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Study of the anti-inflammatory roles of the exosomes from intestinal epithelial cells in sepsis via a paracrine effect

Research Project

Project/Area Number 19K09392
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 55060:Emergency medicine-related
Research InstitutionMie University

Principal Investigator

PARK Eun Jeong  三重大学, 医学系研究科, 准教授 (20644587)

Co-Investigator(Kenkyū-buntansha) 川本 英嗣  三重大学, 医学部附属病院, 講師 (20577415)
島岡 要  三重大学, 医学系研究科, 教授 (40281133)
住吉 美穂  三重大学, 医学部附属病院, 助教 (50510971)
Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2021: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords腸管粘膜免疫 / T細胞 / 腸管上皮細胞 / エキソソーム / 細胞接着 / インテグリン / マイクロRNA / 敗血症 / 腸管上皮 / 細胞外小胞 / サイトカイン / 樹状細胞 / 盲腸結紮穿刺(CLP) / マクロファージ
Outline of Research at the Start

敗血症は感染などに起因する制御不能な全身性の炎症反応が、腸管を含む多臓器の機能不全を惹起するショック病態である。腸管上皮細胞は、炎症の波及により透過性亢進が惹起されるなど傷害を受ける標的細胞であると同時に、メディエーター分泌を介して免疫麻痺など敗血症重症化病態の形成にも関わる制御細胞としても機能する可能性が示唆されるが、その詳細なメカニズムは不明である。本研究では腸管上皮細胞の敗血症での炎症制御における役割を、エキソソーム機能に注目して検討する。

Outline of Final Research Achievements

We have tested a possibility that functions of dendritic cells (DCs) are altered in sepsis, especially between different immune tissues. Using a sepsis model of cecal ligation and puncture (CLP), DCs were isolated from spleen and mesenteric lymph nodes (MLNs) and subjected to analyzing induction of T-cell activation. We have found that spleen DCs and MLN DCs display different activities in eliciting T cell immune responses (Darkwah et al. 2019 Biomedicines). In addition, we examined if intestinal epithelium-derived luminally released exosomes exhibit the capacity in regulating expressions of proinflammatory cytokines. As a result, we found that some of functional miRNAs were supposed to possess an ability to suppress expressions of TNF-alpha and IL-17A (Appiah et al. 2020 International Journal of Molecular Sciences).

Academic Significance and Societal Importance of the Research Achievements

本研究課題で得られた研究成果は、敗血症での樹状細胞の免疫誘導機能が全身誘導組織と粘膜誘導組織にて異なる可能性の発見であり、この研究成果をベースにして、将来、免疫反応の促進もしく抑制を目指す免疫疾患治療に向けての新しい基盤研究の設計に寄与すると考えられる。また、敗血症腸管上皮由来のエキソソームを用いての研究成果においては、腸管上皮細胞エキソソームが腸管の局所組織だけでなく、敗血症に疲弊される他器官の組織に対しての抗炎症作用や症状緩和の効果のもつ可能性を提示したことに、本研究の科学的意義があると考えられる。

Report

(4 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (57 results)

All 2022 2021 2020 2019 2018

All Journal Article (39 results) (of which Int'l Joint Research: 16 results,  Peer Reviewed: 29 results,  Open Access: 24 results) Presentation (17 results) (of which Int'l Joint Research: 3 results,  Invited: 2 results) Book (1 results)

  • [Journal Article] 成体幹細胞マーカーLGR5: 構造とシグナル伝達2022

    • Author(s)
      阿栄 高娃、朴 恩正、島岡 要
    • Journal Title

      消化器病学サイエンス

      Volume: 6 Pages: 47-47

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ヒトトロンボモジュリンの新たな抗炎症作用 -白血球インテグリンと相互作用-2021

    • Author(s)
      川本英嗣、中森裕毅、朴恩正、島岡要
    • Journal Title

      炎症と免疫

      Volume: 29 Pages: 74-81

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Recombinant soluble thrombomodulin accelerates epithelial stem cell proliferation in mouse intestinal organoids and promotes the mucosal healing in colitis2021

    • Author(s)
      Gaowa A, Park EJ, Kawamoto E, Qin Y, Shimaoka M.
    • Journal Title

      J Gastroenterol Hepatol.

