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Effect of periodontal disease on circulatory system via vascular endothelial function

Research Project

Project/Area Number 19K10119
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 57030:Conservative dentistry-related
Research InstitutionKanagawa Dental College

Principal Investigator

Aoyama Norio  神奈川歯科大学, 歯学部, 准教授 (30611024)

Project Period (FY) 2019-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2021: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords歯周病 / 血管内皮細胞 / 循環器疾患 / 感染 / 炎症 / ペリオドンタルメディシン / 血管内皮機能 / 食事 / 生活習慣 / 咀嚼機能 / 血管内皮
Outline of Research at the Start

歯周病と循環器疾患の関連が示されています。しかし、歯周病が循環器疾患を悪化させるのか、それともただ単に歯周病になりやすい人が循環器疾患にもなりやすいのか、詳しいことはわかっていません。これまでのわれわれの研究結果から、血管を構成する要素のひとつである血管内皮細胞の機能が悪くなることで、歯周病の患者さんは循環器疾患を発症しやすい可能性がわかってきました。この点に着目して、さらに研究を進めていきます。

Outline of Final Research Achievements

We hypothesized that periodontal disease induces bacterial infection and systemic inflammation, and affects the function of vascular endothelial cells, particularly leading to the onset and progression of vascular disease. The purpose of this study was to compare the conditions of periodontal disease and systemic inflammation in peripheral vascular disease patients and healthy subjects. Healthy subjects and patients with peripheral vascular disease were recruited as subjects for this study at multiple medical institutions. A test of vascular endothelial function and periodontal disease examinations were performed. We found that the group with worsened vascular endothelial function had increased tooth mobility.

Academic Significance and Societal Importance of the Research Achievements

歯周病と循環器疾患の関連が知られているが、歯周病治療によって循環器疾患が抑制できるかについてはわかっていない。そこで我々は血管内皮細胞に着目し、歯周病との関連を調査した。歯周病と循環器疾患とが関連する理由がわかれば、治療のターゲットとして制御することにより、歯周病の管理が最終的に循環器疾患予防につながる可能性があり、多くの循環器疾患患者および生活習慣病を有する予備軍の人たちの健康に対して、大きな利益が得られる。

Report

(5 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (15 results)

All 2022 2021 2020 2019

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Open Access: 5 results) Presentation (10 results) (of which Int'l Joint Research: 5 results,  Invited: 2 results)

  • [Journal Article] Effect of Periodontal Disease on Long-Term Outcomes After Percutaneous Coronary Intervention for De Novo Coronary Lesions in Non-Smokers2022

    • Author(s)
      Fukushima Taku、Yonetsu Taishi、Aoyama Norio、Tashiro Akira、Niida Takayuki、Shiheido-Watanabe Yuka、Maejima Yasuhiro、Isobe Mitsuaki、Iwata Takanori、Sasano Tetsuo
    • Journal Title

      Circulation Journal

      Volume: 86 Issue: 5 Pages: 811-818

    • DOI

      10.1253/circj.CJ-21-0720

    • NAID

      130008118595

    • ISSN
      1346-9843, 1347-4820
    • Year and Date
      2022-04-25
    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association of Periodontal Status, Number of Teeth, and Obesity: A Cross-Sectional Study in Japan.2021

    • Author(s)
      Aoyama N, Fujii T, Kida S, Nozawa I, Taniguchi K, Fujiwara M, Iwane T, Tamaki K, Minabe M.
    • Journal Title

      J Clin Med.

      Volume: 10 Issue: 2 Pages: 208-208

    • DOI

      10.3390/jcm10020208

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association between periodontitis and vascular endothelial function using noninvasive medical device-A pilot study.2020

    • Author(s)
      Fujitani T, Aoyama N, Hirata F, Minabe M.
    • Journal Title

      Clin Exp Dent Res.

      Volume: 6 Issue: 5 Pages: 576-582

    • DOI

      10.1002/cre2.312

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Increased Heart Failure Prevalence in Patients with a High Antibody Level Against Periodontal Pathogen2019

    • Author(s)
      Aoyama N, Kure K, Minabe M, Izumi Y.
    • Journal Title

      International Heart Journal

      Volume: 60 Issue: 5 Pages: 1142-1146

    • DOI

      10.1536/ihj.19-010

    • NAID

      130007718936

    • ISSN
      1349-2365, 1349-3299
    • Year and Date
      2019-09-27
    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Oral-bacterial-induced arterial and venous thrombus in rats: Pathological and immunological studies.2019

    • Author(s)
      Iwai T, Matsui Y, Homma K, Takemura T, Fujiwara M, Aoyama N, Sato H, Izumi Y.
    • Journal Title

      Clin Exp Dent Res.

      Volume: 5 Issue: 5 Pages: 497-504

    • DOI

      10.1002/cre2.215

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Impaired oral functions in subjects with insufficient recognition of umami.2022

    • Author(s)
      Aoyama N, Yata T, Kida S, Iwane T, Fujii T, Taniguchi K, Komaki M.
    • Organizer
      The 108th Annual Meeting of the American Academy of Periodontology
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Food intake order affects nutrients only in people with teeth.2022

    • Author(s)
      Aoyama N, Kida S, Iwane T, Fujii T, Taniguchi K, Yata T, Komaki M.
    • Organizer
      IADR 100th General Session
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 歯周炎症面積と歯数および肥満の関連2021

    • Author(s)
      青山典生、藤井利哉、喜田さゆり、谷口健太郎、野澤一郎太、藤原基、岩根泰蔵、玉置勝司、三辺正人
    • Organizer
      第64回春季日本歯周病学会学術大会
    • Related Report
      2021 Research-status Report
  • [Presentation] 食事に対する意識と口腔の指標の関係2021

    • Author(s)
      青山典生、喜田さゆり、矢田朋美、藤井利哉、谷口健太郎、岩根泰蔵、野澤一郎太、藤原基、玉置勝司
    • Organizer
      第56回神奈川歯科大学学会総会
    • Related Report
      2021 Research-status Report
  • [Presentation] Relationship between periodontitis and cardiovascular diseases.2020

    • Author(s)
      Aoyama N.
    • Organizer
      The American Academy of Periodontology 106th annual meeting
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Increased level of periodontal inflamed surface area in obese Japanese population.2019

    • Author(s)
      Aoyama N, Fujii T, Fujiwara M, Haruta M, Takuma R, Kida S, Tamaki K, Minabe M.
    • Organizer
      The American Academy of Periodontology 105th annual meeting
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 生活習慣病予防への意識改善につながった歯周治療の一症例2019

    • Author(s)
      青山典生、高瀬雅大、藤井利哉、三辺正人
    • Organizer
      第62回秋季日本歯周病学会学術大会
    • Related Report
      2019 Research-status Report
  • [Presentation] Associations among periodontal status, oral frailty and general condition.2019

    • Author(s)
      Aoyama N, Fujii T, Fujiwara M, Tamaki K, Minabe M.
    • Organizer
      13th Asian Pacific Society of Periodontology Meeting.
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 医科歯科連携に向けた口腔と全身の関連検査の実際2019

    • Author(s)
      青山典生
    • Organizer
      第62回春季日本歯周病学会学術大会
    • Related Report
      2019 Research-status Report
  • [Presentation] 歯周病と循環器疾患の関連解明を目指す基礎的および臨床的解析2019

    • Author(s)
      青山典生
    • Organizer
      第62回春季日本歯周病学会学術大会
    • Related Report
      2019 Research-status Report
    • Invited

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Published: 2019-04-18   Modified: 2024-01-30  

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