The role of inhibitory synaptic inputs in the acquisition of feeding

• Project/Area Number: 19K10048
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 57010:Oral biological science-related
• Research Institution: Showa University
• Principal Investigator: Nakamura Shiro 昭和大学, 歯学部, 教授 (60384187)
• Co-Investigator(Kenkyū-buntansha): 井上 富雄 昭和大学, 歯学部, 教授 (70184760) ; 弘中 祥司 昭和大学, 歯学部, 教授 (20333619)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Project Status: Completed (Fiscal Year 2022)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2021: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 抑制性シナプス伝達 / 咀嚼 / 生後発達 / 三叉神経運動ニューロン / 摂食行動 / 顎運動 / 吸啜 / シナプス伝達

Outline of Research at the Start

近年咀嚼機能に問題のある子どもが報告されている。この問題解決には咀嚼を獲得するメカニズムを解明することが重要である。本研究では、①咀嚼の獲得期における抑制性シナプスの形成・成熟パターンを電気生理学的・組織学的に解析する、②抑制性シナプス形成の時期特異的抑制が咀嚼に与える影響を調べる、③抑制性シナプス形成に対する口腔感覚の役割を調べることを目的とし、咀嚼機能の獲得に対する抑制性シナプス形成の役割の解明を目指す。本研究によって咀嚼機能の獲得に関わる神経メカニズムの新たな知見が得られるとともに、神経科学を基盤とした新たな咀嚼訓練法の開発や、摂食に問題のある子どもの対処法の確立に大きく貢献できる。

Outline of Final Research Achievements

In this study, the characteristics of postnatal development of GABAergic and glycinergic currents evoked on the jaw-closing and jaw-opening motoneurons were analyzed to clarify the role of the inhibitory synapse formation in the acquisition of mastication in early postnatal period using patch clamp. The frequency and amplitude of glycinergic miniature inhibitory postsynaptic currents (mIPSCs) increased with postnatal development in both motoneurons; however, they were higher in masseter motoneurons than in digastric motoneurons throughout all age groups. The frequency of GABAergic mIPSCs was also higher in masseter motoneurons than in digastric motoneurons in the early postnatal period. These results indicated that the developmental characteristics of inhibitory synaptic inputs differ between motoneuron populations that perform different functions.

Academic Significance and Societal Importance of the Research Achievements

本研究の遂行により明らかとなった顎筋支配運動ニューロンにおけるGABA性・グリシン性シナプス伝達機構の生後発達様式は、吸啜から咀嚼への運動機能発達に重要な役割を果たしていると考えられる。今回得られた細胞生理学的データは、摂食行動の発達メカニズムの解明に大きく寄与するだけでなく、GABA性・グリシン性シナプス伝達をターゲットとした神経科学基盤型の新たな咀嚼訓練法や摂食に問題のある子どもの対処法の確立につながる波及効果が期待でき、歯科だけでなく小児医学・生涯発達学などの多くの分野に多大なインパクトを与えることができると期待される。

Research Products

• [Journal Article] Involvement of ghrelin in the regulation of swallowing motor activity in an arterially perfused rat preparation (2023)
  • Author(s): Ishiguro Mitsunori、Nakayama Kiyomi、Nakamura Shiro、Mochizuki Ayako、Dantsuji Masanori、Ihara Yoshiaki、Inoue Tomio
  • Journal Title: Brain Research Bulletin Volume: 192 Pages: 62-69
  • DOI: 10.1016/j.brainresbull.2022.11.006
  • Peer Reviewed / Open Access
• [Journal Article] Human induced pluripotent stem cell-derived salivary gland organoids model SARS-CoV-2 infection and replication. (2022)
  • Author(s): Junichi Tanaka, Hidenobu Senpuku, Miho Ogawa, Rika Yasuhara, Shintaro Ohnuma, Koki Takamatsu, Takashi Watanabe, Yo Mabuchi, Shiro Nakamura, Shoko Ishida, Tomohiko Sadaoka, Takashi Takaki, Tatsuo Shirota, Toshikazu Shimane, Tomio Inoue, Takayoshi Sakai, Munemasa Mori, Takashi Tsuji, Ichiro Saito, Kenji Mishima
  • Journal Title: Nat Cell Biol. Volume: 24(11) Issue: 11 Pages: 1595-1605
  • DOI: 10.1038/s41556-022-01007-6
  • Peer Reviewed / Open Access
• [Journal Article] Increased excitability of human iPSC-derived neurons in HTR2A variant-related sleep bruxism (2022)