      Volume: 36 Issue: 11 Pages: 3149-3157

    • DOI

      10.1111/jgh.15656

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Endothelial connexin-integrin crosstalk in vascular inflammation2021

    • Author(s)
      Okamoto Takayuki、Park Eun Jeong、Kawamoto Eiji、Usuda Haruki、Wada Koichiro、Taguchi Akihiko、Shimaoka Motomu
    • Journal Title

      Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

      Volume: 1867 Issue: 9 Pages: 166168-166168

    • DOI

      10.1016/j.bbadis.2021.166168

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] SARS-CoV-2のスパイクタンパク質が宿主細胞膜上のインテグリンに結合しウイルスの細胞内侵入に寄与する2021

    • Author(s)
      阿栄 高娃、朴 恩正、島岡 要
    • Journal Title

      アレルギーの臨床

      Volume: 41 Pages: 594-596

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cellular and exosomal regulations of sepsis-induced metabolic alterations2021

    • Author(s)
      Appiah G. Michael, Park Eun Jeong, Akama Y, Nakamori Y, Kawamoto E, Gaowa A, Shimaoka M
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 22 Issue: 15 Pages: 8295-8295

    • DOI

      10.3390/ijms22158295

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Elevated plasma soluble PD-L1 levels in out-of-hospital cardiac arrest patients2021

    • Author(s)
      Sumiyoshi Miho, Kawamoto Eiji, Nakamori Yuki, Esumi Ryo, Ikejiri Kaoru, Shinkai Toru, Akama Yuichi, Ito-Masui Asami, Imai Hiroshi, Gaowa Arong, Park Eun Jeong, Shimaoka Motomu
    • Journal Title

      Journal of Clinical Medicine

      Volume: 10 Pages: 4188-4188

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] miRNA-200c-3p targets talin-1 to regulate integrin-mediated cell adhesion.2021

    • Author(s)
      Obeng G, Park EJ, Appiah MG, Kawamoto E, Gaowa A, Shimaoka M.
    • Journal Title

      Sci Rep.

      Volume: 11 Issue: 1 Pages: 21597-21597

    • DOI

      10.1038/s41598-021-01143-3

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 腸管上皮が分泌するエキソソームの敗血症における新規抗炎症作用機序2021

    • Author(s)
      朴 恩正、川本 英嗣、赤間 悠一、阿栄 高娃、島岡 要
    • Journal Title

      Medical Science Digest

      Volume: 46 Pages: 690-691

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PD-1が敗血症性肺傷害における2型自然リンパ球の疲弊を起こす2021

    • Author(s)
      赤間 悠一, 朴 恩正, 佐藤 尚子, 川本 英嗣, 阿栄高娃 , 伊藤 温志, 江角 亮, 池尻 薫, 今井 寛, 島岡 要
    • Journal Title

      Shock: 日本Shock学会雑誌

      Volume: 35 Pages: 38-38

    • Related Report
      2021 Annual Research Report
  • [Journal Article] Sepsis Induces Deregulation of IL-13 Production and PD-1 Expression in Lung Group 2 Innate Lymphoid Cells.2021

    • Author(s)
      Akama Y, Park EJ, Satoh-Takayama N, Gaowa A, Ito A, Kawamoto E, Darkwah S, Appiah MG, Myint PK, Ohno H, Imai H, Shimaoka M.
    • Journal Title

      Shock

      Volume: 55 Issue: 3 Pages: 357-370

    • DOI

      10.1097/shk.0000000000001647

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Ligand-competent fractalkine receptor is expressed on exosomes.2021

    • Author(s)
      Park EJ, Myint PK, Appiah MG, Worawattananutai P, Inprasit J, Prajuabjinda O, Soe ZY, Gaowa A, Kawamoto E, Shimaoka M.
    • Journal Title

      Biochem Biophys Rep.

      Volume: 26 Pages: 100932-100932

    • DOI

      10.1016/j.bbrep.2021.100932

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The Lectin-Like Domain of Thrombomodulin Inhibits β1 Integrin-Dependent Binding of Human Breast Cancer-Derived Cell Lines to Fibronectin.2021

    • Author(s)
      Kawamoto E, Nago N, Okamoto T, Gaowa A, Masui-Ito A, Akama Y, Darkwah S, Appiah MG, Myint PK, Obeng G, Ito A, Caidengbate S, Esumi R, Yamaguchi T, Park EJ, Imai H, Shimaoka M.
    • Journal Title

      Biomedicines

      Volume: 9 Issue: 2 Pages: 162-162

    • DOI

      10.3390/biomedicines9020162

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Potential Roles of Muscle-Derived Extracellular Vesicles in Remodeling Cellular Microenvironment: Proposed Implications of the Exercise-Induced Myokine, Irisin2021

    • Author(s)
      Darkwah Samuel、Park Eun Jeong、Myint Phyoe Kyawe、Ito Atsushi、Appiah Michael G.、Obeng Gideon、Kawamoto Eiji、Shimaoka Motomu
    • Journal Title

      Frontiers in Cell and Developmental Biology

      Volume: 9 Pages: 1-1

    • DOI

      10.3389/fcell.2021.634853

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Remodeling of Bone Marrow Niches and Roles of Exosomes in Leukemia.2021

    • Author(s)
      Yamaguchi T, Kawamoto E, Gaowa A, Park EJ, Shimaoka M.
    • Journal Title

      Int J Mol Sci.

      Volume: 22 Issue: 4 Pages: 1881-1881

    • DOI

      10.3390/ijms22041881

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Integrin Regulation in Immunological and Cancerous Cells and Exosomes2021

    • Author(s)
      Soe Zay Yar、Park Eun Jeong、Shimaoka Motomu
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 22 Issue: 4 Pages: 2193-2193

    • DOI

      10.3390/ijms22042193

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Immune Deregulation in Sepsis and Septic Shock: Reversing Immune Paralysis by Targeting PD-1/PD-L1 Pathway2021

    • Author(s)
      Nakamori Yuki、Park Eun Jeong、Shimaoka Motomu
    • Journal Title

      Frontiers in Immunology

      Volume: 11 Pages: 11-11

    • DOI

      10.3389/fimmu.2020.624279

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Irisin supports integrin-mediated cell adhesion of lymphocytes.2021

    • Author(s)
      Myint PK, Ito A, Appiah MG, Obeng G, Darkwah S, Kawamoto E, Gaowa A, Park EJ, Shimaoka M
    • Journal Title

      Biochem Biophys Rep.

      Volume: 26 Pages: 100977-100977

    • DOI

      10.1016/j.bbrep.2021.100977

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Distinct Age-Specific miRegulome Profiling of Isolated Small and Large Intestinal Epithelial Cells in Mice2021

    • Author(s)
      Lee Juneyoung、Mohsen Attayeb、Banerjee Anik、McCullough Louise D.、Mizuguchi Kenji、Shimaoka Motomu、Kiyono Hiroshi、Park Eun Jeong
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 22 Issue: 7 Pages: 3544-3544

    • DOI

      10.3390/ijms22073544

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] リコモジュリンによる白血球インテグリンと 血管内皮細胞上のインテグリンリガンドを介した接着制御作用2021

    • Author(s)
      長太 のどか, 川本 英嗣, 朴 恩正, 島岡 要
    • Journal Title

      鈴鹿医療科学大学紀要

      Volume: 27 Pages: 41-54

    • Related Report
      2020 Research-status Report
  • [Journal Article] 腸管上皮由来エキソソームがキャリアーするマイクロRNAによる炎症性サイトカインの発現抑制2021

    • Author(s)
      阿栄 高娃, Michael G. Appiah, 朴 恩正, 島岡 要
    • Journal Title

      アレルギーの臨床

      Volume: 41 Pages: 181-184

    • Related Report
      2020 Research-status Report
  • [Journal Article] Targeted remodeling of breast cancer and immune cell homing niches by exosomal integrins.2020

    • Author(s)
      Myint PK, Park EJ, Gaowa A, Kawamoto E, Shimaoka M.
    • Journal Title

      Diagn Pathol.

      Volume: 15 Issue: 1 Pages: 38-38

    • DOI

      10.1186/s13000-020-00959-3

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Role of Innate Lymphoid Cells in the Regulation of Immune Homeostasis in Sepsis-Mediated Lung Inflammation.2020

    • Author(s)
      Akama Y, Park EJ, Satoh-Takayama N, Gaowa A, Ito A, Kawamoto E, Darkwah S, Appiah MG, Myint PK, Ohno H, Imai H, Shimaoka M.
    • Journal Title

      Diagnostics (Basel)

      Volume: 10 Issue: 10 Pages: 808-808

    • DOI

      10.3390/diagnostics10100808

    • NAID

      120006941006

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Intestinal Epithelium-Derived Luminally Released Extracellular Vesicles in Sepsis Exhibit the Ability to Suppress TNF-a and IL-17A Expression in Mucosal Inflammation.2020

    • Author(s)
      Appiah MG, Park EJ, Darkwah S, Kawamoto E, Akama Y, Gaowa A, Kalsan M, Ahmad S, Shimaoka M.
    • Journal Title

      Int J Mol Sci.

