Relationship between immune response in therapies for malignant glioma and tymor heterogeneity

• Project/Area Number: 19K09457
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 56010:Neurosurgery-related
• Research Institution: Osaka University
• Principal Investigator: Naoki Kagawa 大阪大学, 大学院医学系研究科, 講師 (50444542)
• Co-Investigator(Kenkyū-buntansha): 坪井 昭博 大阪大学, 大学院医学系研究科, 招へい教授 (10372608)
• Project Period (FY): 2019-04-01 – 2024-03-31
• Project Status: Completed (Fiscal Year 2023)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2021: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 悪性神経膠腫 / 免疫応答 / heterogeneity / 腫瘍幹細胞 / 腫瘍血管正常化

Outline of Research at the Start

神経膠腫のゲノム・エピゲノムを含むheterogeneityと免疫応答の関係性を明らかにするとともに、腫瘍幹細胞や微小環境による腫瘍免疫抑制の解明、免疫療法と新生血管抑制因子を含む分子標的薬との組み合わせやタイミングなどを検討する基礎的な研究を模索することにより、我が国発信の免疫療法を含んだ新たな臨床試験の可能性が広がり、治療成績を改善させる礎となることを期待する。

Outline of Final Research Achievements

We showed the signaling pathway mediated through the lysophosphatidic acid receptor 4 (LPA4) promote vascular network formation to restore normal vascular barrier function and improve drug delivery in xenograft model of glioblastomas. LPA4 promotes fine vascular formation and induces functional vasculature in malignant brain tumors.
LPA4 injection resulted in increased tumor-infiltrating lymphocytes in brain tumors. LPA4 improved delivery of exogenous IgG into brain tumors and enhanced the anticancer effect of anti-programmed cell death-1 antibody therapy. A combination of LPA4 and anti-PD-1 antibody extended median survival relative to the single-agent anti-PD-1 antibody. LPA4 enhanced the anticancer effect of anti-PD-1 antibody therapy.

Academic Significance and Societal Importance of the Research Achievements

近年急速に解明が進んでいる神経膠腫のゲノム異常と分子分類による予後予測に加えて、腫瘍幹細胞や微小環境による腫瘍免疫抑制の解明、免疫療法（ワクチンや細胞療法）と新生血管抑制因子を含む分子標的薬との組み合わせやタイミングなどを模索することにより、我が国発信の免疫療法を含んだ新たな臨床試験の可能性が広がり、治療成績を改善させる礎となることを期待するものである。

Research Products

• [Journal Article] WT1 Trio Peptide-Based Cancer Vaccine for Rare Cancers Expressing Shared Target WT1 (2023)
  • Author(s): Oji Y, Kagawa N, Arita H, Naka N, Hamada KI, Outani H, Shintani Y, Takeda Y, Morii E, Shimazu K, Suzuki M, Nishida S, Nakata J, Tsuboi A, Iwai M, Hayashi S, Imanishi R, Ikejima S, Kanegae M, Iwamoto M, Ikeda M, Yagi K, Shimokado H, Nakajima H, Hasegawa K, Morimoto S, Fujiki F 他
  • Journal Title: Cancers Volume: 15 Issue: 2 Pages: 393-393
  • DOI: 10.3390/cancers15020393
  • Peer Reviewed / Open Access
• [Journal Article] Subtyping of Group 3/4 medulloblastoma as a potential prognostic biomarker among patients treated with reduced dose of craniospinal irradiation: a Japanese Pediatric Molecular Neuro-Oncology Group study. (2023)
  • Author(s): Fukuoka K, Kurihara J, Shofuda T, Kagawa N, Yamasaki K, Ando R, Ishida J, Kanamori M, Kawamura A, Park YS, Kiyotani C, Akai T, Keino D, Miyairi Y, Sasaki A, Hirato J, Inoue T, Nakazawa A, Koh K, Nishikawa R, Date I, Nagane M, Ichimura K, Kanemura Y
  • Journal Title: Acta Neuropathol Commun. Volume: 11(1) Issue: 1 Pages: 153-153
  • DOI: 10.1186/s40478-023-01652-4
  • Peer Reviewed / Open Access
• [Journal Article] Surgical resection of glioblastoma in basal ganglia and utility of exoscope: Technical case reports (2023)
