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Investigation for mechanism of metastasis using molecular imaging

Research Project

Project/Area Number 19K09571
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 56020:Orthopedics-related
Research InstitutionKanazawa University

Principal Investigator

Tuchiya Hiroyuki  金沢大学, 医学系, 教授 (40227434)

Co-Investigator(Kenkyū-buntansha) 三輪 真嗣  金沢大学, 医学系, 助教 (40753455)
林 克洋  金沢大学, 医薬保健学総合研究科, 特任教授 (80507054)
五十嵐 健太郎  金沢大学, 医薬保健学総合研究科, 特任助教 (80622860)
山本 憲男  金沢大学, 医薬保健学総合研究科, 特任教授 (90332668)
Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2021: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords骨肉腫 / 転移 / エクソソーム / 細胞外小胞 / 破骨細胞 / miRNA / 蛍光イメージング / 肺転移 / 骨髄由来マクロファージ / イメージング / 肉腫
Outline of Research at the Start

近年,がんの浸潤,転移の研究において,循環系に存在する腫瘍細胞(circulating tumor cell:CTC)やエクソソーム,がん微小環境が注目されている.本研究では,腫瘍細胞が循環系を介して遠隔臓器に到達し,腫瘍を形成するまでの過程におけるエクソソームや微小環境の作用を観察するために,蛍光イメージングにより腫瘍細胞,エクソソームを異なる蛍光タンパクで可視化し,継時的に観察することにより転移機序を明らかにする.また,腫瘍が転移を形成するまでの間に腫瘍細胞がどのように性質を変えるかを調べることにより転移巣形成機序を明らかにし,新たな治療標的を特定する.

Outline of Final Research Achievements

The roles of small extracellular vesicles (SEVs) in enhancing metastases have been demonstrated in multiple tumors, but they are still poorly understood in osteosarcoma. Hence, this study investigated the effects of SEVs on progression and the tumor microenvironment in mice and patients. In an orthotopic implantation study, we found that osteosarcoma-derived SEVs had the potential to enhance metastases and angiogenesis. In addition, osteosarcoma-derived SEVs decreased the number of mature osteoclasts in vivo. In vitro osteoclastogenesis studies revealed that the inhibition of osteoclast maturation by osteosarcoma-derived SEVs was mediated by suppressing the NF-κB signal pathway. MicroRNA analysis of SEVs from different malignant human osteosarcomas revealed that miR-146a-5p was involved in the inhibition of osteoclastogenesis. In osteosarcoma patients, lower numbers of osteoclasts in biopsy specimens at the first visits were correlated with higher malignancy.

Academic Significance and Societal Importance of the Research Achievements

本研究は骨肉腫におけるエクソソーム,miRNA,マクロファージ,破骨細胞の役割を明らかにすることで骨肉腫の進展・転移機序を解明する研究である。miRNAは骨肉腫の診断バイオマーカーとなる可能性があり,また,エクソソームやマクロファージ,破骨細胞は骨肉腫の治療標的となる可能性があり,新たな診断・治療方法の開発へと発展することが期待される。

Report

(4 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report

Research Products

(127 results)

All 2022 2021 2020 2019 Other

All Int'l Joint Research (1 results) Journal Article (111 results) (of which Int'l Joint Research: 21 results,  Peer Reviewed: 111 results,  Open Access: 45 results) Presentation (15 results) (of which Int'l Joint Research: 10 results,  Invited: 15 results)

  • [Int'l Joint Research] カリフォルニア大学サンディエゴ校(米国)

    • Related Report
      2019 Research-status Report
  • [Journal Article] Suture Bridge Fixation for Posterior Cruciate Ligament Tibial Avulsion Fracture in Children2022

    • Author(s)
      Kanayama Tomoyuki、Nakase Junsuke、Asai Kazuki、Yoshimizu Rikuto、Kimura Mitsuhiro、Tsuchiya Hiroyuki
    • Journal Title

      Arthroscopy Techniques

      Volume: 11

    • DOI

      10.1016/j.eats.2021.12.012

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tibial graft fixation methods and bone tunnel enlargement: A comparison between the TensionLoc implant system and the double-spike plate2022

    • Author(s)
      Kimura Mitsuhiro、Nakase Junsuke、Asai Kazuki、Yoshimizu Rikuto、Kanayama Tomoyuki、Tsuchiya Hiroyuki
    • Journal Title

      Asia-Pacific Journal of Sports Medicine, Arthroscopy, Rehabilitation and Technology

      Volume: 28 Pages: 31-37

    • DOI

      10.1016/j.asmart.2022.03.003

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Profunda femoris artery perforator flap for lateral knee joint reconstruction: A report of two cases2022

    • Author(s)
      Tada Kaoru、Matsuta Masashi、Murai Atsuro、Nakamura Yuta、Suganuma Seigo、Tsuchiya Hiroyuki
    • Journal Title

      JPRAS Open

      Volume: 32 Pages: 144-149

    • DOI

      10.1016/j.jpra.2022.02.003

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Therapeutic Effect and Clinical Outcome of Immune Checkpoint Inhibitors on Bone Metastasis in Advanced Non-Small-Cell Lung Cancer2022

    • Author(s)
      Asano Yohei、Yamamoto Norio、Demura Satoru、Hayashi Katsuhiro、Takeuchi Akihiko、Kato Satoshi、Miwa Shinji、Igarashi Kentaro、Higuchi Takashi、Yonezawa Hirotaka、Araki Yoshihiro、Morinaga Sei、Saito Shiro、Sone Takashi、Kasahara Kazuo、Tsuchiya Hiroyuki
    • Journal Title

      Frontiers in Oncology

      Volume: 12 Pages: 871675-871675

    • DOI

      10.3389/fonc.2022.871675

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Monostotic Fibrous Dysplasia in the Femur Strongly Expressing RANKL With Concomitant Osteoporotic Vertebral Compression Fracture: A Case Report2022

    • Author(s)
      AZURIN EDELYN S.、YAMAMOTO NORIO、HAYASHI KATSUHIRO、TAKEUCHI AKIHIKO、MIWA SHINJI、IGARASHI KENTARO、HIGUCHI TAKASHI、YONEZAWA HIROTAKA、MORINAGA SEI、ASANO YOHEI、SAITO SHIRO、TSUCHIYA HIROYUKI
    • Journal Title

      Cancer Diagnosis & Prognosis

      Volume: 2 Pages: 93-100

    • DOI

      10.21873/cdp.10082

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Iatrogenic sciatic nerve injury due to cerclage wiring for proximal periprosthetic femoral fracture: A rare case report2022

    • Author(s)
      Nakamura Yuta、Tada Kaoru、Murai Atsuro、Tsuchiya Hiroyuki
    • Journal Title

      JPRAS Open

      Volume: 32 Pages: 54-60

    • DOI

      10.1016/j.jpra.2022.02.002

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Deep inferior epigastric artery as a collateral pathway to the lower extremities: A case report2022

    • Author(s)
      Tada Kaoru、Murai Atsuro、Nakamura Yuta、Suganuma Seigo、Tsuchiya Hiroyuki
    • Journal Title

      JPRAS Open

      Volume: 32 Pages: 13-17

    • DOI

      10.1016/j.jpra.2022.01.003

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Management of Soft-tissue Tumors With a Size of 2-5 cm, Including Malignancy2022

    • Author(s)
      ARAKI YOSHIHIRO、YAMAMOTO NORIO、MAEDA TORU、KIMURA HIROAKI、OTA TAKASHI、SHIMOZAKI SHINGO、KATO TAKASHI、INOUE DAISUKE、HIGUCHI TAKASHI、ABE KENSAKU、TANIGUCHI YUTA、TSUCHIYA HIROYUKI
    • Journal Title

      Anticancer Research

      Volume: 42 Pages: 1555-1562

    • DOI

      10.21873/anticanres.15629

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Therapeutic Targets and Emerging Treatments in Advanced Chondrosarcoma2022

    • Author(s)
      Miwa Shinji、Yamamoto Norio、Hayashi Katsuhiro、Takeuchi Akihiko、Igarashi Kentaro、Tsuchiya Hiroyuki
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 23 Pages: 1096-1096

    • DOI

      10.3390/ijms23031096

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Equinus foot deformity and malunion of the medial malleolus caused by tibialis posterior tendon interposition following irreducible fracture dislocation of the ankle: A case report and literature review2022

    • Author(s)
      Hikichi Toshifumi、Matsubara Hidenori、Shimokawa Kanu、Watanabe Koji、Tsuchiya Hiroyuki
    • Journal Title

      Trauma Case Reports

      Volume: 38 Pages: 100618-100618

    • DOI

      10.1016/j.tcr.2022.100618

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pretreatment Neutrophil Count and Platelet-lymphocyte Ratio as Predictors of Metastasis in Patients With Osteosarcoma2022

