• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Next generation epigenomics using artificial intelligence and robotics in ovarian cancer

Research Project

Project/Area Number 19K09768
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 56040:Obstetrics and gynecology-related
Research InstitutionInstitute of Physical and Chemical Research

Principal Investigator

Komatsu Masaaki  国立研究開発法人理化学研究所, 革新知能統合研究センター, 副チームリーダー (70750842)

Co-Investigator(Kenkyū-buntansha) 浜本 隆二  国立研究開発法人国立がん研究センター, 研究所, 分野長 (80321800)
金子 修三  国立研究開発法人国立がん研究センター, 研究所, ユニット長 (10777006)
浅田 健  国立研究開発法人理化学研究所, 革新知能統合研究センター, 研究員 (70773414)
Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2021: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2020: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords卵巣がん / 人工知能 / ロボット技術 / マルチオミックス解析 / ChIP-seq / ロボット / エピゲノム
Outline of Research at the Start

卵巣がんの新規治療標的・感受性マーカーを探索するため、機械学習・深層学習などの人工知能技術を用いて、臨床情報・病理画像データおよびゲノム・エピゲノム解析データ等の多層化データを統合的に解析する。また、汎用ヒト型ロボット「まほろ」を技術的難易度の高いエピゲノム解析に適用することで、 大規模数の臨床検体に対して効率的に実施し、かつ再現性の高いデータを得る。
これらの新規技術の融合により、卵巣がんの発生・進展に関する分子生物学的メカニズムを包括的に解明し、早期診断や治療効果・副作用予測などの重要な臨床的知見を得て、将来的なPrecision Medicine (精密医療)の実現に貢献する。

Outline of Final Research Achievements

Ovarian cancer is the most lethal gynecological cancer. To its early detection and novel therapeutic approaches toward precision medicine, it requires further investigation of molecular mechanisms underlying ovarian tumorigenesis and progression. To deal with the technical difficulties of epigenetic histone modification analyses with clinical samples, we introduced the humanoid robot that can perform complex experiments with higher accuracy and reproducibility. Furthermore, we apply artificial intelligence to systematically integrate the massive datasets including ChIP-seq, RNA-seq, and clinical records. We demonstrated that the peaks of the histone marks in ovarian tumors were significantly diminished in the promoter regions of several critical genes associated with tumorigenesis. These results suggest that our experimental platform can identify novel epigenetic signatures relevant to biomarkers and drug targets for ovarian cancer.

Academic Significance and Societal Importance of the Research Achievements

卵巣がんの予後改善に向けた個別化・精密医療の実現を目指して、その複雑な発がん機序を解明するための新たなエピゲノム解析手法を構築した。まず煩雑なエピゲノム解析手法にロボット技術を導入して、その実験精度・再現性を高めた。さらに、人工知能技術を用いて卵巣がん臨床検体のオミックスデータを多層解析し、発がん段階における複雑なクロマチン構造変化の網羅的解析を進めた。

Report

(4 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (19 results)

All 2022 2021 2020 2019

All Journal Article (7 results) (of which Int'l Joint Research: 6 results,  Peer Reviewed: 7 results,  Open Access: 7 results) Presentation (12 results)

  • [Journal Article] The metabolic stress-activated checkpoint LKB1-MARK3 axis acts as a tumor suppressor in high-grade serous ovarian carcinoma2022

    • Author(s)
      Hidenori Machino, Syuzo Kaneko, Masaaki Komatsu, Noriko Ikawa, Ken Asada, Ryuichiro Nakato, Kanto Shozu, Ai Dozen, Kenbun Sone, Hiroshi Yoshida, Tomoyasu Kato, Katsutoshi Oda, Yutaka Osuga, Tomoyuki Fujii, Gottfried von Keudell, Vassiliki Saloura, Ryuji Hamamoto
    • Journal Title

      Communications Biology

      Volume: 5 Issue: 1 Pages: 39-39

    • DOI

      10.1038/s42003-021-02992-4

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Integrated Analysis of Whole Genome and Epigenome Data Using Machine Learning Technology: Toward the Establishment of Precision Oncology2021

    • Author(s)
      Ken Asada, Syuzo Kaneko, Ken Takasawa, Hidenori Machino, Satoshi Takahashi, Norio Shinkai, Ryo Shimoyama, Masaaki Komatsu, Ryuji Hamamoto
    • Journal Title