  • Author(s): Kijima Noriyuki、Kinoshita Manabu、Kagawa Naoki、Okita Yoshiko、Hirayama Ryuichi、Kishima Haruhiko
  • Journal Title: Surgical Neurology International Volume: 14 Pages: 213-213
  • DOI: 10.25259/sni_53_2023
  • Peer Reviewed / Open Access
• [Journal Article] Qualitative MR features to identify non-enhancing tumors within glioblastoma’s T2-FLAIR hyperintense lesions (2023)
  • Author(s): Yamamoto Shota、Okita Yoshiko、Arita Hideyuki、Sanada Takahiro、Sakai Mio、Arisawa Atsuko、Kagawa Naoki、Shimosegawa Eku、Nakanishi Katsuyuki、Kinoshita Manabu、Kishima Haruhiko
  • Journal Title: Journal of Neuro-Oncology Volume: 165 Issue: 2 Pages: 251-259
  • DOI: 10.1007/s11060-023-04454-9
  • Peer Reviewed / Open Access
• [Journal Article] 小児上衣腫の治療と臨床試験. (2023)
  • Author(s): 香川尚己
  • Journal Title: 日本臨牀 Volume: 81(suppl 9). Pages: 534-542
• [Journal Article] 脊髄髄膜瘤胎児手術の外科治療 (2023)
  • Author(s): 香川尚己、渡邊美穂、遠藤誠之
  • Journal Title: 小児外科 Volume: 55(1). Pages: 56-62
• [Journal Article] 脳腫瘍-WHO脳腫瘍分類2021改訂のポイント Pediatric-type diffuse low-grade gliomas. (2023)
  • Author(s): 香川尚己, 貴島晴彦.
  • Journal Title: Clinical Neuroscience別冊. Volume: 41(4). Pages: 496-500
• [Journal Article] 小児脳室内腫瘍における神経内視鏡手術. (2023)
  • Author(s): 香川尚己
  • Journal Title: 脳神経外科. Volume: 50(6) Pages: 1340-1352
• [Journal Article] 特集 小児脳神経外科-エキスパートはこうしている Ⅷ小児脳腫瘍 脳室内腫瘍-神経内視鏡-小児脳室内腫瘍における神経内視鏡手術 (2022)
  • Author(s): Kagawa N.
  • Journal Title: Neurological Surgery 脳神経外科 Volume: 50 Issue: 6 Pages: 1340-1352
  • DOI: 10.11477/mf.1436204700
  • ISSN: 0301-2603, 1882-1251
  • Year and Date: 2022-11-10
  • Peer Reviewed / Open Access
• [Journal Article] Prediction and Visualization of Non-Enhancing Tumor in Glioblastoma via T1w/T2w-Ratio Map (2022)
  • Author(s): Yamamoto Shota、Sanada Takahiro、Sakai Mio、Arisawa Atsuko、Kagawa Naoki、Shimosegawa Eku、Nakanishi Katsuyuki、Kanemura Yonehiro、Kinoshita Manabu、Kishima Haruhiko
  • Journal Title: Brain Sciences Volume: 12 Issue: 1 Pages: 99-99
  • DOI: 10.3390/brainsci12010099
  • Peer Reviewed / Open Access
• [Journal Article] Successful separation of male pygopagus with anal canal and urethral reconstruction: a case report (2022)
  • Author(s): Toyama C, Nomura M, Tazuke Y, Yokota C, Kagawa N, Kishima H, Yoshimura A, Ujike T, Nagahara A, Nonomura N, Kubo T, Matsui F, Matsumoto F, Okuyama H.
  • Journal Title: Surg Case Rep. Volume: 8(1) Issue: 1 Pages: 43-43
  • DOI: 10.1186/s40792-022-01398-6
  • Peer Reviewed / Open Access
• [Journal Article] Cerebellopontine angle metastasis of a neuroendocrine tumor mimicking vestibular schwannoma: A case report. (2022)
  • Author(s): Yamada S, Kijima N†, Kinoshita M, Shinzaki S, Sato K, Kido K, Hirayama R, Kagawa N, Takehara T, Morii E, Kishima H.
  • Journal Title: Surgical Neurology International Volume: 13 Pages: 264-264
  • DOI: 10.25259/sni_117_2022
  • Peer Reviewed / Open Access
• [Journal Article] Growth risk classification and typical growth speed of convexity, parasagittal, and falx meningiomas: a retrospective cohort study (2022)
  • Author(s): Yamada S, Hirayama R, Iwata T, Kuroda H, Nakagawa T, Takenaka T, Kijima N, Okita Y, Kagawa N, Kishima H.
