Elucidation of new molecular mechanisms involved in postnatal testicular development and functional acquisition
Project/Area Number |
19K09682
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 56030:Urology-related
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Research Institution | National Center for Child Health and Development |
Principal Investigator |
Miyado Mami 国立研究開発法人国立成育医療研究センター, 分子内分泌研究部, 上級研究員 (00386252)
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Project Period (FY) |
2019-04-01 – 2022-03-31
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Project Status |
Completed (Fiscal Year 2021)
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Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2021: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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Keywords | 精巣 / 生殖機能 / モデル動物 / Y染色体喪失 / 性分化疾患 / 子宮内低栄養 / MAMLD1 / 培養細胞 |
Outline of Research at the Start |
本研究では、性分化関連因子であるMAMLD1が生後の精巣の発育および機能獲得にどのように関与しているかを明らかにし、生後の精巣においてMAMLD1を介する新たな分子機構を解明する。モデル動物の表現型解析と培養細胞をもちいて機能解析を行い、MAMLD1が男性ホルモン産生・代謝に与える影響を明らかにする。本研究により得られる知見は、雄性生殖機能獲得の理解につながり、性分化疾患および生殖機能障害の発症機序の解明に貢献すると考えられる。
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Outline of Final Research Achievements |
To identify missing pieces hidden in already known mechanisms of postnatal testicular development and functional acquisition, we performed this study using a set of disease model animals and samples obtained from patients. Subsequently, we obtained remarkable results as followings: (1) Extra-mitochondrial CS (eCS) suppresses age-dependent male infertility; (2) The frequency of leukocyte mLOY in reproductive-aged men with spermatogenic failure is rare; (3) Major histocompatibility complex class I expressed in sperm blocks polyspermy; and (4) Intrauterine hyponutrition reduces fetal testosterone production and postnatal sperm count in the mouse.
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Academic Significance and Societal Importance of the Research Achievements |
本研究では、遺伝子機能の変化やY染色体のコピー変化が精巣機能や精子形成に与える影響を明らかにした。モデル動物と疾患患者の解析を行い、精巣・精子形成および男性ホルモン産生に関わる新たな分子機構を見出した。本研究の成果は、性分化疾患や男性不妊症などの生殖機能障害発症機序の解明に結び付くことが期待される。
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Report
(4 results)
Research Products
(33 results)
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[Journal Article] Suppressive role of lactoferrin in overweight-related female fertility problems.2022
Author(s)
Sato B, Kanai S, Sakaguchi D, Yajima K, Matsumoto Y, Morohoshi K, Kagaya S, Izumo N, Ichinose M, Kang W, Miyado M, Miyado K and Kawano N.
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Journal Title
Nutrients
Volume: 14
Issue: 5
Pages: 938-938
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Suppression of Non-Random Fertilization by MHC Class I Antigens2020
Author(s)
Kamiya Junki、Kang Woojin、Yoshida Keiichi、Takagi Ryota、Kanai Seiya、Hanai Maito、Nakamura Akihiro、Yamada Mitsutoshi、Miyamoto Yoshitaka、Miyado Mami、Kuroki Yoko、Hayashi Yoshiki、Umezawa Akihiro、Kawano Natsuko、Miyado Kenji
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Journal Title
International Journal of Molecular Sciences
Volume: 21
Issue: 22
Pages: 8731-8731
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Nonsense-associated altered splicing of MAP3K1 in two siblings with 46,XY disorders of sex development.2020
Author(s)
Igarashi M, Masunaga Y, Hasegawa Y, Kinjo K, Miyado M, Saitsu H, Kato-Fukui Y, Horikawa R, Okubo Y, Ogata T and Fukami M.
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Journal Title
Scientific Reports
Volume: 10
Issue: 1
Pages: 17375-17375
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Rare variant of the epigenetic regulator SMCHD1 in a patient with pituitary hormone deficiency.2020
Author(s)
Kinjo K, Nagasaki K, Muroya K, Suzuki E, Ishiwata K, Nakabayashi K, Hattori A, Nagao K, Nozawa R-S, Obuse C, Miyado K, Ogata T, Fukami M and Miyado M.
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Journal Title
Scientific Reports
Volume: 10
Issue: 1
Pages: 10985-10985
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Extra-mitochondrial citrate synthase initiates calcium oscillation and suppresses age-dependent sperm dysfunction.2020
Author(s)
Kang W, Harada Y, Yamatoya K, Kawano N, Kanai S, Miyamoto Y, Nakamura A, Miyado M, Hayashi Y, Kuroki Y, Saito H, Iwao Y, Umezawa A and Miyado K.
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Journal Title
Lab Invest.
Volume: 100
Issue: 4
Pages: 665-665
DOI
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Peer Reviewed / Open Access
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[Journal Article] Endometrial preparation methods for frozen-thawed embryo transfer are associated with altered risks of hypertensive disorders of pregnancy, placenta accreta, and gestational diabetes mellitus.2019
Author(s)
Saito K, Kuwahara A, Ishikawa T, Morisaki N, Miyado M, Miyado K, Fukami M, Miyasaka N, Ishihara O, Irahara M and Saito H.
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Journal Title
Human Reproduction
Volume: 34
Issue: 8
Pages: 1567-1575
DOI
Related Report
Peer Reviewed
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[Journal Article] Calaxin is required for cilia-driven determination of vertebrate laterality2019
Author(s)
Sasaki Keita、Shiba Kogiku、Nakamura Akihiro、Kawano Natsuko、Satouh Yuhkoh、Yamaguchi Hiroshi、Morikawa Motohiro、Shibata Daisuke、Yanase Ryuji、Jokura Kei、Nomura Mami、Miyado Mami、Takada Shuji、Ueno Hironori、Nonaka Shigenori、Baba Tadashi、Ikawa Masahito、Kikkawa Masahide、Miyado Kenji、Inaba Kazuo
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Journal Title
Communications Biology
Volume: 2
Issue: 1
Pages: 226-226
DOI
NAID
Related Report
Peer Reviewed / Open Access
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