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Development of physiological monitoring method by NIRS to evaluate appropriate chest compression at cardiac arrest

Research Project

Project/Area Number 19K09400
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 55060:Emergency medicine-related
Research InstitutionKagoshima University

Principal Investigator

Kakihana Yasuyuki  鹿児島大学, 医歯学域医学系, 教授 (20264426)

Co-Investigator(Kenkyū-buntansha) 伊藤 隆史  鹿児島大学, 医歯学総合研究科, 特任准教授 (20381171)
上國料 千夏  鹿児島大学, 医歯学総合研究科, 特任助教 (50751278)
Project Period (FY) 2019-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2021: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords心肺蘇生法 / 胸骨圧迫 / 自己心拍再開 / 近赤外線分光法 / NIRO装置 / パルス波形 / 脳内酸素飽和度 / 逆行性脳血流 / 時間分解分光法 / 空間分解分光法 / 胸骨圧迫法 / 心肺停止 / 脳酸素飽和度 / 順行性脳血流
Outline of Research at the Start

近年、近赤外線分光法で測定した脳内酸素飽和度が胸骨圧迫の指標になる可能性が指摘され、さらに、脳内酸素飽和度が一定値以上になると自己心拍再開(ROSC)が期待できることもわかってきた。そこで我々は、「心停止時における胸骨圧迫時に、(1)脳内酸素飽和度は順行性脳血流の指標になる」、(2)脳内酸素飽和度はROSCの指標になる」と仮定し本研究を計画した。本研究の目的は、中型動物の心原性心停止(VF)モデルを作成し、心停止時の適切な胸骨圧迫を評価する生理学的モニタリング法の構築を目指すものである。

Outline of Final Research Achievements

In recent years, it has been pointed out that cerebral oxygen saturation may be an indicator of resuscitation. Therefore, we conducted this study on the assumption that during resuscitation, "cerebral oxygen saturation is an indicator of (1) antegrade cerebral blood flow, and (2) return of spontaneous circulation (ROSC)." Retrograde cerebral blood flow during resuscitation was not confirmed, although contrast medium was injected into the right atrium. On the other hand, it was found that the difference in the site of chest compression greatly affects the resuscitation effect, and the time phase changes of oxygenated and deoxygenated Hb in the NIRO device pulse waveform were shown to be useful for evaluating antegrade/retrograde cerebral blood flow during chest compression. In addition, although it was not possible to obtain the absolute value of cerebral oxygen saturation as an indicator of ROSC, the pulse waveform and cerebral oxygen saturation were useful for evaluating ROSC.

Academic Significance and Societal Importance of the Research Achievements

今回の研究から、胸骨圧迫部位の違いが蘇生効果に大きく影響することが判明し、NIRO装置パルス波形の酸素化型Hbと脱酸素化型Hbの時相変化は、胸骨圧迫時の順行性/逆行性脳血流の評価にも有用であることが示された。また、蘇生時の胸骨圧迫法が適切かつ有効に実施されているのかをNIRO装置パルス波形で連続的に評価できることから、ROSCの評価にも有用であることが示された。この研究成果は、これまで10%以下であった心原性心停止症例の社会復帰率向上につながることが期待される。

Report

(6 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (1 results)

All 2024

All Journal Article (1 results)

  • [Journal Article] Observation of blood motion in the internal jugular vein by contact and contactless photoplethysmography during physiological testing: case studies2024

    • Author(s)
      Saiko G, Burton T, Kakihana Y, Hatanaka K, Takahito O, Douplik A
    • Journal Title

      Biomed Opt Express

      Volume: 25 Issue: 4 Pages: 2578-2589

    • DOI

      10.1364/boe.516609

    • Related Report
      2023 Annual Research Report

URL: 

Published: 2019-04-18   Modified: 2025-01-30  

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