  • Journal Title: J Neurosurg. Volume: 138(5) Issue: 5 Pages: 1235-1241
  • DOI: 10.3171/2022.8.jns221290
  • Peer Reviewed / Open Access
• [Journal Article] Optic nerve sheath meningioma presenting as progressive visual disturbance during pregnancy: A case report (2022)
  • Author(s): Utsugi R, Okita Y, Kagawa N, Kishima H.
  • Journal Title: Exp Ther Med. Volume: 25(1) Issue: 1 Pages: 65-65
  • DOI: 10.3892/etm.2022.11764
  • Peer Reviewed / Open Access
• [Journal Article] Revisiting the definition of glioma recurrence based on a phylogenetic investigation of primary and re-emerging tumor samples: a case report (2022)
  • Author(s): Umehara T, Arita H, Miya F, Achiha T, Shofuda T, Yoshioka E, Kanematsu D, Nakagawa T, Kinoshita M, Kagawa N, Fujimoto Y, Hashimoto N, Kiyokawa H, Morii E, Tsunoda T, Kanemura Y, Kishima H.
  • Journal Title: Brain Tumor Pathol. Volume: 39(4) Issue: 4 Pages: 218-224
  • DOI: 10.1007/s10014-022-00438-1
  • Peer Reviewed / Open Access
• [Journal Article] Identification of glioblastoma-specific antigens expressed in patient-derived tumor cells as candidate targets for chimeric antigen receptor T cell therapy (2022)
  • Author(s): Nakagawa T, Kijima N, Hasegawa K, Ikeda S, Yaga M, Wibowo T, Tachi T, Kuroda H, Hirayama R, Okita Y, Kinoshita M, Kagawa N, Kanemura Y, Hosen N, Kishima H.
  • Journal Title: Neurooncol Adv. Volume: 5(1) Issue: 1
  • DOI: 10.1093/noajnl/vdac177
  • Peer Reviewed / Open Access
• [Journal Article] Maintenance of WT1 expression in tumor cells is associated with a good prognosis in malignant glioma patients treated with WT1 peptide vaccine immunotherapy (2021)
  • Author(s): Yokota Chisato、Kagawa Naoki、Takano Koji、Chiba Yasuyoshi、Kinoshita Manabu、Kijima Noriyuki、Oji Yusuke、Oka Yoshihiro、Sugiyama Haruo、Tsuboi Akihiro、Izumoto Shuichi、Kishima Haruhiko、Hashimoto Naoya
  • Journal Title: Cancer Immunology, Immunotherapy Volume: 71 Issue: 1 Pages: 189-201
  • DOI: 10.1007/s00262-021-02954-z
  • Peer Reviewed / Open Access
• [Journal Article] Distinct difference in tumor-infiltrating immune cells between Wilms’ tumor gene 1 peptide vaccine and anti-programmed cell death-1 antibody therapies (2021)
  • Author(s): Yokota Chisato、Nakata Jun、Takano Koji、Nakajima Hiroko、Hayashibara Hiromu、Minagawa Hikaru、Chiba Yasuyoshi、Hirayama Ryuichi、Kijima Noriyuki、Kinoshita Manabu、Hashii Yoshiko、Tsuboi Akihiro、Oka Yoshihiro、Oji Yusuke、Kumanogoh Atsushi、Sugiyama Haruo、Kagawa Naoki、Kishima Haruhiko
  • Journal Title: Neuro-Oncology Advances Volume: 3 Issue: 1 Pages: 1-10
  • DOI: 10.1093/noajnl/vdab091
  • Peer Reviewed / Open Access
• [Journal Article] The impact of 5-year tumor doubling time to predict the subsequent long-term natural history of asymptomatic meningiomas. (2021)
  • Author(s): Yamada S, Kinoshita M, Nakagawa T, Hirayama R, Kijima N, Kagawa N, Kishima H.
