Development of a novel therapy for periodontitis with metabolic syndrome

• Project/Area Number: 19K10121
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 57030:Conservative dentistry-related
• Research Institution: Aichi Gakuin University
• Principal Investigator: Naruse Keiko 愛知学院大学, 歯学部, 教授 (30387576)
• Co-Investigator(Kenkyū-buntansha): 菊池 毅 愛知学院大学, 歯学部, 准教授 (40421242)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2021: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 糖尿病 / 歯周病 / メタボリックシンドローム / 歯周炎

Outline of Research at the Start

歯周病とメタボリックシンドロームの関連が注目されているが，積極的な治療介入はなされていない．GLP-1（glucagon-like peptide-1）は，食事摂取に応じて分泌されインスリン分泌を増強することにより糖尿病治療に用いられるだけでなく，摂食を抑制し体重増加を抑制することから，海外では抗肥満薬としても用いられている．さらに GLP-1受容体は全身に分布し，抗炎症が注目されている．そこで本研究では，メタボリックシンドローム合併歯周炎の治療としてGLP-1作動薬が有効であることを証明するとともにそのメカニズムを解明し，新規治療法の開発を目指す．

Outline of Final Research Achievements

In this study, we investigated the effect of metabolic syndrome on periodontitis. As a result, it was clarified that periodontitis was exacerbated in the metabolic syndrome model rats as compared with the control rats. Furthermore, the continuous administration of the GLP-1 receptor agonist, liraglutide, which is currently used as a therapeutic drug for diabetes in Japan, for 2 weeks significantly improved periodontitis in metabolic syndrome rats. These results indicate that periodontitis is exacerbated by having metabolic syndrome, and that GLP-1 receptor agonists may be effective for periodontitis with metabolic syndrome.

Academic Significance and Societal Importance of the Research Achievements

本研究において我々は、メタボリックシンドロームモデルラットであるZucker fatty ラットを用いて、メタボリックシンドローム状態でプラークが停滞すると、対照ラットに比較し歯周炎が増悪することを実験的に証明するとともに、新規治療薬としてGLP-1作動薬が有効であることを明らかにした。GLP-1は，糖尿病治療だけでなく、迷走神経を介して摂食を抑制し体重増加を抑制することから、海外では抗肥満薬としても用いられている。 GLP-1受容体作動薬は様々な作用時間を持つ注射製剤だけでなく、経口薬がすでに我が国で上市されており、今後歯周病への適応も期待できる。

Research Products

• [Journal Article] Long-term safety and efficacy of alogliptin, a DPP-4 inhibitor, in patients with type 2 diabetes: a 3-year prospective, controlled, observational study (J-BRAND Registry) (2021)
  • Author(s): Ueki K, Tanizawa Y, Nakamura J, Yamada Y, Inagaki N, Watada H, Shimomura I, Nishimura R, Miyoshi H, Abiko A, Katagiri H, Hayashi M, Shimada A, Naruse K, Fujimoto S, Fujiwara M, Shikata K, Okada Y, Araki E, Yamazaki T, Kadowaki T; J-BRAND Registry Group.
  • Journal Title: BMJ Open Diabetes Research & Care Volume: 9 Issue: 1 Pages: e001787-e001787
  • DOI: 10.1136/bmjdrc-2020-001787
  • Peer Reviewed / Open Access
• [Journal Article] Efficacy of extracellular vesicles from dental pulp stem cells for bone regeneration in rat calvarial bone defects (2021)
  • Author(s): Yuka Imanishi, Masaki Hata, Ryohei Matsukawa, Atsushi Aoyagi, Maiko Omi, Makoto Mizutani, Keiko Naruse, Shogo Ozawa, Masaki Honda , Tatsuaki Matsubara,Jun Takebe
  • Journal Title: Inflamm Regen Volume: 41 Issue: 1 Pages: 12-12
  • DOI: 10.1186/s41232-021-00163-w
  • Peer Reviewed / Open Access
• [Journal Article] β-Aminoisobutyric acid, L-BAIBA, protects PC12 cells from hydrogen peroxide-induced oxidative stress and apoptosis via activation of the AMPK and PI3K/Akt pathway (2021)
  • Author(s): Tomomi Minato, Nobuhisa Nakamura, Tomokazu Saiki, Megumi Miyabe, Mizuho Ito, Tatsuaki Matsubara, Keiko Naruse
  • Journal Title: IBRO Neurosci Rep Volume: 12 Pages: 65-72
  • DOI: 10.1016/j.ibneur.2021.12.001
  • Peer Reviewed / Open Access
• [Journal Article] Sustainable Effects of Human Dental Pulp Stem Cell Transplantation on Diabetic Polyneuropathy in Streptozotocine-Induced Type 1 Diabetes Model Mice. (2021)
  • Author(s): Masaki Hata, Maiko Omi, Yasuko Kobayashi, Nobuhisa Nakamura, Megumi Miyabe, Mizuho Ito, Tasuku Ohno, Yuka Imanishi, Tatsuhito Himeno, Hideki Kamiya, Jiro Nakamura, Hitoshi Miyachi, Shogo Ozawa, Ken Miyazawa, Akio Mitani, Toru Nagao, Shigemi Goto, Jun Takebe, Tatsuaki Matsubara, Keiko Naruse
  • Journal Title: Cells Volume: 10 Issue: 9 Pages: 2473-2473
  • DOI: 10.3390/cells10092473
  • Peer Reviewed / Open Access
• [Journal Article] The Effects of Insulin on Immortalized Rat Schwann Cells, IFRS1 (2021)
  • Author(s): Tomokazu Saiki, Nobuhisa Nakamura, Megumi Miyabe, Mizuho Ito, Tomomi Minato, Kazunori Sango, Tatsuaki Matsubara, Keiko Naruse
  • Journal Title: Int J Mol Sci Volume: 22 Issue: 11 Pages: 5505-5505
  • DOI: 10.3390/ijms22115505
  • Peer Reviewed / Open Access
• [Journal Article] Case Report: Non-episodic Angioedema With Eosinophilia in a Young Lactating Woman. (2021)
  • Author(s): Mizuho Hirmatsu-Ito, Nobuhisa Nakamura, Megumi Miyabe, Tatsuaki Matsubar, Keiko Naruse
  • Journal Title: Front Immunol Volume: 12 Pages: 627360-627360
  • DOI: 10.3389/fimmu.2021.627360
  • Peer Reviewed / Open Access
• [Journal Article] Transplantation of human dental pulp stem cells ameliorates diabetic polyneuropathy in streptozotocin-induced diabetic nude mice: the role of angiogenic and neurotrophic factors (2020)
  • Author(s): Masaki Hata, Maiko Omi, Yasuko Kobayashi, Nobuhisa Nakamura, Megumi Miyabe, Mizuho Ito, Eriko Makino, Saki Kanada, Tomokazu Saiki, Tasuku Ohno, Yuka Imanishi, Tatsuhito Himeno, Hideki Kamiya, Jiro Nakamura, Shogo Ozawa, Ken Miyazawa, Kenichi Kurita, Shigemi Goto, Jun Takebe, Tatsuaki Matsubara, Keiko Naruse
  • Journal Title: Stem cell research and therapy Volume: 11 Issue: 1 Pages: 236-236
  • DOI: 10.1186/s13287-020-01758-9
  • Peer Reviewed / Open Access
• [Journal Article] Direct comparison of therapeutic effects on diabetic polyneuropathy between transplantation of dental pulp stem cells and administration of dental pulp stem cell-secreted factors (2020)
  • Author(s): Saki Kanada, Eriko Makino, Nobuhisa Nakamura, Megumi Miyabe, Mizuho Ito, Masaki Hata, Taisuke Yamauchi, Noritaka Sawada, Shun Kondo, Tomokazu Saiki, Tomomi Minato, Ken Miyazawa, Shigemi Goto, Tatsuaki Matsubara, Keiko Naruse
  • Journal Title: International journal of molecular sciences Volume: 21 Issue: 17 Pages: 6064-6064
  • DOI: 10.3390/ijms21176064
  • Peer Reviewed
• [Journal Article] Does glycemic control rescue type 2 diabetes patients from COVID-19-related deaths? (2020)
  • Author(s): Keiko Naruse
  • Journal Title: Journal of diabetes investigation Volume: 11 Issue: 4 Pages: 792-794
  • DOI: 10.1111/jdi.13320
  • Peer Reviewed
• [Journal Article] The work style and living condition survey of diabetologists and the expectations for the Japan Diabetes Society: results of questionnaires about the current state and the future prospect of their carrier in 2017 (2020)
  • Author(s): Keiko Naruse, Atsuko Abiko, Hitomi Nakayama, Nobue Tanaka, Kaori Ikeda, Hitomi Imachi, Emi Usigome, Yutaka Umayahara, Setsu Ota, Yukiko Okada, Noriko Kodani, Noriko Takahashi, Ai Terai, Akinobu Nakamura, Rumi Fujikawa, Junnosuke Miura, Emiko Morita, Miyuki Yanagimachi, Kojiro Ueki
  • Journal Title: Diabetology international Volume: 11 Issue: 4 Pages: 299-308
  • DOI: 10.1007/s13340-020-00441-x
  • NAID: 130007655699
  • Peer Reviewed
• [Journal Article] Deficiency of glucagon gene-derived peptides induces peripheral polyneuropathy in mice. (2020)
  • Author(s): Mikio Motegi, Tatsuhito Himeno, Hiromi Nakai-Shimoda, Rieko Inoue, Norio Ozeki, Keiko Naruse, Yusuke Seino, Yoshitaka Hayashi, Jiro Nakamura, Hideki Kamiya, et al.
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 532 Issue: 1 Pages: 47-53
  • DOI: 10.1016/j.bbrc.2020.08.007
  • Peer Reviewed / Open Access
• [Journal Article] Therapeutic potential for insulin on type 1 diabetes-associated periodontitis: analysis of experimental periodontitis in streptozotocin-induced diabetic rats. (2020)
  • Author(s): Nishikawa T, Suzuki Y, Sawada N, Kobayashi Y, Nakamura N, Miyabe M, Miyajima SI, Adachi K, Minato T, Mizutani M, Toriumi T, Ohno N, Kikuchi T, Honda M, Noguchi T, Mitani A, Matsubara T, Naruse K.
  • Journal Title: Journal of Diabetes Investigation Volume: Epub ahead of print Issue: 6 Pages: 1482-1489
  • DOI: 10.1111/jdi.13276
  • Peer Reviewed / Open Access
• [Journal Article] A large-scale observational study to investigate the current status of diabetic complications and their prevention in Japan (JDCP study 6): baseline dental and oral findings. (2020)
  • Author(s): Koji Inagaki, Takeshi Kikuchi, Toshihide Noguchi, Akio Mitani, Keiko Naruse, Tatsuaki Matsubara, Masamitsu Kawanami, Jun Negishi, Yasushi Furuichi, Eiji Nemoto, Satoru Yamada, Hiromasa Yoshie, Koichi Tabeta, Sachiyo Tomita, Atsushi Saito, Sayaka Katagiri, Yuichi Izumi, Hiroshi Nitta, Naoko Kojima, et al.
  • Journal Title: Diabetology International Volume: 12 Issue: 1 Pages: 52-61
  • DOI: 10.1007/s13340-020-00465-3
  • NAID: 40022457390
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Secreted factors from stem cells of human exfoliated deciduous teeth directly activate endothelial cells to promote all processes of angiogenesis (2020)
  • Author(s): Makoto Kato, Shin Tsunekawa, Nobuhisa Nakamura, Emiri Miura-Yura, \Yoshiro Kato, Takako Izumoto-Akita, Akihito Yamamoto, Keiko Naruse, Jiro Nakamura, Hideki Kamiya, et al.
  • Journal Title: Cells Volume: 9 Issue: 11 Pages: 2385-2385
  • DOI: 10.3390/cells9112385
  • Peer Reviewed / Open Access
• [Journal Article] Glucagon-like peptide-1 receptor agonist liraglutide ameliorates the development of periodontitis (2020)
  • Author(s): Noritaka Sawada, Kei Adachi, Nobuhisa Nakamura, Megumi Miyabe, Mizuho Ito, Shuichiro Kobayashi, Shin-ichi Miyajima, Yuki Suzuki, Takeshi Kikuchi, Makoto Mizutani, Taku Toriumi, Masaki Honda, Akio Mitani, Tatsuaki Matsubara, Keiko Naruse
  • Journal Title: Journal of Diabetes Research Volume: 2020 Pages: 8843310-8843310
  • DOI: 10.1155/2020/8843310
  • Peer Reviewed / Open Access
• [Journal Article] Secreted factors from cultured dental pulp stem cells promoted neurite outgrowth of dorsal root ganglion neurons and ameliorated neural functions in streptozotocin‐induced diabetic mice (2019)
  • Author(s): Miura‐Yura Emiri、Tsunekawa Shin、Naruse Keiko、Nakamura Nobuhisa、Motegi Mikio、Nakai‐Shimoda Hiromi、Asano Saeko、Kato Makoto、Yamada Yuichiro、Izumoto‐Akita Takako、Yamamoto Akihito、Himeno Tatsuhito、Kondo Masaki、Kato Yoshiro、Nakamura Jiro、Kamiya Hideki
  • Journal Title: Journal of Diabetes Investigation Volume: 11 Issue: 1 Pages: 28-38
  • DOI: 10.1111/jdi.13085
  • NAID: 120006980549
  • Peer Reviewed / Open Access
• [Journal Article] Glucagon-like peptide-1 receptor agonist protects dorsal root ganglion neurons against oxidative insult (2019)
  • Author(s): Mohiuddin MS, Himeno T, Inoue R, Miura-Yura E, Yamada Y, Nakai-Shimoda H, Asano S, Kato M, Motegi M, Kondo M, Seino Y, Tsunekawa S, Kato Y, Suzuki A, Naruse K, Kato K, Nakamura J, Kamiya H.
  • Journal Title: Journal of Diabetes Reserch Volume: 2019 Pages: 9426014-9426014
  • DOI: 10.1155/2019/9426014
  • Peer Reviewed / Open Access
• [Journal Article] Conditioned media from dental pulp stem cells improved diabetic polyneuropathy through anti‐inflammatory, neuroprotective and angiogenic actions: Cell‐free regenerative medicine for diabetic polyneuropathy (2019)
  • Author(s): Makino Eriko、Nakamura Nobuhisa、Miyabe Megumi、Ito Mizuho、Kanada Saki、Hata Masaki、Saiki Tomokazu、Sango Kazunori、Kamiya Hideki、Nakamura Jiro、Miyazawa Ken、Goto Shigemi、Matsubara Tatsuaki、Naruse Keiko
  • Journal Title: Journal of Diabetes Investigation Volume: 印刷中 Issue: 5 Pages: 1199-1208
  • DOI: 10.1111/jdi.13045
  • Peer Reviewed / Open Access
• [Journal Article] Ranirestat Improved Nerve Conduction Velocities, Sensory Perception, and Intraepidermal Nerve Fiber Density in Rats with Overt Diabetic Polyneuropathy (2019)