      Frontiers in Oncology

      Volume: 11 Pages: 666937-666937

    • DOI

      10.3389/fonc.2021.666937

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Genome-Wide Chromatin Analysis of FFPE Tissues Using a Dual-Arm Robot with Clinical Potential2021

    • Author(s)
      Kaneko S、Mitsuyama T、Shiraishi K、Ikawa N、Shozu K、Dozen A、Machino H、Asada K、Komatsu M、Kukita A、Sone K、Yoshida H、Motoi N、Hayami S、Yoneoka Y、Kato T、Kohno T、Natsume T、Keudell GV、Saloura V、Yamaue H、Hamamoto R
    • Journal Title

      Cancers

      Volume: 13 Issue: 9 Pages: 2126-2126

    • DOI

      10.3390/cancers13092126

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Epigenetic Modifier SETD8 as a Therapeutic Target for High-Grade Serous Ovarian Cancer2020

    • Author(s)
      Wada Miku、Kukita Asako、Sone Kenbun、Hamamoto Ryuji、Kaneko Syuzo、Komatsu Masaaki、Takahashi Yu、Inoue Futaba、Kojima Machiko、Honjoh Harunori、Taguchi Ayumi、Kashiyama Tomoko、Miyamoto Yuichiro、Tanikawa Michihiro、Tsuruga Tetsushi、Mori-Uchino Mayuyo、Wada-Hiraike Osamu、Osuga Yutaka、Fujii Tomoyuki
    • Journal Title

      Biomolecules

      Volume: 10 Issue: 12 Pages: 1686-1686

    • DOI

      10.3390/biom10121686

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Application of Artificial Intelligence Technology in Oncology: Towards the Establishment of Precision Medicine2020

    • Author(s)
      Hamamoto Ryuji、Suvarna Kruthi、Yamada Masayoshi、Kobayashi Kazuma、Shinkai Norio、Miyake Mototaka、Takahashi Masamichi、Jinnai Shunichi、Shimoyama Ryo、Sakai Akira、Takasawa Ken、Bolatkan Amina、Shozu Kanto、Dozen Ai、Machino Hidenori、Takahashi Satoshi、Asada Ken、Komatsu Masaaki、Sese Jun、Kaneko Syuzo
    • Journal Title

      Cancers

      Volume: 12 Issue: 12 Pages: 3532-3532

    • DOI

      10.3390/cancers12123532

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Critical Roles of N6-Methyladenosine (m6A) in Cancer and Virus Infection2020

    • Author(s)
      Asada Ken、Bolatkan Amina、Takasawa Ken、Komatsu Masaaki、Kaneko Syuzo、Hamamoto Ryuji
    • Journal Title

      Biomolecules

      Volume: 10 Issue: 7 Pages: 1071-1071

    • DOI

      10.3390/biom10071071

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Epigenetics Analysis and Integrated Analysis of Multiomics Data, Including Epigenetic Data, Using Artificial Intelligence in the Era of Precision Medicine2019

    • Author(s)
      Hamamoto Ryuji、Komatsu Masaaki、Takasawa Ken、Asada Ken、Kaneko Syuzo
    • Journal Title

      Biomolecules

      Volume: 10 Issue: 1 Pages: 62-62

    • DOI

      10.3390/biom10010062

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Epigenetic and functional analyses of PRELP gene in ovarian cancer2021

    • Author(s)
      Masaaki Komatsu, Ai Dozen, Kanto Shozu, Syuzo Kaneko, Hidenori Machino, Ken Asada, Hiroshi Yoshida, Tomoyasu Kato, Ryuji Hamamoto
    • Organizer
      第80回日本癌学会学術総会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Integrative analysis revealed early epigenetic changes in high-grade serous ovarian carcinogenesis2021

    • Author(s)
      Hidenori Machino, Ai Dozen, Masaaki Komatsu, Kohei Nakamura, Kanto Shozu, Syuzo Kaneko, Ken Asada, Hiroshi Yoshida, Tomoyasu Kato, Kentaro Nakayama, Satoru Kyo, Ryuji Hamamoto
    • Organizer
      第80回日本癌学会学術総会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Clinical epigenetic analysis with robotics in ovarian cancer.2020

