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Antioxidative activity of remifentanil: Does remifentanil directly scavenge free radicals?

Research Project

Project/Area Number 19K09329
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 55050:Anesthesiology-related
Research InstitutionOita University

Principal Investigator

Tokumaru Osamu  大分大学, 福祉健康科学部, 教授 (40360151)

Co-Investigator(Kenkyū-buntansha) 北野 敬明  大分大学, 医学部, 教授 (20211196)
松本 重清  大分大学, 医学部, 准教授 (90274761)
江島 伸興  京都大学, 高大接続・入試センター, 特定教授 (20203630)
Project Period (FY) 2019-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2021: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsレミフェンタニル / 抗酸化作用 / フリーラジカル / ラジカル消去作用 / 電子スピン共鳴法 / remifentanil / 術後認知機能障害 / μオピオイド受容体作動薬
Outline of Research at the Start

超高齢社会を迎えた我が国では高齢者の手術が増加している。神経炎症や酸化ストレスが原因とされる術後認知機能障害は高齢者でリスクが高く,その予防や治療の開発が急務である。手術中に鎮静剤として使用される レミフェンタニルは抗酸化作用をもち,術後認知機能障害の予防に有効であると期待されている。本研究課題は,レミフェンタニルの抗酸化作用の機序(フリーラジカル消去活性)を明らかにすることを目的として実施する。

Outline of Final Research Achievements

Remifentanil is an ultra-short acting opioid used for general anesthesia. Recently, it is reported that remifentanil has anti-oxidative activity, and is preventive against oxidative stress including ischemia/reperfusion injury and inflammation. However, the mechanism of antioxidative activity is not fully understood. The aim of the present study was to investigate direct free radical scavenging activity of remifentanil as an antioxidant. Scavenging activity against nine kinds of free radicals were investigated. Free radicals were observed using electron spin resonance spectrometry. Remifentanil significantly scavenged five kinds of free radicals out of nine in dose-dependent manners, including hydroxyl radical that is one of the most harmful radicals in living body. Theses results indicate that the mechanisms of antioxidative activity of remifentanil include direct dose-dependent free radical scavenging activity with selectivity.

Academic Significance and Societal Importance of the Research Achievements

超高齢社会を迎えた日本では, 術後認知機能障害 (POCD) のリスクを抱えた高齢者の手術症例の増加が予想される。POCDは酸化ストレスが原因とされているが, 近年の研究でその予防にレミフェンタニルが有効である可能性が示唆されている。本課題はレミフェンタニルの抗酸化作用の機序の一つが,レミフェンタニルがフリーラジカルを直接消去する作用であることを明らかにした。高齢者の全身麻酔でのレミフェンタニルの使用が,POCDの予防に対して有効であることを裏付ける知見であると考える。

Report

(5 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (6 results)

All 2023 2022 2021 Other

All Int'l Joint Research (1 results) Journal Article (2 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (3 results)

  • [Int'l Joint Research] University of Auckland(ニュージーランド)

    • Related Report
      2022 Annual Research Report
  • [Journal Article] The dose-response relationships of the direct scavenging activity of amide-based local anesthetics against multiple free radicals2023

    • Author(s)
      Sato Yukiko, Matsumoto Shigekiyo, Ogata Kazue, Kira Bacal, Nakatake Misato, Kitano Takaaki, Tokumaru Osamu
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 73 Issue: 1 Pages: 16-23

    • DOI

      10.3164/jcbn.22-131

    • ISSN
      0912-0009, 1880-5086
    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Dose-dependent scavenging activity of the ultra-short-acting β1-blocker landiolol against specific free radicals2022

    • Author(s)
      Matsumoto Shigekiyo、Tokumaru Osamu、Ogata Kazue、Kuribayashi Yoshihide、Oyama Yoshimasa、Shingu Chihiro、Yokoi Isao、Kitano Takaaki
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 71 Issue: 3 Pages: 185-190

    • DOI

      10.3164/jcbn.21-157

    • ISSN
      0912-0009, 1880-5086
    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Antioxidative activity of remifentanil as a direct free radical scavenger2022

    • Author(s)
      Osamu Tokumaru, Leon Yamasaki, Kazue Ogata, Shigekiyo Matsumoto, Takaaki Kitano
    • Organizer
      第96回日本薬理学会年会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Free radical direct scavenging activity of sitagliptin as an antioxidant2022

    • Author(s)
      Misato Nakatake, Kazue Ogata, Ryohei Umeda, Hiroki Takanari, OsamuTokumaru
    • Organizer
      日本生理学会 第100回記念大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Antioxidative activity of ketamineas a direct radical scavenger2021

    • Author(s)
      Tokumaru O, Ozaki Y, Kawano T, Ogata K, Eshima N, Matsumoto S, Kitano T
    • Organizer
      第95回日本薬理学会年会
    • Related Report
      2021 Research-status Report

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Published: 2019-04-18   Modified: 2024-01-30  

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