      Volume: 21 Issue: 22 Pages: 8445-8445

    • DOI

      10.3390/ijms21228445

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Integrin-Ligand Interactions in Inflammation, Cancer, and Metabolic Disease: Insights Into the Multifaceted Roles of an Emerging Ligand Irisin2020

    • Author(s)
      Park Eun Jeong、Myint Phyoe Kyawe、Ito Atsushi、Appiah Michael G.、Darkwah Samuel、Kawamoto Eiji、Shimaoka Motomu
    • Journal Title

      Frontiers in Cell and Developmental Biology

      Volume: 8 Pages: 588066-588066

    • DOI

      10.3389/fcell.2020.588066

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Methods to Study Integrin Functions on Exosomes2020

    • Author(s)
      Kawamoto Eiji、Park Eun Jeong、Shimaoka Motomu
    • Journal Title

      Methods in Molecular Biology

      Volume: 2217 Pages: 265-281

    • DOI

      10.1007/978-1-0716-0962-0_15

    • ISBN
      9781071609613, 9781071609620
    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 炎症性腸疾患に対するトロンボモジュリンの粘膜治癒促進効果の検討2020

    • Author(s)
      阿栄高娃, Qin Yan, 朴 恩正, 島岡 要
    • Journal Title

      日本血栓止血学会誌

      Volume: 31

    • Related Report
      2020 Research-status Report
  • [Journal Article] Integrin-mediated tissue-specific homing of lymphocytes and exosomes to the gut2020

    • Author(s)
      Onmanee Prajuabjinda, Zay Yar Soe, Eun Jeong Park
    • Journal Title

      日本Shock学会誌

      Volume: 34 Pages: 37-42

    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Journal Article] The mucosal immune system as a control mechanism of septic shock2020

    • Author(s)
      Eun Jeong Park, Samuel Darkwah, Michael G. Appiah, Motomu Shimaoka, Hiroshi Kiyono
    • Journal Title

      日本Shock学会誌

      Volume: 34 Pages: 44-64

    • Related Report
      2020 Research-status Report
  • [Journal Article] Intestinal Epithelial Organoids: A Platform for Discovering Mucosal Healing Drug Candidates for the Treatment of Inflammatory Bowel Diseases2020

    • Author(s)
      Qin Yan, Arong Gaowa, Eiji Kawamoto, Eun Jeong Park, Motomu Shimaoka
    • Journal Title

      Diagnostic Pathology Open

      Volume: 5 Pages: 1-3

    • Related Report
      2020 Research-status Report
  • [Journal Article] 腸管上皮再生を目指した新規治療法の開発2020

    • Author(s)
      阿栄高娃, 朴 恩正, 島岡 要
    • Journal Title

      アレルギーの臨床

      Volume: 40 Pages: 658-661

    • Related Report
      2020 Research-status Report
  • [Journal Article] 腸上皮オルガノイドを用いた炎症性腸疾患の病態解明と治療展望2020

    • Author(s)
      阿栄高娃, 秦 艶, 朴 恩正, 島岡 要
    • Journal Title

      Medical Science Digest

      Volume: 46 Pages: 410-412

    • Related Report
      2020 Research-status Report
  • [Journal Article] Micro-MRI-based detection of tissue damage in the liver, pancreas, and kidney during the early phases of an LPS and D-galactosamine-induced hepatic injury model in mice2020

    • Author(s)
      Nodoka Nago, Misao Yoneda, Samuel Darkwah, Eiji Kawamoto, Eun Jeong Park, Motomu Shimaoka
    • Journal Title

      Diagnostic Pathology Open

      Volume: 5 Pages: 1-8

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Anti-adhesive effects of human soluble thrombomodulin and its domains2019