    • Author(s)
      ARAKI YOSHIHIRO、YAMAMOTO NORIO、HAYASHI KATSUHIRO、TAKEUCHI AKIHIKO、MIWA SHINJI、IGARASHI KENTARO、HIGUCHI TAKASHI、ABE KENSAKU、TANIGUCHI YUTA、YONEZAWA HIROTAKA、MORINAGA SEI、ASANO YOHEI、TSUCHIYA HIROYUKI
    • Journal Title

      Anticancer Research

      Volume: 42 Pages: 1081-1089

    • DOI

      10.21873/anticanres.15570

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anterior cruciate ligament reconstruction with ultrasound-guided femoral nerve block does not adversely affect knee extensor strength beyond that seen with intravenous patient-controlled analgesia at 3 and 6?months postoperatively2022

    • Author(s)
      Sengoku Takuya、Nakase Junsuke、Morita Yui、Asai Kazuki、Yoshimizu Rikuto、Kimura Mitsuhiro、Sakurai Goro、Yoshida Shinya、Yahata Tetsutaro、Tsuchiya Hiroyuki
    • Journal Title

      The Knee

      Volume: 34 Pages: 252-258

    • DOI

      10.1016/j.knee.2022.01.006

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Does Dosage or Duration of Concurrent Oral Corticosteroid Influence Elevated Risk of Postoperative Complications After Total Joint Arthroplasty?2022

    • Author(s)
      Inoue Daisuke、Kabata Tamon、Kajino Yoshitomo、Ohmori Takaaki、Yamamuro Yuki、Taninaka Atsushi、Kataoka Tomoyuki、Saiki Yoshitomo、Tsuchiya Hiroyuki
    • Journal Title

      The Journal of Arthroplasty

      Volume: 37 Pages: 652-658

    • DOI

      10.1016/j.arth.2021.12.032

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differences in cellular and microstructural properties of the semitendinosus muscle tendon between young and adult patients2022

    • Author(s)
      Asai Kazuki、Nakase Junsuke、Ishikawa Tatsuya、Yoshimizu Rikuto、Kimura Mitsuhiro、Ozaki Noriyuki、Tsuchiya Hiroyuki
    • Journal Title

      Journal of Orthopaedic Science

      Volume: 27 Pages: 478-485

    • DOI

      10.1016/j.jos.2021.01.012

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Safety and Neurologic Recovery of L2 Nerve Root Sacrificed in Total En Bloc Spondylectomy Involving the L2 Vertebra2021

    • Author(s)
      Paholpak Permsak、Sangsin Apiruk、Sirichativapee Winai、Wisanuyotin Taweechok、Kosuwon Weerachai、Kasai Yuichi、Murakami Hideki、Tsuchiya Hiroyuki
    • Journal Title

      International Journal of Spine Surgery

      Volume: 15 Pages: 1217-1222

    • DOI

      10.14444/8154

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anaphylactic Reactions Caused by Nafamostat Mesylate during Hemodialysis before Surgery for Carpal Tunnel Syndrome2021

    • Author(s)
      Nakamura Yuta、Tada Kaoru、Matsuta Masashi、Murai Atsuro、Tsuchiya Hiroyuki
    • Journal Title

      Case Reports in Nephrology

      Volume: 2021 Pages: 1-4

    • DOI

      10.1155/2021/1148156

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impact of Tumor Growth Speed of Primary Lesions on the Clinical Outcomes of Appendicular Skeletal Metastases2021

    • Author(s)
      ASANO YOHEI、YAMAMOTO NORIO、HAYASHI KATSUHIRO、TAKEUCHI AKIHIKO、MIWA SHINJI、IGARASHI KENTARO、YONEZAWA HIROTAKA、ARAKI YOSHIHIRO、MORINAGA SEI、SAITO SHIRO、NOJIMA TAKAYUKI、TSUCHIYA HIROYUKI
    • Journal Title

      Anticancer Research

      Volume: 42 Pages: 229-236

    • DOI

      10.21873/anticanres.15477

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Insufficient Augmentation of Bone Cement Causes Recompression of Augmented Vertebra after Balloon Kyphoplasty2021

    • Author(s)
      Kobayashi Motoya、Toribatake Yasumitsu、Okamoto Shunpei、Kato Satoshi、Tsuchiya Hiroyuki
    • Journal Title

      Spine Surg Relat Res

      Volume: 5 Issue: 6 Pages: 375-380

    • DOI

      10.22603/ssrr.2020-0019

    • NAID

      130008121075

    • ISSN
      2432-261X
    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The prevalence and impact of sarcopenia in females undergoing total hip arthroplasty: A prospective study2021

    • Author(s)
      Ueoka Ken、Kabata Tamon、Kajino Yoshitomo、Inoue Daisuke、Ohmori Takaaki、Ueno Takuro、Yoshitani Junya、Yamamuro Yuki、Taninaka Atsushi、Kato Satoshi、Yahata Tetsutaro、Tsuchiya Hiroyuki
    • Journal Title

      Modern Rheumatology

      Volume: 32 Pages: 193-198

    • DOI

      10.1080/14397595.2021.1899603

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Multifocal Epithelioid Hemangioendothelioma Complicated with Disseminated Intravascular Coagulation2021

    • Author(s)
      Kimura Hiroaki、Yamamoto Norio、Hayashi Katsuhiro、Higuchi Takashi、Tsuchiya Hiroyuki
    • Journal Title

      Case Reports in Oncology

      Volume: 14 Pages: 1490-1496

    • DOI

      10.1159/000519212

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical characteristics of patients with undergoing unplanned excisions of malignant soft tissue tumors2021

    • Author(s)
      Morinaga Sei、Miwa Shinji、Yamamoto Norio、Hayashi Katsuhiro、Takeuchi Akihiko、Igarashi Kentaro、Tada Kaoru、Langit Mickhael B、Yonezawa Hirotaka、Araki Yoshihiro、Asano Yohei、Tsuchiya Hiroyuki
    • Journal Title

      Journal of Orthopaedic Surgery

      Volume: 29 Pages: 1-12

    • DOI

      10.1177/23094990211057597

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Does remnant tissue preservation in anterior cruciate ligament reconstruction influence the creation of the rectangular femoral tunnel?2021

    • Author(s)
      Asai Kazuki、Nakase Junsuke、Yoshimizu Rikuto、Kimura Mitsuhiro、Tsuchiya Hiroyuki
    • Journal Title

      Journal of Orthopaedic Surgery

      Volume: 29

    • DOI

      10.1177/23094990211061249

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Osteosarcoma Patient-derived Orthotopic Xenograft (PDOX) Models Used to Identify Novel and Effective Therapeutics: A Review2021

    • Author(s)
      HIGUCHI TAKASHI、IGARASHI KENTARO、YAMAMOTO NORIO、HAYASHI KATSUHIRO、KIMURA HIROAKI、MIWA SHINJI、BOUVET MICHAEL、TSUCHIYA HIROYUKI、HOFFMAN ROBERT M.
    • Journal Title

      Anticancer Research

      Volume: 41 Pages: 5865-5871

    • DOI

      10.21873/anticanres.15406

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Accuracy of different navigation systems for femoral and tibial implantation in total knee arthroplasty: a randomised comparative study2021

    • Author(s)
      Saiki Yoshitomo、Ojima Tomohiro、Kabata Tamon、Hayashi Seigaku、Tsuchiya Hiroyuki
    • Journal Title

      Archives of Orthopaedic and Trauma Surgery

      Volume: 141 Pages: 2267-2276

    • DOI

      10.1007/s00402-021-04205-3

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Usefulness of ultrasonography for dynamic evaluation of medial meniscus hoop function in early knee osteoarthritis2021

    • Author(s)
      Shimozaki Kengo、Nakase Junsuke、Asai Kazuki、Yoshimizu Rikuto、Kimura Mitsuhiro、Kanayama Tomoyuki、Kitagawa Takashi、Tsuchiya Hiroyuki
    • Journal Title

      Scientific Reports

      Volume: 11

    • DOI

      10.1038/s41598-021-99576-3

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Skeletally immature patient showed lower graft maturity than skeletally mature patient after ACL reconstruction with a rounded rectangular femoral tunnel2021

    • Author(s)
      Asai Kazuki、Nakase Junsuke、Shimozaki Kengo、Yoshimizu Rikuto、Kimura Mitsuhiro、Tsuchiya Hiroyuki
    • Journal Title

      Scientific Reports

      Volume: 11

    • DOI

      10.1038/s41598-021-99532-1

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Reverse digital artery flap for Pacinian hypertrophy of the fingertip: A rare case report2021

    • Author(s)
      Suganuma Seigo、Tada Kaoru、Yamauchi Daisuke、Takagawa Shingo、Yasutake Hidetoshi、Shimanuki Keito、Minato Hiroshi、Tsuchiya Hiroyuki
    • Journal Title

      JPRAS Open

      Volume: 30 Pages: 91-96

    • DOI

      10.1016/j.jpra.2021.08.001

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Rat model of an autologous cancellous bone graft2021

    • Author(s)
      Hamada Tomo、Matsubara Hidenori、Hikichi Toshifumi、Shimokawa Kanu、Tsuchiya Hiroyuki
    • Journal Title

      Scientific Reports

      Volume: 11

    • DOI

      10.1038/s41598-021-97573-0

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Current Management of Bone Metastases from Differentiated Thyroid Cancer2021

    • Author(s)
      Kato Satoshi、Demura Satoru、Shinmura Kazuya、Yokogawa Noriaki、Shimizu Takaki、Tsuchiya Hiroyuki
    • Journal Title

      Cancers

      Volume: 13 Pages: 4429-4429

    • DOI

      10.3390/cancers13174429

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The influence of pelvic tilt on stress distribution in the acetabulum: finite element analysis2021

    • Author(s)
      Hasegawa Kazuhiro、Kabata Tamon、Kajino Yoshitomo、Inoue Daisuke、Sakamoto Jiro、Tsuchiya Hiroyuki
    • Journal Title

      BMC Musculoskeletal Disorders

      Volume: 22

    • DOI

      10.1186/s12891-021-04500-5

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Multikinase-Inhibitor Screening in Drug-resistant Osteosarcoma Patient-derived Orthotopic Xenograft Mouse Models Identifies the Clinical Potential of Regorafenib2021

    • Author(s)
      HIGUCHI TAKASHI、IGARASHI KENTARO、YAMAMOTO NORIO、HAYASHI KATSUHIRO、KIMURA HIROAKI、MIWA SHINJI、BOUVET MICHAEL、TSUCHIYA HIROYUKI、HOFFMAN ROBERT M.
    • Journal Title

      Cancer Genomics Proteomics

      Volume: 18 Pages: 637-643

    • DOI

      10.21873/cgp.20286

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Intrathecal baclofen therapy for severe spasticity in an adult with tethered cord syndrome: a case report2021

    • Author(s)
      Takagi Yasutaka、Yamada Hiroshi、Ebara Hidehumi、Hayashi Hiroyuki、Kidani Satoshi、Toyooka Kazu、Ishino Yuji、Kitano Yoshiyuki、Nakanami Aki、Kagechika Kenji、Yahata Tetsutaro、Tsuchiya Hiroyuki
    • Journal Title

      Journal of Medical Case Reports

      Volume: 15

    • DOI

      10.1186/s13256-021-03049-0

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical outcomes of frozen autograft reconstruction for the treatment of primary bone sarcoma in adolescents and young adults2021

    • Author(s)
      Araki Yoshihiro、Yamamoto Norio、Hayashi Katsuhiro、Takeuchi Akihiko、Miwa Shinji、Igarashi Kentaro、Higuchi Takashi、Abe Kensaku、Taniguchi Yuta、Yonezawa Hirotaka、Morinaga Sei、Asano Yohei、Tsuchiya Hiroyuki
    • Journal Title

      Scientific Reports

      Volume: 11 Pages: 17291-17291

    • DOI

      10.1038/s41598-021-96162-5

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Distal Radius Fracture with Bone Fragment Protruded into the Radiocarpal Joint: Two Case Reports2021

    • Author(s)
      Tada Kaoru、Ikeda Kazuo、Tsuchiya Hiroyuki
    • Journal Title

      The Journal of Hand Surgery (Asian-Pacific Volume)

      Volume: 26 Pages: 460-462

    • DOI

      10.1142/s2424835521720164

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vertebra-Pediculoplasty: A New Approach to Treatment of Split-Type and Delayed-Union Osteoporotic Vertebral Fracture with a Risk of Cement Dislodgement2021

    • Author(s)
      Yonezawa Noritaka、Yonezawa Yoshiro、Nishimura Tatsuya、Yamashiro Teruhisa、Shimozaki Kengo、Mori Akari、Demura Satoru、Tsuchiya Hiroyuki
    • Journal Title

      World Neurosurgery

      Volume: 155

    • DOI

      10.1016/j.wneu.2021.07.142

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Patient-reported Outcome and Quality of Life after Treatment with External Fixation: A Questionnaire-based Survey2021

    • Author(s)
      Tsuchiya Hiroyuki、Ugaji Shuhei、Matsubara Hidenori、Kato Satoshi、Yoshida Yasuhisa、Hamada Tomo
    • Journal Title

      Strategies in Trauma and Limb Reconstruction

      Volume: 16 Pages: 27-31

    • DOI

      10.5005/jp-journals-10080-1519

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Radiological Scoring System for Differentiation between Enchondroma and Chondrosarcoma2021

    • Author(s)
      Miwa Shinji、Yamamoto Norio、Hayashi Katsuhiro、Takeuchi Akihiko、Igarashi Kentaro、Tada Kaoru、Yonezawa Hirotaka、Morinaga Sei、Araki Yoshihiro、Asano Yohei、Saito Shiro、Okuda Miho、Taki Junichi、Ikeda Hiroko、Nojima Takayuki、Tsuchiya Hiroyuki
    • Journal Title

      Cancers

      Volume: 13 Pages: 3558-3558

    • DOI

      10.3390/cancers13143558

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Excessive anterior tibial translation in the contralateral uninjured limb is significantly associated with ramp lesion in anterior cruciate ligament injury2021

    • Author(s)
      Asai Kazuki、Nakase Junsuke、Yoshimizu Rikuto、Kimura Mitsuhiro、Tsuchiya Hiroyuki
    • Journal Title

      Journal of Experimental Orthopaedics

      Volume: 8

    • DOI

      10.1186/s40634-021-00372-9

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] How to Detect Meniscal Ramp Lesions Using?Ultrasound2021

    • Author(s)
      Nakase Junsuke、Asai Kazuki、Yoshimizu Rikuto、Kimura Mitsuhiro、Tsuchiya Hiroyuki
    • Journal Title

      Arthroscopy Techniques

      Volume: 10

    • DOI

      10.1016/j.eats.2021.02.022

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Efficacy of perioperative chemotherapy for synovial sarcoma: a retrospective analysis of a Nationwide database in Japan2021

    • Author(s)
      Xu Gang、Aiba Hisaki、Yamamoto Norio、Hayashi Katsuhiro、Takeuchi Akihiko、Miwa Shinji、Higuchi Takashi、Abe Kensaku、Taniguchi Yuta、Araki Yoshihiro、Saito Shiro、Yoshimura Kenichi、Murakami Hideki、Tsuchiya Hiroyuki、Kawai Akira
    • Journal Title

      BMC Cancer

      Volume: 21 Pages: 773-773

    • DOI

      10.1186/s12885-021-08485-1

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Correlation between lag screw route and the ideal insertion point of the intramedullary nail2021

    • Author(s)
      Yoshitani Junya、Kabata Tamon、Kajino Yoshitomo、Inoue Daisuke、Ohmori Takaaki、Ueoka Ken、Yamamuro Yuki、Taninaka Atsushi、Tsuchiya Hiroyuki
    • Journal Title

      Scientific Reports

      Volume: 11

    • DOI

      10.1038/s41598-021-93348-9

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Delayed Initiation of Treatment Is Associated With Metastasis of Malignant Bone Tumor2021

    • Author(s)
      ARAKI YOSHIHIRO、YAMAMOTO NORIO、HAYASHI KATSUHIRO、TAKEUCHI AKIHIKO、MIWA SHINJI、IGARASHI KENTARO、HIGUCHI TAKASHI、ABE KENSAKU、TANIGUCHI YUTA、YONEZAWA HIROTAKA、MORINAGA SEI、ASANO YOHEI、TSUCHIYA HIROYUKI
    • Journal Title

      Anticancer Research

      Volume: 41 Pages: 2993-2999

    • DOI

      10.21873/anticanres.15081

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Surgical Metastasectomy in the Spine: A Review Article2021

    • Author(s)
      Kato Satoshi、Demura Satoru、Shinmura Kazuya、Yokogawa Noriaki、Shimizu Takaki、Murakami Hideki、Kawahara Norio、Tomita Katsuro、Tsuchiya Hiroyuki
    • Journal Title

      Oncologist

      Volume: 26

    • DOI

      10.1002/onco.13840

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Osteosarcoma-Derived Small Extracellular Vesicles Enhance Tumor Metastasis and Suppress Osteoclastogenesis by miR-146a-5p2021

    • Author(s)
      Yoshihiro Araki, Hisaki Aiba, Takeshi Yoshida, Norio Yamamoto, Katsuhiro Hayashi, Akihiko Takeuchi, Shinji Miwa, Kentaro Igarashi, Tuan D. Nguyen, Kiyo-aki Ishii, Takayuki Nojima, Satoru Takahashi, Hideki Murakami, Hiroyuki Tsuchiya and Rikinari Hanayama
    • Journal Title

      Frontiers in Oncology

      Volume: 11 Pages: 667109-667109

    • DOI

      10.3389/fonc.2021.667109

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Change in leg length after open-wedge high tibial osteotomy can be predicted from the opening width: A three-dimensional analysis2021

    • Author(s)
      Yamamuro Yuki、Kabata Tamon、Goshima Kenichi、Kajino Yoshitomo、Inoue Daisuke、Ohmori Takaaki、Ueno Takuro、Takagi Tomoharu、Yoshitani Junya、Ueoka Ken、Taninaka Atsushi、Tsuchiya Hiroyuki
    • Journal Title

      The Knee

      Volume: 30 Pages: 185-194

    • DOI

      10.1016/j.knee.2021.04.010

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Perioperative complications of total en bloc spondylectomy for spinal tumours2021

    • Author(s)
      Demura Satoru、Kato Satoshi、Shinmura Kazuya、Yokogawa Noriaki、Shimizu Takaki、Handa Makoto、Annen Ryohei、Kobayashi Motoya、Yamada Yohei、Murakami Hideki、Kawahara Norio、Tomita Katsuro、Tsuchiya Hiroyuki
    • Journal Title

      The Bone & Joint Journal

      Volume: 103-B Pages: 976-983

    • DOI

      10.1302/0301-620x.103b5.bjj-2020-1777.r1

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bone and Soft Tissue Tumors: New Treatment Approaches2021

    • Author(s)
      Miwa Shinji、Yamamoto Norio、Tsuchiya Hiroyuki
    • Journal Title

      Cancers

      Volume: 13 Pages: 1832-1832

    • DOI

      10.3390/cancers13081832

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Total en bloc spondylectomy is worth doing in complete paralysis spinal giant cell tumor, a minimum 1-year follow-up2021

    • Author(s)
      Paholpak Permsak、Sangsin Apiruk、Sirichativapee Winai、Wisanuyotin Taweechok、Kosuwon Weerachai、Sumnanoont Chat、Thammaroj Puntip、Ungarreevittaya Piti、Kasai Yuichi、Murakami Hideki、Tsuchiya Hiroyuki
    • Journal Title

      Journal of Orthopaedic Surgery

      Volume: 29

    • DOI

      10.1177/23094990211005900

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antibacterial Activity in Iodine-coated Implants Under Conditions of Iodine Loss: Study in a Rat Model Plus In Vitro Analysis2021

    • Author(s)
      Ueoka Ken、Kabata Tamon、Tokoro Masaharu、Kajino Yoshitomo、Inoue Daisuke、Takagi Tomoharu、Ohmori Takaaki、Yoshitani Junya、Ueno Takuro、Yamamuro Yuki、Taninaka Atsushi、Tsuchiya Hiroyuki
    • Journal Title

      Clinical Orthopaedics & Related Research

      Volume: 479 Pages: 1613-1623

    • DOI

      10.1097/corr.0000000000001753

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The effect of gracilis tendon harvesting in addition to semitendinosus tendon harvesting on knee extensor and flexor strength after anterior cruciate ligament reconstruction2021

    • Author(s)
      Sengoku Takuya、Nakase Junsuke、Asai Kazuki、Yoshimizu Rikuto、Sakurai Goro、Yoshida Shinya、Yahata Tetsutaro、Tsuchiya Hiroyuki
    • Journal Title

      Archives of Orthopaedic and Trauma Surgery

      Volume: 142 Pages: 465-470

    • DOI

      10.1007/s00402-021-03877-1

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Complete Response of Bone Metastasis in Non-small Cell Lung Cancer With Pembrolizumab: Two Case Reports2021

    • Author(s)
      ASANO YOHEI、YAMAMOTO NORIO、HAYASHI KATSUHIRO、TAKEUCHI AKIHIKO、MIWA SHINJI、IGARASHI KENTARO、YONEZAWA HIROTAKA、ARAKI YOSHIHIRO、MORINAGA SEI、KASAHARA KAZUO、SONE TAKASHI、TSUCHIYA HIROYUKI
    • Journal Title

      Anticancer Research

      Volume: 41 Pages: 1693-1699

    • DOI

      10.21873/anticanres.14933

    • Related Report
      2021 Annual Research Report 2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Spontaneous extensor tendon rupture due to scaphoid osteophyte: A case report and literature review2021

    • Author(s)
      Suganuma Seigo、Tada Kaoru、Takagawa Shingo、Yasutake Hidetoshi、Shimanuki Keito、Tsuchiya Hiroyuki
    • Journal Title

      JPRAS Open

      Volume: 28 Pages: 66-71

    • DOI

      10.1016/j.jpra.2021.02.006

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinical outcomes and prognostic factors following the surgical resection of renal cell carcinoma spinal metastases2021

    • Author(s)
      Kato Satoshi、Demura Satoru、Murakami Hideki、Yoshioka Katsuhito、Shinmura Kazuya、Yokogawa Noriaki、Shimizu Takaki、Kawahara Norio、Tsuchiya Hiroyuki
    • Journal Title

      Cancer Science

      Volume: 112 Pages: 2416-2425

    • DOI

      10.1111/cas.14902

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Contralateral Lower-Limb Functional Status Before Total Hip Arthroplasty2021

    • Author(s)
      Ohmori Takaaki、Kabata Tamon、Kajino Yoshitomo、Inoue Daisuke、Kato Satoshi、Tsuchiya Hiroyuki
    • Journal Title

      Journal of Bone and Joint Surgery

      Volume: 103 Pages: 1093-1103

    • DOI

      10.2106/jbjs.20.00949

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Heritage and Invention ? Dream, Dare and Do2021

    • Author(s)
      Tsuchiya Hiroyuki
    • Journal Title

      Journal of Orthopaedic Science

      Volume: 26 Pages: 201-202

    • DOI

      10.1016/j.jos.2021.02.002

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Abscopal Effect of Frozen Autograft Reconstruction Combined with an Immune Checkpoint Inhibitor Analyzed Using a Metastatic Bone Tumor Model2021

    • Author(s)
      Yonezawa Noritaka、Murakami Hideki、Demura Satoru、Kato Satoshi、Miwa Shinji、Yoshioka Katsuhito、Shinmura Kazuya、Yokogawa Noriaki、Shimizu Takaki、Oku Norihiro、Kitagawa Ryo、Handa Makoto、Annen Ryohei、Kurokawa Yuki、Fushimi Kazumi、Mizukoshi Eishiro、Tsuchiya Hiroyuki
    • Journal Title

      international journal of molecular sciences

      Volume: 22 Pages: 1-15

    • DOI

      10.3390/ijms22041973

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Combination Methionine-methylation-axis Blockade: A Novel Approach to Target the Methionine Addiction of Cancer2021

    • Author(s)
      HIGUCHI TAKASHI、HAN QINGHONG、SUGISAWA NORIHIKO、YAMAMOTO JUN、YAMAMOTO NORIO、HAYASHI KATSUHIRO、KIMURA HIROAKI、MIWA SHINJI、IGARASHI KENTARO、BOUVET MICHAEL、SINGH SHREE RAM、TSUCHIYA HIROYUKI、HOFFMAN ROBERT M.
    • Journal Title

      Cancer Genomics - Proteomics

      Volume: 18 Pages: 113-120

    • DOI

      10.21873/cgp.20246

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] The number of osteoclasts in a biopsy specimen can predict the efficacy of neoadjuvant chemotherapy for primary osteosarcoma2021

    • Author(s)
      Araki Yoshihiro、Yamamoto Norio、Hayashi Katsuhiro、Takeuchi Akihiko、Miwa Shinji、Igarashi Kentaro、Higuchi Takashi、Abe Kensaku、Taniguchi Yuta、Yonezawa Hirotaka、Morinaga Sei、Asano Yohei、Ikeda Hiroko、Nojima Takayuki、Tsuchiya Hiroyuki
    • Journal Title

      Scientific Reports

      Volume: 11 Pages: 1989-1989

    • DOI

      10.1038/s41598-020-80504-w

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The Utility of the Energy Subtraction Method for Thoracic Spine Radiography in Clinical Practice: An Analysis of 25 Patients With Multiple Myeloma2021

    • Author(s)
      Shimizu Takaki、Sasagawa Takeshi、Kawamura Naohiro、Masuyama Shigeru、Tachibana Naohiro、Emori Haruka、Iizuka Masaaki、Ishikura Hisatoshi、Suzuki Kenshi、Kuwabara Takeshi、Tsuchiya Hiroyuki、Kunogi Junichi
    • Journal Title

      Orthopedics

      Volume: 44

    • DOI

      10.3928/01477447-20201202-05

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] PhaseIIclinical trial of pazopanib for patients with unresectable or metastatic malignant peripheral nerve sheath tumors2021

