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Basic study of the bioactive substances of a skin of citrus fruits for periodontal disease treatment

Research Project

Project/Area Number 19K10151
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 57030:Conservative dentistry-related
Research InstitutionThe University of Tokushima

Principal Investigator

HOSOKAWA Yoshitaka  徳島大学, 病院, 講師 (90346601)

Co-Investigator(Kenkyū-buntansha) 中西 正  徳島大学, 大学院医歯薬学研究部(歯学域), 准教授 (00217770)
細川 育子  徳島大学, 大学院医歯薬学研究部(歯学域), 助教 (50707908)
Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2021: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords歯周炎 / 柑橘類果皮 / 生理活性物質 / 抗炎症作用 / ノビレチン / 歯根膜由来細胞 / スダチチン / ヒト歯根膜由来細胞 / 炎症性メディエーター / シグナル伝達 / MMP / Akt / 柑橘類果皮含有生理活性物質
Outline of Research at the Start

歯周炎は歯周病原性細菌により惹起される慢性炎症性疾患である。これまでの研究により宿主の過剰な免疫応答が歯周組織破壊に関与している事が明らかとされており、歯周組織破壊を抑制する目的から炎症局所での過剰な炎症を軽減できる事が出来る物質を発見しようと様々な研究がなされている。本研究で我々は柑橘類果皮含有生理活性物質を歯周炎治療に用いる可能性に着目し、その基礎的研究として柑橘類果皮含有生理活性物質が歯周組織構成細胞の炎症性メディエーター産生に影響を与えるか否かに関して検討する事を目的とする事とした。

Outline of Final Research Achievements

Periodontitis is a chronic inflammatory disease caused by periodontal pathogen, and it is reported that excessive immune response participates in periodontium destruction. Thus, it is thought that it is important to find new candidates of the bioactive substance which have anti-inflammatory effects. I focus on nobiletin and sudachitin which were the bioactive substance included in the skin of citrus fruits in this study and I examined the anti-inflammatory effects of nobiletin and sudachitin in vitro study. As a result, I found that nobiletin and sudachitin inhibited the inflammatory mediator productions such as chemokines in human periodontal ligament cells. Thus, this results suggested that the local application of nobiletin and sudachitin might decrease the inflammatory mediator expression in periodontal lesion.

Academic Significance and Societal Importance of the Research Achievements

歯周炎はその進行により歯を喪失し国民のQOLの低下に関与する慢性炎症性疾患であり、糖尿病や心筋梗塞など他の疾患の病態への関与も報告されている。ゆえに歯周炎の進行や発症を抑える可能性がある抗炎症作用がある生理活性物質の候補を増やす事は重要であると考えられる。本研究では柑橘類果皮に含まれる生理活性物質であるノビレチンとスダチチンが歯周組織構成細胞に対して抗炎症作用がある事を明らかとした。普段廃棄される果皮に含まれる生理活性物質でもありSDGsの観点からも環境に優しい歯周炎に使用できる生理活性物質候補であると考えている。

Report

(4 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (13 results)

All 2021 2020 2019

All Journal Article (10 results) (of which Peer Reviewed: 6 results,  Open Access: 6 results) Presentation (3 results)

  • [Journal Article] Nobiletin inhibits inflammatory reaction in interleukin-1β-stimulated human periodontal ligament cells.2021

    • Author(s)
      Yoshitaka Hosokawa, Ikuko Hosokawa, Kazumi Ozaki, Takashi Matsuo.
    • Journal Title

      Pharmaceutics

      Volume: 13 Issue: 5 Pages: 667-667

    • DOI

      10.3390/pharmaceutics13050667

    • NAID

      120007188425

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Nobiletin Decreases Inflammatory Mediator Expression in Tumor Necrosis Factor-Stimulated Human Periodontal Ligament Cells.,2021

    • Author(s)
      Yoshitaka Hosokawa, Ikuko Hosokawa, Kazumi Ozaki
    • Journal Title

      Mediators of Inflammation

      Volume: 2021 Pages: 1-7

    • DOI

      10.1155/2021/5535844

    • NAID

      120007185165

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 香辛料含有成分を歯周炎治療に用いるための基礎的研究2021

