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The Association between the ocular surface temperature and corneal nervous system

Research Project

Project/Area Number 19K09961
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 56060:Ophthalmology-related
Research InstitutionToho University

Principal Investigator

HORI Yuichi  東邦大学, 医学部, 教授 (70379171)

Co-Investigator(Kenkyū-buntansha) 益岡 尚由  金沢医科大学, 医学部, 教授 (80509307)
Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2021: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords眼表面温度 / 角膜知覚 / 前眼部血流 / ドライアイ / オキュラーサーフェス
Outline of Research at the Start

近年、温度受容器(TRPチャネル)を介した角結膜知覚神経による応答機構が報告され、眼表面温度変化がオキュラーサーフェスの恒常性維持に関与していると考えられている。
今回の研究において、眼表面温度・眼表面温度変化や温度感受性角膜知覚神経を制御する因子として前眼部血流が関与しているかを明らかにし、オキュラーサーフェスの恒常性維持に関わるメカニズムを解明することにより、オキュラーサーフェス疾患の病態の解明や、新規診断法や治療法の開発など幅広い領域において大きなインパクトを与える可能性が十分にある。

Outline of Final Research Achievements

The purpose of this study was to clarify the relationship between ocular surface temperature (OST) and anterior segment blood flow, and to further elucidate the mechanisms involved in maintaining ocular surface homeostasis, to which corneal perception contributes. First of all, we established a method for measuring human ocular surface blood flow and OST using an LSFG and thermographer for the anterior segment or the eye, followed by the measurement of blood flow and temperature in normal volunteers (Itokawa et al. Diagnositics 2020), meibomian gland dysfunction (MGD) (Sumazaki et al., Japan Corneal Conference 2021), dry eye (Itokawa et al. Japan Corneal Conferences 2022), and the contact lens wearer (Itokawa et al. ARVO 2022), demonstrating changes in the ocular surface in terms of temperature and blood flow. We have presented and published many new findings.

Academic Significance and Societal Importance of the Research Achievements

ドライアイやアレルギー性結膜炎などのオキュラーサーフェス疾患はcommon diseaseであり、わが国でも患者数が増加している。両疾患とも眼表面の恒常性が様々な原因で破綻し、眼表面の知覚神経である三叉神経を介して「目の乾き」や「目のかゆみ」を自覚する。これらの自覚症状はQOLの低下や、仕事の生産性の低下につながるため、本疾患は社会的な影響が大きい。本研究で扱った眼表面の恒常性維持に関わる「温度」や「血流」という因子は、これらオキュラーサーフェス疾患の病態解明だけでなく、自覚症状の改善に効果のある新規治療の開発につながると考えられ、その社会的意義は大きいと思われる。

Report

(4 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (29 results)

All 2022 2021 2020 2019

All Journal Article (15 results) (of which Peer Reviewed: 15 results,  Open Access: 11 results) Presentation (12 results) (of which Int'l Joint Research: 7 results) Book (2 results)

  • [Journal Article] Pathogenic Mechanism of Dry Eye-Induced Chronic Ocular Pain and a Mechanism-Based Therapeutic Approach2022

    • Author(s)
      Tei Y, Mikami Y, Ito M, Tomida T, Ohshima D, Hori Y, Adachi-Akahane S
    • Journal Title

      Investigative Ophthalmology & Visual Science

      Volume: 63 Issue: 1 Pages: 7-7

    • DOI

      10.1167/iovs.63.1.7

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Evaluation of the Lubricating Effect of Hyaluronic Acid on Contact Lens Using a Pendulum-Type Friction Tester Under Mimicking Physiological Conditions.2022

    • Author(s)
      Hiroko Iwashita, Kiyoshi Mabuchi, Takashi Itokawa, Yuckinobu Okajima, Takashi Suzuki, Yuichi Hori
    • Journal Title

      Eye & contact lens

      Volume: 48 Issue: 2 Pages: 83-87

    • DOI

      10.1097/icl.0000000000000853

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Adherence to Eye Drops Usage in Dry Eye Patients and Reasons for Non-Compliance: A Web-Based Survey.2022

    • Author(s)
      Uchino M, Yokoi N, Shimazaki J, Hori Y, Tsubota K
    • Journal Title

      Journal of Clinical Medicine

      Volume: 11 Issue: 2 Pages: 367-367

    • DOI

      10.3390/jcm11020367

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Metagenomic Shotgun Sequencing Analysis of Canalicular Concretions in Lacrimal Canaliculitis Cases2021

    • Author(s)
      Yukinobu Okajima,Takashi Suzuki,Chika Miyazaki,Satoshi Goto,Sho Ishikawa,Yuka Suzuki, Kotaro Aoki, Yoshikazu Ishii, Kazuhiro Tateda, Yuichi Hori
    • Journal Title

      Current issues in molecular biology

      Volume: 43 Issue: 2 Pages: 676-686

    • DOI

      10.3390/cimb43020049

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development of a pendulum machine for measuring contact lens friction2021

    • Author(s)
      Kiyoshi Mabuchi, Hiroko Iwashita, Rina Sakai, Masanobu Ujihira, Yuichi Hori
    • Journal Title

      Biosurface and Biotribology

      Volume: 2021 Issue: 3 Pages: 1-8

    • DOI

      10.1049/bsb2.12004

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of In Vitro Wettability of Soft Contact Lenses Using Tear Supplements2021

    • Author(s)
      Hiroko Iwashita, Takashi Itokawa, Takashi Suzuki, Yukinobu Okajima, Koji Kakisu, Yuichi Hori
    • Journal Title

      Eye & contact lens

      Volume: 47 Issue: 5 Pages: 244-248

    • DOI

      10.1097/icl.0000000000000698

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Comparison and Evaluation of Prelens Tear Film Stability by Different Noninvasive in vivo Methods2020

    • Author(s)
      Itokawa T, Suzuki T, Iwashita H, Hori Y
    • Journal Title

      Clinical Ophthalmology

      Volume: 14 Pages: 4459-4468

    • DOI

      10.2147/opth.s288047

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comparison of Two Preparation Methods for Platelet-Rich Plasma Eye Drops for Release of Growth Factors and De-Epithelization Rabbit Model2020

    • Author(s)
      Kobayashi T, Suzuki T, Saito T, Itokawa T, Hori Y
    • Journal Title

      Journal of Ophthalmology

      Volume: 5 Pages: 1-9

    • DOI

      10.1155/2020/6634744

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Correlation between Blood Flow and Temperature of the Ocular Anterior Segment in Normal Subjects2020

    • Author(s)
      Itokawa T, Suzuki T, Okajima Y, Kobayashi T, Iwashita H, Gotoda S, Kakisu K, Tei Y, Hori Y
    • Journal Title

      Diagnostics

      Volume: 10 Issue: 9 Pages: 695-695

    • DOI

      10.3390/diagnostics10090695

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Bacterial keratoconjunctivitis caused by Staphylococcus argenteus belonging to sequence type 1223 isolated in Japan2020

    • Author(s)
      Yamada K, Sasaki M, Imai W, Kato M, Maehara C, Yasui K, Fukuzawa S, Murakami H, Kakisu K, Hori Y, Nagasawa T, Aoki K, Yamaguchi T, Ishii Y, Tateda K
    • Journal Title

      Journal of infection and chemotherapy

      Volume: 26 Issue: 9 Pages: 1002-1004

    • DOI

      10.1016/j.jiac.2020.04.026

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Gender differences in the influence of obstructive sleep apnea on optic nerve head circulation2019

    • Author(s)
      Shiba Tomoaki、Takahashi Mao、Matsumoto Tadashi、Hori Yuichi
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 18849-18849

    • DOI

      10.1038/s41598-019-55470-7

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sleep-Disordered Breathing Is a Stronger Risk Factor for Proliferative Diabetic Retinopathy than Metabolic Syndrome and the Number of Its Individual Components2019

    • Author(s)
      Shiba Tomoaki、Takahashi Mao、Matsumoto Tadashi、Hori Yuichi
    • Journal Title

      Seminars in Ophthalmology

      Volume: 34 Issue: 2 Pages: 59-65

    • DOI

      10.1080/08820538.2019.1569074

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Influence of age and gender on the pulse waveform in optic nerve head circulation in healthy men and women2019

    • Author(s)
      Kobayashi Tatsuhiko、Shiba Tomoaki、Nishiwaki Yuji、Kinoshita Ayako、Matsumoto Tadashi、Hori Yuichi
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 17895-17895

    • DOI

      10.1038/s41598-019-54470-x

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The influences of gender and aging on optic nerve head microcirculation in healthy adults2019

    • Author(s)
      Kobayashi Tatsuhiko、Shiba Tomoaki、Kinoshita Ayako、Matsumoto Tadashi、Hori Yuichi
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 15636-15636

    • DOI

      10.1038/s41598-019-52145-1

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association among Blink Rate, Changes in Ocular Surface Temperature, Tear Film Stability, and Functional Visual Acuity in Patients after Cataract Surgery2019