  • Journal Title: World Neurosurg Volume: 151 Pages: e943-e949
  • DOI: 10.1016/j.wneu.2021.05.023
  • Peer Reviewed / Open Access
• [Journal Article] Efficacy and safety of nivolumab in Japanese patients with first recurrence of glioblastoma: an open-label, non-comparative study. (2021)
  • Author(s): Aoki T, Kagawa N, Sugiyama K, Wakabayashi T, Arakawa Y, Yamaguchi S, Tanaka S, Ishikawa E, Muragaki Y, Nagane M, Nakada M, Suehiro S, Hata N, Kuroda J, Narita Y, Sonoda Y, Iwadate Y, Natsumeda M, Nakazato Y, Minami H, Hirata Y, Hagihara S, Nishikawa R.
  • Journal Title: Int J Clin Oncol. Volume: - Issue: 12 Pages: 2205-2215
  • DOI: 10.1007/s10147-021-02028-1
  • Peer Reviewed
• [Journal Article] Determining the extent of tumor resection at surgical planning with 18F-fluciclovine PET/CT in patients with suspected glioma: multicenter phase III trials (2021)
  • Author(s): Wakabayashi T、Hirose Y、Miyake K、Arakawa Y、Kagawa N、Nariai T、Narita Y、Nishikawa R、Tsuyuguchi N、Fukami T、Sasaki H、Sasayama T、Kondo A、Iuchi T、Matsuda H、Kubota K、Minamimoto R、Terauchi T、Nakazato Y、Kubomura K、Wada M
  • Journal Title: Annals of Nuclear Medicine Volume: 35 Issue: 12 Pages: 1279-1292
  • DOI: 10.1007/s12149-021-01670-z
  • Peer Reviewed / Open Access
• [Journal Article] Impact of Inversion Time for FLAIR Acquisition on the T2-FLAIR Mismatch Detectability for IDH-Mutant, Non-CODEL Astrocytomas (2021)
  • Author(s): Manabu Kinoshita, Hideyuki Arita, Masamichi Takahashi, Takehiro Uda, Junya Fukai, Kenichi Ishibashi, Noriyuki Kijima, Ryuichi Hirayama, Mio Sakai, Atsuko Arisawa, Hiroto Takahashi, Katsuyuki Nakanishi, Naoki Kagawa, Kouichi Ichimura, Yonehiro Kanemura, Yoshitaka Narita, Haruhiko Kishima
  • Journal Title: Frontiers in Oncology Volume: 10 Pages: 596448-596448
  • DOI: 10.3389/fonc.2020.596448
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Efficacy of endovascular intratumoral embolization for meningioma: assessment using dynamic susceptibility contrast-enhanced perfusion-weighted imaging. (2021)
  • Author(s): Asai K, Nakamura H, Watanabe Y, Nishida T, Sakai M, Arisawa A, Takagaki M, Arita H, Ozaki T, Kagawa N, Fujimoto Y, Nakanishi K, Kinoshita M, Kishima H.
  • Journal Title: J Neurointerv Surg. Volume: - Issue: 12 Pages: 1167-1171
  • DOI: 10.1136/neurintsurg-2020-017116
  • Peer Reviewed
• [Journal Article] Primary central nervous system lymphoma of the bilateral Bochdalek’s flower baskets: A case report (2020)
  • Author(s): Nakagawa Tomoyoshi、Arita Hideyuki、Kijima Noriyuki、Fujita Jiro、Nagate Yasuhiro、Hirayama Ryuichi、Kinoshita Manabu、Kagawa Naoki、Kishima Haruhiko
  • Journal Title: Interdisciplinary Neurosurgery Volume: 21 Pages: 100756-100756
  • DOI: 10.1016/j.inat.2020.100756
  • Peer Reviewed
• [Journal Article] Activated leukocyte cell adhesion molecule expression correlates with the WNT subgroup in medulloblastoma and is involved in regulating tumor cell proliferation and invasion (2020)
  • Author(s): Achiha T, Kijima N, Kodama Y, Kagawa N, Kinoshita M, Fujimoto Y, Nonaka M, Fukai J, Inoue A, Nishida N, Yamanaka T, Harada A, Mori K, Tsuyuguchi N, Uda T, Ishibashi K, Tomogane Y, Sakamoto D, Shofuda T, Yoshioka E, Kanematsu D, Mano M, Luu B, Taylor MD, Kanemura Y, Kishima H.
