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Analysis of epidermal growth factor receptor dependent inflammation amplifier activation in uveitis

Research Project

Project/Area Number 19K09985
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 56060:Ophthalmology-related
Research InstitutionHokkaido University

Principal Investigator

Namba Kenichi  北海道大学, 大学病院, 講師 (70333599)

Co-Investigator(Kenkyū-buntansha) 村上 正晃  北海道大学, 遺伝子病制御研究所, 教授 (00250514)
北市 伸義  北海道医療大学, 予防医療科学センター, 教授 (40431366)
Project Period (FY) 2019-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2021: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords上皮増殖因子受容体 / ぶどう膜炎 / 実験的自己免疫性ぶどう膜網膜炎 / EGFR / EAU / ベタセルリン / 非免疫系細胞 / EGF / 上皮増殖因子 / エピレグリン / 炎症増幅回路 / 線維芽細胞 / 急性炎症
Outline of Research at the Start

関節リウマチ、糖尿病など多くの全身性炎症疾患は、数年から数十年におよぶ「慢性」かつ「緩徐」な炎症により組織破壊が進行して発症に至る。一方、多くのぶどう膜炎では急性に発症することが多く、その急性炎症が激烈であるほど視力予後は不良となる。急性に発症するには何らかのメカニズムがあることが考えられてきた。
近年急性炎症に関与する炎症増幅回路が存在することが示唆され、そこには上皮増殖因子(EGF)受容体とそのリガンドが関与していることが判明した。ぶどう膜炎でも同様の炎症増幅回路が発症の急性化に関与していることを明らかにする

Outline of Final Research Achievements

Ligand for epidermal growth factor receptor (EGFR) was shown to be increased in the sera of patients with uveitis.
When mice were immunized with peptides derived from the retinal antigen to induce experimental autoimmune uveoretinitis (EAU) and their mRNA expression in the retinal choroidal tissue was examined, only betacellulin among the EGFR ligands was upregulated, which increased on days 14 and 17 after immunization and decreased on day 21 thereafter. When we examined whether gefitinib, an EGFR tyrosine kinase inhibitor, suppressed mouse EAU, we found that EAU was significantly suppressed in the gefitinib-treated group.

Academic Significance and Societal Importance of the Research Achievements

ぶどう膜炎の治療には従来より主としてステロイド薬が用いられ、近年ではさらに免疫抑制薬やtumor necrosis factor (TNF)阻害薬といった免疫系細胞を標的とした治療薬が登場してきた。しかし、それらの薬剤にて十分な効果が得られない症例が多くみられる。本研究では、EGFR介した非免疫系細胞による局所炎症増幅回路に着目し、EGFRがぶどう膜炎の病態に関与していること、EGFRの阻害によりぶどう膜炎が抑制される可能性を示した。非免疫系細胞を標的とする治療が実現されれば、これまでの治療とは異なる分子標的治療が誕生する可能性がある。

Report

(5 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (65 results)

All 2022 2021 2020 2019 2018

All Journal Article (29 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 28 results,  Open Access: 14 results) Presentation (36 results) (of which Int'l Joint Research: 6 results,  Invited: 11 results)

  • [Journal Article] Clinical features of ocular sarcoidosis: severe, refractory, and prolonged inflammation2022

    • Author(s)
      Suzuki Kayo、Ishihara Mami、Namba Kenichi、Ohno Shigeaki、Goto Hiroshi、Takase Hiroshi、Kawano Shigeru、Shibuya Etsuko、Hase Keitaro、Iwata Daiju、Mizuuchi Kazuomi、Kitaichi Nobuyoshi、 Mizuki Nobuhisa、Ishida Susumu
    • Journal Title

      Japanese Journal of Ophthalmology

      Volume: 66 Issue: 5 Pages: 447-454

    • DOI

      10.1007/s10384-022-00927-y

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diagnostic Accuracy of Cell Block Preparations and Clinical Features Affecting It in Vitreoretinal Lymphoma.2022

    • Author(s)
      Kase S, Namba K, Iwata D, Mizuuchi K, Suzuki K, Ito T, Hase K, Kitaichi N, Ishida S.
    • Journal Title

      J Clin Med

      Volume: 11 Issue: 5 Pages: 1391-1391

    • DOI

      10.3390/jcm11051391

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinical significance of serum and vitreous soluble interleukin-2 receptor in patients with intraocular lymphoma2022

    • Author(s)
      Suzuki K, Namba K, Kase S, Ogino Y, Hase K, Iwata D, Mizuuchi K, Hiraoka M, Kitaichi N, Ishida S.
    • Journal Title

      BMC Ophthalmol.

      Volume: 22 Issue: 1 Pages: 428-428

    • DOI

      10.1186/s12886-022-02677-4

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Steroid-Sparing Effect of Adalimumab in the Treatment for the Recurrent Phase of Vogt-Koyanagi-Harada Disease.2022

    • Author(s)
      Shinagawa M, Namba K, Mizuuchi K, Iwata D, Hase K, Suzuki K, Hirooka K, Kitaichi N, Hiraoka M, Ishida S
    • Journal Title

      Ocul Immunol Inflamm

      Volume: ahead of print Issue: 3 Pages: 1-5

    • DOI

      10.1080/09273948.2022.2037657

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Long-Term Safety and Effectiveness of Adalimumab in Japanese Patients with Noninfectious Intermediate, Posterior, or Panuveitis: Post-Marketing Surveillance of 251 Patients2022

    • Author(s)
      Kenichi Namba, Toshikatsu Kaburaki, Hidekazu Tsuruga, Yohei Ogawa, Eri Iwashita, Hiroshi Goto
    • Journal Title

      Ophthalmology Therapy

      Volume: 11 Issue: 3 Pages: 1147-1161

    • DOI

      10.1007/s40123-022-00493-z

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A case of Epstein-Barr virus acute retinal necrosis successfully treated with foscarnet.2022

    • Author(s)
      Suzuki K, Namba K, Hase K, Mizuuchi K, Iwata D, Ito T, Kitaichi N, Takase H, Ishida S.
    • Journal Title

      Am J Ophthalmol Case Rep

      Volume: 25 Pages: 101363-101363

    • DOI

      10.1016/j.ajoc.2022.101363

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Posterior scleritis with anti-neutrophil cytoplasmic antibody-associated vasculitis utilizing rituximab therapy to maintain remission: A case report2022

    • Author(s)
      Weng Xinyu、Iwata Daiju、Namba Kenichi、Suzuki Kayo、Mizuuchi Kazuomi、Nakamura Hiroyuki、Atsumi Tatsuya、Ishida Susumu
    • Journal Title

      American Journal of Ophthalmology Case Reports

      Volume: 25 Pages: 101333-101333

    • DOI

      10.1016/j.ajoc.2022.101333

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Multicenter, retrospective, observational study for the Treatment Pattern of systemic corticoSTERoids for relapse of non-infectious uveitis accompanying Vogt-Koyanagi-Harada disease or sarcoidosis2022

    • Author(s)
      Namba Kenichi、Takase Hiroshi、Usui Yoshihiko、Nitta Fumihiko、Maruyama Kazuichi、Kusuhara Sentaro、Takeuchi Masaki、Azumi Atsushi、Yanai Ryoji、Kaneko Yutaka、Hasegawa Eiichi、Nakai Kei、Tsuruga Hidekazu、Morita Kazuo、Kaburaki Toshikatsu
    • Journal Title

      Japanese Journal of Ophthalmology

      Volume: 66 Issue: 2 Pages: 130-141

    • DOI

      10.1007/s10384-021-00897-7

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Recent Clinical Features of Intraocular Inflammation in Hokkaido, Japan - Comparison with the Previous Decade -2021

    • Author(s)
      Iwata Daiju、Namba Kenichi、Yamamoto Taku、Mizuuchi Kazuomi、Saito Wataru、Ohno Shigeaki、Kitaichi Nobuyoshi、Ishida Susumu
    • Journal Title

      Ocular Immunology and Inflammation

      Volume: 2020 Issue: 4 Pages: 1-7

    • DOI

      10.1080/09273948.2020.1836565

    • Related Report
      2022 Annual Research Report 2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Validation of systemic parameters for the diagnosis of ocular sarcoidosis.2021

    • Author(s)
      Suzuki K, Namba K, Mizuuchi K, Iwata D, Ito T, Hase K, Kitaichi N, Ishida S.
    • Journal Title

      Jpn J Ophthalmol

      Volume: 65 Issue: 2 Pages: 191-198

    • DOI

      10.1007/s10384-020-00793-6

    • NAID

      40022523133

    • Related Report
      2022 Annual Research Report 2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Macrophage-like iPS-derived Suppressor Cells Reduce Th1-mediated Immune Response to a Retinal Antigen.2021

    • Author(s)
      Hase K, Namba K, Wada H, Tsuji H, Maeda A, Murata T, Otsuka R, Iwata D, Kanda A, Noda K, Kitaichi N, Seino KI, Ishida S.
    • Journal Title

      Curr Eye Res.

      Volume: 46 Issue: 12 Pages: 1908-1916

    • DOI

      10.1080/02713683.2021.1952605

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Prevalence and incidence rates and treatment patterns of non-infectious uveitis in Japan: real-world data using a claims database.2021

    • Author(s)
      Umazume A, Ohguro N, Okada AA, Namba K, Sonoda KH, Tsuruga H, Morita K, Goto H.
    • Journal Title

      Jpn J Ophthalmol

      Volume: 65 Issue: 5 Pages: 657-665

    • DOI

      10.1007/s10384-021-00850-8

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Surgical Outcomes of Trabeculectomy in Uveitic Glaucoma: A Long-Term, Single-Center, Retrospective Case-Control Study2021

    • Author(s)
      Kanaya Rina、Kijima Riki、Shinmei Yasuhiro、Shinkai Akihiro、Ohguchi Takeshi、Namba Kenichi、Chin Shinki、Ishida Susumu
    • Journal Title

      Journal of Ophthalmology

      Volume: 2021 Pages: 1-8

    • DOI

      10.1155/2021/5550776

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Distinguishing Features of Anterior Uveitis Caused by Herpes Simplex Virus, Varicella-Zoster Virus and Cytomegalovirus2021

    • Author(s)
      Terada Yukiko、Kaburaki Toshikatsu、Takase Hiroshi、Goto Hiroshi、Nakano Satoko、Inoue Yoshitsugu、Maruyama Kazuichi、Miyata Kazunori、Namba Kenichi、Sonoda Koh-Hei、Kaneko Yutaka、Numaga Jiro、Fukushima Masaya、Horiguchi Noe、Ide Mitsunao、Ehara Fumie、Miyazaki Dai、Hasegawa Eiichi、Mochizuki Manabu
    • Journal Title

      American Journal of Ophthalmology

      Volume: in press Pages: 191-200

    • DOI

      10.1016/j.ajo.2021.03.020

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Epidemiology of uveitis in Japan: a 2016 retrospective nationwide survey.2021

    • Author(s)
      Sonoda K, Hasegawa E, Namba K, Okada AA, Ohguro N, Goto H, JOIS (Japanese Ocular Inflammation Society) Uveitis Survey Working Group.
    • Journal Title

      Jpn J Ophthalmol.

      Volume: 65 Issue: 2 Pages: 184-190

    • DOI

      10.1007/s10384-020-00809-1

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Alteration of oral flora in Mongolian patients with Behcet's disease: a multicentre study2020

    • Author(s)
      Balt J, Uehara O, Abiko Y, Jamyanjav B, Jav S, Nagasawa T, Horie Y, Mori M, Fujita M, Lennikov A, Ohta T, Hiraoka M, Iwata D, Namba K, Ohno S, Kitaichi N.
    • Journal Title

      Clin Exp Rheumatol

      Volume: 027 Pages: 80-85

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Pseudo-inflammatory manifestations of choroidal lymphoma resembling Vogt-Koyanagi-Harada disease: case report based on multimodal imaging2020

    • Author(s)
      Fukutsu Kanae、Namba Kenichi、Iwata Daiju、Mizuuchi Kazuomi、Kase Satoru、Suzuki Kayo、Shimizu Hiroshi、Shibata Yukiko、Yamawaki Fumihiko、Onozawa Masahiro、Ishida Susumu
    • Journal Title

      BMC Ophthalmology

      Volume: 20 Issue: 1 Pages: 94-94

    • DOI

      10.1186/s12886-020-01353-9

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Intraocular pressure-lowering effects of ripasudil in uveitic glaucoma, exfoliation glaucoma, and steroid-induced glaucoma patients: ROCK-S, a multicentre historical cohort study2020

    • Author(s)
      Futakuchi A, Morimoto T, Ikeda Y, Tanihara H, Inoue T, ROCK-S study group collaborators.
    • Journal Title

      Sci Rep

      Volume: 10 Issue: 1 Pages: 10308-10308

    • DOI

      10.1038/s41598-020-66928-4

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Attenuation of experimental autoimmune uveoretinitis in mice by IKKβ inhibitor IMD-03542020

    • Author(s)
      Liu Y, Kitaichi N, Wu D, Hase K, Satoh M, Iwata D, Namba K, Kanda A, Noda K, Itai A, Iwabuchi K, Ishida S
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 525 Issue: 3 Pages: 589-594

    • DOI

      10.1016/j.bbrc.2020.02.117

    • Related Report
      2020 Research-status Report 2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Genetic control of CCL24, POR, and IL23R contributes to the pathogenesis of sarcoidosis2020

    • Author(s)
      Meguro A, Ishihara M, Petrek M, Yamamoto K, Takeuchi M, Mrazek F, Kolek V, Benicka A, Yamane T, Shibuya E, Yoshino A, Isomoto A, Ota M, Yatsu K, Shijubo N, Nagai S, Yamaguchi E, Yamaguchi T, Namba K,28名省略, Mizuki N
    • Journal Title

      Communications Biology

      Volume: 3 Issue: 1 Pages: 465-465

    • DOI

      10.1038/s42003-020-01185-9

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Multiple evanescent white dot syndrome and panuveitis: a case report2020

    • Author(s)
      Mizuuchi Kazuomi、Saito Wataru、Namba Kenichi、Ishida Susumu
    • Journal Title

      Journal of Ophthalmic Inflammation and Infection

      Volume: 10 Issue: 1 Pages: 26-26

    • DOI

      10.1186/s12348-020-00221-3

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Evaluation of a Multiplex Strip PCR Test for Infectious Uveitis: A Prospective Multicenter Study2020

    • Author(s)
      Nakano Satoko、Tomaru Yasuhiro、Kubota Toshiaki、Takase Hiroshi、Mochizuki Manabu、Shimizu Norio、Sugita Sunao
    • Journal Title

      American Journal of Ophthalmology

      Volume: 213 Pages: 252-259

    • DOI

      10.1016/j.ajo.2019.10.031

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Variants in IL23R-C1orf141 and ADO-ZNF365-EGR2 are associated with susceptibility to Vogt-Koyanagi-Harada disease in Japanese population.2020

    • Author(s)
      Sakono T, Meguro A, Takeuchi M, Yamane T, Teshigawara T, Kitaichi N, Horie Y, Namba K, Ohno S, Nakao K, Sakamoto T, Sakai T, Nakano T, Keino H, Okada AA, Takeda A, Ito T, Mashimo H, Ohguro N, Oono S, Enaida H, Okinami S, Horita N, Ota M, Mizuki N.
    • Journal Title

      PLoS One

      Volume: 15 Issue: 5 Pages: 233464-233464

    • DOI

      10.1371/journal.pone.0233464

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] ぶどう膜炎における生物学的製剤治療. 眼科医の手引き.2020

    • Author(s)
      南場研一
    • Journal Title

      日本の眼科

      Volume: 91 Pages: 188-189

    • Related Report
      2020 Research-status Report
  • [Journal Article] Comparison of clinical characteristics in patients with Vogt-Koyanagi-Harada disease with and without anti-retinal antibodies2019

    • Author(s)
      Hashimoto Yuki、Saito Wataru、Namba Kenichi、Mizuuchi Kazuomi、Iwata Daiju、Noda Kousuke、Kanda Atsuhiro、Ishida Susumu
    • Journal Title

      Graefe's Archive for Clinical and Experimental Ophthalmology

      Volume: 257 Issue: 8 Pages: 1751-1758

    • DOI

      10.1007/s00417-019-04330-1

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Real-world evidence of treatment for relapse of noninfectious uveitis in tertiary centers in Japan2019

    • Author(s)
      Takeuchi Masaru、Kanda Takayuki、Kaburaki Toshikatsu、Tanaka Rie、Namba Kenichi、Kamoi Koju、Maruyama Kazuichi、Shibuya Etsuko、Mizuki Nobuhisa
    • Journal Title

