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Effects of insulin-like growth factor-1 and vitamin D on age-related olfactory dysfunction

Research Project

Project/Area Number 19K09841
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 56050:Otorhinolaryngology-related
Research InstitutionThe University of Tokyo

Principal Investigator

Ueha Rumi  東京大学, 医学部附属病院, 准教授 (10597131)

Co-Investigator(Kenkyū-buntansha) 上羽 悟史  東京理科大学, 研究推進機構生命医科学研究所, 准教授 (00447385)
近藤 健二  東京大学, 医学部附属病院, 教授 (40334370)
Project Period (FY) 2019-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2021: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords嗅覚障害 / 加齢 / IGF-1 / Vit D / 嗅神経上皮 / VitD / ビタミンD
Outline of Research at the Start

加齢動物を用いて,IGF-1の加齢嗅神経上皮への効果を組織学的・分子生物学的・行動
学的観点より解明し,その上で,臨床応用で重要となるIGF-1の投与条件(投与方法,投
与量)を検証する.
IGF-1機能増強効果のあるビタミンDによる嗅神経細胞系への影響を検証し,嗅覚障害へ
のIGF-1・ビタミンD併用療法に関して,臨床応用に向けた基礎的研究を遂行する.

Outline of Final Research Achievements

Administering low doses of IGF-1 has demonstrated effectiveness in reducing age-related olfactory nerve cell damage. Long-term administration showed no adverse effects on the hematopoietic and immune systems in the bone marrow, spleen, and thymus, ensuring the safety of low-dose IGF-1. However, the effectiveness of IGF-1 in reducing olfactory epithelium damage differs depending on its concentration, and further research is needed to determine the optimal dose and administration schedule. Conversely, Vitamin D had neither a positive nor negative impact on the olfactory nerve cell system.
It is thought that IGF-1 administration alleviates age-related damage to the olfactory nerve cell system by reducing inflammatory cytokines and enhancing the extracellular matrix. Conversely, Vitamin D does not appear to have a promising therapeutic effect on olfactory impairment.

Academic Significance and Societal Importance of the Research Achievements

現在治療方法のない加齢性嗅覚障害への新規治療へのターゲットとしてIGF-1が重要であることが明らかになった.一方、加齢性嗅覚障害へのビタミンDの経口摂取による効果は認められなかった。今後IGF-1による嗅覚障害への臨床応用に向けた研究が必要である.

Report

(6 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (31 results)

All 2024 2023 2022 2021 2020 2019

All Journal Article (13 results) (of which Peer Reviewed: 6 results,  Open Access: 7 results) Presentation (18 results) (of which Int'l Joint Research: 2 results,  Invited: 8 results)

  • [Journal Article] Oral SARS-CoV-2 Inoculation Causes Nasal Viral Infection Leading to Olfactory Bulb Infection: An Experimental Study2022

    • Author(s)
      Ueha Rumi、Ito Toshihiro、Furukawa Ryutaro、Kitabatake Masahiro、Ouji-Sageshima Noriko、Ueha Satoshi、Koyama Misaki、Uranaka Tsukasa、Kondo Kenji、Yamasoba Tatsuya
    • Journal Title

      Frontiers in Cellular and Infection Microbiology

      Volume: 12 Pages: 924725-924725

    • DOI

      10.3389/fcimb.2022.924725

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Evidence for the spread of SARS-CoV-2 and olfactory cell lineage impairment in close-contact infection Syrian hamster models2022

    • Author(s)
      Ueha Rumi、Ito Toshihiro、Ueha Satoshi、Furukawa Ryutaro、Kitabatake Masahiro、Ouji-Sageshima Noriko、Uranaka Tsukasa、Tanaka Hirotaka、Nishijima Hironobu、Kondo Kenji、Yamasoba Tatsuya
    • Journal Title

      Frontiers in Cellular and Infection Microbiology

      Volume: 12 Pages: 1019723-1019723

    • DOI

      10.3389/fcimb.2022.1019723

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Insight into the mechanisms of olfactory dysfunction by COVID-192022

    • Author(s)
      Koyama Sachiko、Mori Eri、Ueha Rumi
    • Journal Title

      Auris Nasus Larynx

      Volume: - Issue: 4 Pages: 490-498

    • DOI

      10.1016/j.anl.2022.12.002

    • Related Report
      2022 Research-status Report
  • [Journal Article] Squamous and Respiratory Metaplasia After Olfactory Mucosal Resection2021

    • Author(s)
      Mori Eri、Ueha Rumi、Kondo Kenji、Funada Shotaro、Shimmura Hajime、Kanemoto Kai、Tanaka Hirotaka、Nishijima Hironobu、Otori Nobuyoshi、Yamasoba Tatsuya、Kojima Hiromi
    • Journal Title

      Frontiers in Neuroscience

      Volume: 15 Pages: 1-10

    • DOI

      10.3389/fnins.2021.695653

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Loss of Smell and Taste in Patients With Suspected COVID-19: Analyses of Patients’ Reports on Social Media2021

    • Author(s)
      Koyama Sachiko、Ueha Rumi、Kondo Kenji
    • Journal Title

      Journal of Medical Internet Research

      Volume: 23 Issue: 4 Pages: e26459-e26459

    • DOI

      10.2196/26459

    • Related Report
      2021 Research-status Report
  • [Journal Article] Possible Use of Phytochemicals for Recovery from COVID-19-Induced Anosmia and Ageusia2021

    • Author(s)
      Koyama Sachiko、Kondo Kenji、Ueha Rumi、Kashiwadani Hideki、Heinbockel Thomas
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 22 Issue: 16 Pages: 8912-8912

    • DOI

      10.3390/ijms22168912

    • Related Report
      2021 Research-status Report
  • [Journal Article] ACE2, TMPRSS2, and Furin expression in the nose and olfactory bulb in mice and human2020

    • Author(s)
      Ueha R.、Kondo K.、Kagoya R.、Shichino S.、Ueha S.、Yamasoba T.
    • Journal Title

      Rhinology journal

      Volume: 0 Issue: 0 Pages: 0-0

    • DOI

      10.4193/rhin20.324

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Age-Related Olfactory Dysfunction: Epidemiology, Pathophysiology, and Clinical Management2020

    • Author(s)
      Kondo Kenji、Kikuta Shu、Ueha Rumi、Suzukawa Keigo、Yamasoba Tatsuya
    • Journal Title

      Frontiers in Aging Neuroscience

      Volume: 12 Pages: 208-208

    • DOI

      10.3389/fnagi.2020.00208

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of Cigarette Smoke on the Nasal Respiratory and Olfactory Mucosa in Allergic Rhinitis Mice2020

    • Author(s)
      Ueha Rumi、Ueha Satoshi、Kondo Kenji、Nishijima Hironobu、Yamasoba Tatsuya
    • Journal Title

      Frontiers in Neuroscience

      Volume: 14 Pages: 126-126

    • DOI

      10.3389/fnins.2020.00126

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Molecular mechanism of smoking smell and elucidation of regeneration environment of olfactory epithelium2019

    • Author(s)
      Rumi Ueha
    • Journal Title

      Impact

      Volume: 6 Pages: 68-70

    • Related Report
      2019 Research-status Report
    • Open Access
  • [Journal Article] 患者さんにも知ってほしい 嗅覚のしくみ2019

    • Author(s)
      上羽瑠美
    • Journal Title

      耳鼻咽喉科・頭頸部外科

      Volume: 91 Pages: 1014-1018

    • Related Report
      2019 Research-status Report
  • [Journal Article] タバコ煙による細胞死誘導により,加齢マウスでの嗅覚障害が持続する2019

    • Author(s)
      上羽瑠美,近藤健二,菊田 周,山岨達也
    • Journal Title

      日本鼻科学会誌

      Volume: 58 Pages: 126-129

    • NAID

      130007636263

    • Related Report
      2019 Research-status Report
  • [Journal Article] たばこ煙と上気道炎症が嗅覚障害に及ぼす影響の解明2019

    • Author(s)
      上羽瑠美
    • Journal Title

      Smoking Science

      Volume: 33 Pages: 7-7

    • Related Report
      2019 Research-status Report
  • [Presentation] Symposium: Clinical aspects and pathophysiology of olfactory dysfunction in COVID-192024

    • Author(s)
      Rumi Ueha
    • Organizer
      67th Korean Rhinological Society Annual Congress
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 嗅神経上皮・嗅粘膜の障害と再生2023

    • Author(s)
      上羽瑠美
    • Organizer
      2023 再生医療カンファレンス
    • Related Report
      2022 Research-status Report
    • Invited
  • [Presentation] 興味から深めた嗅覚と嚥下の世界2023

    • Author(s)
      上羽瑠美
    • Organizer
      第12回武蔵小杉耳鼻咽喉科セミナー
    • Related Report
      2022 Research-status Report
    • Invited
  • [Presentation] COVID-19による嗅覚障害の臨床像と基礎的背景2023

    • Author(s)
      上羽瑠美
    • Organizer
      第34回日本耳鼻咽喉科頭頸部外科学会三重県地方部会研修会
    • Related Report
      2022 Research-status Report
    • Invited
  • [Presentation] シンポジウム:COVID-19による嗅覚障害の臨床像と基礎的背景2022

    • Author(s)
      上羽瑠美
    • Organizer
      第123回日本耳鼻咽喉科学会総会
    • Related Report
      2022 Research-status Report
  • [Presentation] 新型コロナウイルス感染及び短期濃厚接触による嗅神経上皮への影響2022

    • Author(s)
      上羽瑠美、近藤健二、西嶌大宣、山岨達也
    • Organizer
      第61回日本鼻科学会
    • Related Report
      2022 Research-status Report
  • [Presentation] 新型コロナウイルス感染症による嗅覚・味覚障害のメカニズムと臨床像2021

    • Author(s)
      上羽瑠美
    • Organizer
      第11回CSJ化学フェスタ2021
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] シンポジウム:COVID-19による嗅覚障害の 臨床像と基礎的背景2021

    • Author(s)
      上羽瑠美
    • Organizer
      第60回日本鼻科学会
    • Related Report
      2021 Research-status Report
  • [Presentation] シンポジウム:さまざまな原因による嗅神経上皮障害の機序と上皮再生について2021

    • Author(s)
      上羽瑠美
    • Organizer
      第21回日本再生医療学会総会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] 嗅粘膜除去後の上皮再生の検証2021

    • Author(s)
      森 恵莉、上羽瑠美、近藤健二、他
    • Organizer
      第60回日本鼻科学会
    • Related Report
      2021 Research-status Report
  • [Presentation] アレルギー・喫煙・ウイルス感染による 鼻粘膜への影響2021

    • Author(s)
      上羽瑠美
    • Organizer
      金沢市耳鼻咽喉科医会 学術講演会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] 新型コロナウイルスと嗅覚障害2020

    • Author(s)
      上羽瑠美
    • Organizer
      第59回日本鼻科学会
    • Related Report
      2020 Research-status Report
  • [Presentation] 新型コロナウイルスと嗅覚障害2020

    • Author(s)
      上羽瑠美
    • Organizer
      日本味と匂学会
    • Related Report
      2020 Research-status Report
  • [Presentation] COVID-19の嗅覚・味覚障害の機構と実態2020

    • Author(s)
      上羽瑠美
    • Organizer
      第4回感覚研究フロンティアシンポジウム
    • Related Report
      2020 Research-status Report
  • [Presentation] 新型コロナウイルス感染症と味覚・嗅覚障害2020

    • Author(s)
      上羽瑠美
    • Organizer
      千葉県ENTカンファレンス
    • Related Report
      2020 Research-status Report
  • [Presentation] 新型コロナウイルス感染症と味覚・嗅覚障害2020

    • Author(s)
      上羽瑠美
    • Organizer
      第4回東京耳鼻咽喉科講演会
    • Related Report
      2020 Research-status Report
  • [Presentation] Panelist: Inflammatory effects of smoking and aging on the olfactory epithelium2019

    • Author(s)
      Rumi Ueha, Tatsuya Yamasoba
    • Organizer
      AAO-HNSF 2019
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] ミニシンポジウム:タバコ煙と加齢による嗅覚障害の機序-嗅神経上皮障害を中心に-2019

    • Author(s)
      上羽瑠美,近藤健二,菊田周,山岨達也
    • Organizer
      第58回日本鼻科学会
    • Related Report
      2019 Research-status Report

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Published: 2019-04-18   Modified: 2025-01-30  

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