  • Journal Title: PLoS One Volume: 15 Issue: 12 Pages: e0243272-e0243272
  • DOI: 10.1371/journal.pone.0243272
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] PD-L1 and PD-L2 expression in the tumor microenvironment including peritumoral tissue in primary central nervous system lymphoma (2020)
  • Author(s): Furuse Motomasa、Kuwabara Hiroko、Ikeda Naokado、Hattori Yasuhiko、Ichikawa Tomotsugu、Kagawa Naoki、Kikuta Kenichiro、Tamai Sho、Nakada Mitsutoshi、Wakabayashi Toshihiko、Wanibuchi Masahiko、Kuroiwa Toshihiko、Hirose Yoshinobu、Miyatake Shin-Ichi
  • Journal Title: BMC Cancer Volume: 20 Issue: 1 Pages: 277-277
  • DOI: 10.1186/s12885-020-06755-y
  • Peer Reviewed / Open Access
• [Journal Article] Encouraging Clinical Evolution of a Pediatric Patient With Relapsed Diffuse Midline Glioma Who Underwent WT1-Targeting Immunotherapy: A Case Report and Literature Review (2020)
  • Author(s): Hashii Yoshiko、Oka Yoshihiro、Kagawa Naoki、Hashimoto Naoya、Saitou Hiroyuki、Fukuya Syogo、Kanegae Mizuki、Ikejima Sayaka、Oji Yusuke、Ozono Keiichi、Tsuboi Akihiro、Sugiyama Haruo
  • Journal Title: Frontiers in Oncology Volume: 10 Pages: 1188-1188
  • DOI: 10.3389/fonc.2020.01188
  • Peer Reviewed / Open Access
• [Presentation] 再発神経膠腫に対する3種混合WT1ペプチドワクチン療法の長期治療成績 (2023)
  • Author(s): 香川尚己、尾路祐介、平山龍一、木嶋教行、岡芳弘、杉山治夫、貴島晴彦
  • Organizer: 第41回日本脳腫瘍学会学術集会
• [Presentation] 小児第4脳室内腫瘍摘出術における 4K3D外視鏡手術の有用性 (2023)
  • Author(s): 香川 尚己、平山龍一、木嶋教行、沖田典子、貴島晴彦
  • Organizer: 第41回日本小児神経外科学会
• [Presentation] Usefullness of 4K3D-exoscopic removal for pediatric fourth ventricular tumors (2023)
  • Author(s): Naoki Kagawa, Ryuichi Hirayama, Noriyuki Kijima, Yoshiko Okita, Haruhiko Kishima
  • Organizer: 4th Congress of Asian-Australasian Society for Pediatric Neurosurgery
  • Int'l Joint Research
• [Presentation] 内視鏡下および内視鏡併用脳腫瘍摘出術の安全性と合併症回避 (2023)
  • Author(s): 香川 尚己、平山龍一、木嶋教行、黒田秀樹、館哲郎、宇津木玲奈、沖田典子、貴島晴彦
  • Organizer: 第30回日本神経内視鏡学会
• [Presentation] 軟骨無形成症における大後頭孔狭窄および水頭症の診断と治療 (2023)
  • Author(s): 香川尚己
  • Organizer: 第56回日本小児内分泌学会
  • Invited
• [Presentation] 本邦における脊髄髄膜瘤胎児手術導入に向けての現状と方向性 (2023)
  • Author(s): 香川尚己、遠藤誠之、渡邊美穂、味村和哉、田附裕子、北畠康司、荒堀仁美、吉田清志、平山龍一、中川智義、貴島晴彦、奥山宏臣、木村正
  • Organizer: 日本脳神経外科学会第82回学術集会
• [Presentation] 小児脳腫瘍における術中蛍光診断の意義と有用性 (2023)
  • Author(s): 香川尚己、木嶋教行、平山龍一、黒田秀樹、館哲郎、 宇津木玲奈、川本有輝、村上皓紀、沖田典子、貴島晴彦
  • Organizer: 第19回日本脳神経外科光線力学学会
• [Presentation] 再増大時に放射線再照射を行ったびまん性正中神経膠腫の1例 (2023)