    • Author(s)
      Nishida Yoshihiro、Urakawa Hiroshi、Nakayama Robert、Kobayashi Eisuke、Ozaki Toshifumi、Ae Keisuke、Matsumoto Yoshihiro、Tsuchiya Hiroyuki、Goto Takahiro、Hiraga Hiroaki、Naka Norifumi、Takahashi Shunji、Ando Yuichi、Ando Masahiko、Kuwatsuka Yachiyo、Hamada Shunsuke、Ueda Takafumi、Kawai Akira
    • Journal Title

      International Journal of Cancer

      Volume: 148 Pages: 140-149

    • DOI

      10.1002/ijc.33201

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Delayed Initiation of Treatment Is Associated With Metastasis of Soft-tissue Sarcoma2020

    • Author(s)
      ARAKI YOSHIHIRO、YAMAMOTO NORIO、HAYASHI KATSUHIRO、TAKEUCHI AKIHIKO、MIWA SHINJI、IGARASHI KENTARO、TAKASHI HIGUCHI、KENSAKU ABE、TANIGUCHI YUTA、YONEZAWA HIROTAKA、MORINAGA SEI、ASANO YOHEI、TSUCHIYA HIROYUKI
    • Journal Title

      Anticancer Research

      Volume: 40 Pages: 7009-7015

    • DOI

      10.21873/anticanres.14726

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Diagnostic accuracies of intraoperative frozen section and permanent section examinations for histological grades during open biopsy of bone tumors2020

    • Author(s)
      Miwa Shinji、Yamamoto Norio、Hayashi Katsuhiro、Takeuchi Akihiko、Igarashi Kentaro、Tada Kaoru、Higuchi Takashi、Yonezawa Hirotaka、Morinaga Sei、Araki Yoshihiro、Asano Yohei、Ikeda Hiroko、Nojima Takayuki、Tsuchiya Hiroyuki
    • Journal Title

      International Journal of Clinical Oncology

      Volume: 26 Pages: 613-619

    • DOI

      10.1007/s10147-020-01836-1

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Structural Origin and Surgical Complications of Peripheral Schwannomas2020

    • Author(s)
      YONEZAWA HIROTAKA、MIWA SHINJI、YAMAMOTO NORIO、HAYASHI KATSUHIRO、TAKEUCHI AKIHIKO、IGARASHI KENTARO、TADA KAORU、LANGIT MICKHAEL B.、HIGUCHI TAKASHI、ABE KENSAKU、TANIGUCHI YUTA、MORINAGA SEI、ARAKI YOSHIHIRO、ASANO YOHEI、TSUCHIYA HIROYUKI
    • Journal Title

      Anticancer Research

      Volume: 40 Pages: 6563-6570

    • DOI

      10.21873/anticanres.14681

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Intraoperative ultrasonography‐guided surgery for malignant soft tissue tumor2020

    • Author(s)
      Takeuchi Akihiko、Yamamoto Norio、Hayashi Katsuhiro、Miwa Shinji、Igarashi Kentaro、Yonezawa Hirotaka、Morinaga Sei、Araki Yoshihiro、Asano Yohei、Ikeda Hiroko、Tsuchiya Hiroyuki
    • Journal Title

      Journal of Surgical Oncology

      Volume: 122 Pages: 1791-1801

    • DOI

      10.1002/jso.26181

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Clinical course of grafted cartilage in osteoarticular frozen autografts for reconstruction after resection of malignant bone and soft-tissue tumor involving an epiphysis2020

    • Author(s)
      Hayashi Katsuhiro、Yamamoto Norio、Takeuchi Akihiko、Miwa Shinji、Igarashi Kentaro、Higuchi Takashi、Abe Kensaku、Taniguchi Yuta、Aiba Hisaki、Araki Yoshihiro、Yonezawa Hirotaka、Morinaga Sei、Tsuchiya Hiroyuki
    • Journal Title

      Journal of Bone Oncology

      Volume: 24 Pages: 100310-100310

    • DOI

      10.1016/j.jbo.2020.100310

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Accuracy of histological grades from intraoperative frozen-section diagnoses of soft-tissue tumors2020

    • Author(s)
      Miwa Shinji、Yamamoto Norio、Hayashi Katsuhiro、Takeuchi Akihiko、Igarashi Kentaro、Tada Kaoru、Higuchi Takashi、Yonezawa Hirotaka、Morinaga Sei、Araki Yoshihiro、Asano Yohei、Ikeda Hiroko、Nojima Takayuki、Tsuchiya Hiroyuki
    • Journal Title

      International Journal of Clinical Oncology

      Volume: 25 Pages: 2158-2165

    • DOI

      10.1007/s10147-020-01762-2

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Osimertinib regressed an EGFR-mutant lung-adenocarcinoma bone-metastasis mouse model and increased long-term survival2020

    • Author(s)
      Higuchi Takashi、Sugisawa Norihiko、Park Jun Ho、Sun Yu、Zhu Guangwei、Yamamoto Norio、Hayashi Katsuhiro、Kimura Hiroaki、Miwa Shinji、Igarashi Kentaro、Bouvet Michael、Singh Shree Ram、Tsuchiya Hiroyuki、Hoffman Robert M.
    • Journal Title

      Translational Oncology

      Volume: 13 Pages: 100826-100826

    • DOI

      10.1016/j.tranon.2020.100826

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Recent Advances and Challenges in the Treatment of Rhabdomyosarcoma2020

    • Author(s)
      Miwa Shinji、Yamamoto Norio、Hayashi Katsuhiro、Takeuchi Akihiko、Igarashi Kentaro、Tsuchiya Hiroyuki
    • Journal Title

      Cancers

      Volume: 12 Pages: 1758-1758

    • DOI

      10.3390/cancers12071758

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Phase II trial of pazopanib in patients with metastatic or unresectable chemoresistant sarcomas: A Japanese Musculoskeletal Oncology Group study2020

    • Author(s)
      Urakawa Hiroshi、Kawai Akira、Goto Takahiro、Hiraga Hiroaki、Ozaki Toshifumi、Tsuchiya Hiroyuki、Nakayama Robert、Naka Norifumi、Matsumoto Yoshihiro、Kobayashi Eisuke、Okuma Tomotake、Kunisada Toshiyuki、Ando Masahiko、Ueda Takafumi、Nishida Yoshihiro
    • Journal Title

      Cancer Science

      Volume: 111 Pages: 3303-3312

    • DOI

      10.1111/cas.14542

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Eribulin Regresses a Doxorubicin-resistant Dedifferentiated Liposarcoma in a Patient-derived Orthotopic Xenograft Mouse Model2020

    • Author(s)
      IGARASHI KENTARO、KAWAGUCHI KEI、KIYUNA TASUKU、MIYAKE KENTARO、HIGUCHI TAKASHI、YAMAMOTO NORIO、HAYASHI KATSUHIRO、KIMURA HIROAKI、MIWA SHINJI、SINGH SHREE RAM、TSUCHIYA HIROYUKI、HOFFMAN ROBERT M.
    • Journal Title

      Cancer Genomics - Proteomics

      Volume: 17 Pages: 351-358

    • DOI

      10.21873/cgp.20194

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Risk Factors for Postoperative Deep Infection After Malignant Bone Tumor Surgery of the Extremities2020

    • Author(s)
      LANGIT MICKHAEL BANG、MIWA SHINJI、YAMAMOTO NORIO、HAYASHI KATSUHIRO、TAKEUCHI AKIHIKO、IGARASHI KENTARO、TADA KAORU、HIGUCHI TAKASHI、YONEZAWA HIROTAKA、MORINAGA SEI、ARAKI YOSHIHIRO、ASANO YOHEI、TSUCHIYA HIROYUKI
    • Journal Title

      Anticancer Research

      Volume: 40 Pages: 3551-3557

    • DOI

      10.21873/anticanres.14344

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Recombinant Methioninase Combined With Tumor-targeting Salmonella typhimurium A1-R Induced Regression in a PDOX Mouse Model of Doxorubicin-resistant Dedifferentiated Liposarcoma2020

    • Author(s)
      IGARASHI KENTARO、KAWAGUCHI KEI、ZHAO MING、HAN QINGHONG、TAN YUYING、KIYUNA TASUKU、MIYAKE KENTARO、HIGUCHI TAKASHI、NELSON SCOTT D.、DRY SARAH M.、LI YUNFENG、YAMAMOTO NORIO、HAYASHI KATSUHIRO、KIMURA HIROAKI、MIWA SHINJI、SINGH SHREE RAM、TSUCHIYA HIROYUKI、HOFFMAN ROBERT M.
    • Journal Title

      Anticancer Research

      Volume: 40 Pages: 2515-2523

    • DOI

      10.21873/anticanres.14222

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A Novel Anionic-phosphate-platinum Complex Effectively Targets a Cisplatinum-resistant Osteosarcoma in a Patient-derived Orthotopic Xenograft Mouse Model2020

