The role of galectin-1 in the pathophysiology of ocular disorder
| Project/Area Number |
19K09944
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 56060:Ophthalmology-related
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| Research Institution | Hokkaido University |
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Principal Investigator |
Kanda Atsuhiro 北海道大学, 医学研究院, 客員研究員 (80342707)
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2021: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | ガレクチンー1 / 炎症 / 糖鎖 / 線維化 / 網脈絡膜疾患 / 血管新生 |
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| Outline of Research at the Start |
これまでに得られたガレクチン-1の血管新生・線維化に関する研究成果をさらに発展させ、網脈絡膜疾患病態の炎症におけるガレクチン-1の病態制御および生理的役割の知見を蓄える。そして、これを基盤とし網脈絡膜疾患に対する新たな分子標的としての治療戦略に確立して、臨床における疾患治療への貢献を目指す。
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| Outline of Final Research Achievements |
We revealed that the glycan-binding protein galectin-1 binds to VEGFR-2 in retinal vascular endothelial cells in a VEGF-independent manner, promotes receptor phosphorylation and cell proliferation, and induces angiogenesis. In diabetic retinopathy, we clarified the mechanism by which IL-1β stimulates the IL-1 receptor in Muller cells and promotes the synthesis of galectin-1 starting from the advanced glycation end products. In this study, we further developed the research results on angiogenesis and fibrosis of galectin-1 obtained so far, and further clarified the pathological control and physiological role of galectin-1 in inflammation of retinal disease pathology.
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| Academic Significance and Societal Importance of the Research Achievements |
現在、眼科領域の分子標的療法では抗VEGF療法が臨床応用されたが、その抗VEGF療法に対して抵抗性を示す症例が多数報告されている。糖鎖結合タンパク質のガレクチン-1はVEGF非依存的に血管新生を眼内で惹起することから、糖鎖および糖鎖結合タンパク質の機能を理解することは糖尿病網膜症や加齢黄斑変性の新たな創薬に繋がる可能性が十分に高い。本研究計画により、眼科創薬が起点となって幅広理分野の研究が活性化され、我が国の医療水準の向上に貢献することが期待される。
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Report
(4 results)
Research Products
(38 results)
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[Journal Article] Macrophage-like iPS-derived Suppressor Cells Reduce Th1-mediated Immune Response to a Retinal Antigen.2021
Author(s)
Hase K, Namba K, Wada H, Tsuji H, Maeda A, Murata T, Otsuka R, Iwata D, Kanda A, Noda K, Kitaichi N, Seino KI, Ishida S.
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Journal Title
Curr Eye Res.
Volume: 46
Issue: 12
Pages: 1908-1916
DOI
Related Report
Peer Reviewed
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[Journal Article] Attenuation of experimental autoimmune uveoretinitis in mice by IKKβ inhibitor IMD-03542020
Author(s)
Liu Y, Kitaichi N, Wu D, Hase K, Satoh M, Iwata D, Namba K, Kanda A, Noda K, Itai A, Iwabuchi K, Ishida S
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Journal Title
Biochem Biophys Res Commun
Volume: 525
Issue: 3
Pages: 589-594
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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