| Project/Area Number |
19K09841
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 56050:Otorhinolaryngology-related
|
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Ueha Rumi 東京大学, 医学部附属病院, 准教授 (10597131)
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| Co-Investigator(Kenkyū-buntansha) |
上羽 悟史 東京理科大学, 研究推進機構生命医科学研究所, 准教授 (00447385)
近藤 健二 東京大学, 医学部附属病院, 教授 (40334370)
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| Project Period (FY) |
2019-04-01 – 2024-03-31
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| Project Status |
Completed (Fiscal Year 2023)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2021: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 嗅覚障害 / 加齢 / IGF-1 / Vit D / 嗅神経上皮 / VitD / ビタミンD |
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| Outline of Research at the Start |
加齢動物を用いて，IGF-1の加齢嗅神経上皮への効果を組織学的・分子生物学的・行動
学的観点より解明し，その上で，臨床応用で重要となるIGF-1の投与条件（投与方法，投
与量）を検証する．
IGF-1機能増強効果のあるビタミンDによる嗅神経細胞系への影響を検証し，嗅覚障害へ
のIGF-1・ビタミンD併用療法に関して，臨床応用に向けた基礎的研究を遂行する．
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| Outline of Final Research Achievements |
Administering low doses of IGF-1 has demonstrated effectiveness in reducing age-related olfactory nerve cell damage. Long-term administration showed no adverse effects on the hematopoietic and immune systems in the bone marrow, spleen, and thymus, ensuring the safety of low-dose IGF-1. However, the effectiveness of IGF-1 in reducing olfactory epithelium damage differs depending on its concentration, and further research is needed to determine the optimal dose and administration schedule. Conversely, Vitamin D had neither a positive nor negative impact on the olfactory nerve cell system.
It is thought that IGF-1 administration alleviates age-related damage to the olfactory nerve cell system by reducing inflammatory cytokines and enhancing the extracellular matrix. Conversely, Vitamin D does not appear to have a promising therapeutic effect on olfactory impairment.
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| Academic Significance and Societal Importance of the Research Achievements |
現在治療方法のない加齢性嗅覚障害への新規治療へのターゲットとしてIGF-1が重要であることが明らかになった．一方、加齢性嗅覚障害へのビタミンDの経口摂取による効果は認められなかった。今後IGF-1による嗅覚障害への臨床応用に向けた研究が必要である.
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