi T, Kawajiri Y, Nakayama K, Li T, Tominaga M.
    • Organizer
      National Institute of Physiological Sciences International Workshop on Frontiers in Defensive Survival Circuit Research “Pain and Survival Strategy (The 2nd Pain and Amygdala Symposium)”.
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] L-Lactate-induced activation of PKA pathway sensitizes nociceptive transmission in mice.2020

    • Author(s)
      Ohsawa M, Miyamoto K, Uta D, Kume K.
    • Organizer
      7th meeting of the Hungarian neuroscience society IBRO2020 workshop
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 慢性疼痛モデルラットを用いた電気生理学的解析.2020

    • Author(s)
      歌大介
    • Organizer
      第2回運動神経変性疾患の治療を目指した創薬研究会
    • Related Report
      2019 Research-status Report
  • [Presentation] In vivo標本からの電気生理学的記録-神経障害性疼痛モデルラットを用いた解析結果と新規in vivo記録法の紹介-.2020

    • Author(s)
      歌大介
    • Organizer
      新潟大学医学部麻酔科セミナー
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 慢性疼痛モデルラットは脊髄後角における自発的興奮性伝達を促進する.2020

    • Author(s)
      歌大介、吉村惠、古賀浩平.
    • Organizer
      第41回脊髄機能診断研究会
    • Related Report
      2019 Research-status Report
  • [Presentation] 運動神経変性疾患の治療を目指した創薬研究.2020

    • Author(s)
      歌大介
    • Organizer
      令和元年度北陸地区国立大学学術研究推進支援研究成果報告会
    • Related Report
      2019 Research-status Report
  • [Presentation] Thromboxane A2 is involve in the skin inflammation in mice with atopy-like dermatitis.2020

    • Author(s)
      安東嗣修、安藤有紀、歌大介、久米利明.
    • Organizer
      The 93th Annual Meeting of the Japan Pharmacological Society
    • Related Report
      2019 Research-status Report
  • [Presentation] Neuropathic and inflammatory pain increases glutamatergic excitatory postsynaptic current on adult rat spinal dorsal horn neurons.2020

    • Author(s)
      歌大介、安東嗣修、久米利明、吉村惠、古賀 浩平.
    • Organizer
      The 93th Annual Meeting of the Japan Pharmacological Society
    • Related Report
      2019 Research-status Report
  • [Presentation] Characterization of responses to pain and itch stimuli in adult rats with neonatal dopamine depletion.2019

    • Author(s)
      Ogata M, Uta D, Akita H, Ishibashi H.
    • Organizer
      The 49th Annual Meeting of the Society for Neuroscience.
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Electrophysiological and behavioral analysis of NC/Nga mice with atopic dermatitis-like symptoms.2019

    • Author(s)
      Uta D, Kiguchi N, Kume T, Andoh T.
    • Organizer
      The 10th World Congress on ITCH.
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Mechanisms of sensory hypersensitivity in surfactant-induced irritant contact dermatitis mouse model.2019

    • Author(s)
      Inami Y, Uta D, Andoh T.
    • Organizer
      The 10th World Congress on ITCH.
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Electrophysiological and morphological analyzes of excitatory effect of TRPA1 agonists on synaptic transmission in excitatory interneurons in rat spinal dorsal horn neurons.2019

    • Author(s)
      Uta D, Furue H, Yoshimura M.
    • Organizer
      Toyama Forum for Academic Summit on “Dynamic Brain”
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 蚊の唾液成分の感覚神経への作用の検討 -動物の反射行動実験-2019

    • Author(s)
      青柳誠司、酒井裕也、駒走仁哉、鈴木昌人、高橋智一、細見亮太、福永健治、歌大介、安東嗣修、高澤知規、引土和幸、川尻由美、中山幸治.
    • Organizer
      第71回日本衛生動物学会大会
    • Related Report
      2019 Research-status Report
  • [Presentation] 尿毒症毒素誘発性そう;痒のメカニズム解明を目指して-電気生理学的解析を用いた痒み情報伝達機構の解析-2019

    • Author(s)
      歌大介、牧俊人、李嗣凱、久米利明、安東嗣修.
    • Organizer
      第3回日本Uremic Toxin研究会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] Chronic pain animal models enhance spontaneous glutamatergic transmission on adult rat spinal dorsal horn in vitro and in vivo.2019

    • Author(s)
      Uta D, Andoh T, Kume T, Yoshimura M, Koga K.
    • Organizer
      第41回日本疼痛学会
    • Related Report
      2019 Research-status Report
  • [Presentation] Spinal mechanisms of nociception in a rat model of chronic fatigue syndrome.2019

    • Author(s)
      Uta D, Tsuboshima K, Wakatsuki K, Taguchi T.
    • Organizer
      第41回日本疼痛学会
    • Related Report
      2019 Research-status Report
  • [Presentation] Study on Analgesic effect of Mosquito Saliva― Examination of the action on TRPVl using a patch clamp method―.2019

    • Author(s)
      Aoyagi S, Sakai Y, Takahashi T, Suzuki M, Hosomi R, Fukunaga K, Uta D, Takazawa T, Hikitsuchi T, Kawajiri Y, Nakayama K, Li T.
    • Organizer
      第41回日本疼痛学会
    • Related Report
      2019 Research-status Report
  • [Presentation] Spinal microglial activation in a mouse model of psoriasis.2019