  • Author(s): Asano Saeko、Himeno Tatsuhito、Hayami Tomohide、Motegi Mikio、Inoue Rieko、Nakai-Shimoda Hiromi、Miura-Yura Emiri、Morishita Yoshiaki、Kondo Masaki、Tsunekawa Shin、Kato Yoshiro、Kato Koichi、Naruse Keiko、Nakamura Jiro、Kamiya Hideki
  • Journal Title: Journal of Diabetes Research Volume: 2019 Pages: 1-7
  • DOI: 10.1155/2019/2756020
  • Peer Reviewed / Open Access
• [Journal Article] Schwann Cells as Crucial Players in Diabetic Neuropathy (2019)
  • Author(s): Naruse Keiko
  • Journal Title: Advances in Experimental Medicine and Biology Volume: 1190 Pages: 345-356
  • DOI: 10.1007/978-981-32-9636-7_22
  • ISBN: 9789813296350, 9789813296367
  • Peer Reviewed
• [Presentation] 歯髄幹細胞と歯髄幹細胞分泌因子投与の直接比較―糖尿病性神経障害に対する治療効果― (2021)
  • Author(s): 金田紗季、牧野衣利子、中村信久、宮部 愛、伊藤瑞穂、秦 正樹，山内大輔、澤田憲孝、近藤 駿、齊木智一、湊 智美、宮澤 健，後藤滋巳、松原達昭，成瀬桂子
  • Organizer: 第20回日本再生医療学会（Web開催）
• [Presentation] BAIBA enhances viability and protects from oxidative stress in PC12 cells (2021)
  • Author(s): Tomomi Minato, Tomokazu Saiki, Nobuhisa Nakamura, Megumi Miyabe, Mizuho Ito, Tatsuaki Matsubara, Keiko Naruse
  • Organizer: 第62回日本神経学会学術大会（京都）
• [Presentation] 糖尿病併存疾患としての歯周病―今求められる適切な対応ー (2021)
  • Author(s): 成瀬桂子
  • Organizer: 第64回日本糖尿病学会年次学術集会(Web開催）
  • Invited
• [Presentation] 歯周病と糖尿病における負のスパイラルとその対処法 (2021)
  • Author(s): 成瀬桂子
  • Organizer: 第36回日本糖尿病合併症学会（大津・Webハイブリッド開催）
  • Invited
• [Presentation] GLP-1の歯周炎抑制効果とそのメカニズムの解明 (2021)
  • Author(s): 澤田憲孝、足立圭、中村信久、宮部愛、伊藤瑞穂、小林周一郎、鈴木佑基、水谷誠、鳥海拓、菊池毅、本田雅規、三谷章雄、松原達昭、成瀬桂子
  • Organizer: 第64回日本糖尿病学会年次学術集会（Web開催）
• [Presentation] 糖尿病性神経障害に対する歯髄幹細胞を用いた細胞移植療法の長期的治療効果の検討 (2021)
  • Author(s): 秦 正樹、大見真衣子、小林泰子、中村信久、宮部 愛、伊藤瑞穂、大野 祐、今西悠華、宮地斉、尾澤昌悟、宮澤健、三谷章雄、長尾徹、後藤滋巳、武部 純、松原達昭、成瀬 桂子
  • Organizer: 第98回愛知学院大学歯学会（誌上開催）
• [Presentation] Mechanism of insulin-induced proliferation and myelin formation in Schwann cell (2021)
  • Author(s): Nakamura N, Saiki T, Miyabe M, Ito M, Minato T, Sango T, Matsubara T, Naruse K.
  • Organizer: The 57th EASD Annual Meeting
  • Int'l Joint Research
• [Presentation] 歯周病原細菌由来LPSは血管平滑筋細胞の増殖・遊走を促進する (2021)
  • Author(s): 宮部 愛、中村 信久、伊藤 瑞穂、斎木 智一、松原 達昭、成瀬 桂子
  • Organizer: 第36回糖尿病合併症学会（web開催）
• [Presentation] 糖尿病性神経障害に対するヒト歯髄幹細胞移植療法の長期的治療効果の検討. (2021)
  • Author(s): 秦 正樹、大見真衣子、小林泰子、中村信久、宮部 愛、伊藤瑞穂、大野 祐、今西悠華、尾澤昌悟、宮澤 健、姫野龍仁、神谷英紀、中村二郎、三谷章雄、後藤滋巳、武部 純、松原達昭、成瀬桂子
  • Organizer: 第36 回日本糖尿病合併症学会（web開催）
• [Presentation] 歯周病が動脈硬化の促進に及ぼす可能性についての検討 (2021)
