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Inflammatory transformation of myofibers via neutrophil fusion - Elucidation of the onset mechanism of chronic myalgia-

Research Project

Project/Area Number 19K10229
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 57050:Prosthodontics-related
Research InstitutionTohoku University (2020-2023)
Tohoku Fukushi University (2019)

Principal Investigator

TSUCHIYA MASAHIRO  東北大学, 歯学研究科, 非常勤講師 (60372322)

Co-Investigator(Kenkyū-buntansha) 神崎 展  東北大学, 医工学研究科, 教授 (10272262)
萩原 嘉廣  東北大学, 医学系研究科, 大学院非常勤講師 (90436139)
四釜 洋介  国立研究開発法人国立長寿医療研究センター, 研究所 口腔疾患研究部, 副部長 (10588908)
Project Period (FY) 2019-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2022: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2021: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords筋-筋膜性疼痛 / 顎関節症 / 好中球 / サイトカイン / 筋衛星細胞 / 好中球細胞外トラップ / エラスターゼ / 慢性疼痛 / 慢性筋痛
Outline of Research at the Start

顎関節症に伴う慢性痛の多くは筋・筋膜性疼痛疾患と同様の症状を含み,異常な線維性構造(索状硬結)の存在と遷延化した炎症性サイトカイン産生を特徴とする.しかし,その発症メカニズムは不明な点も多く,治療法も確立されていない.
運動後の筋の超回復では細胞融合/取り込みが活発化し,障害(壊死)細胞をも取り込むことが報告されている2).本研究ではその現象に着目し,運動後に浸潤する好中球の取込み(細胞融合のエラー)が炎症性筋線維の形質転換に繋がることを明らかとする.以上を目的として,筋細胞の好中球取込みと炎症性筋線維の形成,および慢性筋痛組織における好中球の動態と炎症性について検討を行う.

Outline of Final Research Achievements

The inflammatory process in skeletal muscle after excessive activities involves a complicated mechanism with the cellular and molecular dynamics. Neutrophils are the main immune cells during acute inflammation and have pleiotropic effects by producing several activators including inflammatory cytokines. We investigated the role of neutrophils in the development process of chronic myalgia in skeletal muscle. In a chronic myalgia model conducted in neutrophil-depleted mice, increased pain thresholds were observed. Not only decreased production of local inflammatory cytokines, but also increased level of end products of NETs were confirmed in region with chronic myalgia. The above results indicate that neutrophils play a very important role in the development process of chronic myalgia.

Academic Significance and Societal Importance of the Research Achievements

顎関節症に伴う慢性筋痛の多くは筋・筋膜性疼痛疾患(MPS)と同様の症状を含み,異常な線維性構造(索状硬結)の存在と遷延化した炎症性サイトカイン産生を特徴とする.しかしながら,その発症メカニズムは不明であり,治療法も確立されていない.
運動後の筋組織では特徴的な好中球の浸潤と細胞融合の活性化が報告されている.本研究ではその現象に着目し,運動後に浸潤する好中球がIL-1産生を介して筋痛を誘導することを明らかとした.好中球は急性炎症時の主要な免疫細胞としての働きが知られる一方で,その役割についての理解は限定的であった.我々の結果は好中球の新規性のある働きを示すものであると考えられる.

Report

(6 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (46 results)

All 2023 2022 2021 2020 2019

All Journal Article (34 results) (of which Int'l Joint Research: 6 results,  Peer Reviewed: 34 results,  Open Access: 28 results) Presentation (11 results) (of which Invited: 3 results) Book (1 results)

  • [Journal Article] Impact of Habitual Yogurt Intake in Mother?Child Dyads on Incidence of Childhood Otitis Media: The Japan Environment and Children’s Study (JECS)2023

    • Author(s)
      Tsuchiya Masahiro、Tsuchiya Shinobu、Momma Haruki、Ikeda Ryoukichi、Suzuki Jun、Nagatomi Ryoichi、Yaegashi Nobuo、Arima Takahiro、Igarashi Kaoru、the Japan Environment and Children’s Study Group
    • Journal Title

      Probiotics and Antimicrobial Proteins

      Volume: - Issue: 3 Pages: 884-893

    • DOI

      10.1007/s12602-023-10086-2

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Knee pain in young sports players aged 6?15?years: a cross-sectional study in Japan2023

    • Author(s)
      Iwatsu Jun、Yabe Yutaka、Sekiguchi Takuya、Momma Haruki、Tsuchiya Masahiro、Kanazawa Kenji、Yoshida Shinichirou、Sogi Yasuhito、Nagatomi Ryoichi、Hagiwara Yoshihiro
    • Journal Title