      Medicine

      Volume: 98 Issue: 9 Pages: e14668-e14668

    • DOI

      10.1097/md.0000000000014668

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Immunohistochemical and Immunocytochemical Analyses in Patients with Vitreoretinal Lymphoma2018

    • Author(s)
      Kase Satoru、Namba Kenichi、Kanno-Okada Hiromi、Onozawa Masahiro、Hidaka Daisuke、Iwata Daiju、Mizuuchi Kazuomi、Fukuhara Takako、Fukuhara Junichi、Kitaichi Nobuyoshi、Matsuno Yoshihiro、Ishida Susumu
    • Journal Title

      Ocular Immunology and Inflammation

      Volume: epub ahead of print Issue: 1 Pages: 1-9

    • DOI

      10.1080/09273948.2018.1533984

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Adalimumab in Active and Inactive, Non-Infectious Uveitis: Global Results from the VISUAL I and VISUAL II Trials2018

    • Author(s)
      Goto Hiroshi、Zako Masahiro、Namba Kenichi、Hashida Noriyasu、Kaburaki Toshikatsu、Miyazaki Masanori、Sonoda Koh-Hei、Abe Toshiaki、Mizuki Nobuhisa、Kamoi Koju et. al.
    • Journal Title

      Ocular Immunology and Inflammation

      Volume: 27 Issue: 1 Pages: 40-50

    • DOI

      10.1080/09273948.2018.1491605

    • NAID

      120006643596

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Association Study of ARMC9 Gene Variants with Vogt-Koyanagi-Harada Disease in Japanese Patients2018

    • Author(s)
      Ohno Tomoko、Meguro Akira、Takeuchi Masaki、Yamane Takahiro、Teshigawara Takeshi、Kitaichi Nobuyoshi et al
    • Journal Title

      Ocular Immunology and Inflammation

      Volume: epub ahead of print Issue: 5 Pages: 1-7

    • DOI

      10.1080/09273948.2018.1523438

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Presentation] Diagnosis and Management of Posterior Segment Inflammation2021

    • Author(s)
      Kenichi Namba
    • Organizer
      International Ocular Inflammation Society (IOIS) 2021
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 治療中に逆説的憎悪がみられた結核性ぶどう膜炎の一例2021

    • Author(s)
      荻野 陽、南場研一、岩田大樹、長谷敬太郎、鈴木佳代、北市伸義、平岡美紀、外丸靖浩、秋山也寸史、石田 晋
    • Organizer
      第75回日本臨床眼科学会
    • Related Report
      2021 Research-status Report
  • [Presentation] 眼内リンパ腫における血清と硝子体液中の可溶性インターロイキン2受容体の検討2021

    • Author(s)
      鈴木佳代、南場研一、加瀬 諭、荻野 陽、岩田大樹、水内一臣、平岡美紀、北市伸義、石田 晋
    • Organizer
      フォーサム2021仙台
    • Related Report
      2021 Research-status Report
  • [Presentation] 非感染性ぶどう膜炎患者251例を対象としたアダリムマブの市販後調査報告2021

    • Author(s)
      南場研一、蕪城俊克、鶴我英知、小川洋平、岩下恵理、後藤 浩
    • Organizer
      フォーサム2021仙台
    • Related Report
      2021 Research-status Report
  • [Presentation] 脈絡膜炎の併発が考えられた特発性視神経網膜炎の1例2021

    • Author(s)
      廣岡季里子、南場研一、有塚 舞、清野修平、田川義晃、山下結衣、岩田大樹、石田 晋
    • Organizer
      フォーサム2021仙台
    • Related Report
      2021 Research-status Report
  • [Presentation] 眼底自発蛍光が再発検出・治療選択に有用であった急性後部多発性斑状色素上皮症の1例2021

    • Author(s)
      横井康一、南場研一、岩田大樹、水内一臣、長谷敬太郎、鈴木佳代、廣岡季里子、関根伸子、石田 晋
    • Organizer
      フォーサム2021仙台
    • Related Report
      2021 Research-status Report
  • [Presentation] VKH病及び眼サルコイドーシス再燃時における全身ステロイド薬の使用実態調査2021

