Multimodal approaches for the recovery of retinal function and morphology in retinal degeneration

• Project/Area Number: 19K09989
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 56060:Ophthalmology-related
• Research Institution: Nagoya University
• Principal Investigator: Terasaki Hiroko 名古屋大学, 未来社会創造機構, 特任教授 (40207478)
• Co-Investigator(Kenkyū-buntansha): 伊藤 逸毅 藤田医科大学, 医学部, 教授 (10313991) ; 上野 真治 名古屋大学, 医学部附属病院, 講師 (80528670)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2021: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 網膜リモデリング / 黄斑円孔 / 強度近視 / 網膜色素変性 / 遺伝性網膜疾患 / 画像診断 / 自己網膜パッチ / 自己網膜移植 / 網膜色素変性症 / ベスト病 / 網膜再生 / 光干渉断層計 / リモデリング / トランスジェニックウサギ / 光干渉断層血管撮影

Outline of Research at the Start

本研究では、網膜色素変性、重症網膜剥離など治療がない、またはあっても重篤な視細胞障害をきたす疾患について、病態解明ならびに新規視機能回復治療を研究する。１.網膜色素変性患者における将来のiPS細胞の移植を見据え、当研究室で開発したトランスジェニック家兎を用い、経年的に変化する神経ネットワークのリモデリングについて各種の組織学的、電気生理学的検討を行う。２．人工網膜治療の成功に不可欠な網膜内層機能と形態の評価法を開発し、的確な人工網膜の治療適応を確立する。３.強度近視に伴う黄斑円孔に対し自己網膜移植を行い、網膜形態、機能さらには血管構築の変化について多面的なアプローチで研究する。

Outline of Final Research Achievements

Transgenic rabbits as the medium-sized animal model of retinitis pigmentosa, which is one of the target of visual regeneration, showed the rod bipolar and horizontal cells still remained in the inner nuclear layer in the histological examination at late stage. In the patients, there were cases in which good visual function was obtained by an autologous retinal patch applied to a large macular hole. The origin of the gained function was analyzed by focal electroretinogram or SS-OCT. From the above studies, it was found that the regaining the original neural retinal function would be possible more than expected.
Genetic and multimodal imaging of hereditary retinal diseases such as retinitis pigmentosa were performed as a nation-wide to analyze genetic and clinical characteristics of these diseases.

Academic Significance and Societal Importance of the Research Achievements

視覚再生の一対象である網膜色素変性の中型動物モデルの残存神経機能は高く、組織学的にも神経細胞は十分に残存している可能性がある。ヒトにおいて自己網膜パッチを移植すると機能が上がる症例があり、詳細な検討では移植前の本来の細胞が、移植片によって、形態機能が回復されたと考えられ、動物、ヒトにおいて本来ある神経網膜の賦活化は想定以上であることがわかり、今後の再生医療に一石を投じたと考える。
網膜色素変性をはじめとする遺伝性網膜疾患をNation-wideで遺伝子検査をしたことやmultimodalなimagingで臨床的特徴を解析したことは、今後の遺伝子治療のベースとして必須の研究であったと考える。

Research Products

• [Journal Article] Efficacy, durability, and safety of intravitreal faricimab up to every 16 weeks for neovascular age-related macular degeneration (TENAYA and LUCERNE): two randomised, double-masked, phase 3, non-inferiority trials (2022)
  • Author(s): Heier JS, Khanani AM, Quezada Ruiz C, Basu K, Ferrone PJ, Brittain C; TENAYA and LUCERNE Investigators
  • Journal Title: The Lancet Volume: 399 Issue: 10326 Pages: 729-740
  • DOI: 10.1016/s0140-6736(22)00010-1
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Regional and sex differences in retinal detachment surgery: Japan-retinal detachment registry report (2021)
  • Author(s): Funatsu Ryoh、Terasaki Hiroto、Sakamoto Taiji、the Japan Retinal Detachment Registry study group
  • Journal Title: Scientific Reports Volume: 11 Issue: 1 Pages: 20611-20611
  • DOI: 10.1038/s41598-021-00186-w
  • Peer Reviewed / Open Access
• [Journal Article] Clinical findings in eyes with BEST1-related retinopathy complicated by choroidal neovascularization (2021)
  • Author(s): Miyagi Mai、Takeuchi Jun、Koyanagi Yoshito、Mizobuchi Kei、Hayashi Takaaki、Ito Yasuki、Terasaki Hiroko、Nishiguchi Koji M.、Ueno Shinji
  • Journal Title: Graefe's Archive for Clinical and Experimental Ophthalmology Volume: 260 Issue: 4 Pages: 1125-1137
  • DOI: 10.1007/s00417-021-05447-y
  • Peer Reviewed
