Interactions between inflammation and coagulation by disease type and the significance of vasoactive substances in DIC
| Project/Area Number |
19K09430
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Review Section |
Basic Section 55060:Emergency medicine-related
|
|---|
| Research Institution | Kanazawa University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2019-04-01 – 2022-03-31
|
| Project Status |
Completed (Fiscal Year 2021)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2021: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Keywords | DIC |
|---|
| Outline of Research at the Start |
DICの本態である凝固活性化状態と微小循環障害、および炎症と血管作動性物質との関連について、TF＆LPS誘発DICモデルの２種類のDICモデルを用いて究明する。
臓器障害や血管内皮障害の見られないTF誘発DICモデルでは、臓器障害が高度なLPS誘発DICモデルを凌駕する一酸化窒素（NO）の産生が見られるが、その産生機序を解明することで、DICにおけるNOの役割を明らかにする。また、炎症と凝固のクロストークを遮断する方法を検討する。
|
| Outline of Final Research Achievements |
The significance of vasoactive substances was investigated using a rat model of disseminated intravascular coagulation (DIC). Even in the same DIC model, the LPS model showed severe organ damage, but the tissue factor (TF) model showed almost no organ damage. The reason for this is considered to be that the TF model has high fibrinolytic activation (thrombi is easily dissolved) and that the production of nitric oxide (NO), which is a vasodilator, is enhanced. Conventional DIC treatment has mainly been anticoagulant therapy, but there is a possibility that vasodilator regulators will be developed as new therapeutic agents.
|
| Academic Significance and Societal Importance of the Research Achievements |
DICは、全身臓器に微小血栓が多発して、究極の血栓症とも言える病態である。DICにおける病態解析の手法や、治療法改善の研究は、そのまま一般的な血栓症（脳梗塞、心筋梗塞、いわゆるエコノミークラス症候群など）に対しても応用可能である。ラットなどの動物を用いてDICモデルを作成することは容易であり、今後もDICモデルを用いた研究は、広く血栓症全体に対しても診療レベルの向上につながる可能性が高い。
|
Report
(4 results)
Research Products
(113 results)
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] Molecular genetic analysis of inherited protein C deficiency caused by the novel large deletion across two exons of PROC2020
Author(s)
Togashi T, Meguro-Horike M, Nagaya S, Sugihara S, Ichinohe T, Araiso Y, Yamaguchi K, Mori K, Imai Y, Kuzasa K, Horike SI, Asakura H, Watanabe A, Morishita E.
-
Journal Title
Thromb Res
Volume: -
Pages: 115-118
DOI
Related Report
Peer Reviewed / Open Access
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] Genetic analysis of a compound heterozygous patient with congenital factor X deficiency and regular replacement therapy with a prothrombin complex concentrate2020
Author(s)
6)Togashi T, Nagaya S, Nagasawa M, Meguro-Horike M, Nogami K, Imai Y, Kuzasa K, Sekiya A, Horike SI, Asakura H, Morishita E
-
Journal Title
Int J Hematol
Volume: 111
Issue: 1
Pages: 51-56
DOI
Related Report
Peer Reviewed / Open Access
-
-
-
-
-
-
-
-
[Journal Article] DIC の診断2019
Author(s)
朝倉英策
-
Journal Title
Japanese Journal of Thrombosis and Hemostasis
Volume: 30
Issue: 1
Pages: 193-200
DOI
NAID
ISSN
0915-7441, 1880-8808
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