    • Author(s)
      Kawamoto Eiji、Nago Nodoka、Okamoto Takayuki、Gaowa Arong、Masui-Ito Asami、Sakakura Yosuke、Akama Yuichi、Soe Zay Yar、Prajuabjinda Onmanee、Darkwah Samuel、Appiah Michael G.、Myint Phyoe Kyawe、Obeng Gideon、Park Eun Jeong、Imai Hiroshi、Shimaoka Motomu
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 511 Issue: 2 Pages: 312-317

    • DOI

      10.1016/j.bbrc.2019.02.041

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Talin-2 regulates integrin functions in exosomes2019

    • Author(s)
      Soe Zay Yar、Prajuabjinda Onmanee、Myint Phyoe Kyawe、Gaowa Arong、Kawamoto Eiji、Park Eun Jeong、Shimaoka Motomu
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 512 Issue: 3 Pages: 429-434

    • DOI

      10.1016/j.bbrc.2019.03.027

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Differential roles of dendritic cells in expanding CD4 T cells in sepsis2019

    • Author(s)
      Samuel Darkwah, Nodoka Nago, Michael G. Appiah, Phyoe Kyawe Myint, Eiji Kawamoto, Motomu Shimaoka, Eun Jeong Park
    • Journal Title

      Biomedicines

      Volume: 7 Pages: 1-18

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Exosomes in Sepsis and Inflammatory Tissue Injury2019

    • Author(s)
      Park EJ, Appiah MG, Myint PK, Gaowa A, 他2名
    • Journal Title

      Curr Pharm Des

      Volume: 25 Issue: 42 Pages: 4486-4495

    • DOI

      10.2174/1381612825666191116125525

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 腸管上皮幹細胞の増殖促進及び上皮分化誘導に着目した粘膜治癒の新規治療法の開発に向けて2019

    • Author(s)
      阿栄 高娃、朴 恩正、島岡 要
    • Journal Title

      アレルギーの臨床

      Volume: 39 Pages: 1055-1058

    • Related Report
      2019 Research-status Report
  • [Journal Article] Integrin and PD-1 Ligand Expression on Circulating Extracellular Vesicles in Systemic Inflammatory Response Syndrome and Sepsis2018

    • Author(s)
      Kawamoto Eiji、Masui-Ito Asami、Eguchi Akiko、Soe Zay Yar、Prajuabjinda Onmanee、Darkwah Samuel、Park Eun Jeong、Imai Hiroshi、Shimaoka Motomu
    • Journal Title

      SHOCK

      Volume: - Issue: 1 Pages: 1-1

    • DOI

      10.1097/shk.0000000000001228

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] PD-1が敗血症性肺傷害における2型自然リンパ球の疲弊を起こす2021

    • Author(s)
      赤間悠一、朴恩正、佐藤尚子、川本英嗣、阿栄高娃、伊藤温志、江角亮、池尻薫、今井寛、島岡要
    • Organizer
      第35回 日本ショック学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 院外心停止患者の血中sPD-L1濃度は上昇し炎症反応亢進や免疫麻痺と相関する2021

    • Author(s)
      住吉美穂、川本英嗣、中森裕毅、江角亮、池尻薫、新貝達、阿栄高娃、 朴恩正、今井寛、島岡要
    • Organizer
      日本集中治療医学会第5回東海北陸支部学術集会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 新規インテグリンリガンドの研究:白血球インテグリンはCOVID-19スパイク蛋白やイリシンに結合する2021

    • Author(s)
      Myint Phyoe Kyawe, 朴恩正、Appiah G. Michael, Darkwah Samuel, Caidengbate Siqingaowa, 伊藤温志、松尾映里、川本英嗣、阿栄高娃、島岡要
    • Organizer
      日本集中治療医学会第5回東海北陸支部学術集会
    • Related Report
      2021 Annual Research Report
  • [Presentation] SARS-CoV-2 S1 protein binds to beta1 integrins to trigger integrin-mediated activation pathway2021

    • Author(s)
      Park Eun Jeong, Mokmued Khwanchanok, Matsuo Eri, Caidengbate Siqingaowa, Ito Atsushi, Kawamoto Eiji, Gaowa Arong, Shimaoka Motomu
    • Organizer
      The 50th Annual Meeting of Japanese Society for Immunology
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Recombinant soluble thrombomodulin promotes intestinal stem cell-mediated epithelial regeneration2021

    • Author(s)
      Gaowa Arong, Park Eun Jeong, Shimaoka Motomu
    • Organizer
      The 50th Annual Meeting of Japanese Society for Immunology
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Crucial roles of miR-200c in regulating integrin-mediated cell adhesion via targeting talins2020