• [Journal Article] Elevated retinal artery vascular resistance determined by novel visualized technique of laser speckle flowgraphy in branch retinal vein occlusion (2021)
  • Author(s): Tomita Ryo、Iwase Takeshi、Fukami Marie、Goto Kensuke、Ra Eimei、Terasaki Hiroko
  • Journal Title: Scientific Reports Volume: 11 Issue: 1 Pages: 20034-20034
  • DOI: 10.1038/s41598-021-99572-7
  • NAID: 120007172086
  • Peer Reviewed / Open Access
• [Journal Article] Alu complementary DNA is enriched in atrophic macular degeneration and triggers retinal pigmented epithelium toxicity via cytosolic innate immunity (2021)
  • Author(s): Fukuda Shinichi、Terasaki Hiroko、Oshika Tetsuro、Bhattarai Deepak、Kim Kyung Bo、Feldman Sanford H.、Aguirre J. Ignacio、Hinton David R.、Kerur Nagaraj、Sadda Srinivas R.、Schumann Gerald G.、Gelfand Bradley D.、Ambati Jayakrishna
  • Journal Title: Science Advances Volume: 7 Issue: 40
  • DOI: 10.1126/sciadv.abj3658
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Changes in pulse waveforms in response to intraocular pressure elevation determined by laser speckle flowgraphy in healthy subjects (2021)
  • Author(s): Iwase Chie、Iwase Takeshi、Tomita Ryo、Akahori Tomohiko、Yamamoto Kentaro、Ra Eimei、Terasaki Hiroko
  • Journal Title: BMC Ophthalmology Volume: 21 Issue: 1 Pages: 303-303
  • DOI: 10.1186/s12886-021-02070-7
  • NAID: 120007172091
  • Peer Reviewed / Open Access
• [Journal Article] Seasonal variation in submacular hemorrhages in retinal macroaneurysms and its disappearance in age-related macular degeneration (2021)
  • Author(s): Kaneko Hiroki、Takashi Noriko、Matsunaga Masaaki、Ito Yasuki、Takeuchi Jun、Terasaki Hiroko、Yatsuya Hiroshi、Nishiguchi Koji M.
  • Journal Title: Graefe's Archive for Clinical and Experimental Ophthalmology Volume: 259 Issue: 12 Pages: 3589-3596
  • DOI: 10.1007/s00417-021-05280-3
  • Peer Reviewed
• [Journal Article] Prevalence of and factors associated with dilated choroidal vessels beneath the retinal pigment epithelium among the Japanese (2021)
  • Author(s): Ito Yasuki、Ito Mari、Iwase Takeshi、Kataoka Keiko、Yamada Kazuhisa、Yasuda Sayuri、Ito Hiroki、Takeuchi Jun、Nakano Yuyako、Fujita Ai、Horiguchi Etsuyo、Taki Yosuke、Yatsuya Hiroshi、Terasaki Hiroko
  • Journal Title: Scientific Reports Volume: 11 Issue: 1 Pages: 11278-11278
  • DOI: 10.1038/s41598-021-90493-z
  • Peer Reviewed / Open Access
• [Journal Article] Prediction of causative genes in inherited retinal disorder from fundus photography and autofluorescence imaging using deep learning techniques. (2021)
  • Author(s): Fujinami-Yokokawa Y, Ninomiya H, Liu X, Yang L, Pontikos N, Yoshitake K, Iwata T, Sato Y, Hashimoto T, Tsunoda K, Miyata H, Fujinami K; Japan Eye Genetics Study (JEGC) Group.
  • Journal Title: Br J Ophthalmol Volume: - Issue: 9 Pages: 1272-1279
  • DOI: 10.1136/bjophthalmol-2020-318544
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Erratum to Association between retinal layer thickness and perfusion status in extramacular areas in diabetic retinopathy. Am J Ophthalmol 2020; 215:25?36 (2021)
  • Author(s): Ito Hirotaka、Ito Yasuki、Kataoka Keiko、Ueno Shinji、Takeuchi Jun、Nakano Yuyako、Fujita Ai、Horiguchi Etsuyo、Kaneko Hiroki、Iwase Takeshi、Terasaki Hiroko
  • Journal Title: American Journal of Ophthalmology Volume: 227 Pages: 287-287
  • DOI: 10.1016/j.ajo.2020.12.017
  • Peer Reviewed
• [Journal Article] Scleral buckling versus pars plana vitrectomy in simple phakic macula-on retinal detachment: a propensity score-matched, registry-based study. (2021)
  • Author(s): Kawano Sumihiro, Imai Takumi. Sakamoto Taiji, Japan-Retinal Detachment Registry Group.
  • Journal Title: British Journal of Ophthalmology Volume: bjophthalmol-2020-318451 Issue: 6 Pages: 2020-318451
  • DOI: 10.1136/bjophthalmol-2020-318451
  • Peer Reviewed
• [Journal Article] Spontaneous closure of macular hole after vitrectomy for myopic retinoschisis with foveal detachment (2021)
  • Author(s): Funahashi Shoko、Ito Yasuki、Kataoka Keiko、Takeuchi Jun、Nakano Yuyako、Fujita Ai、Horiguchi Etsuyo、Taki Yosuke、Terasaki Hiroko
  • Journal Title: RETINAL Cases and Brief Reports Volume: Publish Ahead of Print Issue: 2 Pages: 98-100
  • DOI: 10.1097/icb.0000000000001130
  • Peer Reviewed
• [Journal Article] Investigation of causative factors for unusual shape of macula in eyes with macula-off rhegmatogenous retinal detachment (2021)
  • Author(s): Iwase Takeshi、Tomita Ryo、Ra Eimei、Iwase Chie、Terasaki Hiroko
  • Journal Title: Japanese Journal of Ophthalmology Volume: 65 Issue: 3 Pages: 363-371
  • DOI: 10.1007/s10384-020-00810-8
  • NAID: 40022561964
  • Peer Reviewed / Open Access
• [Journal Article] Four-year outcome of aflibercept administration using a treat-and-extend regimen in eyes with recurrent neovascular age-related macular degeneration (2021)
  • Author(s): Tsunekawa Yuma、Kataoka Keiko、Asai Keiko、Ito Yasuki、Terasaki Hiroko
  • Journal Title: Japanese Journal of Ophthalmology Volume: 65 Issue: 1 Pages: 69-76
  • DOI: 10.1007/s10384-020-00783-8
  • NAID: 210000170204
  • Peer Reviewed
• [Journal Article] Genotype and Long-term Clinical Course of Bietti Crystalline Dystrophy in Korean and Japanese Patients. (2021)
  • Author(s): Murakami Y, Koyanagi Y, Fukushima M, Yoshimura M, Fujiwara K, Akiyama M, Momozawa Y, Ueno S, Terasaki H, Oishi A, Miyata M, Ikeda H, Tsujikawa A, Mizobuchi K, Hayashi T, Fujinami K, Tsunoda K, Park JY, Han J, Kim M, Lee CS, Kim SJ, Park TK, Joo K, Woo SJ, Ikeda Y, Sonoda KH.
  • Journal Title: Ophthalmol Retina Volume: - Issue: 12 Pages: 1269-1279
  • DOI: 10.1016/j.oret.2021.02.009
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Association of changes of retinal vessels diameter with ocular blood flow in eyes with diabetic retinopathy. (2021)
  • Author(s): Ueno Y, Iwase T, Goto K, Tomita R, Ra E, Yamamoto K, Terasaki H.
  • Journal Title: Sci Rep Volume: 11 Issue: 1 Pages: 4653-4653
  • DOI: 10.1038/s41598-021-84067-2
  • NAID: 120007172087
  • Peer Reviewed / Open Access
• [Journal Article] Regional differences in genes and variants causing retinitis pigmentosa in Japan. (2021)
  • Author(s): Koyanagi Y, Akiyama M, Nishiguchi KM, Momozawa Y, Kamatani Y, Takata S, Inai C, Iwasaki Y, Kumano M, Murakami Y, Komori S, Gao D, Kurata K, Hosono K, Ueno S, Hotta Y, Murakami A, Terasaki H, Wada Y, Nakazawa T, Ishibashi T, Ikeda Y, Kubo M, Sonoda KH.
  • Journal Title: Jpn J Ophthalmol Volume: 65 Issue: 3 Pages: 338-343
  • DOI: 10.1007/s10384-021-00824-w
  • NAID: 40022561942
  • Peer Reviewed
• [Journal Article] Three cases of brolucizumab-associated retinal vasculitis treated with systemic and local steroid therapy. (2021)
  • Author(s): Kataoka K, Horiguchi E, Kawano K, Ushida H, Nakano Y, Ito Y, Terasaki H.
  • Journal Title: Jpn J Ophthalmol Volume: 65 Issue: 2 Pages: 199-207
  • DOI: 10.1007/s10384-021-00818-8
  • NAID: 40022522729
  • Peer Reviewed
• [Journal Article] Effect of internal limiting membrane peeling on visual field sensitivity in eyes with epiretinal membrane accompanied by glaucoma with hemifield defect and myopia (2021)
  • Author(s): Kaneko H, Hirata N, Shimizu H, Kataoka K, Nonobe N, Mokuno K, Terasaki H.
  • Journal Title: Jpn J Ophthalmol Volume: 65 Issue: 6 Pages: 380-387
  • DOI: 10.1073/pnas.2022751118
  • NAID: 40022562044
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A hypomorphic variant in EYS detected by genome-wide association study contributes toward retinitis pigmentosa. (2021)
  • Author(s): Nishiguchi KM, Miya F, Mori Y, Fujita K, Akiyama M, Kamatani T, Koyanagi Y, Sato K, Takigawa T, Ueno S, Tsugita M, Kunikata H, Cisarova K, Nishino J, Murakami A, Abe T, Momozawa Y, Terasaki H, Wada Y, Sonoda KH, Rivolta C, Tsunoda T, Tsujikawa M, Ikeda Y, Nakazawa T.
  • Journal Title: Commun Biol Volume: 4 Issue: 1 Pages: 140-140
  • DOI: 10.1038/s42003-021-01662-9
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Correction to: Clinical and genetic characteristics of 14 patients from 13 Japanese families with RPGR-associated retinal disorder: report of eight novel variants. (2020)
  • Author(s): Mawatari G, Fujinami K, Liu X, Yang L, Fujinami-Yokokawa Y, Komori S, Ueno S, Terasaki H, Katagiri S, Hayashi T, Kuniyoshi K, Miyake Y, Tsunoda K, Yoshitake K, Iwata T, Nao-I N; JEGC study group.
  • Journal Title: Human Genome Varriation Volume: 7 Issue: 1 Pages: 1-3
  • DOI: 10.1038/s41439-019-0086-2
  • Peer Reviewed / Open Access
• [Journal Article] Intra- and Postoperative Monitoring of Autologous Neurosensory Retinal Flap Transplantation for Refractory Macular Hole Associated with High Myopia (2020)
  • Author(s): Takeuchi J, Kataoka K, Shimizu H, Tomita R, Kominami T, Ushida H, Kaneko H, Ito Y, Terasaki H.
  • Journal Title: Retina Volume: - Issue: 5 Pages: 921-930
  • DOI: 10.1097/iae.0000000000003000
  • Peer Reviewed / Open Access
• [Journal Article] Caveolin-1 Promotes Cellular Senescence in Exchange for Blocking Subretinal Fibrosis in Age-Related Macular Degeneration (2020)
  • Author(s): Shimizu H, Yamada K, Suzumura A, Kataoka K, Takayama K, Sugimoto M, Terasaki H, Kaneko H
  • Journal Title: Invest Ophthalmol Vis Sci Volume: 61 Issue: 11 Pages: 21-21
  • DOI: 10.1167/iovs.61.11.21
  • Peer Reviewed / Open Access
• [Journal Article] RP2-associated retinal disorder in a Japanese cohort: Report of novel variants and a literature review, identifying a genotype-phenotype association. (2020)
  • Author(s): Fujinami K, Liu X, Ueno S, Mizota A, Shinoda K, Kuniyoshi K, Fujinami-Yokokawa Y, Yang L, Arno G, Pontikos N, Kameya S, Kominami T, Terasaki H, Sakuramoto H, Nakamura N, Kurihara T, Tsubota K, Miyake Y, Yoshiake K, Iwata T, Tsunoda K; Japan Eye Genetics Consortium Study Group.
  • Journal Title: Am J Med Genet C Semin Med Genet. Volume: 184 Issue: 3 Pages: 675-693
  • DOI: 10.1002/ajmg.c.31830
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Relationship between macular curvature and common causative genes of retinitis pigmentosa in Japanese patients. (2020)
  • Author(s): Koyanagi Y, Ueno S, Ito Y, Kominami T, Komori S, Akiyama M, Murakami Y, Ikeda Y, Sonoda KH, Terasaki H.
  • Journal Title: Invest Ophthalmol Vis Sci Volume: 61 Issue: 10 Pages: 6-6
  • DOI: 10.1167/iovs.61.10.6
  • Peer Reviewed / Open Access
• [Journal Article] RDH5-Related Fundus Albipunctatus in a Large Japanese Cohort. (2020)
  • Author(s): Katagiri S, Hayashi T, Nakamura M, Mizobuchi K, Gekka T, Komori S, Ueno S, Terasaki H, Sakuramoto H, Kuniyoshi K, Kusaka S, Nagashima R, Kondo M, Fujinami K, Tsunoda K, Matsuura T, Kondo H, Yoshitake K, Iwata T, Nakano T.
  • Journal Title: Investigative Ophthalmology & Visual Science Volume: 61 Issue: 3 Pages: 53-53
  • DOI: 10.1167/iovs.61.3.53
  • Peer Reviewed / Open Access
• [Journal Article] Association between retinal layer thickness and perfusion status in extramacular areas in diabetic retinopathy. (2020)
  • Author(s): Ito H, Ito Y, Kataoka K, Ueno S, Takeuchi J, Nakano Y, Fujita A, Horiguchi E, Kaneko H, Iwase T, Terasaki H.
  • Journal Title: American Journal of Ophthalmology Volume: S0002-9394 Pages: 30119-7
  • DOI: 10.1016/j.ajo.2020.03.019
  • Peer Reviewed
• [Journal Article] Genetic Spectrum of EYS-associated Retinal Disease in a Large Japanese Cohort: Identification of Disease-associated Variants with Relatively High Allele Frequency. (2020)
  • Author(s): Yang L, Fujinami K, Ueno S, Kuniyoshi K, Hayashi T, Kondo M, Mizota A, Naoi N, Shinoda K, Kameya S, Fujinami-Yokokawa Y, Liu X, Arno G, Pontikos N, Kominami T, Terasaki H, Sakuramoto H, Katagiri S, Mizobuchi K, Nakamura N, Mawatari G, Kurihara T, Tsubota K, Miyake Y, Yoshitake K, Iwata T, Tsunoda K; JEGC study group.
  • Journal Title: Sci Rep. Volume: 10 Issue: 1 Pages: 1-10
  • DOI: 10.1038/s41598-020-62119-3
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Changes in intraocular pressure and aqueous flare in eyes with multiple evanescent white dot syndrome. (2020)
  • Author(s): Ito Y, Ito M, Ueno S, Kataoka K, Takeuchi J, Kominami T, Takayama K, Terasaki H.
  • Journal Title: Japanese Journal of Ophthalmology Volume: 220 Issue: 4 Pages: 378-384
  • DOI: 10.1007/s10384-020-00738-z
  • Peer Reviewed
• [Journal Article] Analysis of macular curvature in normal eyes using swept-source optical coherence tomography. (2020)
  • Author(s): Minami S, Ito Y, Ueno S, Kataoka K, Takeuchi J, Ito H, Nakano Y, Kitagawa M, Leahy C, Straub J, Terasaki H.
  • Journal Title: Japanese Journal of Ophthalmology Volume: 64 Issue: 2 Pages: 180-186
  • DOI: 10.1007/s10384-020-00721-8
• [Journal Article] Characterization of GUCA1A-associated dominant cone/cone-rod dystrophy: low prevalence among Japanese patients with inherited retinal dystrophies. (2019)
  • Author(s): Mizobuchi K, Hayashi T, Katagiri S, Yoshitake K, Fujinami K, Yang L, Kuniyoshi K, Shinoda K, Machida S, Kondo M, Ueno S, Terasaki H, Matsuura T, Tsunoda K, Iwata T, Nakano T.
  • Journal Title: Sci Rep. Volume: 9 Issue: 1 Pages: 1-9
  • DOI: 10.1038/s41598-019-52660-1
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Clinical and genetic characteristics of 14 patients from 13 Japanese families with RPGR-associated retinal disorder: report of eight novel variants. (2019)
  • Author(s): Mawatari G, Fujinami K, Liu X, Yang L, Yokokawa YF, Komori S, Ueno S, Terasaki H, Katagiri S, Hayashi T, Kuniyoshi K, Miyake Y, Tsunoda K, Yoshitake K, Iwata T, Nao-I N; JEGC study group.
  • Journal Title: Human Genome Varriation Volume: 6 Issue: 1 Pages: 34-34
  • DOI: 10.1038/s41439-019-0065-7
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Phenotypical Characteristics of POC1B-Associated Retinopathy in Japanese Cohort: Cone Dystrophy With Normal Funduscopic Appearance (2019)
  • Author(s): Kameya Shuhei、Fujinami Kaoru、Ueno Shinji、Hayashi Takaaki、Kuniyoshi Kazuki、Ideta Ryuichi、Kikuchi Sachiko、Kubota Daiki、Yoshitake Kazutoshi、Katagiri Satoshi、Sakuramoto Hiroyuki、Kominami Taro、Terasaki Hiroko、Yang Lizhu、Fujinami-Yokokawa Yu、Liu Xiao、Arno Gavin、Pontikos Nikolas、
  • Journal Title: Investigative Opthalmology & Visual Science Volume: 60 Issue: 10 Pages: 3432-3432
  • DOI: 10.1167/iovs.19-26650
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Steeper Macular Curvature in Eyes With Non-Highly Myopic Retinitis Pigmentosa. (2019)
  • Author(s): Komori S, Ueno S, Ito Y, Sayo A, Meinert M, Kominami T, Inooka D, Kitagawa M, Nishida K, Takahashi K, Matsui S, Terasaki H.
  • Journal Title: Investigative Ophthalmology & Visual Science Volume: 60 Issue: 8 Pages: 3135-3141
  • DOI: 10.1167/iovs.19-27334
  • Peer Reviewed
• [Journal Article] A frequent variant in the Japanese population determines quasi-Mendelian inheritance of rare retinal ciliopathy. (2019)
  • Author(s): Nikopoulos K, Cisarova K, Quinodoz M, Koskiniemi-Kuendig H, Miyake N, Farinelli P, Rehman AU, Khan MI, Prunotto A, Akiyama M, Kamatani Y, Terao C, Miya F, Ikeda Y, Ueno S, Fuse N, Murakami A, Wada Y, Terasaki H, Sonoda KH, Ishibashi T, Kubo M, Cremers FPM, Kutalik Z, Matsumoto N, Nishiguchi KM, Nakazawa T, Rivolta C.
  • Journal Title: Nature Communications Volume: 10 Issue: 1 Pages: 2884-2884
  • DOI: 10.1038/s41467-019-10746-4
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Genetic characteristics of retinitis pigmentosa in 1204 Japanese patients. (2019)
  • Author(s): Koyanagi Y, Akiyama M, Nishiguchi KM, Momozawa Y, Kamatani Y, Takata S, Inai C, Iwasaki Y, Kumano M, Murakami Y, Omodaka K, Abe T, Komori S, Gao D, Hirakata T, Kurata K, Hosono K, Ueno S, Hotta Y, Murakami A, Terasaki H, Wada Y, Nakazawa T, Ishibashi T, Ikeda Y, Kubo M, Sonoda KH.
  • Journal Title: Jounal of Medical Genetics Volume: 56 Issue: 10 Pages: 662-670
  • DOI: 10.1136/jmedgenet-2018-105691
  • Peer Reviewed
• [Journal Article] Electrically Evoked Potentials Are Reduced Compared to Axon Numbers in Rhodopsin P347L Transgenic Rabbits With Severe Photoreceptor Degeneration. (2019)
  • Author(s): Kominami T, Ueno S, Nishida K, Inooka D, Kominami A, Kondo M, Terasaki H.
  • Journal Title: Investigative Ophthalmology & Visual Science Volume: 60 Issue: 7 Pages: 2543-2550
  • DOI: 10.1167/iovs.19-26972
  • Peer Reviewed / Open Access
• [Journal Article] Course of loss of photoreceptor function and progressive Mueller cell gliosis in rhodopsin P347L transgenic rabbits. (2019)
  • Author(s): Ueno S, Kominami T, Okado S, Inooka D, Kondo M, Terasaki H.
  • Journal Title: Experimental Eye Research Volume: 184 Pages: 192-200
  • DOI: 10.1016/j.exer.2019.04.026
  • Peer Reviewed / Open Access
• [Journal Article] Novel mutations in the RS1 gene in Japanese patients with X-linked congenital retinoschisis (2019)
  • Author(s): Kondo Hiroyuki、Oku Kazuma、Katagiri Satoshi、Hayashi Takaaki、Nakano Tadashi、et al.
  • Journal Title: Human Genome Variation Volume: 6 Issue: 1 Pages: 3-3
  • DOI: 10.1038/s41439-018-0034-6
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Three cases of acute-onset bilateral photophobia (2019)
  • Author(s): Ueno Shinji、Inooka Daiki、Meinert Monika、Ito Yasuki、Tsunoda Kazushige、Fujinami Kaoru、Iwata Takeshi、Ohde Hisao、Terasaki Hiroko
  • Journal Title: Japanese Journal of Ophthalmology Volume: 63 Issue: 2 Pages: 172-180
  • DOI: 10.1007/s10384-018-00649-0
  • Peer Reviewed / Open Access
• [Presentation] Macular surgery: Not for the Faint of Heart Panel discussion. (2022)
  • Author(s): Terasaki H.
  • Organizer: Retina World Congress
  • Int'l Joint Research / Invited
• [Presentation] OCT angiography in the different types of AMD. (2021)
  • Author(s): Terasaki H.
  • Organizer: Asia Pacific Retinal Imaging Society Meeting
  • Int'l Joint Research / Invited
• [Presentation] Keynote Lecture. Challenges in the treatment for severe retinopathy of prematurity. (2021)
  • Author(s): Terasaki H.
  • Organizer: Am Pediatric Retina Course
  • Int'l Joint Research / Invited
• [Presentation] Matsuyama Award Lecture. Challenges in the management for macular vascular disorders. 第2回国際眼循環学会・第37回日本眼循環学会 合同開催 (2021)
  • Author(s): Terasaki H.
  • Organizer: 第2回国際眼循環学会・第37回日本眼循環学会 合同開催
  • Int'l Joint Research / Invited
• [Presentation] Innovation and Controversies in Surgical Retina Is Intraoperative OCT A Necessity for VR Surgery? (2021)
  • Author(s): Terasaki H.
  • Organizer: Asia-Pacific Vitreo-retinal Society Meeting
  • Int'l Joint Research / Invited
• [Presentation] Morphological and Functional Analysis in Eyes Treated with Autologous Retinal Flap Transplantation. (2021)
  • Author(s): Terasaki H.
  • Organizer: Retina World Congress E-live.
  • Int'l Joint Research / Invited
• [Presentation] Morphological and functional analysis in eyes treated with autologous retinal transplant (2020)
  • Author(s): Terasaki H, Takeuchi J, Ueno S, Kataoka K, Tomita R, Kominami S, Okado S Shimizu H
  • Organizer: Club Jules Gonin Meeting
  • Int'l Joint Research / Invited
• [Presentation] Diagnosis of PCV using SS-OCTA (2020)
  • Author(s): Terasaki H.
  • Organizer: Angiogenesis, Exudation, and Degeneration 2020. Miami, USA, 2002.2
  • Int'l Joint Research / Invited
• [Presentation] Three-year outcomes of treat and extend aflibercept treatment for neovascular age-related macular degeneration. (2019)
  • Author(s): Kataoka K, Asai K, Tsunekawa Y, Ito H, Terasaki H.
  • Organizer: ARVO 2019 Annual Meeting. Vancouver, Canada, 2019.4-5
  • Int'l Joint Research
• [Presentation] Investigation of the number of intravitreal injections of the anti-VEGF agent using OCT angiography for macular edema due to retinal vein branch occlusion. (2019)
  • Author(s): Tomita R, Iwase T, Ogasawara Y, Suwa S, Terasaki H.
  • Organizer: ARVO 2019 Annual Meeting. Vancouver, Canada, 2019.4-5
  • Int'l Joint Research
• [Presentation] Clinical findings of paraneoplastic retinopathy with retinal ON bipolar cell dysfunction in Japanese cohort. (2019)
  • Author(s): Okado S, Ueno S, Nakanishi A, Inooka D, Terasaki H.
  • Organizer: ARVO 2019 Annual Meeting. Vancouver, Canada, 2019.4-5
  • Int'l Joint Research
• [Presentation] Distinguishing polypoidal choroidal vasculopathy from typical age-related macular degeneration, type3 neovascularization, and chronic central serous chorioretinopathy using swept source optical coherence tomography angiography. (2019)
  • Author(s): Fujita A, Kataoka K, Nakano Y, Takeuchi J, Ito Y, Terasaki H.
  • Organizer: ARVO 2019 Annual Meeting. Vancouver, Canada, 2019.4-5
  • Int'l Joint Research
• [Presentation] Relationship between abnormalities of retinal structures and vascular structures determined by optical coherence tomography angiography in eyes with branch retinal vein occlusion. (2019)
  • Author(s): Iwase T, Ogasawara Y, Yamamoto K, Ra E, Terasaki H.
  • Organizer: ARVO 2019 Annual Meeting. Vancouver, Canada, 2019.4-5
  • Int'l Joint Research
• [Presentation] Investigation of macular fundus shape in patients with retinitis pigmentosa using curvature maps constructed from optical coherence tomography. (2019)
  • Author(s): Meinert M, Komori S, Ueno S, Terasaki H.
  • Organizer: ARVO 2019 Annual Meeting. Vancouver, Canada, 2019.4-5
  • Int'l Joint Research
• [Presentation] Steeper macula curvature in eyes with non- highly myopic retinitis pigmentosa. (2019)
  • Author(s): Ueno S, Komori S, Ito Y, Meinert M, Terasaki H.
  • Organizer: ARVO 2019 Annual Meeting. Vancouver, Canada, 2019.4-5
  • Int'l Joint Research
• [Presentation] Association between the retinal vessel caliber and the ocular blood flow in diabetic retinopathy. (2019)
  • Author(s): Ueno Y, Iwase T, Tomita R, Goto K, Terasaki H.
  • Organizer: ARVO 2019 Annual Meeting. Vancouver, Canada, 2019.4-5
  • Int'l Joint Research
• [Presentation] Characteristics of outer choroidal vessels in eyes with chronic central serous chorioretinopathy assessed by en face optical coherence tomography. (2019)
  • Author(s): Takeuchi J, Kataoka K, Nakano Y, Fujita A, Ito Y, Terasaki H.
  • Organizer: ARVO 2019 Annual Meeting. Vancouver, Canada, 2019.4-5
  • Int'l Joint Research
• [Presentation] Relationship between the retinal displacement and the thickness change after vitrectomy in MH eyes. (2019)
  • Author(s): Goto K, Iwase T, Akahori T, Terasaki H.
  • Organizer: ARVO 2019 Annual Meeting. Vancouver, Canada, 2019.4-5
  • Int'l Joint Research
• [Presentation] Visualization of cone cells without adaptive optics. (2019)
  • Author(s): Ito Y, Takeuchi J, Kataoka K, Terasaki H.
  • Organizer: ARVO 2019 Annual Meeting. Vancouver, Canada, 2019.4-5
  • Int'l Joint Research
• [Presentation] Diagnostic characteristics of polypoidal choroidal vasculopathy evaluated with b-scan images of swept source optical coherence tomography angiography. (2019)
  • Author(s): Kataoka K, Fujita A, Takeuchi J, Horiguchi E, Ito Y, Terasaki H.
  • Organizer: The 121st Annual Meeting of the Korean Ophthalmological Society. Busan, Korea, 2019.4
  • Int'l Joint Research / Invited
• [Presentation] Can we diagnose PCV using SS-OCTA? (2019)
  • Author(s): Terasaki H.
  • Organizer: Asia Pacific Retinal Imaging Society. Seoul, Korea, 2019.7
  • Int'l Joint Research / Invited
• [Presentation] Macular changes after internal limiting membrane peeling and Alport syndrome. (2019)
  • Author(s): Ito Y.
  • Organizer: Asia Pacific Retinal Imaging Society. Seoul, Korea, 2019.7
  • Int'l Joint Research / Invited
• [Presentation] Inner macular displacement toward optic disc in eyes after vitrectomy with internal limiting membrane peeling for epiretinal membrane. (2019)
  • Author(s): Taki Y, Fujita A, Takeuchi J, Ito Y, Terasaki H.
  • Organizer: The 19th EURETINA Congress. Paris, France, 2019.9
  • Int'l Joint Research
• [Presentation] Three-year outcomes of a treat-and-extend regimen with intravitreal aflibercept injections for neovascular age-related macular degeneration. (2019)
  • Author(s): Kataoka K, Asai K, Tsunekawa Y, Ito Y, Terasaki H.
  • Organizer: The 19th EURETINA Congress. Paris, France, 2019.9
  • Int'l Joint Research
• [Presentation] Optical coherence tomography angiography in myopic choroidal neovascularization to predictive anti-vascular endothelial growth factor treatment outcomes. (2019)
  • Author(s): Horiguchi E, Kataoka K, Fujita A, Takeuchi J, Ito Y, Terasaki H.
  • Organizer: The 19th EURETINA Congress. Paris, France, 2019.9
  • Int'l Joint Research
• [Presentation] Microvascular changes in polypoidal choroidal vasculopathy assessed by optical coherence tomography angiography in response to anti-vascular endothelial growth factor. (2019)
  • Author(s): Nakano Y, Kataoka K, Takeuchi J, Ito Y, Terasaki H.
  • Organizer: The 19th EURETINA Congress. Paris, France, 2019.9
  • Int'l Joint Research
• [Presentation] Clinical course of paraneoplastic retinopathy with anti-TRPM1 autoantibody in Japanese cohort. (2019)
  • Author(s): Ueno S, Inooka D, Kominami T, Kondo M, Terasaki H.
  • Organizer: 57th ISCEV. Seoul, Korea, 2019.10
  • Int'l Joint Research
• [Presentation] Electrical evoked potentials are reduced compared to axon numbers in rhodopsin P347L transgenic rabbits with severe photoreceptor degeneration. (2019)
  • Author(s): Kominami T, Ueno S, Nishida K, Inooka D, Kominami A, Kondo M, Terasaki H.
  • Organizer: 57th ISCEV. Seoul, Korea, 2019.10
  • Int'l Joint Research
• [Presentation] Clinical findings in three cases with acute-onset bilateral photophobia. (2019)
  • Author(s): Koyanagi Y, Ueno S, Inooka D, Terasaki H.
  • Organizer: 57th ISCEV. Seoul, Korea, 2019.10
  • Int'l Joint Research
• [Presentation] Autologous retina graft for high myopic macular holes. (2019)
  • Author(s): Terasaki H.
  • Organizer: FLOREtina 2019. Florence, Italy, 2019.6
  • Int'l Joint Research / Invited
• [Presentation] Etiology and current management;Myopic macular schisis and holes-Classification and current management. (2019)
  • Author(s): Terasaki H.
  • Organizer: European Society of Ophthalmology. Nice, France, 2019.6
  • Int'l Joint Research / Invited
• [Presentation] Challenging in diagnosis and treatment for CNV in hereditary retinal diseases. (2019)
  • Author(s): Terasaki H.
  • Organizer: The 19th EURETINA Congress. Paris, France, 2019.9
  • Int'l Joint Research / Invited
• [Presentation] Recovery of photoreceptors after repair of retinal detachment. (2019)
  • Author(s): Terasaki H.
  • Organizer: Academia Ophthalmologia Internationals Inguinal Lecture. San Francisco, USA, 2019.10
  • Int'l Joint Research / Invited
• [Presentation] Mystery cases go non-macular,retinal surgery. (2019)
  • Author(s): Terasaki H.
  • Organizer: The 13th APVRS Congress. Shanghai, China, 2019.11
  • Int'l Joint Research / Invited
• [Book] The Retina Illustrated (2019)
  • Author(s): Kataoka K, Terasaki H
  • Total Pages: 448
  • Publisher: Thieme Medical Publishers
  • ISBN: 9781626238312