• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Metabolomic analysis of malignant ocular tumors-Creation of new biomarkers

Research Project

Project/Area Number 19K09981
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 56060:Ophthalmology-related
Research InstitutionTokyo Medical University

Principal Investigator

Goto Hiroshi  東京医科大学, 医学部, 主任教授 (10201500)

Co-Investigator(Kenkyū-buntansha) 杉本 昌弘  東京医科大学, 医学部, 教授 (30458963)
臼井 嘉彦  東京医科大学, 医学部, 准教授 (50408142)
Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2021: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2020: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords眼腫瘍 / メタボロミクス / 眼窩悪性リンパ腫 / IgG4関連眼疾患 / 眼部悪性腫瘍 / 眼窩リンパ増殖性疾患 / 眼窩MALTリンパ腫 / メタボローム / IgG4関連眼疾患 / メタボローム解析
Outline of Research at the Start

代謝物は低酸素状況等に過敏に反応するため、個々の病態を評価するには最適なツールの一つと考えられる。患者ごとにみられる代謝異常を網羅的に解析し、疾患の特徴を多面的に解析することは、病態の解明や治療の個別化に必須であると考えられる。ヒトから得られた検体を用いた解析のみならず、動物モデルを用いたマルチオミックス解析も行い、代謝異常の原因を追究しつつ、データに基づいた個別化治療に繋がる指標を見い出すことを最大の目標とする。

Outline of Final Research Achievements

In this study, we used metabolomics to clarify the metabolic profile of orbital lymphoproliferative disease and IgG4-related ophthalmic disease. In particular, in the tissue metabolism map, glycolysis and metabolites belonging to the TCA cycle were elevated in orbital MALT lymphoma, and polyamine was elevated in IgG4-related ophthalmic diseases. As a result of selecting these highly discriminating tissue metabolites by artificial intelligence, the final combination of 5 types (spermine, glycolate, uridine, malate, N1, N12-diacetylspermine) is AUC 0.98, which is the highest discrimination.

Academic Significance and Societal Importance of the Research Achievements

眼部悪性腫瘍は稀少疾患であるが故に、悪性腫瘍に対する代謝産物の解析はほとんど行われていない。眼窩MALTリンパ腫とIgG4関連眼疾患は、いずれも眼付属器の腫脹や肥大を主徴とする臨床症状を呈し、類似した画像所見を示すこともあるため、臨床的に鑑別が困難であることが多い。両疾患の治療方法は全く異なるため、両者を鑑別するバイオマーカーの創出は重要である。代謝物発現の違いは診断のバイオマーカーとして有用なだけでなく、代謝物自体の発現を調節することで新たな治療標的として有用な可能性がある。

Report

(4 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (57 results)

All 2022 2021 2020 2019

All Journal Article (25 results) (of which Peer Reviewed: 24 results,  Open Access: 13 results) Presentation (29 results) (of which Int'l Joint Research: 5 results,  Invited: 6 results) Book (3 results)

  • [Journal Article] 眼窩腫瘍の症状・診断・疫学2022

    • Author(s)
      後藤 浩
    • Journal Title

      眼科64:33-39, 2022.

      Volume: 64 Pages: 33-39

    • NAID

      40022814485

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 同側のfree tarsal flapを用いた悪性眼瞼腫瘍切除後の再建2022

    • Author(s)
      後藤 浩, 新留翔一郎, 嶺崎輝海
    • Journal Title

      眼臨紀

      Volume: 15 Pages: 152-152

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical features and symptoms of IgG4-related ophthalmic disease: a multicenter study2021

    • Author(s)
      Goto H、Ueda S、Nemoto R、Ohshima K、Sogabe Y、Kitagawa K、Ogawa Y、Oyama T、Furuta M、Azumi A、Takahira M
    • Journal Title

      Japanese Journal of Ophthalmology

      Volume: 65 Issue: 5 Pages: 651-656

    • DOI

      10.1007/s10384-021-00847-3

    • NAID

      40022680331

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinico-epidemiological analysis of 1000 cases of orbital tumors2021

    • Author(s)
      Goto H、Yamakawa N、Komatsu H、Asakage M、Tsubota K、Ueda S、Nemoto R、Umazume K、Usui Y、Mori H
    • Journal Title

      Japanese Journal of Ophthalmology

      Volume: 65 Issue: 5 Pages: 704-723

    • DOI

      10.1007/s10384-021-00857-1

    • NAID

      40022680448

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Iris Melanoma in a Patient with Retinitis Pigmentosa2021

    • Author(s)
      Goto H、Yamakawa N
    • Journal Title

      Ocular Oncology and Pathology

      Volume: 7 Issue: 4 Pages: 267-271

    • DOI

      10.1159/000511550

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Histopathology and immunohistochemistry of choroidal melanocytoma demonstrated by local resection: A case report2021

    • Author(s)
      Goto H、Yamakawa N、Komatsu H
    • Journal Title

      American Journal of Ophthalmology Case Reports

      Volume: 23 Pages: 101147-101147

    • DOI

      10.1016/j.ajoc.2021.101147

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A case of intravascular lymphoma diagnosed with a primary vitreoretinal lymphoma-like fundus lesion2021

    • Author(s)
      Asakage M、Umazume K、Takoi H、Akahane D、Ishibashi Y、Yamaguchi H、Gondo M、Goto H
    • Journal Title

      Journal of Ophthalmic Inflammation and Infection

      Volume: 11 Issue: 1

    • DOI

      10.1186/s12348-021-00280-0

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Vitreoretinal lymphoma occurring after systemic chemotherapy for primary conjunctival diffuse large B cell lymphoma2021

    • Author(s)
      Niidome E、Usui Y、Takahashi R、Nagao T、Goto H
    • Journal Title

      Medicine

      Volume: 100 Issue: 39 Pages: e27347-e27347

    • DOI

      10.1097/md.0000000000027347

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Magnetic Resonance Imaging of Orbital Solitary Fibrous Tumors: Radiological-Pathological Correlation Analysis2021

    • Author(s)
      Masuno Ryuhei、Yunaiyama Daisuke、Shishido-Hara Yukiko、Yoshimaru Daisuke、Maruyama Chifumi、Araki Yoichi、Goto Hiroshi、Nagao Toshitaka、Saito Kazuhiro
    • Journal Title

      Journal of the Belgian Society of Radiology

      Volume: 105 Issue: 1 Pages: 1-7

    • DOI

      10.5334/jbsr.2097

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 汎ぶどう膜炎 眼内リンパ腫(硝子体網膜リンパ腫)2021

    • Author(s)
      後藤 浩
    • Journal Title

      臨眼

      Volume: 75 Pages: 63-68

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 眼内リンパ腫の診断と治療2021

    • Author(s)
      後藤 浩
    • Journal Title

      血液内科

      Volume: 83 Pages: 772-777

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 2020年改訂 IgG4関連疾患包括診断基準 The 2020 revised comprehensive diagnostic(RCD) criteria for IgG4-RD.2021

    • Author(s)
      梅原久範、岡崎和一、川 茂幸、高橋裕樹、後藤 浩、松井祥子、石坂信和、赤水尚史、佐藤康晴、川野充弘、厚生労働省難治性疾患等政策研究事業IgG4関連疾患の診断基準並びに診療指針の確立を目指す研究班
    • Journal Title

      日内会誌

      Volume: 110 Pages: 962-969

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comprehensive Gene Analysis of IgG4-Related Ophthalmic Disease Using RNA Sequencing2021

    • Author(s)
      Asakage M, Usui Y, Nezu N, Shimizu H, Tsubota K, Umazume K, Yamakawa N, Umezu T, Suwanai H, Kuroda M, Goto H.
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: in press Issue: 11 Pages: 3548-3548

    • DOI

      10.3390/jcm9113458

    • NAID

      120007183860

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Share Differential Tissue Metabolic Signatures in IgG4-Related Ophthalmic Disease and Orbital Mucosa-Associated Lymphoid Tissue Lymphoma.2021

    • Author(s)
      Shimizu H, Usui Y, Wakita R, Aita Y, Tomita A, Tsubota K, Asakage M, Nezu N, Komatsu H, Umazume K, Sugimoto M, Goto H.
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: in press Issue: 1 Pages: 15-15

    • DOI

      10.1167/iovs.62.1.15

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The 2020 revised comprehensive diagnostic (RCD) criteria for IgG4-RD2021

    • Author(s)
      Umehara H、Okazaki K、Kawa S、Takahashi H、Goto H、Matsui S、Ishizaka N、Akamizu T、Sato Y、Kawano M.
    • Journal Title

      Modern Rheumatology

      Volume: 31 Issue: 3 Pages: 529-533

    • DOI

      10.1080/14397595.2020.1859710

    • NAID

      40022596934

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinicopathologic analysis of 32 ciliary body tumors2021

    • Author(s)
      Goto H、Yamakawa N、Tsubota Ki、Umazume K、Usui Y.
    • Journal Title

      Japanese Journal of Ophthalmology

      Volume: 65 Issue: 2 Pages: 237-249

    • DOI

      10.1007/s10384-021-00814-y

    • NAID

      40022522747

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] 眼内リンパ腫(硝子体網膜リンパ腫)2021

    • Author(s)
      後藤 浩
    • Journal Title

      臨眼

      Volume: 75 Pages: 63-68

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Clinical features and prognosis of sebaceous carcinoma arising in the eyelid or conjunctiva2020

    • Author(s)
      Goto H、Tsubota K、Nemoto R、Ueda S、Umazume K、Usui Y、Matsumura H.
    • Journal Title

      Japanese Journal of Ophthalmology

      Volume: 64 Issue: 5 Pages: 549-554

    • DOI

      10.1007/s10384-020-00756-x

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Serum Metabolomic Profiling of Patients with Non-Infectious Uveitis.2020

    • Author(s)
      Shimizu H, Usui Y, Asakage M, Nezu N, Wakita R, Tsubota K, Sugimoto M, Goto H.
    • Journal Title

      J Clin Med

      Volume: 9 Issue: 12 Pages: 3955-3955

    • DOI

      10.3390/jcm9123955

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Share Distinctive Tissue and Serum MicroRNA Profile of IgG4-Related Ophthalmic Disease and MALT Lymphoma.2020

    • Author(s)
      Nezu N, Usui Y, Asakage M, Shimizu H, Tsubota K, Narimatsu A, Umazume K, Yamakawa N, Ohno SI, Takanashi M, Kuroda M, Goto H.
    • Journal Title

      J Clin Med.

      Volume: 9(8) Issue: 8 Pages: 2530-2530

    • DOI

      10.3390/jcm9082530

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] High-Throughput MicroRNA Profiling of Vitreoretinal Lymphoma: Vitreous and Serum MicroRNA Profiles Distinct from Uveitis.2020

    • Author(s)
      Minezaki T, Usui Y, Asakage M, Takanashi M, Shimizu H, Nezu N, Narimatsu A, Tsubota K, Umazume K, Yamakawa N, Kuroda M, Goto H.
    • Journal Title

      J Clin Med.

      Volume: 9(6) Issue: 6 Pages: 1844-1844

    • DOI

      10.3390/jcm9061844

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification of Prognostic Markers in Patients with Primary Vitreoretinal Lymphoma by Clustering Analysis Using Clinical Data2020

    • Author(s)
      Tsubota K、Usui Y、Goto H.
    • Journal Title

      Journal of Clinical Medicine

      Volume: 9 Issue: 7 Pages: 2298-2298

    • DOI

      10.3390/jcm9072298

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification of Markers Predicting Clinical Course in Patients with IgG4-Related Ophthalmic Disease by Unbiased Clustering Analysis2020

    • Author(s)
      Tsubota K, Usui Y, Nemoto R, Goto H.
    • Journal Title

      J Clin Med

      Volume: 9 Issue: 12 Pages: 4084-4084

    • DOI

      10.3390/jcm9124084

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] IgG4関連眼疾患の診断と治療2020

    • Author(s)
      後藤 浩
    • Journal Title

      カレントテラピー

      Volume: 38 Pages: 61-65

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] 眼内リンパ腫の診断のポイントは?眼所見、臨床経過、ぶどう膜炎の治療薬に対する反応を見きわめ、可能性を疑う2019

    • Author(s)
      後藤 浩
    • Journal Title

      日本医事新報

      Volume: 4955 Pages: 52-53

    • Related Report
      2019 Research-status Report
  • [Presentation] RNAシークエンスによるIgG4関連眼疾患と反応性リンパ過形成の比較検討2021

    • Author(s)
      朝蔭正樹, 臼井嘉彦, 小川麻里奈, 禰津直也, 清水広之, 坪田欣也, 山川直之, 馬詰和比古, 根本 怜, 梅津知宏, 黒田雅彦, 後藤 浩
    • Organizer
      第125回日本眼科学会総会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 眼瞼に発生したメルケル細胞癌におけるメルケル細胞ポリオーマウイルス感染率の検討2021

    • Author(s)
      小松紘之,助田 葵, 山本善也, 長尾俊孝, 臼井嘉彦, 山川直之, 後藤 浩
    • Organizer
      第125回日本眼科学会総会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 原発眼窩腫瘍1,000例の統計および臨床的解析2021

    • Author(s)
      後藤 浩, 山川直之, 小松紘之, 朝蔭正樹, 坪田欣也, 根本 怜, 上田俊一郎, 馬詰和比古, 臼井嘉彦, 森 秀樹
    • Organizer
      第125回日本眼科学会総会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 同側のfree tarsal flapを用いた悪性眼瞼腫瘍切除後の再建2021

    • Author(s)
      後藤 浩, 新留翔一郎, 嶺崎輝海
    • Organizer
      第8回日本眼形成再建外科学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Demography, clinical manifestations and differential diagnosis of IgG4-related ophthalmic disease.2021

    • Author(s)
      Goto H
    • Organizer
      The 4th International Symposium on IgG4-Related Diseases: diagnosis and treatment development. Joint meeting with The 13th Annual Meeting of Japanese Association of IgG4-Related Diseases.
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 眼窩リンパ増殖性疾患におけるmiRNAの網羅的解析2020

    • Author(s)
      禰津直也, 臼井嘉彦, 朝蔭正樹, 清水広之, 坪田欣也, 山川直之, 高梨正勝, 黒田雅彦, 後藤 浩.
    • Organizer
      第124回 日本眼科学会総会
    • Related Report
      2020 Research-status Report
  • [Presentation] 眼内リンパ腫とサルコイドーシス患者の硝子体液および血清中における網羅的miRNA解析2020

    • Author(s)
      嶺崎輝海, 臼井嘉彦, 朝蔭正樹, 禰津直也, 清水広之, 山川直之, 成松明知, 坪田欣也, 馬詰和比古, 黒田雅彦, 後藤 浩
    • Organizer
      第124回 日本眼科学会総会
    • Related Report
      2020 Research-status Report
  • [Presentation] 眼内リンパ腫における硝子体液を用いたプロテオミクス解析2020

    • Author(s)
      坪田欣也, 禰津直也, 臼井嘉彦, 朝蔭正樹, 清水広之, 山川直之, 植田幸嗣, 山口剛史, 後藤 浩
    • Organizer
      第124回 日本眼科学会総会
    • Related Report
      2020 Research-status Report
  • [Presentation] 結膜原発のびまん性大細胞型リンパ腫に発症した眼内リンパ腫の1例2020

    • Author(s)
      新留絵里菜, 臼井嘉彦, 坪田欣也, 後藤 浩
    • Organizer
      第74回 日本臨床眼科学会
    • Related Report
      2020 Research-status Report
  • [Presentation] Determining immune-related factors of intraocular disease by artificial intelligence methods.2019

    • Author(s)
      Usui Y, Nezu N, Tsubota K, Goto H
    • Organizer
      The 15th International Ocular Inflammation Society Congress
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Clustering analysis in IgG4-related ophthalmic disease using data of peripheral blood tests.2019

    • Author(s)
      Tsubota K, Usui Y, Nemoto R, Goto H
    • Organizer
      The 15th International Ocular Inflammation Society Congress
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Cell population having a resistance to melanoma antigen specific T cell in uveal melanoma.2019

    • Author(s)
      Tsubota K, Usui Y, Goto H
    • Organizer
      2019 Annual Meeting of the Association for Research in Vision and Ophthalmology
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Differentiation of orbita lymphoproliferative disease by metabolomics.2019

    • Author(s)
      Shimizu H, Goto H, Usui Y, Nezu N, Tsubota K, Ogawa M, Asakage M
    • Organizer
      2019 Annual Meeting of the Association for Research in Vision and Ophthalmology
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Analysis of heterogeneity in uveal melanoma cell lines using flow cytometry.2019

    • Author(s)
      Tsubota K, Usui Y, Goto H
    • Organizer
      第183回東京医科大学医学会総会
    • Related Report
      2019 Research-status Report
  • [Presentation] Differentiation of orbital lymphoproliferative diseases by metabolomics2019

    • Author(s)
      Shimizu H, Sugimoto M, Usui Y, Tsubota K, Nezu N, Ogawa M, Asakage M, Goto H
    • Organizer
      第183回東京医科大学医学会総会
    • Related Report
      2019 Research-status Report
  • [Presentation] 網膜色素変性に発症した虹彩悪性黒色腫の病理組織所見2019

    • Author(s)
      後藤 浩、谷川真希、松林 純
    • Organizer
      第52回眼科臨床病理組織研究会
    • Related Report
      2019 Research-status Report
  • [Presentation] 眼腫瘍の診断 良性腫瘍と悪性腫瘍の鑑別のポイント2019