    • Author(s)
      Obeng Gideon, Park Eun Jeong, Gaowa Arong, Shimaoka Motomu
    • Organizer
      日本血栓止血学会
    • Related Report
      2020 Research-status Report
  • [Presentation] 血漿中PD-1リガンドと敗血症患者の臨床経過や臓器障害との相関の検討2019

    • Author(s)
      川本 英嗣、伊藤 亜紗実、江口 暁子、Zay Yar Soe、Onmanee Prajuabjinda、Samuel Darkwah、朴 恩正、今井 寛、島岡 要
    • Organizer
      第41回日本血栓止血学会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] Tリンパ球エクソソームによる腸管組織特異的ホーミングの制御2019

    • Author(s)
      島岡 要、朴 恩正
    • Organizer
      第41回日本血栓止血学会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] Exosomes in the regulation of lymphocyte trafficking and inflammation2019

    • Author(s)
      朴 恩正
    • Organizer
      第34回日本Shock学会総会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] トロンボモジュリンの粘膜治癒過程における効果と作用機序2019

    • Author(s)
      阿栄 高娃、川本 英嗣、朴 恩正、島岡 要
    • Organizer
      第34回日本Shock学会総会
    • Related Report
      2019 Research-status Report
  • [Presentation] Sepsis induces secretion of the anti-inflammatory exosomes from intestinal epithelial cells2019

    • Author(s)
      Michael G. Appiah, Samuel Darkwah, Eiji Kawamoto, Hiroshi Imai, Motomu Shimaoka, Eun Jeong Park
    • Organizer
      第34回日本Shock学会総会
    • Related Report
      2019 Research-status Report
  • [Presentation] Exosomes from gut-tropic T cells negatively regulate lymphocyte homing to the gut2019

    • Author(s)
      Onmanee Prajuabjinda, Zay Yar Soe, Samuel Darkwah, Eiji Kawamoto, Hiroshi Imai, Motomu Shimaoka, Eun Jeong Park
    • Organizer
      第34回日本Shock学会総会
    • Related Report
      2019 Research-status Report
  • [Presentation] Differential roles of dendritic cells in expanding CD4 T cells in sepsis2019

    • Author(s)
      Samuel Darkwah, Michael G. Appiah, Nodoka Nago, Eiji Kawamoto, Hiroshi Imai, Motomu Shimaoka, Eun Jeong Park
    • Organizer
      第34回日本Shock学会総会
    • Related Report
      2019 Research-status Report
  • [Presentation] Talin-2 regulates integrin activation in T-cell exosomes2019

    • Author(s)
      Zay Yar Soe, Onmanee Projuabjinda, Eiji Kawamoto, Hiroshi Imai, Motomu Shimaoka, Eun Jeong Park
    • Organizer
      第34回日本Shock学会総会
    • Related Report
      2019 Research-status Report
  • [Presentation] Integrin-mediated exosomal control of tissue-specific lymphocyte homing to the gut2019

    • Author(s)
      Eun Jeong Park, Motomu Shimaoka
    • Organizer
      APSEV-2019 Inaugural Annual Meeting
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Differential roles of dendritic cells in expanding CD4 T cells in sepsis2019

    • Author(s)
      Samuel Darkwah, Nodoka Nago, Michael G. Appiah, Phyoe Kyawe Myint, Eiji Kawamoto, Motomu Shimaoka, Eun Jeong Park
    • Organizer
      第48回 日本免疫学会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] Intestinal epithelial cell-derived exosomes carry microRNAs downregulating pro-inflammatory responses in sepsis2019

    • Author(s)
      Eun Jeong Park, Michael G. Appiah, Samuel Darkwah, Eiji Kawamoto, Motomu Shimaoka
    • Organizer
      第48回 日本免疫学会学術集会
    • Related Report
      2019 Research-status Report
  • [Book] Mucosal Vaccines; Chapter 5. Mucosal Immunity for Inflammation: Regulation of gut-specific lymphocyte migration by integrins2020

    • Author(s)
      Eun Jeong Park, Eiji Kawamoto, Motomu Shimaoka
    • Total Pages
      941
    • Publisher
      Elsevier
    • ISBN
      9780128119242
    • Related Report
      2019 Research-status Report

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Published: 2019-04-18   Modified: 2023-01-30  

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