    • Author(s)
      Masaaki Komatsu, Syuzo Kaneko, Ken Asada, Hiroshi Yoshida, Tomoyasu Kato, Ryuji Hamamoto.
    • Organizer
      第79回日本癌学会学術総会
    • Related Report
      2020 Research-status Report
  • [Presentation] LKB1-MARK3 axis is a novel stress-activated cell cycle checkpoint and dysregulated in high-grade serous ovarian cancer.2020

    • Author(s)
      Hidenori Machino, Syuzo Kaneko, Masaaki Komatsu, Ken Asada, Ai Dozen, Kanto Shozu, Ryuji Hamamoto.
    • Organizer
      第79回日本癌学会学術総会
    • Related Report
      2020 Research-status Report
  • [Presentation] Biological mechanisms of PRELP in ovarian cancer.2020

    • Author(s)
      Kanto Shozu, Masaaki Komatsu, Syuzo Kaneko, Ai Dozen, Hidenori Machino, Akitoshi Nakashima, Shigeru Saito, Ken Asada, Ryuji Hamamoto.
    • Organizer
      第79回日本癌学会学術総会
    • Related Report
      2020 Research-status Report
  • [Presentation] Integrative multi-omics analysis of multistage carcinogenesis in high-grade serous ovarian cancer.2020

    • Author(s)
      Ai Dozen, Masaaki Komatsu, Hidenori Machino, Kohei Nakamura, Syuzo Kaneko, Kanto Shozu, Ken Asada, Tatsuaki Chiyoda, Kentaro Nakayama, Daisuke Aoki, Satoru Kyo, Ryuji Hamamoto.
    • Organizer
      第79回日本癌学会学術総会
    • Related Report
      2020 Research-status Report
  • [Presentation] Novel clinical epigenetics using robotics toward precision medicine in ovarian cancer.2020

    • Author(s)
      Masaaki Komatsu, Ai Dozen, Kanto Shozu, Hidenori Machino, Tomoyasu Kato, Ryuji Hamamoto.
    • Organizer
      第72回日本産科婦人科学会学術講演会
    • Related Report
      2020 Research-status Report
  • [Presentation] WNT7A gene was regulated by epigenetic changes and associated with tumorigenesis in ovarian clear cell carcinoma.2020

    • Author(s)
      Kanto Shozu, Masaaki Komatsu, Syuzo Kaneko, Ai Dozen, Hidenori Machino, Akitoshi Nakashima, Shigeru Saito, Tomoyasu Kato, Ryuji Hamamoto.
    • Organizer
      第72回日本産科婦人科学会学術講演会
    • Related Report
      2020 Research-status Report
  • [Presentation] Clinical epigenetics using artificial intelligence and robotics in ovarian cancer2019

    • Author(s)
      Masaaki Komatsu, Syuzo Kaneko, Ken Asada, Tomoyasu Kato, Ryuji Hamamoto
    • Organizer
      第78回日本癌学会学術総会
    • Related Report
      2019 Research-status Report
  • [Presentation] Tumor suppressive roles of MARK3 in high-grade serous ovarian carcinomas2019

    • Author(s)
      Hidenori Machino, Syuzo Kaneko, Masaaki Komatsu, Ai Dozen, Kanto Shozu, Ryuji Hamamoto
    • Organizer
      第78回日本癌学会学術総会
    • Related Report
      2019 Research-status Report
  • [Presentation] Epigenetic regulation of epithelial cell integrity through extracellular matrix in ovarian cancer2019

    • Author(s)
      Ai Dozen, Masaaki Komatsu, Syuzo Kaneko, Kanto Shozu, Hidenori Machino, Tatsuyuki Chiyoda, Daisuke Aoki, Ryuji Hamamoto
    • Organizer
      第78回日本癌学会学術総会
    • Related Report
      2019 Research-status Report
  • [Presentation] Epigenetic regulation of the WNT7A gene in ovarian clear cell carcinoma2019

    • Author(s)
      Kanto Shozu, Masaaki Komatsu, Syuzo Kaneko, Ai Dozen, Hidenori Machino, Akitoshi Nakashima, Shigeru Saito, Ryuji Hamamoto
    • Organizer
      第78回日本癌学会学術総会
    • Related Report
      2019 Research-status Report

URL: 

Published: 2019-04-18   Modified: 2023-01-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi