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Virtual reality simulation system for skull base surgery with machine learning argolism

Research Project

Project/Area Number 19K09500
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 56010:Neurosurgery-related
Research InstitutionTeikyo University (2021-2022)
The University of Tokyo (2019-2020)

Principal Investigator

Shin Masahiro  帝京大学, 医学部, 教授 (70302726)

Co-Investigator(Kenkyū-buntansha) 金 太一  東京大学, 医学部附属病院, 特任准教授 (90447392)
河島 真理子  東京大学, 医学部附属病院, 助教 (40803664)
新谷 祐貴  東京大学, 医学部附属病院, 助教 (20844616)
Project Period (FY) 2019-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2021: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2019: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords頭蓋底手術 / 機械学習 / 仮想現実 / 拡張現実 / シミュレーション
Outline of Research at the Start

本研究では、希少価値を有する少数の学習データを用いた深層学習技術を開発・検証することで、高難度手術治療への支援システムの開発と臨床評価をおこなう。脳深部に発生する頭蓋底腫瘍は、手術が最も難しい疾患の一つであり、治療成績は、腫瘍の病理組織診断や術中所見に大きく左右される。医療画像技術が進歩した現代でも、治療方針や手術アプローチの決定は、未だ、医師の経験に基づいた“臨床的判断”に依存している部分が多く、データの蓄積が非効率的かつ主観的であり、また、共有が難しい。本研究は、現行の頭蓋底外科手術が抱える、こうした問題を、機械学習技術によって解決すべく、術前検討システムの開発を目指したものである。

Outline of Final Research Achievements

① Our study demonstrated that our machine learning method based on the small number of data was quite successful for the preoperative evaluation of skull base tumors. Especially, we tried to distinguish the rare skull base tumors, chordomas and chondrosarcomas, which are radiographic twins but their clinical behavior was totally different, and distinguish them with more than 90% accuracy.
② Using the 3D model creating system, we could swiftly construct the 3D virtual reality models, which facilitated the preoperative discussion of the surgical strategy and enabled the intraoperative 3D atlas of the surgical field.

Academic Significance and Societal Importance of the Research Achievements

脳神経外科手術では、MRIやCTなどの画像を検討しながら、術野の状態や、腫瘍の種類を予測し、治療方針を立てて、手術を行っている。また、術野の把握についても、こうした二次元の画像を元に、自らの経験から、術野の状態を想像し、手術戦略を検討している。
本研究では、こうした術前の病態把握から、術野の状態把握と立体的予測を可能し、病態の正確な予測と、手術における安全性の向上に貢献するものと思われる。

Report

(5 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (18 results)

All 2022 2021 2020

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 1 results) Presentation (15 results) (of which Int'l Joint Research: 5 results,  Invited: 14 results)

  • [Journal Article] Endoscopic Extended Transclival Approach for Lower Clival Meningioma2022

    • Author(s)
      Ai Kawaguchi, Masahiro Shin, Hirotaka Hasegawa, Yuki Shinya, Masaaki Shojima, Kenji Kondo
    • Journal Title

      World Neurosurg

      Volume: 164 Pages: 117

    • DOI

      10.1016/j.wneu.2022.04.115

    • Related Report
      2022 Annual Research Report 2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] High Dose Radiosurgery Targeting the Primary Tumor Sites Contributes to Survival in Patients With Skull Base Chordoma2022

    • Author(s)
      Yuki Shinya, Hirotaka Hasegawa, Masahiro Shin, Mariko Kawashima, Tomoyuki Koga, Shunya Hanakita, Atsuto Katano, Takehiro Sugiyama, Yuki Nozawa, Nobuhito Saito
    • Journal Title

      Int J Radiat Oncol Biol Phys.