    • Author(s)
      南場研一、高瀬 博、臼井嘉彦、新田文彦、丸山和一、楠原仙太郎、竹内正樹、安積 淳、柳井亮二、金子 優、長谷川英一、中井 慶、靏我英和、守田和央、蕪城俊克.
    • Organizer
      第125回日本眼科学会総会
    • Related Report
      2021 Research-status Report
  • [Presentation] ベーチェット病に伴うぶどう膜炎2021

    • Author(s)
      南場研一
    • Organizer
      令和3年度北海道・東北地区のリウマチの治療とケア教育研修会
    • Related Report
      2021 Research-status Report
  • [Presentation] ぶどう膜炎治療戦略・2021 アダリムマブ適応取得5年間の使用経験を中心に2021

    • Author(s)
      南場研一
    • Organizer
      第5回HUMIRA Expert Summit
    • Related Report
      2021 Research-status Report
  • [Presentation] ベーチェット病眼病変の診断と治療 -新ガイドラインより-2021

    • Author(s)
      南場研一
    • Organizer
      ベーチェット病眼病変の診断と治療 -新ガイドラインより-
    • Related Report
      2021 Research-status Report
  • [Presentation] ぶどう膜炎におけるマルチモーダルイメージング2021

    • Author(s)
      南場研一
    • Organizer
      第3回東京オフサルミックセミナー
    • Related Report
      2021 Research-status Report
  • [Presentation] ぶどう膜炎に対する生物学的製剤の使用 実際の使用経験2021

    • Author(s)
      南場研一.
    • Organizer
      第二回沖縄眼炎症疾患セミナー
    • Related Report
      2021 Research-status Report
  • [Presentation] ぶどう膜炎診療におけるフレアメーカーの有用性2021

    • Author(s)
      南場研一.
    • Organizer
      レーザーフレアメーターWebカンファレンス
    • Related Report
      2021 Research-status Report
  • [Presentation] 著明な脈絡膜萎縮に至ったフォークト-小柳-原田病における脈絡膜画像所見2020

    • Author(s)
      荻野 陽、南場研一、岩田大樹、水内一臣、長谷敬太郎、鈴木佳代、石田 晋.
    • Organizer
      第74回日本臨床眼科学会
    • Related Report
      2020 Research-status Report
  • [Presentation] Diagnostic probability of cell block preparations in vitreoretinal lymphoma2019

    • Author(s)
      Kase S, Namba K, Iwata D, Mizuuchi K, Kitaichi N, Ishida S.
    • Organizer
      15th Congress of the International Ocular Inflammation Society (IOIS)
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Usability of blood examinations and imaging examinations in the diagnosis of ocular sarcoidosis2019

    • Author(s)
      Suzuki K, Namba K, Mizuuchi K, Iwata D, Ito T, Ohno S, Kitaichi N, Ishida S.
    • Organizer
      15th Congress of the International Ocular Inflammation Society (IOIS)
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] A case of posterior scleritis with ANCA-associated vasculitis syndrome requiring rituximab therapy2019

    • Author(s)
      Weng XY, Iwata D, Namba K, Suzuki K, Mizuuchi K, Ishida S.
    • Organizer
      15th Congress of the International Ocular Inflammation Society (IOIS)
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Induced pluripotent stem cells- derived suppressor cells ameliorate experimental autoimmune uveoretinitis in mice2019

    • Author(s)
      Hase K, Namba K, Kitaichi N, Iwata D, Tsuji H, Wada H, Seino K, Ishida S.
    • Organizer
      Association for Research in Vision and Ophthalmology (ARVO) Annual Meeting
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Cytopathology of Vitreoretina, Lymphoma: Human Retinal Organoids and Disease Modelling.2019

    • Author(s)
      Namba K.
    • Organizer
      34th Asia-Pacific Academy of Ophthalmology Congress (APAO)
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 間質性腎炎ぶどう膜炎(TINU)症候群32例の臨床像2019

    • Author(s)
      伊東崇子、南場研一、岩田大樹、水内一臣、加瀬 諭、長谷敬太郎、鈴木佳代、北市伸義、大野重昭、石田 晋
    • Organizer
      第73回日本臨床眼科学会
    • Related Report
      2019 Research-status Report
  • [Presentation] 遷延する角結膜炎後に閉瞼固守を伴う眼瞼けいれんを生じた一例2019

