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Impact of blood glucose control on periodontal regenerative therapy and implant treatment.

Research Project

Project/Area Number 19K10125
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 57030:Conservative dentistry-related
Research InstitutionTokyo Medical and Dental University

Principal Investigator

Mizutani Koji  東京医科歯科大学, 大学院医歯学総合研究科, 助教 (60451910)

Co-Investigator(Kenkyū-buntansha) 上野 剛史  東京医科歯科大学, 大学院医歯学総合研究科, 准教授 (30359674)
Project Period (FY) 2019-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2021: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords歯周病 / 糖尿病 / 酸化ストレス / インスリン抵抗性 / インプラント / 歯科用インプラント / 血糖コントロール
Outline of Research at the Start

高血糖によるインスリンのシグナル経路の阻害が骨代謝に及ぼすメカニズムをin vitro にて検索し、その結果に基づき、糖尿病モデル動物への血糖コントロールが歯槽骨の骨代謝の改善をもたらす可能性を、歯周組織再生療法後の治癒、およびインプラントのオッセオインテグレーションの解析から検討する。この研究成果が、糖尿病患者への安全性と予知性の高い歯科治療の確立に貢献できることを目指す。

Outline of Final Research Achievements

In this study, we investigated the mechanism by which hyperglycemia inhibits Akt activation of the insulin signaling pathway in vitro using gingival fibroblasts and bone marrow-derived stem cells. Based on the results of the in vitro experiments, it was shown that hyperglycemia and its glycemic control in diabetic animal models are involved in the improvement of gingival wound healing, healing after periodontal tissue regeneration therapy, and osseointegration of implants. The results of this study may contribute to the establishment of safe and predictable dental treatment for diabetic patients.

Academic Significance and Societal Importance of the Research Achievements

現在、糖尿病はわが国において増加傾向にあることが指摘されており、糖尿病患者の歯周炎は進行しやすいことから、今後、歯科医療の現場において糖尿病患者に対する歯周組織再生療法、およびインプラント治療の安全性や予知性を高めることは喫緊の課題と考えられる。本研究で得られた知見が内科および歯科の臨床現場に与える意義は大きいと考えられる。

Report

(5 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (9 results)

All 2022 2021 2019

All Journal Article (5 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 5 results,  Open Access: 1 results) Presentation (4 results) (of which Int'l Joint Research: 3 results)

  • [Journal Article] Association of Periodontal Disease with Diabetes and Chronic Kidney Disease2022

    • Author(s)
      水谷 幸嗣
    • Journal Title

      The Japanese Journal of Conservative Dentistry

      Volume: 65 Issue: 1 Pages: 25-29

    • DOI

      10.11471/shikahozon.65.25

    • NAID

      130008166417

    • ISSN
      0387-2343, 2188-0808
    • Year and Date
      2022-02-28
    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impaired dental implant osseointegration in rat with streptozotocin‐induced diabetes2022

    • Author(s)
      Saito Natsumi、Mikami Risako、Mizutani Koji、Takeda Kohei、Kominato Hiromi、Kido Daisuke、Ikeda Yuichi、Buranasin Prima、Nakagawa Keita、Takemura Shu、Ueno Takeshi、Hosaka Keiichi、Hanawa Takao、Shinomura Tamayuki、Iwata Takanori
    • Journal Title

      Journal of Periodontal Research

      Volume: 57 Issue: 2 Pages: 412-424

    • DOI

      10.1111/jre.12972

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Antioxidant effect of enamel matrix derivative for early phase of periodontal tissue regeneration in diabetes2022

    • Author(s)
      Takeda Kohei、Mizutani Koji、Matsuura Takanori、Kido Daisuke、Mikami Risako、Buranasin Prima、Saito Natsumi、Kominato Hiromi、Takemura Shu、Nakagawa Keita、Iwata Takanori
    • Journal Title

      Journal of Periodontology

      Volume: - Issue: 8 Pages: 1206-1217

    • DOI

      10.1002/jper.21-0413

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Effects of Antioxidant in Adjunct with Periodontal Therapy in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis2021

    • Author(s)
      Koji Mizutani, Prima Buranasin, Risako Mikami, Kohei Takeda, Daisuke Kido, Kazuki Watanabe, Shu Takemura, Keita Nakagawa, Hiromi Kominato, Natsumi Saito, Atsuhiko Hattori, Takanori Iwata.
    • Journal Title

      Antioxidants

      Volume: 10 Issue: 8 Pages: 1304-1304

    • DOI

      10.3390/antiox10081304

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Periodontal regenerative therapy in patients with type 2 diabetes using minimally invasive surgical technique with enamel matrix derivative under 3‐year observation: A prospective cohort study2021

    • Author(s)
      Mizutani Koji、Shioyama Hidehiro、Matsuura Takanori、Mikami Risako、Takeda Kohei、Izumi Yuichi、Aoki Akira、Iwata Takanori
    • Journal Title

      Journal of Periodontology

      Volume: online ahead Issue: 9 Pages: 1262-1273

    • DOI

      10.1002/jper.20-0590

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] Minimally Invasive Approach for Periodontal Tissue Regeneration in Patients with Diabetes2022

    • Author(s)
      Koji Mizutani
    • Organizer
      アメリカ歯周病学会年次大会
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 糖尿病による歯科用インプラントのオッセオインテグレーションの低下2021

    • Author(s)
      齋藤 夏実,三上 理沙子,水谷 幸嗣,武田 浩平,小湊 広美,城戸 大輔,池田 裕一,中川 佳太,竹村 修,上野 剛史,保坂 啓一,塙 隆夫,篠村 多摩之,岩田 隆紀
    • Organizer
      第64回 春季日本歯周病学会学術大会
    • Related Report
      2021 Research-status Report
  • [Presentation] The impact of diabetes on periodontal parameters in Japanese hemodialysis patients: A cross-sectional study2019

    • Author(s)
      Risako Mikami, Koji Mizutani, Takanori Matsuura, Daisuke Kido, Yoshiyuki Sasaki, Takanori Iwata
    • Organizer
      105th Annual Meeting of the American Academy of Periodontology
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] INSULIN RESISTANCE IMPROVEMENT WITH PERIODONTAL TREATMENT IN TYPE - 2 DIABETIC PATIENTS WITH LOCALIZED, SEVERE CHRONIC PERIODONTITIS2019

    • Author(s)
      Daisuke Kido, Koji Mizutani, Yuichi Izumi, Hiroshi Nitta
    • Organizer
      American Academy of Periodontology 105th ANNUAL MEETING
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research

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Published: 2019-04-18   Modified: 2024-01-30  

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