    • Author(s)
      細川育子、細川義隆
    • Journal Title

      アグリバイオ

      Volume: 5 Pages: 784-788

    • NAID

      40022670021

    • Related Report
      2021 Annual Research Report
  • [Journal Article] 柑橘類果皮含有生理活性物質を歯周病治療に応用するための基礎的研究2021

    • Author(s)
      細川育子、細川義隆
    • Journal Title

      月刊 メディカル・サイエンス・ダイジェスト

      Volume: 47 Pages: 36-37

    • Related Report
      2021 Annual Research Report
  • [Journal Article] 香辛料含有成分を歯周炎治療に用いるための基礎的研究2021

    • Author(s)
      細川育子、細川義隆
    • Journal Title

      地域ケアリング

      Volume: 23 Pages: 75-78

    • NAID

      40022670021

    • Related Report
      2021 Annual Research Report
  • [Journal Article] The Polymethoxy Flavonoid Sudachitin Inhibits Interleukin-1β-Induced Inflammatory Mediator Production in Human Periodontal Ligament Cells2021

    • Author(s)
      Hosokawa Yoshitaka、Hosokawa Ikuko、Ozaki Kazumi、Matsuo Takashi
    • Journal Title

      BioMed Research International

      Volume: 2021 Issue: 1 Pages: 1-6

    • DOI

      10.1155/2021/8826586

    • NAID

      120007147672

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Carnosic acid inhibits inflammatory cytokines production in human periodontal ligament cells.2020

    • Author(s)
      Hosokawa I., Hosokawa Y., Ozaki K., Matsuo T.
    • Journal Title

      Immunopharmacology and Immunotoxicology

      Volume: 42 Issue: 4 Pages: 373-378

    • DOI

      10.1080/08923973.2020.1782427

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Sudachitin Inhibits Matrix Metalloproteinase-1 and -3 Production in Tumor Necrosis Factor-α-Stimulated Human Periodontal Ligament Cells.2019

    • Author(s)
      Yoshitaka Hosokawa, Ikuko Hosokawa, Kazumi Ozaki, Takashi Matsuo
    • Journal Title

      Inflammation

      Volume: 42 Issue: 4 Pages: 1456-1462

    • DOI

      10.1007/s10753-019-01007-z

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Carnosic Acid Inhibits CXCR3 Ligands Production in IL-27-Stimulated Human Oral Epithelial Cells2019

    • Author(s)
      Hosokawa Ikuko、Hosokawa Yoshitaka、Ozaki Kazumi、Matsuo Takashi
    • Journal Title

      Inflammation

      Volume: 印刷中 Issue: 4 Pages: 1311-1316

    • DOI

      10.1007/s10753-019-00991-6

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Investigation of the Mechanism of Leucocyte Infiltration in Periodontal Lesion and Search of Curative Agent of Periodontal Disease2019

    • Author(s)
      細川 義隆
    • Journal Title

      The Japanese Journal of Conservative Dentistry

      Volume: 62 Issue: 6 Pages: 260-262

    • DOI

      10.11471/shikahozon.62.260

    • NAID

      130007783254

    • ISSN
      0387-2343, 2188-0808
    • Related Report
      2019 Research-status Report
    • Open Access
  • [Presentation] Nobiletinはヒト歯根膜由来細胞のIL-1β誘導炎症性メディエーター産生を抑制する2021

    • Author(s)
      細川義隆、細川育子、尾崎和美、松尾敬志
    • Organizer
      2021年度日本歯科保存学会春季学術大会(第154回)
    • Related Report
      2021 Annual Research Report
  • [Presentation] Sudachitinはヒト歯根膜由来細胞のIL-1β誘導炎症性メディエーター産生を抑制する2020

    • Author(s)
      細川義隆、細川育子、尾崎和美
    • Organizer
      2020年度日本歯科保存学会春季学術大会(第152回)
    • Related Report
      2020 Research-status Report
  • [Presentation] Carnosic Acidはヒト歯根膜由来細胞のIL-1β誘導炎症性サイトカイン産生を抑制する2020

    • Author(s)
      細川育子、細川義隆、尾崎和美
    • Organizer
      2020年度日本歯科保存学会春季学術大会(第152回)
    • Related Report
      2020 Research-status Report

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Published: 2019-04-18   Modified: 2023-01-30  

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