The active challenge for caries prevention by titanium compounds
| Project/Area Number |
19K10136
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 57030:Conservative dentistry-related
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| Research Institution | Asahi University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
松田 康裕 北海道医療大学, 歯学部, 准教授 (50431317)
玉置 幸道 朝日大学, 歯学部, 教授 (80197566)
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| Project Period (FY) |
2019-04-01 – 2023-03-31
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| Project Status |
Completed (Fiscal Year 2022)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2022: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2021: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | フッ化チタン / う蝕抑制 / グラスアイオノマーセメント / PIXE/PIGE法 / フッ化物局所応用 |
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| Outline of Research at the Start |
フッ化物の局所応用としてフッ化チタンによるう蝕抑制効果は報告されているが、安全に使用できる適切な酸性度や濃度が不明である。また、チタン存在下でのう蝕やチタン合金への影響が明確でないという問題もある。
本研究では１）局所的フッ化物応用に適正な酸性度、フッ化チタン濃度を確定させる。２）歯科材料へ混合させることによるう蝕への影響の評価。３）チタン合金への影響。を検討する。そのために、TMRやPIXE/PIGE装置、XPSなどを用い、各条件を設定したフッ化チタンによる脱灰抑制やフッ素など各元素（イオン）の歯質への浸透、歯科材料へ混合することによる影響や、チタン合金に対する変化などを分析、評価する。
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| Outline of Final Research Achievements |
The study aims to develop a wide range of applications of titanium fluoride in dentistry, which is not widely used in Japan. The purpose of this study was 1) to estimate the effective concentration and pH of titanium fluoride for topical application to tooth structure and 2) to evaluate the effects of adding titanium fluoride to glass ionomer cement.
The results of this study showed that 0.5% titanium fluoride solution may be the lowest concentration for caries prevention, and there was no significant difference between slightly acidic to neutral solutions. Titanium fluoride appeared to be more effective than sodium fluoride for caries prevention at the same fluoride concentration and pH. The addition of glass ionomer cement increased the caries-preventive effect compared with the original cement, but did not improve the mechanical properties.
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| Academic Significance and Societal Importance of the Research Achievements |
歯科において様々なフッ化物が使用されているが、日本では余り使用されていないフッ化チタンの可能性に着目し、う蝕予防効果などを検討した。他の用途で高濃度の溶液が用いられているが、口腔内での使用を目指し低濃度における効果を検討し、濃度を提示することができた。また既存の材料に添加することで、さらなるう蝕抑制効果の促進が示唆された。これらの結果から、今後のう蝕予防の方法の一つとして提案できるものと思われる。
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Report
(5 results)
Research Products
(49 results)
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[Journal Article] Dentin remineralization enhances by trace-element2023
Author(s)
Matsuda Y, Okuyama K, Yamamoto H, Sakurai M, Naito K, Kanda H, Saito T, Hayashi M, Tamaki Y, Satoh T, Yamada N, Yamagata R, Ishii Y
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Journal Title
QST Takasaki Annual Report 2021
Volume: QST-M-39
Pages: 105-105
Related Report
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[Journal Article] Ion penetration of zinc-containing fluoride material into sound and demineralized dentin2023
Author(s)
Yamamoto H, Okuyama K, Matsuda Y, Naito K, Kanda H, Sakurai M, Hayashi M, Satoh T, Yamada N, Yamagata R, Ishii Y
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Journal Title
QST Takasaki Annual Report 2021
Volume: QST-M-39
Pages: 96-96
Related Report
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[Journal Article] Elemental distribution into root dentin from pilot materials incorporating with titanium fluoride2023
Author(s)
Okuyama K, Matsuda Y, Yamamoto H, Sakurai M, Naito K, Kanda H, Saito T, Hayashi M, Tamaki Y, Satoh T, Yamada N, Yamagata R, Ishii Y
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Journal Title
QST Takasaki Annual Report 2021
Volume: QST-M-39
Pages: 95-95
Related Report
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[Journal Article] Potential of Fluoride-Containing Zinc Oxide and Copper Oxide Nanocomposites on Dentin Bonding Ability2022
Author(s)
Bayarchimeg Altankhishig, Yasuhiro Matsuda, Futami Nagano-Takebe, Katsushi Okuyama, Hiroko Yamamoto, Masahiko Sakurai, Katsuaki Naito, Mikako Hayashi, Hidehiko Sano, Sharanbir K. Sidhu, Takashi Saito
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Journal Title
Nanomaterials
Volume: 12
Issue: 8
Pages: 1291-1291
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Evaluation for acid resistance of root dentin using a fluoride varnish containing tricalcium phosphate2022
Author(s)
Yamamoto H, Uemura R, Naito K, Okuyama K, Matsuda Y, Sakurai M, Saito T, Hayashi M, Satoh T, Yamada N, Yamagata R
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Journal Title
QST Takasaki Annual Report 2020
Volume: QST-M-33
Pages: 97-97
Related Report
Peer Reviewed
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[Journal Article] Effects for distribution of elements and inhibition of demineralization by low concentration of titanium fluoride2022
Author(s)
Okuyama K, Matsuda Y, Yamamoto H, Naito K, Sakurai M, Saito T, Hayashi M, Tamaki Y, Satoh T, Yamada N, Yamagata R
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Journal Title
QST Takasaki Annual Report 2020
Volume: QST-M-33
Pages: 94-94
Related Report
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[Journal Article] Effects of titanium fluoride to inhibition of demineralization and distribution of elements2021
Author(s)
Okuyama K, Matsuda Y, Yamamoto H, Naito K, Sakurai M, Saito T, Hayashi M, Yoshida Y, Tamaki Y, Satoh T, Yamada N
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Journal Title
QST Takasaki Annual Report 2019
Volume: QST-M-29
Pages: 112-112
Related Report
Peer Reviewed
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[Journal Article] Antibacterial effect of a fluoride-containing ZnO/CuO nanocomposite2019
Author(s)
Matsuda Y, Okuyama K, Yamamoto H, Fujita M, Abe S, Sato T, Yamada N, Koka M, Sano H, Hayashi M, Sidhu SK, Saito T
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Journal Title
Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms
Volume: 458
Pages: 184-188
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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