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Investigation of novel regulatory factors of bone formation

Research Project

Project/Area Number 19K09616
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 56020:Orthopedics-related
Research InstitutionTokyo Medical and Dental University

Principal Investigator

Kato Tsuyoshi  東京医科歯科大学, 東京医科歯科大学病院, 非常勤講師 (80447490)

Co-Investigator(Kenkyū-buntansha) 猪瀬 弘之  東京医科歯科大学, 大学院医歯学総合研究科, 寄附講座准教授 (30615711)
Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2021: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords骨代謝 / 骨形成 / 骨粗鬆症
Outline of Research at the Start

骨リモデリングの分子機構のうち、骨形成のメカニズムに関しては未だ不明な点が多い。申請者らは、本研究において、分子生物学的アプローチを用いて転写因子のうち、これまで作用が全く不明とされてきたフォークヘッド遺伝子の骨代謝における意義及び、フォークヘッド遺伝子の新たな生理機能調節機構を明らかにする。

Outline of Final Research Achievements

Much remains unknown about the molecular mechanisms of bone remodeling, especially bone formation. In this study, we focused on the forkhead gene, whose physiological significance has been attracting attention in recent years. So far, the significance of forkhead genes in bone metabolism is mostly unknown, with the exception of Foxo1.The purpose of this study is to elucidate the significance of Foxf2, a forkhead gene whose function has been unknown, in bone metabolism and the new physiological regulatory mechanism of the forkhead gene. Using a molecular biological approach, we found that Foxf2 regulates MSC differentiation into osteoblasts via the Wnt2b/β-catenin signaling pathway.javascript:onTransientSave()

Academic Significance and Societal Importance of the Research Achievements

間葉系幹細胞の骨芽細胞への分化は、骨形成に不可欠である。今回、Foxf2が間葉系幹細胞の骨芽細胞分化の過程で発現が上昇する上位遺伝子の一つであることを見出し、この過程におけるFoxf2の機能を検討した。Foxf2は、間葉系幹細胞の骨芽細胞への分化に重要な役割を担っており、臨床的な観点から、FOXF2の発現を全身的あるいは局所的に抑制することは、骨粗鬆症や骨折などの骨関連疾患の治療戦略として有望であると思われる。

Report

(4 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (4 results)

All 2022 2021 Other

All Int'l Joint Research (1 results) Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (2 results)

  • [Int'l Joint Research] University of Gothenburg(スウェーデン)

    • Related Report
      2021 Annual Research Report
  • [Journal Article] Foxf2 represses bone formation via Wnt2b/beta-catenin signaling2022

    • Author(s)
      Tanaka T, Takahashi A, Kobayashi Y, Saito M, Xiaolong S, Jingquan C, Ito Y, Kato T, Ochi H, Sato S, Yoshii T, Okawa A, Carlsson P, and Inose H
    • Journal Title

      Experimental and Molecular Medicine

      Volume: -

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Foxf2のWntシグナルを介した骨形成制御2021

    • Author(s)
      田中 寛来、佐藤 信吾、越智 広樹、猪瀬 弘之
    • Organizer
      日本骨代謝学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Foxf2はWnt経路を介して骨芽細胞分化を調整する2021

    • Author(s)
      田中 寛来、小林 裕、高橋 晃、斎藤 正徳、加藤 剛、佐藤 信吾、越智 広樹、佐藤 信吾、吉井 俊貴、大川 淳、猪瀬 弘之
    • Organizer
      日本整形外科基礎学術集会
    • Related Report
      2021 Annual Research Report

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Published: 2019-04-18   Modified: 2023-01-30  

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