Assessment of functional aqueous humor outflow and prediction of glaucoma treatment effect using anterior segment optical coherence tomography angiography
| Project/Area Number |
19K09968
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 56060:Ophthalmology-related
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| Research Institution | Niigata University (2021)
Kyoto University (2019-2020) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
池田 華子 京都大学, 医学研究科, 特定准教授 (20372162)
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2021: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 緑内障 / OCTアンギオグラフィー / 房水流出主経路 / 治療効果予測 / 前眼部光干渉血管造影 / 流出路再建術 / 緑内障手術 / 房水主流出路 / 前眼部OCTA / 緑内障点眼 / 房水流出路 / 光干渉断層血管撮影 |
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| Outline of Research at the Start |
緑内障に対する点眼治療や低侵襲な緑内障手術である流出路再建術の眼圧下降効果は個体差が大きく、治療効果をあらかじめ予測することは困難である。本研究では、非侵襲的に施行可能な検査である光干渉断層血管撮影を房水流出主経路の機能評価に用いることで、緑内障治療効果予測に活用できる非侵襲的検査法の確立を目的とする。
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| Outline of Final Research Achievements |
Deep blood flow images by anterior segment OCT angiography (OCTA) reflect the conventional aqueous humor outflow pathway in the superior sclera and intrasclera. There was a significant correlation between deep vessel density and intraocular pressure (IOP) in glaucoma patients. The change over time in the blood flow image in the anterior segment of the eye differed depending on the type of glaucoma instillation, and the effect of reducing IOP by instillation of ripasudil was significantly related to the deep vessel density before instillation. The therapeutic effect of trabecular meshwork-targeted micro-invasive glaucoma surgery was significantly associated with preoperative deep vessel density.
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| Academic Significance and Societal Importance of the Research Achievements |
前眼部OCTAを用いた検査が房水流出主経路の機能評価の参考になりうること、治療前のOCTA画像が一部の緑内障点眼治療や緑内障手術治療の効果と関連することを明らかにした。治療効果に個人差の大きい点眼治療や低侵襲な緑内障手術である流出路再建術の治療効果が治療前に予測可能になれば、患者におけるメリットは大きいと考えられる。
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Report
(4 results)
Research Products
(49 results)
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[Journal Article] Association between topical β-blocker use and asthma attacks in glaucoma patients with asthma: a cohort study using a claims database2021
Author(s)
Kido A, Miyake M, Akagi T, Ikeda HO, Kameda T, Suda K, Hasegawa T, Hiragi S, Yoshida S, Tsujikawa A, Tamura H, Kawakami K
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Journal Title
Graefes Arch Clin Exp Ophthalmol
Volume: 260
Issue: 1
Pages: 271-280
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Relationship between Intraocular Pressure and Coffee Consumption in a Japanese Population without Glaucoma: The Nagahama Study2020
Author(s)
Nakano E, Miyake M, Hosoda Y, Mori Y, Suda K, Kameda T, Ikeda-Ohashi H, Tabara Y, Yamashiro K, Tamura H, Akagi T, Matsuda F, Tsujikawa A; Nagahama Study Group
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Journal Title
Ophthalmol Glaucoma
Volume: 4196
Issue: 3
Pages: 30271-30274
DOI
Related Report
Peer Reviewed
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[Journal Article] Short-Term Effects of Different Types of Anti-Glaucoma Eyedrop on the Sclero-Conjunctival Vasculature Assessed Using Anterior Segment OCTA in Normal Human Eyes: A Pilot Study2020
Author(s)
Akagi T, Okamoto Y, Kameda T, Suda K, Nakanishi H, Miyake M, Ikeda HO, Yamada T, Kadomoto S, Uji A, Tsujikawa A
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Journal Title
J Clin Med
Volume: 9
Issue: 12
Pages: 4016-4016
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Anterior Segment Optical Coherence Tomography Angiography Imaging of Conjunctiva and Intrasclera in Treated Primary Open-Angle Glaucoma2019
Author(s)
Akagi T, Uji A, Okamoto Y, Suda K, Kameda T, Nakanishi H, Ikeda HO, Miyake M, Nakano E, Motozawa N, Tsujikawa A
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Journal Title
Am J Ophthalmol
Volume: 208
Pages: 313-322
DOI
Related Report
Peer Reviewed
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[Presentation] Anterior Segment Optical Coherence Tomography Angiography Imaging of Conjunctiva and Intrasclera in Treated Primary Open-Angle Glaucoma2019
Author(s)
Akagi T, Akihito Uji, Okamoto Y, Suda K, Kameda T, Nakanishi H, Ikeda HO, Miyake M, Eri Nakano, Motozawa N, Tsujikawa A
Organizer
ARVO 2019
Related Report
Int'l Joint Research
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