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Development of a novel navigation system for osteosynthesis

Research Project

Project/Area Number 19K09582
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 56020:Orthopedics-related
Research InstitutionTokyo Medical University

Principal Investigator

Yoshii Yuichi  東京医科大学, 医学部, 准教授 (80617530)

Co-Investigator(Kenkyū-buntansha) 村瀬 剛  大阪大学, 医学系研究科, 准教授 (50335361)
岡 久仁洋  大阪大学, 医学系研究科, 助教 (50724085)
大竹 義人  奈良先端科学技術大学院大学, 先端科学技術研究科, 准教授 (80349563)
Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2021: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords骨接合術 / ナビゲーション / コンピューター支援 / 術前計画 / 3Dリコンストラクション / X線透視 / 3Dリコンストラクション / イメージフュージョン / 形状復元 / 3次元 / トラッキング / X線 / CT / 骨折 / 3次元
Outline of Research at the Start

骨折手術において、失われた機能を回復するためには理想的な整復位と適正な内固定設置が重要である。不適切な整復・内固定設置により骨癒合不全、整復位の再転位などの合併症を生じ、患者の機能回復が遷延する。本研究では骨折手術の新しいナビゲーションシステムの開発を行う。X線透視画像をもとにした術中変化に対応する3次元骨形態・位置推定システムの開発、3D術前計画画像とのリアルタイムレジストレーションの実現により、骨折手術における次世代ナビゲーションシステムを実用化する。手術現場において計測、推定、表示の全処理を実時間で行うことにより、骨折手術におけるナビゲーション技術の実効性を向上させることを目指す。

Outline of Final Research Achievements

The problem with conventional preoperative planning for fracture treatment is not practical, because it is unlike actual surgery. In this study, we attempted to develop a novel navigation system by fusing preoperative planning image and intraoperative fluoroscopic image with computer assisted technology in fracture treatment. First, we developed a method to match the 3D image of the preoperative plan with the intraoperative fluoroscopic image. Second, we established a 3D shape reconstruction technique based on the fluoroscopic image. Third, we established a technique to estimate the 3D position of the fluoroscopy reconstruction image using the deep learning method. Lastly, we verified the clinical significance of the surgical navigation system by aligning the preoperative plan 3D image and the fluoroscopic image. As the result, a navigation system that combines preoperative plan image and intraoperative fluoroscopic image reduced post-operative reduction loss in the fracture surgery.

Academic Significance and Societal Importance of the Research Achievements

本研究はバーチャル空間での骨折整復、骨接合材設置のシミュレーションが、実際の手術と融合する点に特長がある。これまで術中のX線透視画像に対応する3D画像を描出する方法や術中のX線透視画像から3D形状を復元する方法は確立されておらず。この点に学術的意義がある。これらの技術により、術中に変化する対象物の3D形状を描出することが可能となり、術前計画で作成した3D画像と対比しながら手術を行える点に臨床的意義がある。またX線透視画像から3D形状復元する手法は、CTを撮像できない環境でも対象物の3D形態を描出することができるため、CT撮像の必要性、放射線被ばく、医療費の削減などにつながる社会的意義がある。

Report

(4 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (28 results)

All 2022 2021 2020 2019 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results,  Open Access: 5 results) Presentation (19 results) (of which Int'l Joint Research: 8 results,  Invited: 4 results) Remarks (1 results) Patent(Industrial Property Rights) (2 results) (of which Overseas: 1 results)

  • [Journal Article] Preoperative predictions of distal screw length for the osteosynthesis of distal radius fractures.2022

    • Author(s)
      Totoki Y, Yoshii Y, Ogawa T, Hara Y, Ishii T, Yamazaki M.
    • Journal Title

      J Hand Surg Asian Pac Vol.

      Volume: 27 Issue: 01 Pages: 156-162

    • DOI

      10.1142/s2424835522500011

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Computer-Aided Assessment of Displacement and Reduction of Distal Radius Fractures2021

    • Author(s)
      Yoshii Yuichi、Totoki Yasukazu、Shigi Atsuo、Oka Kunihiro、Ogawa Takeshi、Murase Tsuyoshi、Ishii Tomoo
    • Journal Title

      Diagnostics

      Volume: 11 Issue: 4 Pages: 719-719

    • DOI

      10.3390/diagnostics11040719

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] An image fusion system for corrective osteotomy of distal radius malunion.2021

    • Author(s)
      Yoshii Y, Ogawa T, Hara Y, Totoki Y, Ishii T.
    • Journal Title

      Biomed Eng Online.

      Volume: 20 Issue: 1 Pages: 66-66

    • DOI

      10.1186/s12938-021-00901-8

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Three-dimensional evaluations of preoperative planning reproducibility for the osteosynthesis of distal radius fractures2021

    • Author(s)
      Yuichi Yoshii, Takeshi Ogawa, Atsuo Shigi, Kunihiro Oka, Tsuyoshi Murase, Tomoo Ishii
    • Journal Title

      J Orthop Surg Res

      Volume: 16 Issue: 1 Pages: 131-131

    • DOI

      10.1186/s13018-021-02278-9

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development of three-dimensional preoperative planning system for the osteosynthesis of distal humerus fractures2020

    • Author(s)
      Yuichi Yoshii, Shin Teramura, Kazuki Oyama, Takeshi Ogawa, Yuki Hara, Tomoo Ishii
    • Journal Title