  • Author(s): 宇津木玲奈、香川尚己、平山龍一、馬戸史子、松尾怜奈、木嶋教行、沖田典子、原純一、貴島晴彦
  • Organizer: 第40回日本こども病院神経外科医会
• [Presentation] 診断困難であったmedulloblastoma の一例 (2023)
  • Author(s): 西本渓佑、香川尚己、宮村能子、平山龍一、木嶋紀行、沖田典子、森井英一、平戸純子、金村米博、市村幸一、貴島晴彦
  • Organizer: 第2回小児脳腫瘍カンファレンス
• [Presentation] 小児再発悪性神経膠腫に対する化学療法併用Bevacizumab療法の安全性および有効性の検討 (2022)
  • Author(s): 香川尚己、平山龍一、宮村能子、木嶋教行、黒田秀樹、館哲郎、沖田典子、貴島晴彦
  • Organizer: 第40回日本脳腫瘍学会学術集会
• [Presentation] 小児・AYA世代における中枢神経系上衣腫の治療成績と今後の課題 (2022)
  • Author(s): 香川尚己、平山龍一、木嶋教行、中川智義、黒田秀樹、館哲郎、宇津木玲奈、沖田典子、貴島晴彦
  • Organizer: 第27回日本脳腫瘍の外科学会学術集会
• [Presentation] 内視鏡併用外視鏡手術における脳腫瘍摘出：適応と限界 (2022)
  • Author(s): 香川 尚己、平山龍一、木嶋教行、黒田秀樹、館哲郎、宇津木玲奈、沖田典子、貴島晴彦
  • Organizer: 第29回日本神経内視鏡学会学術集会
• [Presentation] 頭蓋内上衣腫における長期治療成績と予後不良因子 (2022)
  • Author(s): 香川尚己、平山龍一、木嶋教行、木下学、中川智義、黒田秀樹、館哲郎、沖田典子、貴島晴彦
  • Organizer: 第50回日本小児神経外科学会
• [Presentation] 4K3D時代の小児脳腫瘍手術における術中蛍光診断の意義と有用性 (2022)
  • Author(s): 香川尚己、木嶋教行、平山龍一、黒田秀樹、館哲郎、宇津木玲奈、沖田典子、貴島晴彦
  • Organizer: 第18回日本脳神経外科光線力学学会
• [Presentation] 小児脳神経外科手術における吸収性プレートおよびスクリューの応用と発展 (2022)
  • Author(s): 香川尚己
  • Organizer: 第50回日本小児神経外科学会
  • Invited
• [Presentation] 小児びまん性悪性神経膠腫における分子分類、発生母地、予後との関係について (2022)
  • Author(s): 中川智義、香川尚己、平山龍一、黒田秀樹、館哲郎、木嶋教行、沖田典子、森井英一、貴島晴彦
  • Organizer: 第40回日本脳腫瘍病理学会
• [Presentation] Long-term outcome and follow up of intracranial germ cell tumors: Reduced-dose radiotherapy and intensified chemotherapy improves clinical outcome and quality of life for long-term survivors (2022)
  • Author(s): Naoki Kagawa, Takako Miyamura, Kai Yamasaki, Ryuichi Hirayama, Noriyuki Kijima, Yoshiko Okita, Tomoyoshi Nakagawa, Junichi Hara, Haruhiko Kishima
  • Organizer: 20th International Symposium on Pediatric Neuro-Oncology (ISPNO2022)
  • Int'l Joint Research
• [Presentation] 頭蓋内胚細胞腫に対する集学的治療と長期治療成績 (2021)
  • Author(s): 香川尚己、宮村能子、山崎夏維、平山龍一、木嶋教行、沖田典子、中川智義、原純一、貴島晴彦
  • Organizer: 第39回日本脳腫瘍学会学術集会
• [Presentation] 小児神経外科における4K3D外視鏡手術 (2021)
  • Author(s): 香川尚己、平山龍一、木嶋教行、中川智義、貴島晴彦
  • Organizer: 第49回日本小児神経外科学会
• [Presentation] 3D内視鏡併用4K3D外視鏡による脳腫瘍摘出術 (2021)
  • Author(s): 香川尚己、平山龍一、木嶋教行、木下学、貴島晴彦
  • Organizer: 第26回日本脳腫瘍の外科学会
• [Presentation] 小児重症頭部外傷に対する外減圧術後の長期治療成績 (2020)
  • Author(s): 香川尚己、平山龍一、千葉泰良、圓尾知之、横田千里、中川智義、貴島晴彦
  • Organizer: 第43回日本脳神経外傷学会
• [Presentation] 再発悪性神経膠腫に対するWT1カクテルワクチン療法（WT1 trio） (2020)
  • Author(s): 香川尚己、尾路祐介、坪井昭博、平山龍一、木嶋教行、木下学、岡芳弘、杉山治夫、貴島晴彦
  • Organizer: 第38回日本脳腫瘍病理学会
• [Presentation] 内視鏡支援下4K3D外視鏡による三叉神経鞘腫摘出術 (2020)
  • Author(s): 香川尚己、梅原徹、平山龍一、木嶋教行、中川智義、木下学、貴島晴彦