    • Author(s)
      IGARASHI KENTARO、KAWAGUCHI KEI、YAMAMOTO NORIO、HAYASHI KATSUHIRO、KIMURA HIROAKI、MIWA SHINJI、HIGUCHI TAKASHI、TANIGUCHI YUTA、YONEZAWA HIROTAKA、ARAKI YOSHIHIRO、MORINAGA SEI、MISRA SWETA、NELSON SCOTT D.、DRY SARAH M.、LI YUNFENG、ODANI AKIRA、SINGH SHREE RAM、TSUCHIYA HIROYUKI、HOFFMAN ROBERT M.
    • Journal Title

      Cancer Genomics - Proteomics

      Volume: 17 Pages: 217-223

    • DOI

      10.21873/cgp.20182

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Pedicle frozen autograft?prosthesis composite reconstructions for malignant bone tumors of the proximal femur2020

    • Author(s)
      Xu Gang、Miwa Shinji、Yamamoto Norio、Hayashi Katsuhiro、Takeuchi Akihiko、Igarashi Kentaro、Higuchi Takashi、Taniguchi Yuta、Araki Yoshihiro、Yonezawa Hirotaka、Morinaga Sei、Tsuchiya Hiroyuki
    • Journal Title

      BMC Musculoskeletal Disorders

      Volume: 21 Pages: 81-81

    • DOI

      10.1186/s12891-020-3112-0

    • NAID

      40017372723

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Exquisite Tumor Targeting by Salmonella A1-R in Combination with Caffeine and Valproic Acid Regresses an Adult Pleomorphic Rhabdomyosarcoma Patient-Derived Orthotopic Xenograft Mouse Model2020

    • Author(s)
      Igarashi Kentaro、Kawaguchi Kei、Zhao Ming、Kiyuna Tasuku、Miyake Kentaro、Miyake Masuyo、Nelson Scott D.、Dry Sarah M.、Li Yunfeng、Yamamoto Norio、Hayashi Katsuhiro、Kimura Hiroaki、Miwa Shinji、Higuchi Takashi、Singh Shree Ram、Tsuchiya Hiroyuki、Hoffman Robert M.
    • Journal Title

      Translational Oncology

      Volume: 13 Pages: 393-400

    • DOI

      10.1016/j.tranon.2019.10.005

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] PPARγ Agonist Pioglitazone in Combination With Cisplatinum Arrests a Chemotherapy-resistant Osteosarcoma PDOX Model.2020

    • Author(s)
      Higuchi T, Yamamoto J, Sugisawa N, Tashiro Y, Nishino H, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Bouvet M, Singh SR, Tsuchiya H, Hoffman RM.
    • Journal Title

      Cancer Genomics - Proteomics

      Volume: 15 Pages: 35-40

    • DOI

      10.21873/cgp.20165

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Combination of oral recombinant methioninase and decitabine arrests a chemotherapy-resistant undifferentiated soft-tissue sarcoma patient-derived orthotopic xenograft mouse model2020

    • Author(s)
      Higuchi Takashi、Han Qinghong、Miyake Kentaro、Oshiro Hiromichi、Sugisawa Norihiko、Tan Yuying、Yamamoto Norio、Hayashi Katsuhiro、Kimura Hiroaki、Miwa Shinji、Igarashi Kentaro、Bouvet Michael、Singh Shree Ram、Tsuchiya Hiroyuki、Hoffman Robert M.
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 523 Pages: 135-139

    • DOI

      10.1016/j.bbrc.2019.12.024

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Glycogen synthase kinase 3β as a potential therapeutic target in synovial sarcoma and fibrosarcoma2020

    • Author(s)
      Abe Kensaku、Yamamoto Norio、Domoto Takahiro、Bolidong Dilireba、Hayashi Katsuhiro、Takeuchi Akihiko、Miwa Shinji、Igarashi Kentaro、Inatani Hiroyuki、Aoki Yu、Higuchi Takashi、Taniguchi Yuta、Yonezawa Hirotaka、Araki Yoshihiro、Aiba Hisaki、Minamoto Toshinari、Tsuchiya Hiroyuki
    • Journal Title

      Cancer Science

      Volume: 111 Pages: 429-440

    • DOI

      10.1111/cas.14271

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Patient-derived orthotopic xenograft models of sarcoma2020

    • Author(s)
      Igarashi Kentaro、Kawaguchi Kei、Murakami Takashi、Miyake Kentaro、Kiyuna Tasuku、Miyake Masuyo、Hiroshima Yukihiko、Higuchi Takashi、Oshiro Hiromichi、Nelson Scott D.、Dry Sarah M.、Li Yunfeng、Yamamoto Norio、Hayashi Katsuhiro、Kimura Hiroaki、Miwa Shinji、Singh Shree Ram、Tsuchiya Hiroyuki、Hoffman Robert M.
    • Journal Title

      Cancer Letters

      Volume: 469 Pages: 332-339

    • DOI

      10.1016/j.canlet.2019.10.028

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Surgical metastasectomy for renal cell carcinoma: which patients are the real candidates for surgery?2019

    • Author(s)
      Kato Satoshi、Demura Satoru、Murakami Hideki、Tsuchiya Hiroyuki
    • Journal Title

      Annals of Translational Medicine

      Volume: 7

    • DOI

      10.21037/atm.2019.11.139

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Anti-tumor Effects of Cyclolinopeptide on Giant-cell Tumor of the Bone2019

    • Author(s)
      TANIGUCHI YUTA、YAMAMOTO NORIO、HAYASHI KATSUHIRO、TAKEUCHI AKIHIKO、MIWA SHINJI、IGARASHI KENTARO、HIGUCHI TAKASHI、ABE KENSAKU、YONEZAWA HIROTAKA、ARAKI YOSHIHIRO、MORINAGA SEI、KAMEI JUNZO、NUGROHO ALFARIUS EKO、KANEDA TOSHIO、MORITA HIROSHI、TSUCHIYA HIROYUKI
    • Journal Title

      Anticancer Research

      Volume: 39 Pages: 6145-6153

    • DOI

      10.21873/anticanres.13822

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] A retrospective study of antibacterial iodine-coated implants for postoperative infection2019

    • Author(s)
      Shirai Toshiharu、Tsuchiya Hiroyuki、Terauchi Ryu、Tsuchida Shinji、Mizoshiri Naoki、Mori Yuki、Takeuchi Akihiko、Hayashi Katsuhiro、Yamamoto Norio、Ikoma Kazuya、Kubo Toshikazu
    • Journal Title

      Medicine

      Volume: 98

    • DOI

      10.1097/md.0000000000017932

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comparison of treatment indices associated with the correction and lengthening of deformities along various lower limb frontal plane directions2019

    • Author(s)
      Hamada Tomo、Matsubara Hidenori、Yoshida Yasuhisa、Ugaji Shuhei、Tsuchiya Hiroyuki
    • Journal Title

      J Clin Orthop Trauma

      Volume: 10 Pages: 57-61

    • DOI

      10.1016/j.jcot.2019.01.003

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Correlation between osteoporotic vertebral fracture and abdominal trunk muscle strength in middle-aged and older women2019

    • Author(s)
      Kato Satoshi、Demura Satoru、Kurokawa Yuki、Shinmura Kazuya、Yokogawa Noriaki、Yonezawa Noritaka、Shimizu Takaki、Oku Norihiro、Kitagawa Ryo、Matsubara Hidenori、Kabata Tamon、Tsuchiya Hiroyuki
    • Journal Title

      Arch Osteoporos

      Volume: 14 Pages: 106-106

    • DOI

      10.1007/s11657-019-0654-6

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Treatment of chordoma?where is it going?2019

    • Author(s)
      Yamamoto Norio、Tsuchiya Hiroyuki
    • Journal Title

      Journal of Spine Surgery

      Volume: 5 Pages: 387-389

    • DOI

      10.21037/jss.2019.09.01

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Distribution of Solitary and Multiple Enchondromas of the Hand2019

    • Author(s)
      MIWA SHINJI、OKAMOTO HIDEKI、YAMADA SATOSHI、KAWAGUCHI YOHEI、ENDO KOJIRO、AIBA HISAKI、HAYASHI KATSUHIRO、KIMURA HIROAKI、SEKIYA ISATO、OTSUKA TAKANOBU、TSUCHIYA HIROYUKI
    • Journal Title

      In Vivo

      Volume: 33 Pages: 2235-2240

    • DOI

      10.21873/invivo.11728

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Internal Oblique Muscle Strain on the Side of the Dominant Arm in a Representative Handball Player2019

    • Author(s)
      Asai Kazuki、Nakase Junsuke、Shimozaki Kengo、Toyooka Kazu、Kitaoka Katsuhiko、Tsuchiya Hiroyuki
    • Journal Title

      Current Sports Medicine Reports

      Volume: 18 Pages: 358-360

    • DOI

      10.1249/jsr.0000000000000640

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Pioglitazone, an agonist of PPARγ, reverses doxorubicin-resistance in an osteosarcoma patient-derived orthotopic xenograft model by downregulating P-glycoprotein expression2019