      Biomed Eng Online

      Volume: 19 Issue: 1 Pages: 56-56

    • DOI

      10.1186/s12938-020-00801-3

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Utility of an image fusion system for the 3D preoperative planning and fluoroscopy in the osteosynthesis of distal radius fracutres.2019

    • Author(s)
      Yoshii Y, Totoki Y, Sashida S, Sakai S, Ishii T.
    • Journal Title

      J Orthop Surg Res

      Volume: 14 Issue: 1 Pages: 342-342

    • DOI

      10.1186/s13018-019-1370-z

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 骨接合術におけるコンピュータ支援のための要素技術開発.2022

    • Author(s)
      吉井雄一
    • Organizer
      第16回日本CAOS研究会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] Improved Accuracy of Three-dimensional Tracking of Distal Radius with QR Code Markers.2022

    • Author(s)
      Yuichi Yoshii
    • Organizer
      Orthopaedic Research Society 2022 Annual Meeting
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 橈骨遠位端骨折骨接合術におけるコンピュータ支援の可能性2021

    • Author(s)
      吉井雄一
    • Organizer
      第47回日本骨折治療学会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 橈骨遠位部の3次元的標準骨形態2021

    • Author(s)
      吉井雄一
    • Organizer
      第47回日本骨折治療学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Evaluations of three-dimensional standard bone morphology of the distal radius2021

    • Author(s)
      Yuichi Yoshii
    • Organizer
      76th annual meeting American Society for Surgery of the Hand
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Recent Topics on Osteosynthesis of Distal Radius Fractures in Japan.2021

    • Author(s)
      Yuichi Yoshii
    • Organizer
      APAC Trauma E-Series Part 3 2021: Updates and logistics.
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Development of 3D Bone Position Estimation System Based on Fluoroscopic Image2021

    • Author(s)
      Yuichi Yoshii
    • Organizer
      Orthopaedic Research Society 2021 Annual Meeting
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] Reproducibility of Osteosynthesis of Distal Radius Fracture Using Image Fusion System2021

    • Author(s)
      Yuichi Yoshii
    • Organizer
      Orthopaedic Research Society 2021 Annual Meeting
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] 骨折手術における次世代ナビゲーションシステムの開発2021

    • Author(s)
      吉井雄一
    • Organizer
      第6回橋渡し研究戦略的推進プログラムシンポジウム
    • Related Report
      2020 Research-status Report
  • [Presentation] 上肢外傷治療におけるコンピュータ支援の可能性2021

    • Author(s)
      吉井雄一
    • Organizer
      第15回日本CAOS研究会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] Image fusion systemを用いた橈骨遠位端骨折骨接合術の3次元的再現性評価2020

    • Author(s)
      吉井雄一
    • Organizer
      第63回日本手外科学会学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] 3次元参照点を基にした橈骨遠位端骨折の転位方向と整復位の評価2020

    • Author(s)
      吉井雄一
    • Organizer
      第63回日本手外科学会学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] Three Dimensional Analysis of Displacement and Reduction of Distal Radius Fractures2020

    • Author(s)
      Yuichi Yoshii
    • Organizer
      XXV Federation of European Societies for the Surgery of the Hand Congress
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] Three-Dimensional Evaluations of Reproducibility of Preoperative Planning for the Osteosynthesis of distal radius fractures2020

    • Author(s)
      Yuichi Yoshii
    • Organizer
      75th Annual Meeting of the American Society for Surgery of the Hand
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] X線透視画像をもとにした3次元骨位置推定システムの開発2020

    • Author(s)
      吉井雄一
    • Organizer
      第35回日本整形外科学会基礎学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] 橈骨遠位端骨折の3D術前計画とX線透視画像の融合による手術支援システム2019

    • Author(s)
      吉井 雄一
    • Organizer
      第62回日本手外科学会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] 橈骨遠位端骨折に対する3D術前計画の再現性2019

    • Author(s)
      吉井 雄一
    • Organizer
      第92回日本整形外科学会学術総会
    • Related Report
      2019 Research-status Report
  • [Presentation] Utility of Image Fusion System for 3D Preoperative Planning in the Osteosynthesis of Distal Radius Fractures2019

    • Author(s)
      Yuichi Yoshii
    • Organizer
      14th IFSSH
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 3D術前計画とX線透視画像の融合による橈骨遠位端骨折手術支援の有用性2019

    • Author(s)
      吉井 雄一
    • Organizer
      第45回日本骨折治療学会
    • Related Report
      2019 Research-status Report
  • [Remarks] 3D Surgical Vision

    • URL

      https://www.youtube.com/watch?v=MFeQzg0Hmb4&t=2s

    • Related Report
      2021 Annual Research Report
  • [Patent(Industrial Property Rights)] 骨部手術の支援装置、支援方法、プログラム、および記録媒体2021

    • Inventor(s)
      吉井雄一
    • Industrial Property Rights Holder
      吉井雄一
    • Industrial Property Rights Type
      特許
    • Filing Date
      2021
    • Related Report
      2020 Research-status Report
    • Overseas
  • [Patent(Industrial Property Rights)] 骨部手術の支援装置、支援方法、プログラム、および記録媒体2020

    • Inventor(s)
      吉井 雄一
    • Industrial Property Rights Holder
      吉井 雄一
    • Industrial Property Rights Type
      特許
    • Filing Date
      2020
    • Related Report
      2019 Research-status Report

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Published: 2019-04-18   Modified: 2023-01-30  

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