    • Author(s)
      Kiguchi N, Uchida H, Uta D, Saiga F, Kobayashi D, Matsuzaki S.
    • Organizer
      第41回日本疼痛学会
    • Related Report
      2019 Research-status Report
  • [Presentation] Facilitated nociceptive processing in the spinal dorsal horn neurons after multiple continuous stress.2019

    • Author(s)
      Uta D, Wakatsuki K, Tsuboshima K, Yasui M, Hamaue Y, Kiyama H, Nishijo H, Mizumura K, Taguchi T.
    • Organizer
      The 42th Annual Meeting of the Japan Neuroscience Society
    • Related Report
      2019 Research-status Report
  • [Presentation] Contribution of gastrin-releasing peptide-expressing neurons in the spinal dorsal horn to pathological itch.2019

    • Author(s)
      Kiguchi N, Uta D, Uchida H, Matsuzaki S, Kishioka S.
    • Organizer
      The 42th Annual Meeting of the Japan Neuroscience Society
    • Related Report
      2019 Research-status Report
  • [Presentation] 線維筋痛症モデルの脊髄後角ニューロンに対する抗うつ薬の抑制効果.2019

    • Author(s)
      田口徹、歌大介、坪島功幸、西条寿夫、水村和枝.
    • Organizer
      日本筋学会第5回学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] アウクビンはアストロサイトの活性化を阻害することでオキサリプラチン誘発機械的アロディニアを抑制する.2019

    • Author(s)
      前坂未紀、當銘一文、小松かつ子、歌大介、久米利明、安東嗣修.
    • Organizer
      第 36 回和漢医薬学会学術大会
    • Related Report
      2019 Research-status Report
  • [Presentation] 慢性疼痛時において脊髄後角ではいかなる変化が起こっているのか?―in vivo及びin vitro標本からの電気生理学的解析―.2019

    • Author(s)
      歌大介
    • Organizer
      和歌山県立医科大学セミナー
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 成熟ラット脊髄膠様質細胞に対するナフトピジルの作用解析.2019

    • Author(s)
      歌大介、服部剛、安東嗣修、久米利明、吉村惠.
    • Organizer
      第70回日本薬理学会北部会
    • Related Report
      2019 Research-status Report
  • [Presentation] 抗癌薬パクリタキセル誘発末梢神経障害性疼痛への芍薬甘草湯の末梢性疼痛抑制効果.2019

    • Author(s)
      安東嗣修、小林奈央、李峰、歌大介、久米利明、倉石泰.
    • Organizer
      第70回日本薬理学会北部会
    • Related Report
      2019 Research-status Report
  • [Presentation] 単純ヘルペスウイルスⅠ型感染マウスにおける帯状疱疹痛へのマクロファージ系細胞の関与.2019

    • Author(s)
      丹保宗一郎、歌大介、久米利明、安東嗣修.
    • Organizer
      日本薬学会北陸支部第131回例会
    • Related Report
      2019 Research-status Report
  • [Presentation] 線維筋痛症モデルラットの脊髄後角ニューロンの興奮性増大に対する抗うつ薬アミトリプチリンの抑制効果.2019

    • Author(s)
      田口徹、歌大介、坪島功幸、西条寿夫.
    • Organizer
      第24回日本基礎理学療法学会
    • Related Report
      2019 Research-status Report
  • [Presentation] 根治困難な疾患を克服するための先制医療の実現を目指して.2019

    • Author(s)
      歌大介
    • Organizer
      第1回運動神経変性疾患の治療を目指した創薬研究会
    • Related Report
      2019 Research-status Report
  • [Book] 週刊医学のあゆみ2022

    • Author(s)
      歌 大介
    • Total Pages
      5
    • Publisher
      医歯薬出版株式会社
    • Related Report
      2022 Research-status Report
  • [Remarks] 富山大学研究者総覧

    • URL

      https://u-toyama.elsevierpure.com/ja/persons/daisuke-uta

    • Related Report
      2023 Annual Research Report
  • [Remarks] 応用薬理学HP

    • URL

      http://www.pha.u-toyama.ac.jp/phapha2/index.html

    • Related Report
      2023 Annual Research Report
  • [Remarks] Reserchmap

    • URL

      https://researchmap.jp/carpmajesta86

    • Related Report
      2023 Annual Research Report
  • [Remarks] 応用薬理学研究室HP

    • URL

      http://www.pha.u-toyama.ac.jp/phapha2/index.html

    • Related Report
      2022 Research-status Report 2021 Research-status Report
  • [Remarks] 富山大学研究者総覧

    • URL

      https://evaweb.u-toyama.ac.jp/html/100000626_ja.html

    • Related Report
      2022 Research-status Report 2021 Research-status Report 2020 Research-status Report 2019 Research-status Report
  • [Remarks] researchmap

    • URL

      https://researchmap.jp/carpmajesta86

    • Related Report
      2022 Research-status Report 2021 Research-status Report
  • [Remarks] 富山大学学術研究部薬学・和漢系応用薬理学研究室ホームページ

    • URL

      http://www.pha.u-toyama.ac.jp/phapha2/index.html

    • Related Report
      2020 Research-status Report 2019 Research-status Report

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Published: 2019-04-18   Modified: 2025-01-30  

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