  • Author(s): 宮部 愛、中村信久、伊藤瑞穂、斉木智一、松原達昭、成瀬桂子
  • Organizer: 第64回秋季日本歯周病学会学術大会
• [Presentation] 口腔粘膜病変の１例 (2021)
  • Author(s): 杉田好彦、久保勝俊、河合遼子、湊 智美、長谷衣里子、成瀬桂子、前田初彦
  • Organizer: 第171回日本臨床細胞学会 東海連合会
• [Presentation] 顎裂部骨移植を想定した歯髄幹細胞による歯槽骨再生の有効性 (2020)
  • Author(s): 秦 正樹，松川良平，青柳敦士，今西悠華，大見真衣子，尾澤昌悟，成瀬桂子，松原達昭，武部 純
  • Organizer: 第44回日本口蓋裂学会総会・学術集会（Web開催）
• [Presentation] 歯髄幹細胞培養上清による骨格筋への効果について (2020)
  • Author(s): 金田紗季，牧野衣利子，秦 正樹，松原達昭，成瀬桂子，宮澤 健，後藤滋巳
  • Organizer: 第44回日本口蓋裂学会総会・学術集会（誌面開催）
• [Presentation] Transplantation of human dental pulp stem cells ameliorates diabetic polyneuropathy via increasing angiogenic and neurotrophic gene expression in the transplanted muscles (2020)
  • Author(s): Masaki Hata, Maiko Omi, Nobuhisa Nakamura, Megumi Miyabe, Mizuho Ito, Eriko Makino, Saki Kanada, Tasuku Ono, Yuka Imanishi, Tatsuhito Himeno, Jiro Nakamura, Hideki Kamiya, Shogo Ozawa, Jun Takebe, Tatsuaki Matsubara, Keiko Naruse,
  • Organizer: 80th Scientific Sessions of American Diabetes Association (Virtual meeting)
  • Int'l Joint Research
• [Presentation] Transplantation of human dental pulp stem cells ameliorates diabetic polyneuropathy via angiogenic and neurotrophic factors (2020)
  • Author(s): Hata M, Omi M, Kobayashi Y, Nakamura N, Miyabe M, Ito M, Makino E, Kanada S, Saiki T, Ono T, Imanishi Y, Tatsuhito H, Kamiya H, Nakamura J, Ozawa S, Miyazawa K, Kurita K, GotoS, Takebe J, Matsubara T, Naruse K.
  • Organizer: ISSCR2020 virtual
  • Int'l Joint Research
• [Presentation] 歯髄幹細胞由来エクソソームの骨組織再生における治療効果について (2020)
  • Author(s): 今西悠華，秦 正樹，松川良平，青柳敦士，大見真衣子，水谷 誠，成瀬桂子，尾澤昌悟，本田雅規，松原達昭，武部 純
  • Organizer: 日本炎症再生学会
• [Presentation] The effect of conditioned media harvested from cultured dental pulp stem cells on myokine expressions in skeletal muscles (2020)
  • Author(s): Saki Kanada，Eriko Makino，Nobuhisa Nakamura，Megumi Miyabe，Mizuho Ito， Masaki Hata，Tomokazu Saiki，Tomomi Minato, Tatsuaki Matsubara，Keiko Naruse， Ken Miyazawa，Shigemi Goto
  • Organizer: 第９回国際矯正歯科学会会議世界大会（Web開催）
  • Int'l Joint Research
• [Presentation] インスリンによるシュワン細胞の増殖促進およびミエリン構成蛋白発現とその機序 (2020)
  • Author(s): 齊木智一、中村信久、宮部 愛、伊藤瑞穂、三五一憲、松原達昭、成瀬桂子
  • Organizer: 第63回日本糖尿病学会年次学術集会(Web開催）
• [Presentation] 世界糖尿病デーイベント開催報告～進化し続けるイベントを目指して～ (2020)
  • Author(s): 田中美加、平山奈奈、中村信久、西郷裕香、橘川義恵、本田美里、後藤賢一、有地淑子、近藤 駿、澤田憲孝、齊木智一、山口正義、若山清美、有地榮一郎、三谷章雄、成瀬桂子、松原達昭
  • Organizer: 第63回日本糖尿病学会年次学術集会(Web開催）
• [Presentation] 糖尿病性神経障害に対するヒト歯髄幹細胞移植療法の作用機序 (2020)