  • Author(s): Sarkar Avijite Kumer、Nakamura Shiro、Nakai Kento、Sato Taro、Shiga Takahiro、Abe Yuka、Hoashi Yurie、Inoue Tomio、Akamatsu Wado、Baba Kazuyoshi
  • Journal Title: Stem Cell Research Volume: 59 Pages: 102658-102658
  • DOI: 10.1016/j.scr.2022.102658
  • Peer Reviewed / Open Access
• [Journal Article] Developmental changes in GABAergic and glycinergic synaptic transmission to rat motoneurons innervating jaw-closing and jaw-opening muscles (2022)
  • Author(s): Noguchi Tsuyoshi、Nakamura Shiro、Nakayama Kiyomi、Mochizuki Ayako、Dantsuji Masanori、Ihara Yoshiaki、Takahashi Koji、Inoue Tomio
  • Journal Title: Brain Research Volume: 1777 Pages: 147753-147753
  • DOI: 10.1016/j.brainres.2021.147753
  • Peer Reviewed
• [Journal Article] Postnatal Maturation of Glutamatergic Inputs onto Rat Jaw-closing and Jaw-opening Motoneurons (2022)
  • Author(s): Nakamura Shiro、Kajiwara Risa、Noguchi Tsuyoshi、Nakayama Kiyomi、Mochizuki Ayako、Dantsuji Masanori、Sarkar Avijite Kumer、Inoue Tomio
  • Journal Title: Neuroscience Volume: 480 Pages: 42-55
  • DOI: 10.1016/j.neuroscience.2021.11.016
  • Peer Reviewed
• [Journal Article] Intrinsic properties and synaptic connectivity of Phox2b-expressing neurons in rat rostral parvocellular reticular formation (2021)
  • Author(s): Kajiwara Risa、Nakamura Shiro、Ikeda Keiko、Onimaru Hiroshi、Yoshida Atsushi、Tsutsumi Yumi、Nakayama Kiyomi、Mochizuki Ayako、Dantsuji Masanori、Nishimura Akiko、Tachikawa Satoshi、Iijima Takehiko、Inoue Tomio
  • Journal Title: Neuroscience Research Volume: - Pages: 41-51
  • DOI: 10.1016/j.neures.2021.12.009
  • Peer Reviewed / Open Access
• [Journal Article] In vitro monitoring of HTR2A-positive neurons derived from human-induced pluripotent stem cells (2021)
  • Author(s): Nakai Kento、Shiga Takahiro、Yasuhara Rika、Sarkar Avijite Kumer、Abe Yuka、Nakamura Shiro、Hoashi Yurie、Kotani Keisuke、Tatsumoto Shoji、Ishikawa Hiroe、Go Yasuhiro、Inoue Tomio、Mishima Kenji、Akamatsu Wado、Baba Kazuyoshi
  • Journal Title: Scientific Reports Volume: 11 Issue: 1 Pages: 15437-15437
  • DOI: 10.1038/s41598-021-95041-3
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Myricetin prevents high molecular weight Aβ1-42 oligomer-induced neurotoxicity through antioxidant effects in cell membranes and mitochondria (2021)
  • Author(s): Kimura Atsushi Michael、Tsuji Mayumi、Yasumoto Taro、Mori Yukiko、Oguchi Tatsunori、Tsuji Yuya、Umino Masakazu、Umino Asami、Nishikawa Toru、Nakamura Shiro、Inoue Tomio、Kiuchi Yuji、Yamada Masahito、Teplow David B.、Ono Kenjiro
  • Journal Title: Free Radical Biology and Medicine Volume: 171 Pages: 232-244
  • DOI: 10.1016/j.freeradbiomed.2021.05.019
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Responses evoked by electrical stimulation of the brainstem reticular formation in the jaw-opening and hypoglossal motor nerves of an arterially perfused rat preparation (2020)
  • Author(s): Ofuji Takuo、Nakayama Kiyomi、Nakamura Shiro、Mochizuki Ayako、Dantsuji Masanori、Ishiguro Mitsunori、Yamamoto Matsuo、Inoue Tomio
  • Journal Title: Neuroscience Letters Volume: 738 Pages: 135400-135400
  • DOI: 10.1016/j.neulet.2020.135400
  • Peer Reviewed
• [Journal Article] 5-HT2A receptor activation enhances NMDA receptor-mediated glutamate responses therough Src kinase in the dendrites of rat jaw-closing motoneurons. (2019)
  • Author(s): Dantsuji M, Nakamura S, Nakayam, K, Mochizuki A, Park SK, Bae YC, Ozeki M, Inoue T.