    • Author(s)
      Higuchi Takashi、Sugisawa Norihiko、Miyake Kentaro、Oshiro Hiromichi、Yamamoto Norio、Hayashi Katsuhiro、Kimura Hiroaki、Miwa Shinji、Igarashi Kentaro、Kline Zoey、Bouvet Michael、Singh Shree Ram、Tsuchiya Hiroyuki、Hoffman Robert M.
    • Journal Title

      Biomedicine & Pharmacotherapy

      Volume: 118 Pages: 109356-109356

    • DOI

      10.1016/j.biopha.2019.109356

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Combination Treatment With Sorafenib and Everolimus Regresses a Doxorubicin-resistant Osteosarcoma in a PDOX Mouse Model2019

    • Author(s)
      HIGUCHI TAKASHI、SUGISAWA NORIHIKO、MIYAKE KENTARO、OSHIRO HIROMICHI、YAMAMOTO NORIO、HAYASHI KATSUHIRO、KIMURA HIROAKI、MIWA SHINJI、IGARASHI KENTARO、KLINE ZOEY、BELT PAIGE、CHAWLA SANT P.、BOUVET MICHAEL、SINGH SHREE RAM、TSUCHIYA HIROYUKI、HOFFMAN ROBERT M.
    • Journal Title

      Anticancer Research

      Volume: 39 Pages: 4781-4786

    • DOI

      10.21873/anticanres.13662

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Oral Recombinant Methioninase, Combined With Oral Caffeine and Injected Cisplatinum, Overcome Cisplatinum-Resistance and Regresses Patient-derived Orthotopic Xenograft Model of Osteosarcoma2019

    • Author(s)
      HIGUCHI TAKASHI、OSHIRO HIROMICHI、MIYAKE KENTARO、SUGISAWA NORIHIKO、HAN QINGHONG、TAN YUYING、PARK JUNHO、ZHANG ZHIYING、RAZMJOOEI SAHAR、YAMAMOTO NORIO、HAYASHI KATSUHIRO、KIMURA HIROAKI、MIWA SHINJI、IGARASHI KENTARO、BOUVET MICHAEL、CHAWLA SANT P.、SINGH SHREE RAM、TSUCHIYA HIROYUKI、HOFFMAN ROBERT M.
    • Journal Title

      Anticancer Research

      Volume: 39 Pages: 4653-4657

    • DOI

      10.21873/anticanres.13646

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Relationship between the deep flexion of the knee joint and the dynamics of the infrapatellar fat pad after anterior cruciate ligament reconstruction via ultrasonography2019

    • Author(s)
      Kitagawa Takashi、Nakase Junsuke、Takata Yasushi、Shimozaki Kengo、Asai Kazuki、Toyooka Kazu、Tsuchiya Hiroyuki
    • Journal Title

      J Phys Ther Sci

      Volume: 31 Issue: 7 Pages: 569-572

    • DOI

      10.1589/jpts.31.569

    • NAID

      130007676712

    • ISSN
      0915-5287, 2187-5626
    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sorafenib and Palbociclib Combination Regresses a Cisplatinum-resistant Osteosarcoma in a PDOX Mouse Model2019

    • Author(s)
      HIGUCHI TAKASHI、SUGISAWA NORIHIKO、MIYAKE KENTARO、OSHIRO HIROMICHI、YAMAMOTO NORIO、HAYASHI KATSUHIRO、KIMURA HIROAKI、MIWA SHINJI、IGARASHI KENTARO、CHAWLA SANT P.、BOUVET MICHAEL、SINGH SHREE RAM、TSUCHIYA HIROYUKI、HOFFMAN ROBERT M.
    • Journal Title

      Anticancer Research

      Volume: 39 Pages: 4079-4084

    • DOI

      10.21873/anticanres.13565

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Effectiveness of Adhering Adipose-Derived Stem Cells to Defective Cartilage in Promoting Cartilage Regeneration in a Rabbit Model2019

    • Author(s)
      Numata Hitoaki、Nakase Junsuke、Oshima Takeshi、Tsuchiya Hiroyuki
    • Journal Title

      Arthroscopy: The Journal of Arthroscopic & Related Surgery

      Volume: 35 Pages: 2619-2626

    • DOI

      10.1016/j.arthro.2019.03.018

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Caffeine citrate enhanced cisplatin antitumor effects in osteosarcoma and fibrosarcoma in vitro and in vivo2019

    • Author(s)
      Abe Kensaku、Yamamoto Norio、Hayashi Katsuhiro、Takeuchi Akihiko、Tsuchiya Hiroyuki
    • Journal Title

      BMC Cancer

      Volume: 19 Pages: 689-689

    • DOI

      10.1186/s12885-019-5891-y

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Combination of Olaratumab with Doxorubicin and Cisplatinum Regresses a Chemotherapy-Resistant Osteosarcoma in a Patient-Derived Orthotopic Xenograft Mouse Model2019

    • Author(s)
      Higuchi Takashi、Sugisawa Norihiko、Miyake Kentaro、Oshiro Hiromichi、Yamamoto Norio、Hayashi Katsuhiro、Kimura Hiroaki、Miwa Shinji、Igarashi Kentaro、Bouvet Michael、Singh Shree Ram、Tsuchiya Hiroyuki、Hoffman Robert M.
    • Journal Title

      Translational Oncology

      Volume: 12 Pages: 1257-1263

    • DOI

      10.1016/j.tranon.2019.06.002

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Asymptomatic Bone Marrow Edema Detected by 67Ga Scintigraphy2019

    • Author(s)
      Miwa Shinji、Otsuka Takanobu、Yamada Satoshi、Aiba Hisaki、Tsuchiya Hiroyuki
    • Journal Title

      Clinical Nuclear Medicine

      Volume: 44 Pages: 680-682

    • DOI

      10.1097/rlu.0000000000002661

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] The Accuracy of the Computed Tomography-Based Navigation System in Total Hip Arthroplasty Is Comparable With Crowe Type IV and Crowe Type I Dysplasia: A Case-Control Study2019

    • Author(s)
      Ueoka Ken、Kabata Tamon、Kajino Yoshitomo、Yoshitani Junya、Ueno Takuro、Tsuchiya Hiroyuki
    • Journal Title

      The Journal of Arthroplasty

      Volume: 34 Pages: 2686-2691

    • DOI

      10.1016/j.arth.2019.06.002

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Utility of bone SPECT/CT to identify the primary cause of pain in elderly patients with degenerative lumbar spine disease2019

    • Author(s)
      Kato Satoshi、Demura Satoru、Matsubara Hidenori、Inaki Anri、Shinmura Kazuya、Yokogawa Noriaki、Murakami Hideki、Kinuya Seigo、Tsuchiya Hiroyuki
    • Journal Title

      J Orthop Surg Res

      Volume: 14 Pages: 185-185

    • DOI

      10.1186/s13018-019-1236-4

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Tilt-adjusted Cup Anteversion in Patients with Severe Backward Pelvic Tilt is Associated with the Risk of Iliopsoas Impingement2019

    • Author(s)
      Ueno Takuro、Kabata Tamon、Kajino Yoshitomo、Ohmori Takaaki、Yoshitani Junya、Ueoka Ken、Tsuchiya Hiroyuki
    • Journal Title

      Clinical Orthopaedics and Related Research

      Volume: 477 Pages: 2243-2254

    • DOI

      10.1097/corr.0000000000000830

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Abdominal trunk muscle weakness and its association with chronic low back pain and risk of falling in older women2019

    • Author(s)
      Kato Satoshi、Murakami Hideki、Demura Satoru、Yoshioka Katsuhito、Shinmura Kazuya、Yokogawa Noriaki、Igarashi Takashi、Yonezawa Noritaka、Shimizu Takaki、Tsuchiya Hiroyuki
    • Journal Title

      BMC Musculoskeletal Disorders

      Volume: 20 Pages: 273-273

    • DOI

      10.1186/s12891-019-2655-4

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pazopanib regresses a doxorubicin-resistant synovial sarcoma in a patient-derived orthotopic xenograft mouse model2019

    • Author(s)
      Igarashi Kentaro、Kawaguchi Kei、Kiyuna Tasuku、Miyake Kentaro、Miyake Masuyo、Nelson Scott D.、Russell Tara A.、Dry Sarah M.、Li Yunfeng、Yamamoto Norio、Hayashi Katsuhiro、Kimura Hiroaki、Miwa Shinji、Higuchi Takashi、Singh Shree Ram、Tsuchiya Hiroyuki、Hoffman Robert M.
    • Journal Title

      Tissue and Cell

      Volume: 58 Pages: 107-111

    • DOI

      10.1016/j.tice.2019.04.010

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] The characteristic findings of an inverted-type discoid lateral meniscus tear: a hidden tear pattern2019

    • Author(s)
      Shimozaki Kengo、Nakase Junsuke、Takata Yasushi、Asai Kazuki、Toyooka Kazu、Kitaoka Katsuhiko、Tsuchiya Hiroyuki
    • Journal Title

      BMC Musculoskeletal Disorders

      Volume: 20 Pages: 223-223

    • DOI

      10.1186/s12891-019-2618-9

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Autologous adipose-derived stem cell transplantation enhances healing of wound with exposed bone in a rat model2019

    • Author(s)
      Hamada Tomo、Matsubara Hidenori、Yoshida Yasuhisa、Ugaji Shuhei、Nomura Issei、Tsuchiya Hiroyuki
    • Journal Title

      PLoS One.