      Volume: 113 Issue: 3 Pages: 582

    • DOI

      10.1016/j.ijrobp.2022.02.024

    • Related Report
      2022 Annual Research Report 2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] MRI-Based Radiomics Differentiates Skull Base Chordoma and Chondrosarcoma: A Preliminary Study2022

    • Author(s)
      Yamazawa E, Takahashi S, Shin M, Tanaka S, Takahashi W, Nakamoto T, Suzuki Y, Takami H, Saito N.
    • Journal Title

      Cancers (Basel)

      Volume: 14 Issue: 13 Pages: 3264-3264

    • DOI

      10.3390/cancers14133264

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Educational Session How to manage the complication of endoscopic skull base surgery: Preservation of the vasucular structure2022

    • Author(s)
      辛 正廣
    • Organizer
      World Federation of Neuro-Oncology Society 2022
    • Related Report
      2022 Annual Research Report 2021 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] プレナリーセッション10 傍鞍部腫瘍に対する神経内視鏡手術:診療連携による多角的治療戦略2022

    • Author(s)
      辛 正廣
    • Organizer
      第42回日本脳神経外科コングレス
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 講演II 誰にでもできる! 頭蓋底腫瘍に対するEndoscopic Microsurgeryのすゝめ2022

    • Author(s)
      辛 正廣
    • Organizer
      CSL脳神経外科 WEBセミナー Expert Surgeonの手術から学ぶ
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] Endoscopic extended transsphenoidal microsurgery for skull base tumors: Focusing on preservation of the vascular structures2022

    • Author(s)
      辛 正廣
    • Organizer
      E-Master Class Webinar
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 頭蓋底脊索腫に対する外科治療:Endoscopic transsphenoidal transclival surgery2022

    • Author(s)
      辛 正廣
    • Organizer
      第34回日本頭蓋底外科学会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 頭蓋底外科における内視鏡のPOWER2022

    • Author(s)
      辛 正廣
    • Organizer
      第34回日本頭蓋底外科学会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 錐体斜台部病変に対する神経内視鏡下経鼻頭蓋底手術における止血のテクニック2021

    • Author(s)
      辛 正廣
    • Organizer
      第80回日本脳神経外科学会総会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] 海綿静脈洞浸潤性頭蓋底腫瘍に対する神経内視鏡下外側拡大蝶形骨洞手術2021

    • Author(s)
      辛 正廣
    • Organizer
      第80回日本脳神経外科学会総会
    • Related Report
      2021 Research-status Report
  • [Presentation] Endoscopic transsphenoidal anterior petrosal and transmastoid posterior petrosal approach2021

    • Author(s)
      辛 正廣
    • Organizer
      Interactive Training for Endoscopic Skull Base Surgery 2021
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 経鼻内視鏡頭蓋底手術「内視鏡ならではのポイント」 後頭蓋窩病変に対する内視鏡下頭蓋底手術2021

    • Author(s)
      辛 正廣
    • Organizer
      第28回日本神経内視鏡学会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] Endoscopic Approaches for Locally Aggressive Tumors in Carious Skull Base Regions.2020

    • Author(s)
      Masahiro SHIN
    • Organizer
      Online practical Couse on “Open Approach to the Skull Base” 2020
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Endoscopic Transnasal Transpharyngeal Surgery for Skull Base Tumors in Cranovertebral Junction.2020

    • Author(s)
      Masahiro SHIN
    • Organizer
      15th Asian-Oceanian International Congress on Skull Base Surgery.
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Endoscopic Extended Transsphenonidal Approach for Tuberculum Sellae Meningiomas: How to achieve safe maximum resection2020

    • Author(s)
      Masahiro SHIN
    • Organizer
      2020 Interactive Training for Endoscopic Skullbase Surgery Course
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 錐体斜台部の頭蓋底腫瘍に対する神経内視鏡手術2020

    • Author(s)
      辛 正廣
    • Organizer
      第7回手技にこだわる脳神経外科ビデオカンファランス
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] Endoscopic Transnasal Surgery for Pediatric Skull Base Tumors: Surgical Techniques Based on our Recent Experience2020

    • Author(s)
      辛 正廣
    • Organizer
      第46回 小児脳神経外科学会
    • Related Report
      2020 Research-status Report
    • Invited

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Published: 2019-04-18   Modified: 2024-01-30  

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