  • Journal Title: J. Physiol. Volume: 印刷中 Issue: 9 Pages: 2565-2589
  • DOI: 10.1113/jp275440
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Serotonin1B receptor-mediated presynaptic inhibition of proprioceptive sensory inputs to jaw-closing motoneurons. (2019)
  • Author(s): Nagata A, Nakayama K, Nakamura S, Mochizuki A, Gemba C, Aoki R, Dantsuji M, Maki K, Inoue T.
  • Journal Title: Brain Res Bull. Volume: 149 Pages: 260-267
  • DOI: 10.1016/j.brainresbull.2019.05.001
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] High molecular weight amyloid β1‐42 oligomers induce neurotoxicity via plasma membrane damage (2019)
  • Author(s): Yasumoto Taro、Takamura Yusaku、Tsuji Mayumi、Watanabe‐Nakayama Takahiro、Imamura Keiko、Inoue Haruhisa、Nakamura Shiro、Inoue Tomio、Kimura Atsushi、Yano Satoshi、Nishijo Hisao、Kiuchi Yuji、Teplow David B.、Ono Kenjiro
  • Journal Title: The FASEB Journal Volume: 33 Issue: 8 Pages: 9220-9234
  • DOI: 10.1096/fj.201900604r
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Enhancement of swallowing motor activity by the ACE inhibitor imidapril in an arterially perfused rat preparation. (2019)
  • Author(s): Moriya T, Nakayama K, Nakamura S, Mochizuki A, Ofuji T, Shirota T, Inoue T.
  • Journal Title: Eur J Pharmacol. Volume: 861 Pages: 172601-172601
  • DOI: 10.1016/j.ejphar.2019.172601
  • Peer Reviewed / Int'l Joint Research
• [Presentation] ラット閉口筋および開口筋運動ニューロンにおける抑制性シナプス伝達の生後発達変化 (2022)
  • Author(s): 野口毅，中村史朗，中山希世美，望月文子，壇辻昌典，井上富雄
  • Organizer: 日本顎口腔機能学会第67回学術大会
• [Presentation] Distinct developmental features of excitatory and inhibitory input to motoneurons innervating jaw-closing and jaw-opening muscles (2022)
  • Author(s): Nakamura S, Noguchi T, Kajiwara R, Nakayama K, Mochizuki A, Dantsuji M, Sarkar AK, Inoue T
  • Organizer: 第45回日本神経科学大会
• [Presentation] 三叉神経中脳路核の末梢ニューロンマーカー・イオンチャネル発現 (2022)
  • Author(s): 田上聖章，黄地健仁，木村麻記，倉島竜哉，石井武展，中村史朗，井上富雄，澁川義幸，西井康
  • Organizer: 第64回歯科基礎医学会学術大会
• [Presentation] 根膜固有感覚を支配する三叉神経中脳路核ニューロンの機械感受性の検討 (2022)
  • Author(s): 権洗眞，黄地健仁，木村麻記，中村史朗，井上富雄，澁川義幸，一戸達也
  • Organizer: 第64回歯科基礎医学会学術大会
• [Presentation] 顎運動制御におけるセロトニン神経系の役割 (2022)
  • Author(s): 壇辻昌典，中村史朗，中山希世美，望月文子，井上富雄
  • Organizer: 第64回歯科基礎医学会学術大会
• [Presentation] 生後発達期における閉口筋・開口筋運動ニューロンの興奮性および抑制性シナプス入力 (2022)
  • Author(s): 中村史朗，野口毅，梶原里紗，中山希世美，望月文子，壇辻昌典，井上富雄
  • Organizer: 第64回歯科基礎医学会学術大会
• [Presentation] 転写調節因子Phox2bを発現するニューロンの咀嚼様顎運動リズム形成と唾液分泌制御に対する役割 (2022)
  • Author(s): 井上富雄，中山希世美，中村史朗，梶原里紗，望月文子，壇辻昌典
  • Organizer: 第64回歯科基礎医学会学術大会
• [Presentation] Differential postnatal development of excitatory and inhibitory synaptic inputs to jaw-closing and jaw-opening motoneurons (2022)