  • Author(s): 秦 正樹、大見真衣子、中村信久、宮部 愛、伊藤瑞穂、牧野衣利子、金田紗季、大野 祐、今西悠華、姫野龍仁、神谷英紀、中村二郎、尾澤昌悟、武部 純、松原達昭、成瀬 桂子
  • Organizer: 第63回日本糖尿病学会年次学術集会(Web開催）
• [Presentation] 血管新生に対するヒト乳歯歯髄幹細胞培養上清の効果の検討 (2020)
  • Author(s): 加藤 誠、恒川 新、中村信久、井上利恵子、林 優佑、三浦絵美梨、山田祐一郎、石川貴大、森下啓明、姫野龍仁、近藤正樹、加藤義郎、神谷英紀、成瀬桂子、中村二郎
  • Organizer: 第63回日本糖尿病学会年次学術集会(Web開催）
• [Presentation] 歯髄幹細胞由来Extracellular vesiclesが骨組織再生に及ぼす効果の検討 (2020)
  • Author(s): 今西悠華，秦 正樹，松川良平，青柳敦士，大見真衣子，水谷 誠，成瀬桂子，尾澤昌悟，本田雅規，松原達昭，武部 純
  • Organizer: 令和２年度日本補綴歯科学会東海支部総会（web開催）
• [Presentation] GLP-1の膵外作用による歯周炎抑制についての検討 (2020)
  • Author(s): 澤田憲孝，足立圭，中村信久，宮部愛，伊藤瑞穂，小林周一郎，鈴木佑基，水谷誠，鳥海拓，菊池毅，本田雅規，三谷章雄，松原達昭，成瀬桂子
  • Organizer: 第96・97回愛知学院大学歯学会（誌上開催）
• [Presentation] 歯周炎に対するGLP-1受容体作動薬（Liraglutdide）の効果 (2019)
  • Author(s): 澤田憲孝，足立圭，中村信久，宮部愛，伊藤瑞穂，鈴木佑基，水谷誠，鳥海拓，菊池毅，本田雅規，三谷章雄，松原達昭，成瀬桂子
  • Organizer: 第33回日本糖尿病・肥満動物学会（福岡）
• [Presentation] 歯周炎に対するGLP-1の治療効果とそのメカニズムの解明 (2019)
  • Author(s): 澤田憲孝，足立 圭，中村信久，宮部 愛，伊藤瑞穂，鈴木佑基，水谷誠，鳥海 拓，菊池 毅，本田雅規，三谷章雄，松原達昭，成瀬桂子
  • Organizer: 第6２回 日本糖尿病学会年次学術集会 （仙台）
• [Presentation] 歯周炎に対するGLP-1の抗炎症作用について (2019)
  • Author(s): 澤田憲孝，足立 圭，中村信久，宮部 愛，伊藤瑞穂，小林周一郎，鈴木佑基，水谷 誠，鳥海 拓，菊池 毅，本田雅規，三谷章雄，松原達昭，成瀬桂子
  • Organizer: 第34回日本糖尿病合併症学会（大阪）
• [Presentation] The exercise-like impacts of conditioned media harvested from cultured dental pulp stem cells on myokine expressions in skeletal muscles (2019)
  • Author(s): Kanada S，Makino E，Nakamura N，Miyabe M，Ito M, Hata M, Saiki T，Minato T, Miyazawa K，Goto S，Matsubara T, Naruse K.
  • Organizer: 79th Scientific Sessions of American Diabetes Association (San Francisco)
  • Int'l Joint Research
• [Presentation] The curetive effect of GLP-1 for periodontitis and elucidation of the mechanism (2019)
  • Author(s): Sawada N, Adachi K, Nakamura N, Miyabe M, Ito M, Kobayashi S, Suzuki Y, Mizutani M, Toriumi T, Kikuchi T, Honda M, Mitani A, Matsubara T, Naruse K.
  • Organizer: 79th Scientific Sessions of American Diabetes Association (San Francisco)
  • Int'l Joint Research
• [Presentation] GLP-1の膵外作用による歯周炎抑制についての検討 (2019)
  • Author(s): 澤田憲孝，足立圭，中村信久，宮部愛，伊藤瑞穂，小林周一郎，鈴木佑基，水谷誠，鳥海拓，菊池毅，本田雅規，三谷章雄，松原達昭，成瀬桂子
  • Organizer: 第62回秋季日本歯周病学会学術大会(北九州）
• [Presentation] 歯髄幹細胞と足場材料が骨組織再生に及ぼす効果の検討 (2019)
  • Author(s): 今西悠華，秦 正樹，松川良平，青柳敦士，大見真衣子，水谷 誠，成瀬桂子，尾澤昌悟，本田雅規，松原達昭，武部 純
  • Organizer: 日本補綴歯科学会 東海支部総会・学術大会(岐阜）
• [Book] 歯科医師のための内科学 (2021)
  • Author(s): 成瀬 桂子
  • Publisher: 医歯薬出版株式会社
  • ISBN: 9784263458617
• [Book] 血糖管理のための糖尿病治療薬活用マニュアル (2020)
  • Author(s): 寺内康夫
  • Total Pages: 316
  • Publisher: 中外医学社
  • ISBN: 9784498123861