    • Author(s)
      後藤 浩
    • Organizer
      第138回沖縄眼科集談会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 眼内腫瘍の診断と治療の実際2019

    • Author(s)
      後藤 浩
    • Organizer
      第9回仙台網膜道場
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 眼腫瘍に対する診断と治療の実際2019

    • Author(s)
      後藤 浩
    • Organizer
      第7回奈良県眼科まほろばフォーラム
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 眼瞼・結膜腫瘍 診断と治療のエッセンス2019

    • Author(s)
      後藤 浩
    • Organizer
      第550回慈眼会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 毛様体腫瘍の外科的治療2019

    • Author(s)
      後藤 浩
    • Organizer
      第73回日本臨床眼科学会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] メタボロミクスを用いた水溶性代謝物の解析による眼窩リンパ増殖性疾患の解析2019

    • Author(s)
      清水広之、臼井嘉彦、坪田欣也、禰津直也、小川麻里奈、朝蔭正樹、後藤 浩、杉本昌弘
    • Organizer
      第73回日本臨床眼科学会
    • Related Report
      2019 Research-status Report
  • [Presentation] 眼内リンパ腫患者硝子体液および血清中における網羅的miRNA解析2019

    • Author(s)
      臼井嘉彦、朝蔭正樹、禰津直也、清水広之、成松明知、坪田欣也、馬詰和比古、後藤 浩、黒田雅彦
    • Organizer
      第37回日本眼腫瘍学会
    • Related Report
      2019 Research-status Report
  • [Presentation] 眼内リンパ腫における採血結果および硝子体中サイトカイン濃度を用いたクラスター解析2019

    • Author(s)
      坪田欣也、臼井嘉彦、後藤 浩
    • Organizer
      第37回日本眼腫瘍学会
    • Related Report
      2019 Research-status Report
  • [Presentation] 機会学習を用いた硝子体液中の免疫液性因子解析による眼内リンパ腫の鑑別検討2019

    • Author(s)
      禰津直也、臼井嘉彦、坪田欣也、朝蔭正樹、山川直之、黒田雅彦、斎藤 彰、杉本昌弘、後藤 浩
    • Organizer
      第37回日本眼腫瘍学会
    • Related Report
      2019 Research-status Report
  • [Presentation] IgG4関連眼疾患における採血データを用いたクラスター解析2019

    • Author(s)
      坪田欣也、臼井嘉彦、根本 怜、後藤 浩
    • Organizer
      IgG4関連疾患の診断基準ならびに診療指針の確立を目指す研究
    • Related Report
      2019 Research-status Report
  • [Presentation] 機会学習を用いた前房水中の免疫液性因子解析によるリンパ腫の識別検討2019

    • Author(s)
      禰津直也、臼井嘉彦、清水広之、朝蔭正樹
    • Organizer
      第39回日本分子腫瘍マーカー研究会
    • Related Report
      2019 Research-status Report
  • [Presentation] メタボロミクスを用いた眼窩リンパ増殖性疾患に対する水溶性代謝物の解析2019

    • Author(s)
      清水広之、臼井嘉彦、坪田欣也、禰津直也、小川麻里奈、朝蔭正樹、後藤 浩、杉本昌弘
    • Organizer
      第39回日本分子腫瘍マーカー研究会
    • Related Report
      2019 Research-status Report
  • [Presentation] メタボロミクスを用いた代謝物の解析による眼窩リンパ増殖性疾患の鑑別2019

    • Author(s)
      清水広之、杉本昌弘、臼井嘉彦、坪田欣也、禰津直也、小川麻里奈、朝蔭正樹、後藤 浩
    • Organizer
      第123回日本眼科学会総会
    • Related Report
      2019 Research-status Report
  • [Book] 眼と全身病アトラス2021

    • Author(s)
      大鹿哲郎、中村 誠、後藤 浩、その他141名
    • Total Pages
      430
    • Publisher
      総合医学社
    • ISBN
      9784883786893
    • Related Report
      2021 Annual Research Report
  • [Book] 眼内腫瘍アトラス2019

    • Author(s)
      後藤 浩
    • Total Pages
      210
    • Publisher
      医学書院
    • ISBN
      9784260038928
    • Related Report
      2019 Research-status Report
  • [Book] 眼科疾患最新の治療2019-20212019

    • Author(s)
      大橋裕一、村上 晶、後藤 浩、他
    • Total Pages
      392
    • Publisher
      南江堂
    • ISBN
      9784524245475
    • Related Report
      2019 Research-status Report

URL: 

Published: 2019-04-18   Modified: 2023-01-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi