Development of new biomarker of Vogt-Koyanagi-Harada disease using microRNA

• Project/Area Number: 19K09999
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 56060:Ophthalmology-related
• Research Institution: Kyorin University
• Principal Investigator: Annabelle A Okada 杏林大学, 医学部, 教授 (50303962)
• Co-Investigator(Kenkyū-buntansha): 渡邊 交世 杏林大学, 医学部, 非常勤講師 (90458901)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2021: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2020: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: ぶどう膜炎 / Vogt-小柳-原田病 / 原田病

Outline of Research at the Start

近年、蛋白質の翻訳に関与しないnon-coding RNAであるmicroRNAが標的mRNAの発現を制御することで細胞の分化・増殖の制御、最近では免疫反応などの微調整因子として機能することが明らかとなってきた。本研究課題ではmicroRNAを用いてVogt-小柳-原田病(以下原田病)における新しいバイオマーカーの確立を目指し、原田病初発患者と他のぶどう膜炎患者、健常人の血液中のmicroRNAの発現を比較し、原田病初発例に特異的なmicroRNAを同定、眼所見、臨床経過との関連を解析することで、診断・予後予測因子としてのmicroRNAの有用性を検証する。

Outline of Final Research Achievements

Vogt-Koyanagi-Harada (VKH) disease is believed to involve an autoimmune mechanism directed against melanocytes, however the molecular mechanism of pathogenesis in VKH disease remains unknown. MicroRNAs (miRNAs) are small noncoding RNA molecules involved in posttranscriptional gene regulation. The present study compared serum miRNA expression profiles between healthy subjects (HS) and patients with acute VKH disease using microarray analysis. Sixteen miRNAs were differentially expressed between 2 groups. Two groups of samples were separately clustered. Principal component analysis also showed the different distribution of miRNAs between HS and VKH disease. Pathway analysis using differentially expressed miRNAs demonstrated cytochrome P 450 and biosynthesis of unsaturated fatty acids. These results suggest that serum miRNA signatures may be feasible biomarker for diagnosis and understanding the pathogenesis of acute VKH disease.

Academic Significance and Societal Importance of the Research Achievements

原田病はメラノサイトに対する全身性自己免疫疾患として知られているが、原田病の発症・病態の分子機序については不明な点が多い。本研究において1) 血清中miRNAは、健常人と急性期原田病では異なる発現パターンを呈していた。2)健常人と比較して原田病患者において発現の上昇、または低下した16種類のmiRNAが同定された。3)pathway解析では酸化ストレスや不飽和脂肪酸の合成に関連するpathwayが抽出された。以上の結果から血清中miRNAが原田病の診断や全身レベルでの病態を理解するうえでの新たなバイオマーカーになりうることが示唆された。

Research Products

• [Journal Article] Summary from Foreign Journals: [Long-term efficacy of early infliximab-induced remission for refractory uveoretinitis associated with Behcet’s disease] (2022)
  • Author(s): 岡田アナベルあやめ、慶野博
  • Journal Title: 日眼会誌 Volume: -
• [Journal Article] Development of a core outcome set for clinical trials in non-infectious posterior segment-involving uveitis. (2021)
  • Author(s): Tallouzi MO, Mathers JM, Moore DJ, Bucknall N, Calvert MJ, Murray PI, Denniston AK, COSUMO Working Group (including Okada AA).
  • Journal Title: Ophthalmology Volume: 128 Issue: 8 Pages: 1209-1221
  • DOI: 10.1016/j.ophtha.2021.01.022
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Development of classification criteria for the uveitides. (2021)
  • Author(s): The Standardization of Uveitis Nomenclature Working Group (including Okada AA).
  • Journal Title: Am J Ophthalmol Volume: 228 Pages: 96-116
  • DOI: 10.1016/j.ajo.2021.03.061
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Classification criteria for cytomegalovirus anterior uveitis. (2021)
  • Author(s): The Standardization of Uveitis Nomenclature Working Group (including Okada AA).
  • Journal Title: Am J Ophthalmol Volume: 228 Pages: 89-95
  • DOI: 10.1016/j.ajo.2021.03.060
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Classification criteria for herpes simplex virus anterior uveitis. (2021)
  • Author(s): The Standardization of Uveitis Nomenclature Working Group (including Okada AA).
  • Journal Title: Am J Ophthalmol Volume: 228 Pages: 231-236
  • DOI: 10.1016/j.ajo.2021.03.053
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Classification criteria for varicella zoster virus anterior uveitis. (2021)
  • Author(s): The Standardization of Uveitis Nomenclature Working Group (including Okada AA).
  • Journal Title: Am J Ophthalmol Volume: 228 Pages: 165-173
  • DOI: 10.1016/j.ajo.2021.03.037
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Classification criteria for Fuchs uveitis syndrome. (2021)
  • Author(s): The Standardization of Uveitis Nomenclature Working Group (including Okada AA).
  • Journal Title: Am J Ophthalmol Volume: 228 Pages: 262-267
  • DOI: 10.1016/j.ajo.2021.03.052
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Classification criteria for juvenile idiopathic arthritis-associated chronic anterior uveitis. (2021)
  • Author(s): The Standardization of Uveitis Nomenclature Working Group (including Okada AA).
  • Journal Title: Am J Ophthalmol Volume: 228 Pages: 192-197
  • DOI: 10.1016/j.ajo.2021.03.055
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Classification criteria for spondyloarthritis/HLA-B27-associated anterior uveitis. (2021)
  • Author(s): The Standardization of Uveitis Nomenclature Working Group (including Okada AA).
  • Journal Title: Am J Ophthalmol Volume: 228 Pages: 117-125
  • DOI: 10.1016/j.ajo.2021.03.049
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Classification criteria for tubulointerstitial nephritis with uveitis syndrome. (2021)
  • Author(s): The Standardization of Uveitis Nomenclature Working Group (including Okada AA).
  • Journal Title: Am J Ophthalmol Volume: 228 Pages: 255-261
  • DOI: 10.1016/j.ajo.2021.03.041
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Classification criteria for multiple sclerosis-associated intermediate uveitis. (2021)
  • Author(s): The Standardization of Uveitis Nomenclature Working Group (including Okada AA).
  • Journal Title: Am J Ophthalmol Volume: 228 Pages: 72-79
  • DOI: 10.1016/j.ajo.2021.03.044
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Classification criteria for pars planitis. (2021)
  • Author(s): The Standardization of Uveitis Nomenclature Working Group (including Okada AA).
  • Journal Title: Am J Ophthalmol Volume: 228 Pages: 268-274
  • DOI: 10.1016/j.ajo.2021.03.045
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Classification criteria for intermediate uveitis, non-pars planitis type. (2021)
  • Author(s): The Standardization of Uveitis Nomenclature Working Group (including Okada AA).
  • Journal Title: Am J Ophthalmol Volume: 228 Pages: 159-164
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Classification criteria for acute retinal necrosis syndrome. (2021)
  • Author(s): The Standardization of Uveitis Nomenclature Working Group (including Okada AA).
  • Journal Title: Am J Ophthalmol Volume: 228 Pages: 237-244
  • DOI: 10.1016/j.ajo.2021.03.054
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Classification criteria for cytomegalovirus retinitis. (2021)
  • Author(s): The Standardization of Uveitis Nomenclature Working Group (including Okada AA).
  • Journal Title: Am J Ophthalmol Volume: 228 Pages: 245-254
  • DOI: 10.1016/j.ajo.2021.03.051
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Classification criteria for syphilitic uveitis. (2021)
  • Author(s): The Standardization of Uveitis Nomenclature Working Group (including Okada AA).
  • Journal Title: Am J Ophthalmol Volume: 228 Pages: 182-191
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Classification criteria for toxoplasmic retinitis. (2021)
  • Author(s): The Standardization of Uveitis Nomenclature Working Group (including Okada AA).
  • Journal Title: Am J Ophthalmol Volume: 228 Pages: 134-141
  • DOI: 10.1016/j.ajo.2021.03.039
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Classification criteria for tubercular uveitis. (2021)
  • Author(s): The Standardization of Uveitis Nomenclature Working Group (including Okada AA).
  • Journal Title: Am J Ophthalmol Volume: 228 Pages: 142-151
  • DOI: 10.1016/j.ajo.2021.03.040
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Classification criteria for acute posterior multifocal placoid pigment epitheliopathy. (2021)
  • Author(s): The Standardization of Uveitis Nomenclature Working Group (including Okada AA).
  • Journal Title: Am J Ophthalmol Volume: 228 Pages: 174-181
  • DOI: 10.1016/j.ajo.2021.03.056
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Classification criteria for birdshot chorioretinitis. (2021)
  • Author(s): The Standardization of Uveitis Nomenclature Working Group (including Okada AA).
  • Journal Title: Am J Ophthalmol Volume: 228 Pages: 65-71
  • DOI: 10.1016/j.ajo.2021.03.059
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Classification criteria for multiple evanescent white dot syndrome. (2021)
  • Author(s): The Standardization of Uveitis Nomenclature Working Group (including Okada AA).
  • Journal Title: Am J Ophthalmol Volume: 228 Pages: 198-204
  • DOI: 10.1016/j.ajo.2021.03.050
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Classification criteria for multifocal choroiditis with panuveitis. (2021)
  • Author(s): The Standardization of Uveitis Nomenclature Working Group (including Okada AA).
  • Journal Title: Am J Ophthalmol Volume: 228 Pages: 152-158
  • DOI: 10.1016/j.ajo.2021.03.043
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Classification criteria for punctate inner choroiditis. (2021)
  • Author(s): The Standardization of Uveitis Nomenclature Working Group (including Okada AA).
  • Journal Title: Am J Ophthalmol Volume: 228 Pages: 275-280
  • DOI: 10.1016/j.ajo.2021.03.046
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Classification criteria for serpiginous choroiditis. (2021)
  • Author(s): The Standardization of Uveitis Nomenclature Working Group (including Okada AA).
  • Journal Title: Am J Ophthalmol Volume: 228 Pages: 126-133
  • DOI: 10.1016/j.ajo.2021.03.038
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Classification criteria for Behcet disease uveitis. (2021)
  • Author(s): The Standardization of Uveitis Nomenclature Working Group (including Okada AA).
  • Journal Title: Am J Ophthalmol Volume: 228 Pages: 80-88
  • DOI: 10.1016/j.ajo.2021.03.058
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Classification criteria for sarcoidosis-associated uveitis. (2021)
  • Author(s): The Standardization of Uveitis Nomenclature Working Group (including Okada AA).
  • Journal Title: Am J Ophthalmol Volume: 228 Pages: 220-230
  • DOI: 10.1016/j.ajo.2021.03.047
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Classification criteria for sympathetic ophthalmia. (2021)
  • Author(s): The Standardization of Uveitis Nomenclature Working Group (including Okada AA).
  • Journal Title: Am J Ophthalmol Volume: 228 Pages: 212-21
  • DOI: 10.1016/j.ajo.2021.03.048
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Prevalence and incidence rates and treatment patterns of non-infectious uveitis in Japan: real-world data using a claims database. (2021)
  • Author(s): Umazume A, Ohguro N, Okada AA, Namba K, Sonoda KH, Tsuruga H, Morita K, Goto H.
  • Journal Title: Jpn J Ophthalmol Volume: 65 Issue: 5 Pages: 657-665
  • DOI: 10.1007/s10384-021-00850-8
  • Peer Reviewed
• [Journal Article] Relationship between retinal fluid and visual acuity in patients with exudative age-related macular degeneration treated with intravitreal aflibercept using a treat-and-extend regimen: subgroup and post-hoc analyses from the ALTAIR study. (2021)
  • Author(s): Ohji M, Okada AA, Sasaki K, Moon SC, Machewitz T, Takahashi K, ALTAIR Investigators.
  • Journal Title: Graefes Arch Clin Exp Ophthalmol Volume: 259 Issue: 12 Pages: 3637-3647
  • DOI: 10.1007/s00417-021-05293-y
  • NAID: 120007127571
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Recommendations for the management of ocular sarcoidosis from the International Workshop on Ocular Sarcoidosis. (2021)
  • Author(s): Takase H, Acharya NR, Babu K, Bodaghi B, Khairallah M, McCluskey PJ, Tesavibul N, Thorne JE, Tugal-Tutkun I, Yamamoto JH, Rao NA, 7th IWOS Study Group (including Okada AA), Smith JR, Mochizuki M.
  • Journal Title: Br J Ophthalmol Volume: 105 Issue: 11 Pages: 1515-1519
  • DOI: 10.1136/bjophthalmol-2020-317354
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Reply to Comment on: “Classification criteria for Behcet disease uveitis.” (2021)
  • Author(s): Okada AA, Palestine A, Kramer M, Jabs DA, Standardization of Uveitis Nomenclature (SUN) Working Group.
  • Journal Title: Am J Ophthalmol Volume: 235 Pages: 339-340
  • DOI: 10.1016/j.ajo.2021.10.020
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Classification criteria for Vogt-Koyanagi-Harada disease. (2021)
  • Author(s): The Standardization of Uveitis Nomenclature Working Group (including Okada AA).
  • Journal Title: Am J Ophthalmol Volume: 228 Pages: 205-211
  • DOI: 10.1016/j.ajo.2021.03.036
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] COVID-19 IMT Study Group. Evolving consensus for immunomodulatory therapy in non-infectious uveitis during the COVID-19 pandemic (2021)
  • Author(s): Agrawal R, Testi I. Lee CS. Tsui E, Blazes M, Thorne JE, Okada AA, Smith JR, McCluskey PJ, Kempen JH, Tappeiner C, Agarwal M, Bodaghi B, Nguyen QD, Gupta V, De Smet MD, Zierhut M, Pavesio C
  • Journal Title: Br J Ophthalmol. Volume: 105 Issue: 5 Pages: 639-647
  • DOI: 10.1136/bjophthalmol-2020-316776
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Collaborative Ocular Tuberculosis Study consensus guidelines on the management of tubercular uveitis- Report 2: Guidelines for initiating antitubercular therapy in anterior uveitis, intermediate uveitis, panuveitis, and retinal vasculitis. (2021)
  • Author(s): Agrawal R, Testi I, Bodaghi B, Barisani-Asenbauer T, McCluskey P, Agarwal A, Kempen JH, Gupta A, Smith JR de Smet MD, Yuen YS, Mahajan S, Kon OM, Nguyen QD, Pavesio C, Gupta V; Collaborative Ocular Tuberculosis Study Consensus Group (including Okada AA).
  • Journal Title: Ophthalmology Volume: 128 Issue: 2 Pages: 277-287
  • DOI: 10.1016/j.ophtha.2020.06.052
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Management of retinal pigment epithelium tear during anti-vascular endothelial growth factor therapy. (2021)
  • Author(s): Mitchell P, Rodriguez FJ, Joussen AM, Koh A, Eter N, Wong DT, Korobelnik JF, Okada AA.
  • Journal Title: Retina Volume: 41 Issue: 4 Pages: 671-678
  • DOI: 10.1097/iae.0000000000003083
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Epidemiology of uveitis in Japan: a 2016 retrospective nationwide survey. (2021)
  • Author(s): Sonoda K, Hasegawa E, Namba K, Okada AA, Ohguro N, Goto H, JOIS (Japanese Ocular Inflammation Society) Uveitis Survey Working Group.
  • Journal Title: Jpn J Ophthalmol. Volume: 65 Issue: 2 Pages: 184-190
  • DOI: 10.1007/s10384-020-00809-1
  • Peer Reviewed
• [Journal Article] Anti-VEGF intravitreal injections in the era of COVID-19: responding to different levels of epidemic pressure. (2021)
  • Author(s): Korobelnik JF, Loewenstein A, Eldem B, Joussen AM, Koh A, Lambrou GN, Lanzetta P, Li X, Lovestam-Adrian M, Navarro R, Okada AA, Pearce I, Rodriguez FJ, Wong DT, Wu L.
  • Journal Title: Graefes Arch Clin Exp Ophthalmol. Volume: 259 Issue: 3 Pages: 567-574
  • DOI: 10.1007/s00417-021-05097-0
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Guidance for anti-VEGF intravitreal injections during the COVID-19 pandemic. (2020)
  • Author(s): Korobelnik JF, Loewenstein A, Eldem B, Joussen AM, Koh A, Lambrou GN, Lanzetta P, Li X, Lovestam-Adrian M, Navarro R, Okada AA, Pearce I, Rodriguez FJ, Wong DT, Wu L.
  • Journal Title: Graefes Arch Clin Exp Ophthalmol. Volume: 258 Issue: 6 Pages: 1149-1156
  • DOI: 10.1007/s00417-020-04703-x
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Variants in IL23R-C1orf141 and ADO-ZNF365-EGR2 are associated with susceptibility to Vogt-Koyanagi-Harada disease in Japanese population. (2020)
  • Author(s): Sakono T, Meguro A, Takeuchi M, Yamane T, Teshigawara T, Kitaichi N, Horie Y, Namba K, Ohno S, Nakao K, Sakamoto T, Sakai T, Nakano T, Keino H, Okada AA, Takeda A, Ito T, Mashimo H, Ohguro N, Oono S, Enaida H, Okinami S, Horita N, Ota M, Mizuki N.
  • Journal Title: PLoS One Volume: 15 Issue: 5 Pages: 233464-233464
  • DOI: 10.1371/journal.pone.0233464
  • Peer Reviewed / Open Access
• [Journal Article] Anti-inflammatory effect of dehydroxymethylepoxyquinomicin, a nuclear factor-kB inhibitor, on endotoxin-induced uveitis in rats in vivo and in vitro (2020)
  • Author(s): Ando Y, Keino H, Kudo A, Hirakata A, Okada AA, Umezawa K
  • Journal Title: Ocul Immunol Inflamm Volume: 28 Issue: 1 Pages: 240-248
  • DOI: 10.3892/mmr.2020.11115
  • Peer Reviewed
• [Journal Article] Macular atrophy after aflibercept therapy for neovascular age-related macular degeneration: outcomes of Japanese multicenter study. (2020)
  • Author(s): Koizumi H, Yamamoto A, Ogasawara M, Maruko I, Hasegawa T, Itagaki K, Sekiryu T, Okada AA, Iida T.
  • Journal Title: Jpn J Ophthalmol. Volume: 64 Issue: 4 Pages: 338-345
  • DOI: 10.1007/s10384-020-00745-0
  • Peer Reviewed
• [Journal Article] Effect of in vivo expansion of regulatory T cells with IL-2/anti-IL-2 antibody complex plus rapamycin on experimental autoimmune uveoretinitis. (2020)
  • Author(s): SatoY, Keino H, Nakayama M, Kano M, Okada AA.
  • Journal Title: Ocul Immunol Inflamm. Volume: - Issue: 7-8 Pages: 1520-1529
  • DOI: 10.1080/09273948.2020.1757119
  • Peer Reviewed
• [Journal Article] with COVID時代の眼科診療 (2020)
  • Author(s): 岡田アナベルあやめ
  • Journal Title: 日本の眼科 Volume: 91 Pages: 44-45
  • Peer Reviewed
• [Journal Article] Long-term efficacy of early infliximab-induced remission for refractory uveoretinitis associated with Behcet’s disease. (2020)
  • Author(s): Keino H, Watanabe T, Nakayama M, Komagata Y, Fukuoka K, Okada AA.
  • Journal Title: Br J Ophthalmol Volume: - Issue: 11 Pages: 1525-1533
  • DOI: 10.1136/bjophthalmol-2020-316892
  • Peer Reviewed
• [Journal Article] Pachychoroid: current concepts on clinical features and pathogenesis. (2020)
  • Author(s): Castro-Navarro V, Behar-Cohen F, Chang W, Joussen AM, Lai TYY, Navarro R, Pearce I, Yanagi Y, Okada AA.
  • Journal Title: Graefes Arch Clin Exp Ophthalmol. Volume: - Issue: 6 Pages: 1385-1400
  • DOI: 10.1007/s00417-020-04940-0
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Clinical Characteristics, Management, and Factors Associated with Poor Visual Prognosis of Acute Retinal Necrosis (2020)
  • Author(s): Takase Hiroshi、Goto Hiroshi、Namba Kenichi、Mizuki Nobuhisa、Okada Annabelle A、Ohguro Nobuyuki、Sonoda Koh-Hei、Tomita Makoto、Keino Hiroshi、Kezuka Takeshi、Kubono Reo、Mizuuchi Kazuomi、Shibuya Etsuko、Takahashi Hiroyuki、Yanai Ryoji、Mochizuki Manabu
  • Journal Title: Ocular Immunology and Inflammation Volume: - Issue: 1 Pages: 1-6
  • DOI: 10.1080/09273948.2020.1789179
  • Peer Reviewed / Open Access
• [Journal Article] Japan AMD Research Consortium. Brolucizumab-related intraocular inflammation in Japanese patients with age-related macular degeneration: A short-term multicenter study. (2020)
  • Author(s): Maruko I, Okada AA, Iida T, Hasegawa T, Izumi T, Kawai M, Maruko R, Nakayama M, Yamamoto A, Koizumi H, Tamashiro T, Terao N, Wakugawa S, Mori R, Onoe H, Tanaka K, Wakatsuki Y, Itagaki K, Kasai A, Ogasawara M, Sekiryu T, Shintake H, Sugano Y
  • Journal Title: Graefes Arch Clin Exp Ophthalmol. Volume: - Issue: 9 Pages: 0-0
  • DOI: 10.1007/s00417-021-05136-w
  • Peer Reviewed / Open Access
• [Journal Article] Clinical features, treatment, and visual outcomes of Japanese patients with posterior scleritis (2020)
  • Author(s): Ando Y, Keino H, Nakayama M, Watanabe T, Okada AA
  • Journal Title: Ocul Immunol Inflamm Volume: 28 Issue: 2 Pages: 209-216
  • DOI: 10.1080/09273948.2019.1574838
  • Peer Reviewed
• [Journal Article] Epidemiology of macular edema in uveitis (2019)
  • Author(s): Accorinti M, Okada AA, Smith JR, Gilardi M
  • Journal Title: Ocul Immunol Inflamm Volume: 27 Issue: 2 Pages: 169-180
  • DOI: 10.1080/09273948.2019.1576910
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] ぶどう膜炎診療ガイドライン (2019)
  • Author(s): 大野重昭、岡田アナベルあやめ、後藤浩、南場研一、北市伸義
  • Journal Title: 日本眼科学会雑誌 Volume: 123 Pages: 635-696
  • Peer Reviewed
• [Journal Article] Association Study of ARMC9 Gene Variants with Vogt-Koyanagi-Harada Disease in Japanese Patients (2018)
  • Author(s): Ohno Tomoko、Meguro Akira、Takeuchi Masaki、Yamane Takahiro、Teshigawara Takeshi、Kitaichi Nobuyoshi et al
  • Journal Title: Ocular Immunology and Inflammation Volume: epub ahead of print Issue: 5 Pages: 1-7
  • DOI: 10.1080/09273948.2018.1523438
  • Peer Reviewed
• [Presentation] Differential diagnosis of posterior uveitis: retinal vasculitis, white dots and serous retinal detachment” International Uveitis Study Group, Basic Uveitis Course Webinar 4, organized by Uveitis Webinar (2021)
  • Author(s): Okada AA
  • Organizer: International Uveitis Study Group, Basic Uveitis Course Webinar 4, organized by Uveitis Webinar
• [Presentation] 杏林アイセンターにおける特発性ぶどう膜炎患者の臨床像． (2021)
  • Author(s): 林勇海，慶野博，中山真紀子，安藤良将，渡邊交世，岡田アナベルあやめ
  • Organizer: 第125回日本眼科学会総会
• [Presentation] ベーチェット病眼病変診療ガイドラインの策定． (2021)
  • Author(s): 竹内正樹，河越龍方，澁谷悦子，山根敬浩，石原麻美，岩田大樹，鴨居功樹，慶野博，毛塚剛司，酒井勉，大黒伸行，岡田アナベルあやめ，川島秀俊，園田康平，髙瀨博，北市伸義，南場研一，蕪城俊克，竹内大，大野重昭，後藤浩，水木信久
  • Organizer: 第125回日本眼科学会総会
• [Presentation] 滲出型加齢黄斑変性に対する brolucizumab 硝子体内注射切替え症例の短期経過． (2021)
  • Author(s): 丸子一朗，田中公二，坂垣可奈子，山本亜希子，玉城環，中山真紀子，湧川空子，寺尾信宏，若月優，小野江元，小笠原雅，菅野幸紀，笠井暁仁，新竹広晃，和泉雅彦，河合萌子，丸子留佳，長谷川泰司，森隆三郎，古泉英貴，石龍鉄樹，岡田アナベルあやめ，飯田知弘
  • Organizer: 第125回日本眼科学会総会
• [Presentation] 治療歴のない滲出型加齢黄斑変性に対する brolucizumab 硝子体内注射の短期成績 (2021)
  • Author(s): 田中公二，丸子一朗，坂垣可奈子，山本亜希子，中山真紀子，玉城環，湧川空子，寺尾信宏，若月優，小野江元，小笠原雅，菅野幸紀，笠井暁仁，新竹広晃，和泉雅彦，河合萌子，丸子留佳，長谷川泰司，森隆三郎，古泉英貴，石龍鉄樹，岡田アナベルあやめ，飯田知弘
  • Organizer: 第125回日本眼科学会総会
• [Presentation] 当院における梅毒性ぶどう膜炎治療の近況報告． (2021)
  • Author(s): 大岩未来、中山真紀子、慶野博、林勇海、島崎鉄兵、倉井大輔、岡田アナベルあやめ．
  • Organizer: 第11回東京多摩眼科連携セミナー
• [Presentation] 当院における近視性脈絡膜新生血管に対する治療成績． (2021)
  • Author(s): 鎌田紗知衣，中山真紀子，篠原大佑，片岡恵子，山本亜希子，岡田アナベルあやめ
  • Organizer: 第3回日本近視学会
• [Presentation] ぶどう膜炎のイメージング． (2021)
  • Author(s): 岡田アナベルあやめ
  • Organizer: 第34回千葉臨床眼科フォーラム
  • Invited
• [Presentation] Management of intraocular pressure elevation in patients with retinal diseases receiving intravitreal injections of anti-vascular endothelial growth factor. (2021)
  • Author(s): Mekjavic PJ, Acon D, Loewenstein A, Lai TYY, D’Amore PA, Daien V, Okada AA.
  • Organizer: Euretina 2021 Virtual Meeting
  • Int'l Joint Research
• [Presentation] brolucizumab 硝子体内注射切替え症例における網膜フルイド． (2021)
  • Author(s): 丸子一朗，田中公二，板垣可奈子，山本亜希子，玉城環，中山真紀子，片岡恵子，湧川空子，寺尾信宏，若月優，小野江元，小笠原雅，菅野幸紀，笠井暁仁，新竹広晃，和泉雅彦，河合萌子，丸子留佳，長谷川泰司，森隆三郎，古泉英貴，石龍鉄樹，岡田アナベルあやめ，飯田知弘
  • Organizer: 第75回日本臨床眼科学会
• [Presentation] Brolucizumab treatment retention in age-related macular degeneration. (2021)
  • Author(s): Maruko I, Tanaka K, Tamashiro T, Itagaki K, Yamamoto A, Izumi T, Kawai M, Maruko R, Hasegawa T, Wakatsuki Y, Onoe H, Wakugawa S, Terao N, Ogasawara M, Sugano Y, Kasai A, Shintake H, Kataoka K, Nakayama M, Mori R, Koizumi H, Sekiryu T, Okada AA, Iida T.
  • Organizer: 第60回網膜硝子体学会
• [Presentation] 治療歴のない滲出型加齢黄斑変性に対する brolucizumab 硝子体内注射の6ヶ月成績． (2021)
  • Author(s): 田中公二，丸子一朗，玉城環，板垣可奈子，中山真紀子，若月優，小野江元，和泉雅彦，河合萌子，丸子留佳，長谷川泰司，湧川空子，寺尾信宏，小笠原雅，菅野幸紀，笠井暁仁，新竹広晃，山本亜希子，片岡恵子，森隆三郎，古泉英貴，石龍鉄樹，岡田アナベルあやめ，飯田知弘
  • Organizer: 第60回網膜硝子体学会
• [Presentation] MEWDS の日本人患者の特徴(1) : 患者背景、症状および季節性について． (2021)
  • Author(s): 近藤峰生，齋藤航，石田晋，國吉一樹，上野真治，林孝彰，中野匡，早川卓浩，角田和繁，慶野博，岡田アナベルあやめ，中村考介，秋山英雄
  • Organizer: 第60回網膜硝子体学会
• [Presentation] Clinical features of unclassified uveitis at the Kyorin Eye Center in Tokyo. (2021)
  • Author(s): Hayashi I, Keino H, Nakayama M, Ando Y, Watanabe T, Okada AA.
  • Organizer: IOIS 2021 Meeting.
  • Int'l Joint Research
• [Presentation] Circulating microRNA alterations in serum during the development of experimental autoimmune uveoretinitis. (2021)
  • Author(s): Saito S, Keino H, Takasaki I, Watanabe T, Okada AA.
  • Organizer: IOIS 2021 Meeting.
  • Int'l Joint Research
• [Presentation] “Risk factors of elevated intraocular pressure in uveitis” (2021)
  • Author(s): Okada AA
  • Organizer: IOIS 2021 Meeting.
  • Int'l Joint Research / Invited
• [Presentation] “Update on the SUN Classification of Uveitis” (2021)
  • Author(s): Okada AA
  • Organizer: The 14th Asia-Pacific Vitreo-retina Society Congress
  • Int'l Joint Research / Invited
• [Presentation] 滲出型加齢黄斑変性に対するブロルシズマブ治療後の脈絡膜厚短期変化． (2021)
  • Author(s): 玉城環，田中公二，板垣可奈子，中山真紀子，丸子一朗，湧川空子，寺尾信宏，森隆三郎，石龍鉄樹，岡田アナベルあやめ，飯田知弘，古泉英貴
  • Organizer: 第37回日本眼循環学会
• [Presentation] ALTAIR Study: baseline features affecting week 16 fluid status in nAMD patients (2020)
  • Author(s): 永井由巳，髙橋寛二，大路正人，岡田アナベルあやめ，小林正人，松田淑美，寺野泰弘
  • Organizer: 第124回日本眼科学会総会
• [Presentation] 両眼強度近視患者に発症した交感性眼炎の一例 (2020)
  • Author(s): 林勇海，慶野博，岡田アナベルあやめ
  • Organizer: 第124回日本眼科学会総会
• [Presentation] 2016年度ぶどう膜炎全国疫学調査の結果報告 (2020)
  • Author(s): 長谷川英一，園田康平，南場研一，岡田アナベルあやめ，大黒伸行，後藤浩
  • Organizer: 第124回日本眼科学会総会
• [Presentation] Comparison of treat-and-extend (T&E) dosing regimens and visual outomes in the ARIES and ALTAIR studies of intravitreal aflibercept in neovascular age-related macular degeneration (nAMD)． (2020)
  • Author(s): Mitchell P, Holz FG, Hykin P, Midena E, Okada AA, Souied E, Takahashi K, Wolf S, Allmeier H, Lambrou G, Schmelter T, Ohji M
  • Organizer: ARVO
  • Int'l Joint Research
• [Presentation] Baseline features affecting week 16 fluid status in patients with exudative age-related macular degeneration treated with intravitreal Aflibercept in a Treat-and-Extend Regimen: Post-hoc Analysis of the ALTAIR Study (2020)
  • Author(s): Okada AA, Takahashi K, Matsuda Y, Sasaki K, Moon SC, Ohji M
  • Organizer: EURETINA
  • Int'l Joint Research
• [Presentation] Relationship between retinal fluid and visual outcomes in patients with exudative age-related macular degeneration treated with intravitreal aflibercept using a treat-and-extend regimen: Post-hoc analysis of the ALTAIR Study (2020)
  • Author(s): Ohji M, Okada AA, Sasaki K, Moon SC, Machewitz T, Takahashi K
  • Organizer: EURETINA
  • Int'l Joint Research
• [Presentation] Comparison of treat-and-extend dosing regimens and visual outomes in the ARIES and ALTAIR studies of intravitreal aflibercept in neovascular age-related macular degeneration (2020)
  • Author(s): Mitchell P, Holz FG, Hykin P, Midena E, Okada AA, Souied E, Takahashi K, Wolf S, Allmeier H, Lambrou G, Schmelter T, Ohji M
  • Organizer: EURETINA
  • Int'l Joint Research
• [Presentation] 原田病初発例における中心窩下脈絡膜厚を指標とした臨床像の検討 (2020)
  • Author(s): 中山真紀子，慶野博，渡辺交世，安藤良将，林勇海，阿部慎也,岡田アナベルあやめ
  • Organizer: 第74回日本臨床眼科学会
• [Presentation] Vogt・小柳・原田病における脈絡膜血流の長期経時変化 (2020)
  • Author(s): 阿部慎也，中村友子，奥村詠里香，岡田アナベルあやめ，林篤志
  • Organizer: 第74回日本臨床眼科学会
• [Presentation] アフリベルセプト導入期治療後に滲出が残存する滲出型加齢黄斑変性の特徴 (2020)
  • Author(s): 丸子留佳， 丸子一朗, 古泉英貴, 山本亜希子, 小笠原雅, 板垣可奈子, 岡田アナベルあやめ, 石龍鉄樹, 飯田知弘
  • Organizer: 第74回日本臨床眼科学会
• [Presentation] Masquerading infection: when should you suspect it? (2020)
  • Author(s): Okada AA
  • Organizer: Jakarta Eye Center Saturday Seminar
  • Int'l Joint Research / Invited
• [Presentation] The gap between WHO treatment for extrapulmonary tuberculosis and real-world ocular tuberculosis (2020)
  • Author(s): Okada AA
  • Organizer: Jakarta Eye Center Saturday Seminar
  • Int'l Joint Research / Invited
• [Presentation] Relationship between retinal fluid and BCVA in patients with nAMD treated with IVT-AFL T&E: Post-hoc analysis of the ALTAIR Study (2020)
  • Author(s): Ohji M, Okada AA, Sasaki K, Moon SC, Machewitz T, Takahashi K
  • Organizer: Annual Meeting of the American Academy of Ophthalmology
  • Int'l Joint Research
• [Presentation] Advancing our understanding of retinal fluid: results from aflibercept clinical trials (2020)
  • Author(s): Okada AA
  • Organizer: Webinar “Retina in Practice: translating clinical data to patient outcomes with aflibercept Melbourne, Australia online
  • Int'l Joint Research / Invited
• [Presentation] Decreased optic nerve head blood flow in acute retinal necrosis (2019)
  • Author(s): Keino H, Nakayama M, Watanabe T, Ando Y, Koto T, Hirota K, Inoue M, Okada AA
  • Organizer: ARVO
  • Int'l Joint Research
• [Presentation] WHO recommended treatment for extrapulmonary tuberculosis (2019)
  • Author(s): Okada AA
  • Organizer: The 6th International Workshop on Ocular Tuberculosis, Global Ocular Inflammation Workshops 2019
  • Int'l Joint Research / Invited
• [Presentation] Paradoxical worsening in a case of tuberculous choroiditis (2019)
  • Author(s): Abe S, Nakamura T, Oiwake T, Okada AA, Hayashi A
  • Organizer: Global Ocular Inflammation Workshops 2019, Sapporo, June 28-30, 2019.
  • Int'l Joint Research
• [Presentation] Anti-inflammatory effects of DHMEQ on ARPE-19 cells (2019)
  • Author(s): Ando Y, Keino H, Kudo A, Hirakata A, Okada AA, Umezawa K
  • Organizer: Global Ocular Inflammation Workshops 2019
  • Int'l Joint Research
• [Presentation] 当院における眼サルコイドーシス60例の臨床経過の検討 (2019)
  • Author(s): 長堀克哉，中山真紀子，慶野博，安藤良将，渡辺交世，岡田アナベルあやめ
  • Organizer: 第53回日本眼炎症学会
  • Int'l Joint Research
• [Presentation] 原田病および交感性眼炎に対するアダリムマブ導入例の検討 (2019)
  • Author(s): 中山真紀子，慶野博，渡辺交世，林勇海，岡田アナベルあやめ
  • Organizer: 第73回日本臨床眼科学会
• [Presentation] Long term efficacy of infliximab in refractory uveoretinitis associated with Behcet’s disease. (2019)
  • Author(s): Keino H, Nakayama M, Watanabe T, Ando Y, Hayashi I, Fukuoka K, Komagata Y, Okada AA
  • Organizer: 15th International Ocular Inflammation Society Congress
  • Int'l Joint Research
• [Presentation] Evaluation of the use of adalimumab in the treatment of VKH disease and sympathetic ophthalmia (2019)
  • Author(s): Nakayama M, Abe S, Hayashi I, Keino H, Watanabe T, Ando Y, Okada AA
  • Organizer: 15th International Ocular Inflammation Society Congress
  • Int'l Joint Research
• [Presentation] A case of HLA-B27 positive acute anterior uveitis with periodontitis (2019)
  • Author(s): Ando Y, Keino H, Nakayama M, Watanabe T, Hirakata A, Okada AA
  • Organizer: 15th International Ocular Inflammation Society Congress
  • Int'l Joint Research
• [Presentation] Patterns of Scleritis in Japan, Scleritis Symposium (2019)
  • Author(s): Okada AA
  • Organizer: 15th International Ocular Inflammation Society Congress
  • Int'l Joint Research / Invited
• [Presentation] OCT imaging of the retina and choroid in uveitis and related diseases (2019)
  • Author(s): Okada AA
  • Organizer: 15th International Ocular Inflammation Society Congress
  • Int'l Joint Research / Invited