  • Author(s): Inoue T, Noguchi T, Kajiwara R, Nakayama K, Mochizuki A, Dantsuji M, Nakamura S
  • Organizer: Society for Neuroscience 52nd annual meeting
  • Int'l Joint Research
• [Presentation] Physiological and morphological characterization of Phox2b-expressing neurons in the rat rostral parvocellular reticular formation (2022)
  • Author(s): Kajiwara R, Nakamura S, Ikeda K, Onimaru H, Yoshida A, Tsutsumi Y, Nakayama K, Mochizuki A, Dantsuji M, Iijima T, Inoue T
  • Organizer: 第99回日本生理学会大会
• [Presentation] 小細胞性網様体尾側領域に存在するPhox2b陽性ニューロンの電気生理学的・形態学的解析 (2021)
  • Author(s): 梶原里紗，中村史朗，池田啓子，鬼丸洋，中山希世美，望月文子，壇辻昌典，西村晶子，立川哲史，飯島毅彦，井上富雄
  • Organizer: 第68回昭和大学学士会総会
• [Presentation] 閉口筋および開口筋運動ニューロンにおける抑制性シナプス伝達の生後変化 (2021)
  • Author(s): 野口毅，中村史朗，中山希世美，望月文子，壇辻昌典，伊原良明，高橋浩二，井上富雄
  • Organizer: 第68回昭和大学学士会総会
• [Presentation] Optogenetic activation of serotonergic neurons in the dorsal raphe nucleus changes masticatory movements in mice (2021)
  • Author(s): Dantsuji M, Mochizuki A, Nakayama K, Nakamura S, Kanamaru M, Izumizaki M, Tanaka KF, Inoue T
  • Organizer: 第44回日本神経科学大会
• [Presentation] Myricetin prevents Aβ oligomer-induced neurotoxicity via cell membrane damage (2020)
  • Author(s): Kimura A, Yasumoto T, Mori Y, Oguchi T, Nakamura S, Inoue T, Yamada M, Teplow D, Ono K, Kiuchi Y, Tsuji M
  • Organizer: Advances in Alzheimer’s and Parkinson’s therapies, an AAT-AD/PDTM focus meeting
  • Int'l Joint Research
• [Presentation] ミリセチンは抗酸化作用を介し、ミトコンドリア・細胞膜でアミロイドβオリゴマーによる神経毒性を抑制する (2020)
  • Author(s): 木村篤史，安本太郎，森友起子，小口達敬，海野真一，海野麻未，宇高結子，中村史朗，井上富雄，辻まゆみ，小野賢二郎，木内祐二
  • Organizer: 第363回昭和大学学士会例会
• [Presentation] Vitamin B12 may prevent Aβ oligomer-induced neurotoxicity in Alzheimer's Disease (2020)
  • Author(s): Kimura AM, Tsuji M, Yasumoto T, Oguchi T, Mori Y, Yano S, Kinnno R, Nakamura S, Inoue T, Teplow DP, Kiuchi Y, Ono K
  • Organizer: Alzheimer's Association International Conference, Amsterdam
  • Int'l Joint Research
• [Presentation] High molecular weight amyloid β1-42 oligomers induce neurotoxicity via plasma membrane damage (2020)
  • Author(s): Yasumoto T, Takamura Y, Tsuji M, Nakayama T, Imamura K, Inoue H, Nakamura S, Inoue T, Kimura AM, Yano S, Nishijo H, Kiuchi Y, Teplow DP, Ono K
  • Organizer: Alzheimer's Association International Conference
  • Int'l Joint Research
• [Presentation] High molecular weight Amyloid b oligomer induces disruption and structural change of cell membrane (2020)
  • Author(s): 安本太郎， 高村雄策， 辻まゆみ， 中山隆宏， 今村恵子， 井上治久， 中村史朗， 井上富雄， 木村篤史， 矢野怜， 西条寿夫， 木内祐二， デービッドテプロフ， 小野賢二郎
  • Organizer: 第61回日本神経学会学術大会
• [Presentation] Responses evoked by electrical stimulation of the brainstem reticular formation in the mylohyoid and hypoglossal motor nerves of an arterially perfused rat preparation (2020)