    • Author(s)
      Itokawa Takashi、Okajima Yukinobu、Suzuki Takashi、Kobayashi Tatsuhiko、Tei Yuto、Kakisu Koji、Hori Yuichi
    • Journal Title

      Journal of Ophthalmology

      Volume: 2019 Pages: 1-8

    • DOI

      10.1155/2019/8189097

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Pregabalin as a pathogenic mechanism-based therapeutic strategy for dry eye-induced chronic ocular pain2022

    • Author(s)
      鄭有人、三上義礼、冨田太一郎、大島大輔、堀裕一、赤羽悟美
    • Organizer
      第95回日本薬理学年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] マスク装用が眼表面に与える影響について2022

    • Author(s)
      糸川貴之, 岡島行伸, 岩下紘子, 鈴木 崇, 堀 裕一
    • Organizer
      角膜カンファランス2022
    • Related Report
      2021 Annual Research Report
  • [Presentation] 振り子式摩擦測定器を用いたコンタクトレンズ上のヒアルロン酸潤滑能評価2022

    • Author(s)
      岩下紘子, 糸川貴之, 岡島行伸, 鈴木 崇, 馬渕清資, 堀 裕一
    • Organizer
      角膜カンファランス2022
    • Related Report
      2021 Annual Research Report
  • [Presentation] ドライアイモデルラットにおける神経障害性疼痛メカニズムとプレガバリン治療効果2021

    • Author(s)
      鄭有人、三上義礼、冨田太一郎、大島大輔、堀裕一、赤羽悟美
    • Organizer
      第41回日本眼薬理学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Ocular Surface Temperature (OST) and Dry Eye2021

    • Author(s)
      Yuichi HORI
    • Organizer
      Asia Dry Eye Summit 2021
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] MGD患者に対するサーマルパルセーションシステム治療前後の前眼部血流と温度の変化について2021

    • Author(s)
      須磨崎さやか、糸川貴之、柿栖康二、岡島行伸、鈴木 崇、堀 裕一
    • Organizer
      角膜カンファランス2021
    • Related Report
      2020 Research-status Report
  • [Presentation] Evaluation of the in vitro effect of hyaluronic acid on soft contact lenses2020

    • Author(s)
      Yuichi HORI
    • Organizer
      WOC2020
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] Association between temperature and blood flow in the ocular anterior segment2019

    • Author(s)
      Takashi Itokawa; Satoshi Gotoda; Yuto Tei; Hiroko Iwashita; Koji Kakisu; yukinobu Okajima; Takashi Suzuki; Yuichi Hori
    • Organizer
      ARVO2019
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Evaluation of eye drop lubrication on contact lenses using a pendulum tester2019

    • Author(s)
      Hiroko Iwashita; Takashi Itokawa; Koji Kakisu; yukinobu Okajima; Takashi Suzuki; Kiyoshi Mabuchi; Yuichi Hori
    • Organizer
      ARVO2019
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Analysis of ocular blood flow waveforms in retinopathy of prematurity model rats using a Laser Speckle Flowgraphy Micro2019

    • Author(s)
      masahiko tomita; Tadashi Matsumoto; Yuta Saito; Takashi Itokawa; Kota Yokoyama; Chiaki Yui; Tomoaki Shiba; Yuichi Hori
    • Organizer
      ARVO2019
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Real-time evaluation of systemic-ocular microcirculation using laser speckle flowgraphy in white rabbits2019

    • Author(s)
      Tetsuya Komatsu; Tomoaki Shiba; Yoshinobu Nagasawa; Megumi Aimoto; Kiyoshi Sakuma; Tatsuo Chiba; Xin Cao; Akira Takahara; Tadashi Matsumoto; Yuichi Hori
    • Organizer
      ARVO2019
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Correlation between Ocular Surface Temperature and Blood Flow in the Ocular Anterior Segment2019

    • Author(s)
      Yuichi Hori, Takashi Itokawa, Takashi Suzuki
    • Organizer
      The 12th Joint Meeting of Chinese-Japanese-Korean Ophthalmologists
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Book] 今日の診断指針第8版2020

    • Author(s)
      堀 裕一(部分執筆)
    • Total Pages
      2114
    • Publisher
      医学書院
    • ISBN
      9784260038089
    • Related Report
      2020 Research-status Report
  • [Book] 今日の診断指針 デスク判 第8版2020

    • Author(s)
      永井 良三
    • Total Pages
      2079
    • Publisher
      医学書院
    • ISBN
      9784260038089
    • Related Report
      2019 Research-status Report

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Published: 2019-04-18   Modified: 2023-01-30  

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