    • Author(s)
      金谷莉奈、大口剛司、田川義晃、木嶋理紀、岩田大樹、田川義継、南場研一、石田 晋
    • Organizer
      第73回日本臨床眼科学会
    • Related Report
      2019 Research-status Report
  • [Presentation] Vogt-小柳-原田病再発例に対するアダリムマブ導入療法の検討2019

    • Author(s)
      品川真有子、水内一臣、南場研一、鈴木佳代、長谷敬太郎、伊東崇子、岩田大樹、北市伸義、石田 晋
    • Organizer
      第73回日本臨床眼科学会
    • Related Report
      2019 Research-status Report
  • [Presentation] 症例から学ぼうぶどう膜炎診療のストラテジー2019

    • Author(s)
      竹内 大、南場研一、蕪城俊克、毛塚剛司、水木信久、園田康平
    • Organizer
      第73回日本臨床眼科学会
    • Related Report
      2019 Research-status Report
  • [Presentation] MPO-ANCA陽性ANCA関連血管炎症候群に伴う後部強膜炎の1例2019

    • Author(s)
      翁 欣瑜、岩田大樹、南場研一、鈴木佳代、水内一臣、石田 晋
    • Organizer
      フォーサム2019京都
    • Related Report
      2019 Research-status Report
  • [Presentation] Epstein-Barr ウイルスによる急性網膜壊死の一例2019

    • Author(s)
      鈴木佳代、南場研一、山口瑞穂、水内一臣、岩田大樹、伊東崇子、北市伸義、高瀬 博、石田 晋
    • Organizer
      フォーサム2019京都
    • Related Report
      2019 Research-status Report
  • [Presentation] 視神経乳頭循環動態の経時変化が観察できた原田病に前部虚血性視神経症を合併した1例2019

    • Author(s)
      廣岡季里子、南場研一、山下結衣、水内一臣、岩田大樹、橋本勇希、石田 晋
    • Organizer
      フォーサム2019京都
    • Related Report
      2019 Research-status Report
  • [Presentation] 人工多能性幹細胞由来マクロファージ様免疫抑制細胞を用いたぶどう膜炎モデルの軽症化2019

    • Author(s)
      長谷敬太郎、南場研一、北市伸義、岩田大樹、辻飛雄馬、和田はるか、清野研一郎、石田 晋
    • Organizer
      第123回日本眼科学会総会
    • Related Report
      2019 Research-status Report
  • [Presentation] ぶどう膜炎におけるマルチモーダルイメージング2019

    • Author(s)
      南場研一
    • Organizer
      第8回栃眼医獨協眼科病診連携の会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 小児ぶどう膜炎の診断と治療2019

    • Author(s)
      南場研一
    • Organizer
      第2回 JIA Expert Meeting in Hokkaido
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 眼サルコイドーシスの診断のポイント2019

    • Author(s)
      南場研一
    • Organizer
      KOWA Web Conference
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] ぶどう膜炎におけるマルチモーダルイメージング2019

    • Author(s)
      南場研一
    • Organizer
      瀬戸内眼科コロシアム2019
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] ぶどう膜炎診療における病診連携2019

    • Author(s)
      南場研一
    • Organizer
      第4回日大板橋病院眼科・病診連携の会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] ベーチェット病に伴う網膜ぶどう膜炎の治療方針~北海道大学病院でのレミケードの使用経験~2019

    • Author(s)
      南場研一
    • Organizer
      TNF-inhibitorのBestUseを考える会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 非感染性ぶどう膜炎に対するTNF阻害薬治療の位置づけ2019

    • Author(s)
      南場研一
    • Organizer
      フォーサム2019京都
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 新ベーチェット病診療ガイドラインについて~眼病変を中心に~2019

    • Author(s)
      南場研一
    • Organizer
      フォーサム2019京都
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 非感染性ぶどう膜炎に対する生物学的製剤の使用~実際の使用経験~2019

    • Author(s)
      南場研一
    • Organizer
      第89回九州眼科学会
    • Related Report
      2019 Research-status Report
    • Invited

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Published: 2019-04-18   Modified: 2024-01-30  

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