  • Organizer: 日本脳神経外科学会 第79回学術総会
• [Presentation] 小児中枢神経系腫瘍経験患者における晩期合併症と長期フォローアップの現状と問題点 (2020)
  • Author(s): 香川尚己、平山龍一、横田千里、木嶋教行、中川智義、宮村能子、木下学、貴島晴彦
  • Organizer: 第48回日本小児神経外科学会
• [Presentation] 当院における脊髄髄膜瘤胎児手術に向けての取り組みと現状 (2020)
  • Author(s): 香川尚己、遠藤誠之、渡邊美穂、味村和哉、北畠康司、田附裕子、荒堀仁美、平山龍一、横田千里、中川智義、貴島晴彦、奥山宏臣、木村正
  • Organizer: 第48回日本小児神経外科学会
• [Presentation] 小児期の中枢神経系腫瘍経験患者における二次性腫瘍の予後と問題点 (2020)
  • Author(s): 香川尚己、横田千里、平山龍一、木嶋教行、中川智義、宮村能子、木下学、貴島晴彦
  • Organizer: 第38回日本脳腫瘍学会学術集会
• [Presentation] Diagnostic exposure to low-dose radiation and spontaneous regression in intracranial germ cell tumors (2020)
  • Author(s): Naoki Kagawa, Ryuichi Hirayama, Shogo Fukuya, Chisato Yokota, Yasunori Fujimoto, Yasuyoshi Chiba, Daisuke Eino, Toru Umehara, Takanori Fukunaga, Manabu Kinoshita, and Haruhiko Kishima
  • Organizer: The 19th International Symposium on Pediatric Neuro-Oncology (ISPNO2020)
  • Int'l Joint Research
• [Presentation] マウスグリオーマモデルに対する WT1ペプチドワクチン・ 抗PD-1抗体併用療法の検討 (2019)
  • Author(s): 横田千里、高野浩司、中田潤、皆川光、中島博子、林原 弘武、磯川和希、中川智義、平山龍一、木嶋教行、木下学、香川尚己、貴島晴彦
  • Organizer: 第20回日本分子脳神経外科学会
• [Presentation] 再発神経膠腫に対する3種混合WT1ペプチドワクチン療法（WT1 trio）の安全性と有効性 (2019)
  • Author(s): 香川尚己、尾路祐介、坪井昭博、平山龍一、木嶋教行、木下学、岡芳弘、杉山治夫、貴島晴彦
  • Organizer: 第37回日本脳腫瘍学会学術集会
• [Presentation] 小児悪性神経膠腫に対する免疫療法の有効性と今後の展開 (2019)
  • Author(s): 香川尚己、橋井佳子、千葉泰良、平山龍一、横田千里、橋本直哉、杉山治夫、貴島晴彦
  • Organizer: 第46回日本小児神経外科学会
• [Presentation] Radiation-associated Intracranial Tumors In Childhood Cancer Survivors: Therapeutic Strategies And Its Problems (2019)
  • Author(s): Naoki Kagawa, Chisato Yokota, Toru Umehara, Takamune Achiha, Takanori Fukunaga, Daisuke Eino, Shogo Fukuya, Yasuyoshi Chiba, Hideyuki Arita, Yasunori Fujimoto, Haruhiko Kishima.
  • Organizer: 3rd Congress of Asian-Australasian Society for Pediatric Neurosurgery (AASPN2019)
  • Int'l Joint Research
• [Presentation] Efficacy and safety of nivolumab in Japanese patients with first recurrence of glioblastoma. A multicenter, open-label, non-comparative study (ONO-4538-19) (2019)
  • Author(s): Naoki Kagawa, Tomokazu Aoki, Kazuhiko Sugiyama, Toshihiko Wakabayashi, Yoshiki Arakawa, Shigeru Yamaguchi, Shota Tanaka, Ryo Nishikawa
  • Organizer: The 24th Annual Meeting of the Society for Neuro-Oncology (SNO2019)
  • Int'l Joint Research
• [Book] 今日の小児治療指針 第17版 (2020)
  • Author(s): 水口 雅
  • Total Pages: 1010
  • Publisher: 医学書院
  • ISBN: 9784260039468