      Volume: 14

    • DOI

      10.1371/journal.pone.0214106

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Trabectedin and irinotecan combination regresses a cisplatinum-resistant osteosarcoma in a patient-derived orthotopic xenograft nude-mouse model2019

    • Author(s)
      Higuchi Takashi、Miyake Kentaro、Oshiro Hiromichi、Sugisawa Norihiko、Yamamoto Norio、Hayashi Katsuhiro、Kimura Hiroaki、Miwa Shinji、Igarashi Kentaro、Chawla Sant P.、Bouvet Michael、Singh Shree Ram、Tsuchiya Hiroyuki、Hoffman Robert M.
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 513 Pages: 326-331

    • DOI

      10.1016/j.bbrc.2019.03.191

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Determining Patient Satisfaction and Treatment Desires in Patients With Musculoskeletal Sarcoma of the Knee After Joint-preservation Surgery Using a Questionnaire Survey2019

    • Author(s)
      ABE KENSAKU、YAMAMOTO NORIO、HAYASHI KATSUHIRO、TAKEUCHI AKIHIKO、KATO SATOSHI、MIWA SHINJI、IGARASHI KENTARO、INATANI HIROYUKI、AOKI YU、HIGUCHI TAKASHI、TANIGUCHI YUTA、TSUCHIYA HIROYUKI
    • Journal Title

      Anticancer Research

      Volume: 39 Pages: 1965-1969

    • DOI

      10.21873/anticanres.13307

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Satisfaction After Joint-preservation Surgery in Patients With Musculoskeletal Knee Sarcoma Based on Various Scores2019

    • Author(s)
      ABE KENSAKU、YAMAMOTO NORIO、HAYASHI KATSUHIRO、TAKEUCHI AKIHIKO、KATO SATOSHI、MIWA SHINJI、IGARASHI KENTARO、INATANI HIROYUKI、AOKI YU、HIGUCHI TAKASHI、TANIGUCHI YUTA、TSUCHIYA HIROYUKI
    • Journal Title

      Anticancer Research

      Volume: 39 Pages: 1959-1964

    • DOI

      10.21873/anticanres.13306

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Morphologic Changes After Denosumab Therapy in Patients with Giant Cell Tumor of the Spine: Report of Four Cases and a Review of the Literature2019

    • Author(s)
      Yonezawa Noritaka、Murakami Hideki、Demura Satoru、Kato Satoshi、Yoshioka Katsuhito、Takeuchi Akihiko、Shinmura Kazuya、Yokogawa Noriaki、Shimizu Takaki、Oku Norihiro、Kitagawa Ryo、Handa Makoto、Tsuchiya Hiroyuki
    • Journal Title

      World Neurosurgery

      Volume: 127 Pages: 38-46

    • DOI

      10.1016/j.wneu.2019.03.185

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Adipose-derived stem cell sheets accelerate bone healing in rat femoral defects.2019

    • Author(s)
      Yoshida Y, Matsubara H, Fang X, Hayashi K, et al
    • Journal Title

      PLOS ONE

      Volume: 14

    • DOI

      10.1371/journal.pone.0214488

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Motor and Sensory Impairments of the Lower Extremities After L2 Nerve Root Transection During Total en Bloc Spondylectomy2019

    • Author(s)
      Kato Satoshi、Murakami Hideki、Demura Satoru、Ota Takashi、Takahashi Naoki、Yoshioka Katsuhito、Shinmura Kazuya、Yokogawa Noriaki、Kawahara Norio、Tomita Katsuro、Tsuchiya Hiroyuki
    • Journal Title

      SPINE

      Volume: 44 Pages: 1129-1136

    • DOI

      10.1097/brs.0000000000003032

    • NAID

      40022371139

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Olaratumab combined with doxorubicin and ifosfamide overcomes individual doxorubicin and olaratumab resistance of an undifferentiated soft-tissue sarcoma in a PDOX mouse model2019

    • Author(s)
      Higuchi Takashi、Miyake Kentaro、Sugisawa Norihiko、Oshiro Hiromichi、Zhang Zhiying、Razmjooei Sahar、Yamamoto Norio、Hayashi Katsuhiro、Kimura Hiroaki、Miwa Shinji、Igarashi Kentaro、Bouvet Michael、Singh Shree Ram、Tsuchiya Hiroyuki、Hoffman Robert M.
    • Journal Title

      Cancer Letters

      Volume: 451 Pages: 122-127

    • DOI

      10.1016/j.canlet.2019.03.003

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Osimertinib Regresses an EGFR-Mutant Cisplatinum- Resistant Lung Adenocarcinoma Growing in the Brain in Nude Mice2019

    • Author(s)
      Higuchi Takashi、Oshiro Hiromichi、Zhang Zhiying、Miyake Kentaro、Sugisawa Norihiko、Katsuya Yuki、Yamamoto Norio、Hayashi Katsuhiro、Kimura Hiroaki、Miwa Shinji、Igarashi Kentaro、Zhao Ming、Bouvet Michael、Singh Shree Ram、Tsuchiya Hiroyuki、Hoffman Robert M
    • Journal Title

      Translational Oncology

      Volume: 12 Pages: 640-645

    • DOI

      10.1016/j.tranon.2019.01.007

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 抗菌インプラントの歴史と現状2020

    • Author(s)
      土屋弘行
    • Organizer
      日本整形外科学会骨軟部腫瘍学術集会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] Deformity correction for benign bone tumors2020

    • Author(s)
      Tsuchiya H
    • Organizer
      16th International Deformity Conference
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Biological reconstruction2019

    • Author(s)
      Hiroyuki Tsuchiya
    • Organizer
      49th Annual Scientific Meeting 2019 of Malaysian Orthopedic Association
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] "Extended curettage :liquid nitrogen" ? How do I do it?2019

    • Author(s)
      Hiroyuki Tsuchiya
    • Organizer
      49th Annual Scientific Meeting 2019 of Malaysian Orthopedic Association
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] Deformity correction for benign tumor2019

    • Author(s)
      Hiroyuki Tsuchiya
    • Organizer
      49th Annual Scientific Meeting 2019 of Malaysian Orthopedic Association
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] Management of implant related infection2019

    • Author(s)
      Hiroyuki Tsuchiya
    • Organizer
      49th Annual Scientific Meeting 2019 of Malaysian Orthopedic Association
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] Recycling intercalary reconstruction: Frozen autograft2019

    • Author(s)
      Hiroyuki Tsuchiya
    • Organizer
      32nd Annual Meeting of the European Musculoskeletal Oncology Society (EMSOS)
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] The history of recycled bone reconstruction2019

    • Author(s)
      Hiroyuki Tsuchiya
    • Organizer
      20th General Meeting of International Society of Limb Salvage (ISOLS)
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Biological reconstruction -now and future- (ISOLS President’s Lecture)2019

    • Author(s)
      Hiroyuki Tsuchiya
    • Organizer
      20th General Meeting of International Society of Limb Salvage (ISOLS)
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] The principles of biological reconstruction2019

    • Author(s)
      Hiroyuki Tsuchiya
    • Organizer
      Ortho KKU Musculoskeletal Oncology Research Group 1st Annual Meeting
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] The progress of limb-sparing surgery with biological reconstruction2019

    • Author(s)
      Hiroyuki Tsuchiya
    • Organizer
      Ortho KKU Musculoskeletal Oncology Research Group 1st Annual Meeting
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Limb-sparing surgery with biological reconstruction2019

    • Author(s)
      Hiroyuki Tsuchiya
    • Organizer
      The 9th International Senior Seminar on the New Progress of Osteosarcoma Limb Salavage
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Effect of timing of pulmonary metastases identification on prognosis of patients with osteosarcoma2019

    • Author(s)
      Hiroyuki Tsuchiya
    • Organizer
      The 9th International Senior Seminar on the New Progress of Osteosarcoma Limb Salavage
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Pelvic chondrosarcoma: How do you treat?2019

    • Author(s)
      Hiroyuki Tsuchiya
    • Organizer
      The 9th International Senior Seminar on the New Progress of Osteosarcoma Limb Salavage
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Improving limb salvage with biological reconstruction2019

    • Author(s)
      Hiroyuki Tsuchiya
    • Organizer
      Muscle flaps and microsurgery for musculoskeletal reconstruction meeting
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited

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Published: 2019-04-18   Modified: 2023-01-30  

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