  • Author(s): Ofuji T, Nakayama K, Nakamura S, Mochizuki A, Dantsuji M, Ishiguro M, Yamamoto M, Inoue T
  • Organizer: 第43回日本神経科学大会
• [Presentation] 高分子Aβオリゴマーは細胞膜完全性を崩壊し細胞毒性を発揮する (2020)
  • Author(s): 安本太郎，高村雄策，辻まゆみ，中山隆宏，今村恵子，井上治久，中村史朗，井上富雄，木村篤史，矢野怜，西条寿夫，木内祐二，デービッドテプロフ，小野賢二郎
  • Organizer: 第39回日本認知症学会学術集会
• [Presentation] ミリセチンは抗酸化作用を介し、ミトコンドリア・細胞膜でアミロイドβオリゴマーによる神経毒性を抑制する (2020)
  • Author(s): 木村篤史，森友起子，小口達敬，海野真一，海野麻未，宇高結子，中村史朗，井上富雄，辻まゆみ，小野賢二郎，木内祐二
  • Organizer: 第39回日本認知症学会学術集会
• [Presentation] 除脳動脈ラット標本を用いた嚥下改善薬の効果の検討 (2020)
  • Author(s): 守谷崇, 中山希世美, 中村史朗, 望月文子, 壇辻昌典, 井上富雄
  • Organizer: 第43回日本嚥下医学会学術講演会
• [Presentation] 除脳ラット動脈灌流標本における顎舌骨筋神経及び舌下神経の脳幹網様体電気刺激による応答 (2020)
  • Author(s): 大藤拓生，中山希世美，中村史朗，望月文子，壇辻昌典，山本松男，井上富雄
  • Organizer: 第63回春季日本歯周病学会学術大会
• [Presentation] 咀嚼運動制御に関わる神経基盤：脳幹に存在する顎運動制御回路について (2020)
  • Author(s): 中村史朗
  • Organizer: 第62回歯科基礎医学会学術大会 日本学術会議シンポジウム
  • Invited
• [Presentation] Postnatal changes of inhibitory synaptic inputs to the rat jaw-closing motoneurons (2020)
  • Author(s): 6.Noguchi T, Nakamura S, Nakayama K, Mochizuki A, Dantsuji M, Inoue T
  • Organizer: 第62回歯科基礎医学会学術大会
• [Presentation] Electrophysiological and morphological analysis of Phox2b-positive neurons situated in the parvocellular reticular nucleus in rats (2020)
  • Author(s): Kajiwara R, Nakamura S, Nakayama K, Mochizuki A, Dantsuji M, Tachikawa S, Iijima T, Inoue T
  • Organizer: 第62回歯科基礎医学会学術大会
• [Presentation] 咬筋運動ニューロン樹状突起における5-HT2A受容体の活性化はSrcを介してGluN2Aを含むNMDA受容体の機能を亢進する (2020)
  • Author(s): 壇辻昌典，中村史朗，中山希世美，望月文子，井上富雄
  • Organizer: 第62回歯科基礎医学会学術大会，歯科基礎医学会学会奨励賞受賞講演会
  • Invited
• [Presentation] Electrophysiological characterization of sleep bruxism patient-specific induced pluripotent stem cell-derived neurons (2020)
  • Author(s): Avijite KS, Nakai K, Nakamura S, Yasuhara R, Shiga T, Abe Y, Hoashi Y, Kotani K, Inoue T, Mishima K, Akamatsu W, Baba K
  • Organizer: 日本顎口腔機能学会第64回学術大会
• [Presentation] 睡眠時ブラキシズム患者特異的iPS細胞由来ニューロンの電気生理学的基本特性 (2020)
  • Author(s): Avijite Kumer Sarkar，中村史朗，中井健人，小渓啓介，安原理佳，安部友佳，美島健二，井上富雄，馬場一美
  • Organizer: 第67回昭和大学学士会総会
• [Presentation] Electrophysiological maturation and characteristics of human stem cells in sleep bruxism (2020)
  • Author(s): Avijite KS, Nakamura S, Abe Y, Nakai K, Yasuhara R, Shiga T, Hoashi Y, Kotani K, Inoue T, Mishima K, Akamatsu W, Baba K
  • Organizer: The 7th Biennial Joint Congress of JPS-CPS-KAP
  • Int'l Joint Research
• [Presentation] 除脳ラット動脈灌流標本を用いた咀嚼様リズム神経活動の誘発 (2019)
  • Author(s): 大藤拓生, 中山希世美, 中村史朗, 望月文子, 壇辻昌典, 井上富雄
  • Organizer: 日本顎口腔機能学会 第63回学術大会
• [Presentation] Serotonin1b receptor mediated presynaptic inhibition of jaw closing motoneurons (2019)
  • Author(s): Nakayama K, Nagata A, Nakamura S, Mochizuki A, Dantsuji M, Maki K, Inoue T
  • Organizer: Society for Neuroscience 49th annual meeting
• [Presentation] Orexin modulates electrophysiological properties of Phox2b neurons located around trigeminal motor nucleus (2019)
  • Author(s): Nagoya K, Nakamura S, Tsujimura T, Inoue M, Inoue T
  • Organizer: Society for Neuroscience 49th annual meeting
• [Presentation] マウス咬筋の筋活動に対するSSRIの影響 (2019)
  • Author(s): 望月文子，池田美菜子，中村史朗，中山希世美，壇辻昌典，加藤隆史，馬場一美，井上富雄
  • Organizer: 第61回歯科基礎医学会学術大会
• [Presentation] 嚥下関連筋支配神経の活動に対するイミダプリルの効果 (2019)
  • Author(s): 守谷崇, 中山希世美, 中村史朗, 望月文子, 壇辻昌典, 井上富雄
  • Organizer: 第61回歯科基礎医学会学術大会
• [Presentation] Serotonin1B receptors are involved in presynaptic inhibition of proprioceptive afferent transmission to jaw-closing motoneurons (2019)
  • Author(s): Inoue T, Nagata A, Nakayama K, Dantsuji M, Nakamura S, Mochizuki A, Maki K
  • Organizer: The 10th IBRO World Congress of Neuroscience
• [Presentation] Presynaptic Activation of 5-HT1B Receptors Inhibits Proprioceptive Sensory Inputs to Jaw-Closing Motoneurons (2019)
  • Author(s): Inoue T, Nagata A, Nakayama K, Dantsuji M, Nakamura S, Mochizuki A, Maki K
  • Organizer: FENS Regional Meeting 2019
• [Presentation] Electrophysiological recordings of neurons derived from sleep bruxism patient-specific iPSCs (2019)
  • Author(s): Nakai K, Shiga T, Abe Y, Hoashi Y, Nakamura S, Yasuhara R, Matsumoto T, Avijite KS, Kotani K, Mishima K, Inoue T, Akamatsu W, Baba K
  • Organizer: ISSCR Annual Meeting
• [Presentation] Patch-clamp recordings of neurons induced from sleep bruxism patient specific iPSCs (2019)
  • Author(s): Nakai K, Hoashi Y, Abe Y, Nakamura S, Siga T, Avijite KS, Yasuhara R, Matsumoto T, Kotani K, Inoue T, Mishima K, Akamatsu W, Baba K
  • Organizer: 97th general session & exhibition of the IADR
• [Presentation] 睡眠時ブラキシズム特異的iPS細胞由来GABA作動性神経細胞の電気生理学的評価 (2019)
  • Author(s): 中井健人，小溪啓介，帆足有理恵，松本貴志，安部友佳，安原理佳，美島健二，中村史朗，井上富雄，志賀孝宏，赤 松和士，馬場一美
  • Organizer: 日本補綴歯科学会128回学術大会
• [Presentation] 嚥下関連筋支配神経への嚥下改善薬の効果 (2019)
  • Author(s): 守谷崇, 中山希世美, 中村史朗, 望月文子, 壇辻昌典, 代田達夫, 井上富雄
  • Organizer: 日本顎口腔機能学会 第62回学術大会
• [Presentation] 転写因子Phox2bを発現する小細胞性網様体ニューロンの生理学的解析 (2019)
  • Author(s): 梶原里紗，中村史朗，中山希世美，望月文子，壇辻昌典，飯島毅彦，井上富雄
  • Organizer: 第13回三叉神経領域の感覚－運動統合機構研究会
• [Book] 歯科衛生学シリーズ 人体の構造と機能1 解剖学・組織発生学・生理学 (2022)
  • Author(s): 一般社団法人全国歯科衛生士教育協議会、前田 健康、井上 富雄、山根 瞳、畠中 能子、山田 小枝子
  • Total Pages: 308
  • Publisher: 医歯薬出版
  • ISBN: 9784263426043
• [Book] 基礎歯科生理学第7版 (2020)
  • Author(s): 岩田幸一，井上富雄，舩橋誠，加藤隆史［編］分担執筆（第20章 咀嚼 井上富雄，中村史朗）
  • Total Pages: 475
  • Publisher: 医歯薬出版