      BMC Sports Science, Medicine and Rehabilitation

      Volume: 15 Issue: 1 Pages: 16-16

    • DOI

      10.1186/s13102-022-00606-y

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comparative proteome analysis of the ligamentum flavum of patients with lumbar spinal canal stenosis2022

    • Author(s)
      Yabe Yutaka、Hagiwara Yoshihiro、Tsuchiya Masahiro、Minowa Takashi、Takemura Taro、Hattori Shinya、Yoshida Shinichirou、Onoki Takahiro、Ishikawa Keisuke
    • Journal Title

      JOR SPINE

      Volume: 5 Issue: 4

    • DOI

      10.1002/jsp2.1210

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prospective association of short sleep duration in newborns with bruxism behavior in children: The Japan Environment and Children's Study (JECS)2022

    • Author(s)
      Tsuchiya Masahiro、Tsuchiya Shinobu、Momma Haruki、Mizuno Koh、Nagatomi Ryoichi、Yaegashi Nobuo、Arima Takahiro
    • Journal Title

      Sleep Medicine

      Volume: 100 Pages: 71-78

    • DOI

      10.1016/j.sleep.2022.07.018

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Impact of habitual chewing on gut motility via microbiota transition2022

    • Author(s)
      Yaoita Fukie、Watanabe Keita、Kimura Ikuo、Miyazawa Masayuki、Tsuchiya Shinobu、Kanzaki Makoto、Tsuchiya Masahiro、Tan-No Koichi
    • Journal Title

      Scientific Reports

      Volume: 12 Issue: 1 Pages: 13819-13819

    • DOI

      10.1038/s41598-022-18095-x

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association between Prior and Later Occurrence of Shoulder Pain Episodes: A 5-Year Longitudinal Study after the Great East Japan Earthquake2022

    • Author(s)
      Hagiwara Yoshihiro、Yabe Yutaka、Sekiguchi Takuya、Sugawara Yumi、Tsuchiya Masahiro、Tsuji Ichiro
    • Journal Title

      The Tohoku Journal of Experimental Medicine

      Volume: 257 Issue: 2 Pages: 107-115

    • DOI

      10.1620/tjem.2022.J023

    • ISSN
      0040-8727, 1349-3329
    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Tissue accumulation of neutrophil extracellular traps mediates muscle hyperalgesia in a mouse model2022

    • Author(s)
      Suzuki Kazuaki、Tsuchiya Masahiro、Yoshida Shinichirou、Ogawa Kazumi、Chen Weijian、Kanzaki Makoto、Takahashi Tadahisa、Fujita Ryo、Li Yuqing、Yabe Yutaka、Aizawa Toshimi、Hagiwara Yoshihiro
    • Journal Title

      Scientific Reports

      Volume: 12 Issue: 1

    • DOI

      10.1038/s41598-022-07916-8

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Neurodevelopmental trajectories in children with cleft lip and palate: A longitudinal study based on the Japan Environment and Children's Study2022

    • Author(s)
      Tsuchiya Shinobu、Tsuchiya Masahiro、Momma Haruki、Aida Jun、Nagatomi Ryoichi、Yaegashi Nobuo、Arima Takahiro、Igarashi Kaoru、the Japan Environment and Children's Study Group
    • Journal Title

      European Journal of Oral Sciences

      Volume: 130 Issue: 2

    • DOI

      10.1111/eos.12857

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Factors Associated with Thickening of the Ligamentum Flavum on Magnetic Resonance Imaging in Patients with Lumbar Spinal Canal Stenosis2022

    • Author(s)
      Yabe Yutaka、Hagiwara Yoshihiro、Tsuchiya Masahiro、Onoda Yoshito、Yoshida Shinichirou、Onoki Takahiro、Ishikawa Keisuke、Kurosawa Daisuke、Murakami Eiichi
    • Journal Title

      Spine

      Volume: Publish Ahead of Print Issue: 14 Pages: 1036-1041

    • DOI

      10.1097/brs.0000000000004341

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Feeder-supported in vitro exercise model using human satellite cells from patients with sporadic inclusion body myositis2022

    • Author(s)
      Li Yuqing、Chen Weijian、Ogawa Kazumi, ...Suzuki Naoki、Aoki Masashi、Kanzaki Makoto
    • Journal Title

      Scientific Reports

      Volume: 12 Issue: 1

    • DOI

      10.1038/s41598-022-05029-w

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Prospective Association between Maternal Bonding Disorders and Child Toothbrushing Frequency: a cross‐sectional study of the Japan Environment and Children’s Study2021

    • Author(s)
      Tsuchiya Shinobu、Tsuchiya Masahiro、Momma Haruki、Nagatomi Ryoichi、Arima Takahiro、Yaegashi Nobuo、Igarashi Kaoru、The Japan Environment, Children’s Study Group
    • Journal Title

      International Journal of Paediatric Dentistry

      Volume: - Issue: 1 Pages: 56-65

    • DOI

      10.1111/ipd.12791

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Characteristics of Parents Who Feel a Lack of Communication with Coaches of Youth Sports2021

    • Author(s)
      Yabe Yutaka、Hagiwara Yoshihiro、Sekiguchi Takuya、Momma Haruki、Tsuchiya Masahiro、Kanazawa Kenji、Yoshida Shinichirou、Itoi Eiji、Nagatomi Ryoichi
    • Journal Title

      The Tohoku Journal of Experimental Medicine

      Volume: 253 Issue: 3 Pages: 191-198

    • DOI

      10.1620/tjem.253.191

    • NAID

      130007997809

    • ISSN
      0040-8727, 1349-3329
    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association of musculoskeletal pain in other body parts with new-onset shoulder pain: a longitudinal study among survivors of the Great East Japan Earthquake2021

    • Author(s)
      Hagiwara Yoshihiro、Yabe Yutaka、Sekiguchi Takuya、Sugawara Yumi、Tsuchiya Masahiro、Yoshida Shinichirou、Onoki Takahiro、Takahashi Tadahisa、Iwatsu Jun、Tsuji Ichiro、Itoi Eiji
    • Journal Title

      BMJ Open

      Volume: 11 Issue: 2 Pages: e041804-e041804

    • DOI

      10.1136/bmjopen-2020-041804

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Involvement of the Hippocampal Alpha2A-Adrenoceptors in Anxiety-Related Behaviors Elicited by Intermittent REM Sleep Deprivation-Induced Stress in Mice2020

    • Author(s)
      Yaoita Fukie、Namura Kouta、Shibata Kaede、Sugawara Sayaka、Tsuchiya Masahiro、Tadano Takeshi、Tan-No Koichi
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 43 Issue: 8 Pages: 1226-1234

    • DOI

      10.1248/bpb.b20-00255

    • NAID

      130007883823

    • ISSN
      0918-6158, 1347-5215
    • Year and Date
      2020-08-01
    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A 5-year Longitudinal Study of Low Back Pain in Survivors of the Great East Japan Earthquake2020

    • Author(s)
      Yabe Yutaka、Hagiwara Yoshihiro、Sekiguchi Takuya、Sugawara Yumi、Tsuchiya Masahiro、Yoshida Shinichirou、Sogi Yasuhito、Onoki Takahiro、Suzuki Kazuaki、Takahashi Tadahisa、Iwatsu Jun、Tsuji Ichiro、Itoi Eiji
    • Journal Title

      Spine

      Volume: Publish Ahead of Print Issue: 10 Pages: 695-701

    • DOI

      10.1097/brs.0000000000003860

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Joint hemorrhage accelerates cartilage degeneration in a rat immobilized knee model2020

    • Author(s)
      Sogi Yasuhito、Yabe Yutaka、Hagiwara Yoshihiro、Tsuchiya Masahiro、Onoda Yoshito、Sekiguchi Takuya、Itaya Nobuyuki、Yoshida Shinichiro、Yano Toshihisa、Suzuki Kazuaki、Onoki Takahiro、Itoi Eiji
    • Journal Title

      BMC Musculoskeletal Disorders

      Volume: 21 Issue: 1 Pages: 761-761

    • DOI

      10.1186/s12891-020-03795-0

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Imaging of muscle activity‐induced morphometric changes in fibril network of myofascia by two‐photon microscopy2020

    • Author(s)
      Chaweewannakorn Chayanit、Harada Takashi、Nyasha Mazvita R.、Koide Masashi、Shikama Yosuke、Hagiwara Yoshihiro、Sasaki Keiichi、Kanzaki Makoto、Tsuchiya Masahiro
    • Journal Title

      Journal of Anatomy

      Volume: 238 Issue: 3 Pages: 515-526

    • DOI

      10.1111/joa.13339

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Low Back Pain in School-Aged Martial Arts Athletes in Japan: A Comparison among Judo, Kendo, and Karate2020

    • Author(s)
      Yabe Yutaka、Hagiwara Yoshihiro、Sekiguchi Takuya、Momma Haruki、Tsuchiya Masahiro、Kanazawa Kenji、Yoshida Shinichirou、Sogi Yasuhito、Yano Toshihisa、Onoki Takahiro、Itoi Eiji、Nagatomi Ryoichi
    • Journal Title

      The Tohoku Journal of Experimental Medicine

      Volume: 251 Issue: 4 Pages: 295-301

    • DOI

      10.1620/tjem.251.295

    • NAID

      130007884396

    • ISSN
      0040-8727, 1349-3329
    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] High prevalence of low back pain among young basketball players with lower extremity pain: a cross-sectional study2020

    • Author(s)
      Yabe Yutaka、Hagiwara Yoshihiro、Sekiguchi Takuya、Momma Haruki、Tsuchiya Masahiro、Kanazawa Kenji、Itaya Nobuyuki、Yoshida Shinichirou、Sogi Yasuhito、Yano Toshihisa、Onoki Takahiro、Itoi Eiji、Nagatomi Ryoichi
    • Journal Title

      BMC Sports Science, Medicine and Rehabilitation

      Volume: 12 Issue: 1 Pages: 40-40

    • DOI

      10.1186/s13102-020-00189-6

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Preceding Poor Physical Function Is Associated with New-Onset Musculoskeletal Pain among Older Natural Disaster Survivors: A Longitudinal Study after the Great East Japan Earthquake2020

    • Author(s)
      Yabe Yutaka、Hagiwara Yoshihiro、Sekiguchi Takuya、Sugawara Yumi、Tsuchiya Masahiro、Yoshida Shinichirou、Sogi Yasuhito、Yano Toshihisa、Onoki Takahiro、Takahashi Tadahisa、Iwatsu Jun、Tsuji Ichiro、Itoi Eiji
    • Journal Title

      The Tohoku Journal of Experimental Medicine

      Volume: 251 Issue: 1 Pages: 19-26

    • DOI

      10.1620/tjem.251.19

    • NAID

      130007844194

    • ISSN
      0040-8727, 1349-3329
    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Musculoskeletal pain in other body sites is associated with new-onset low back pain: a longitudinal study among survivors of the great East Japan earthquake2020

    • Author(s)
      Yabe Yutaka、Hagiwara Yoshihiro、Sekiguchi Takuya、Sugawara Yumi、Tsuchiya Masahiro、Yoshida Shinichirou、Sogi Yasuhito、Yano Toshihisa、Onoki Takahiro、Takahashi Tadahisa、Iwatsu Jun、Tsuji Ichiro、Itoi Eiji
    • Journal Title

      BMC Musculoskeletal Disorders

      Volume: 21 Issue: 1 Pages: 227-227

    • DOI

      10.1186/s12891-020-03234-0

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] RAGE-dependent NF-kB inflammation processes in the capsule of frozen shoulders2020

    • Author(s)
      Yano Toshihisa、Hagiwara Yoshihiro、Ando Akira、Kanazawa Kenji、Koide Masashi、Sekiguchi Takuya、Itaya Nobuyuki、Onoki Takahiro、Suzuki Kazuaki、Tsuchiya Masahiro、Sogi Yasuhito、Yabe Yutaka、Itoi Eiji
    • Journal Title

      Journal of Shoulder and Elbow Surgery

      Volume: 29 Issue: 9 Pages: 1884-1891

    • DOI

      10.1016/j.jse.2020.01.076

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association between lower back pain and lower extremity pain among young volleyball players: A cross-sectional study2020

    • Author(s)
      Yabe Yutaka、Hagiwara Yoshihiro、Sekiguchi Takuya、Momma Haruki、Tsuchiya Masahiro、Kanazawa Kenji、Itaya Nobuyuki、Yoshida Shinichirou、Sogi Yasuhito、Yano Toshihisa、Onoki Takahiro、Itoi Eiji、Nagatomi Ryoichi
    • Journal Title

      Physical Therapy in Sport

      Volume: 43 Pages: 65-69

    • DOI

      10.1016/j.ptsp.2020.02.005

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Upper Extremity Pain Is Associated with Lower Back Pain among Young Basketball Players: A Cross-Sectional Study2020

    • Author(s)
      Hagiwara Yoshihiro、Yabe Yutaka、Sekiguchi Takuya、Momma Haruki、Tsuchiya Masahiro、Kanazawa Kenji、Yoshida Shinichirou、Sogi Yasuhito、Yano Toshihisa、Onoki Takahiro、Itoi Eiji、Nagatomi Ryoichi
    • Journal Title

      The Tohoku Journal of Experimental Medicine

      Volume: 250 Issue: 2 Pages: 79-85

    • DOI

      10.1620/tjem.250.79

    • NAID

      130007798065

    • ISSN
      0040-8727, 1349-3329
    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Restriction in the hip internal rotation of the stride leg is associated with elbow and shoulder pain in elite young baseball players2020

    • Author(s)
      Sekiguchi Takuya、Hagiwara Yoshihiro、Yabe Yutaka、Tsuchiya Masahiro、Itaya Nobuyuki、Yoshida Shinichiro、Yano Toshihisa、Sogi Yasuhito、Suzuki Kazuaki、Itoi Eiji
    • Journal Title

      Journal of Shoulder and Elbow Surgery

      Volume: 29 Issue: 1 Pages: 139-145

    • DOI

      10.1016/j.jse.2019.07.004

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association of cleft lip and palate on mother-to-infant bonding: a cross-sectional study in the Japan Environment and Children’s Study (JECS)2019

    • Author(s)
      Tsuchiya Shinobu、Japan Environment & Children’s Study Group、Tsuchiya Masahiro、Momma Haruki、Koseki Takeyoshi、Igarashi Kaoru、Nagatomi Ryoichi、Arima Takahiro、Yaegashi Nobuo
    • Journal Title

      BMC Pediatrics

      Volume: 19 Issue: 1 Pages: 505-505

    • DOI

      10.1186/s12887-019-1877-9

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Parents’ Own Experience of Verbal Abuse Is Associated with their Acceptance of Abuse towards Children from Youth Sports Coaches2019

    • Author(s)
      Yabe Yutaka、Hagiwara Yoshihiro、Sekiguchi Takuya、Momma Haruki、Tsuchiya Masahiro、Kanazawa Kenji、Koide Masashi、Itaya Nobuyuki、Yoshida Shinichirou、Sogi Yasuhito、Yano Toshihisa、Onoki Takahiro、Itoi Eiji、Nagatomi Ryoichi
    • Journal Title

      The Tohoku Journal of Experimental Medicine

      Volume: 249 Issue: 4 Pages: 249-254

    • DOI

      10.1620/tjem.249.249

    • NAID

      130007761144

    • ISSN
      0040-8727, 1349-3329
    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Exercise‐evoked intramuscular neutrophil‐endothelial interactions support muscle performance and GLUT4 translocation: a mouse gnawing model study2019

    • Author(s)
      Chaweewannakorn Chayanit、Nyasha Mazvita R.、Chen Weijian、Sekiai Shigenori、Tsuchiya Masahiro、Hagiwara Yoshihiro、Bouzakri Karim、Sasaki Keiichi、Kanzaki Makoto
    • Journal Title

      The Journal of Physiology

      Volume: 598 Issue: 1 Pages: 101-122

    • DOI

      10.1113/jp278564

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Musculoskeletal pain and new-onset poor physical function in elderly survivors of a natural disaster: a longitudinal study after the great East Japan earthquake2019

    • Author(s)
      Yabe Yutaka、Hagiwara Yoshihiro、Sekiguchi Takuya、Sugawara Yumi、Tsuchiya Masahiro、Itaya Nobuyuki、Yoshida Shinichirou、Sogi Yasuhito、Yano Toshihisa、Onoki Takahiro、Tsuji Ichiro、Itoi Eiji
    • Journal Title

      BMC Geriatrics

      Volume: 19 Issue: 1 Pages: 274-274

    • DOI

      10.1186/s12877-019-1283-z

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association between continued residence in temporary prefabricated housing and musculoskeletal pain in survivors of the Great East Japan Earthquake: a longitudinal study2019

    • Author(s)
      Sogi Yasuhito、Yabe Yutaka、Hagiwara Yoshihiro、Sekiguchi Takuya、Sugawara Yumi、Tsuchiya Masahiro、Koide Masashi、Itaya Nobuyuki、Yoshida Shinichirou、Yano Toshihisa、Tsuji Ichiro、Itoi Eiji
    • Journal Title

      BMJ Open

      Volume: 9 Issue: 10 Pages: e030761-e030761

    • DOI

      10.1136/bmjopen-2019-030761

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] In vitro exercise model using contractile human and mouse hybrid myotubes2019

    • Author(s)
      Chen Weijian、Nyasha Mazvita R.、Koide Masashi、Tsuchiya Masahiro、Suzuki Naoki、Hagiwara Yoshihiro、Aoki Masashi、Kanzaki Makoto
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 11914-11914

    • DOI

      10.1038/s41598-019-48316-9

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Verbal Abuse from Coaches Is Associated with Loss of Motivation for the Present Sport in Young Athletes: A Cross-Sectional Study in Miyagi Prefecture2019

    • Author(s)
      Yabe Yutaka、Hagiwara Yoshihiro、Sekiguchi Takuya、Momma Haruki、Tsuchiya Masahiro、Kuroki Kaoru、Kanazawa Kenji、Koide Masashi、Itaya Nobuyuki、Yoshida Shinichirou、Sogi Yasuhito、Yano Toshihisa、Itoi Eiji、Nagatomi Ryoichi
    • Journal Title

      The Tohoku Journal of Experimental Medicine

      Volume: 248 Issue: 2 Pages: 107-113

    • DOI

      10.1620/tjem.248.107

    • NAID

      130007666273

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Involvement of inflammasome activation via elevation of uric acid level in nociception in a mouse model of muscle pain2019

    • Author(s)
      Yoshida Shinichirou、Hagiwara Yoshihiro、Tsuchiya Masahiro、Shinoda Masamichi、Koide Masashi、Hatakeyama Hiroyasu、Chaweewannakorn Chayanit、Suzuki Kazuaki、Yano Toshihisa、Sogi Yasuhito、Itaya Nobuyuki、Sekiguchi Takuya、Yabe Yutaka、Sasaki Keiichi、Kanzaki Makoto、Itoi Eiji
    • Journal Title

      Molecular Pain

      Volume: 15 Pages: 1-16

    • DOI

      10.1177/1744806919858797

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] High prevalence of toothache among Great East Japan Earthquake survivors living in temporary housing.2019

    • Author(s)
      Tsuchiya M, Aida J, Watanabe T, Shinoda M, Sugawara Y, Tomata Y, Yabe Y, Sekiguchi T, Watanabe M, Osaka K, Sasaki K, Hagiwara Y, Tsuji I.
    • Journal Title

      Community Dent Oral Epidemiol.

      Volume: 47(2) Issue: 2 Pages: 119-126

    • DOI

      10.1111/cdoe.12433

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 長期粉末食飼育による結腸機能の低下-TRPV1およびTRPV4の関与-2022

    • Author(s)
      八百板富紀枝、土谷昌広、丹野孝一
    • Organizer
      日本薬理学会北部会
    • Related Report
      2021 Research-status Report
  • [Presentation] 長期粉末食飼育マウスにおける結腸機能の低下-好中球およびTRPV4の関連性 -2022

    • Author(s)
      八百板富紀枝、土谷昌広、丹野孝一
    • Organizer
      日本薬学会(名古屋)
    • Related Report
      2021 Research-status Report
  • [Presentation] 長期粉末食飼育による結腸機能の低下における好中球およびTRPV4の関与につ いて2022

    • Author(s)
      八百板富紀枝、土谷昌広、丹野孝一
    • Organizer
      日本薬理学会年会
    • Related Report
      2021 Research-status Report
  • [Presentation] 長期粉末食飼育誘発マウス結腸運動の低下における免疫細胞の関与2020

    • Author(s)
      八百板富紀枝, 宮澤将之, 土谷昌広, 土谷忍, 丹野孝一
    • Organizer
      日本薬学会東北支部大会
    • Related Report
      2020 Research-status Report
  • [Presentation] コーチングとスポーツ関連外傷歯既往の関連:宮城県スポーツ少年団団員の横断調査2020

    • Author(s)
      土谷昌広, 渡部芳彦, 渡辺誠
    • Organizer
      日本補綴歯科学会 第129回学術大会
    • Related Report
      2020 Research-status Report
  • [Presentation] 食事を生涯楽しむための 健口(けんこう)生活2019

    • Author(s)
      土谷昌広
    • Organizer
      歯と健康のつどい
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 東日本大震災後の歯痛罹患と住居形態に関する検討2019

    • Author(s)
      土谷昌広,相田潤,渡邉崇,篠田雅路,菅原由美,遠又靖丈,矢部裕,関口拓矢,渡邉誠,小坂健,佐々木啓一,萩原嘉廣,辻一郎
    • Organizer
      第41回日本疼痛学会
    • Related Report
      2019 Research-status Report
  • [Presentation] お口と健康 20192019

    • Author(s)
      土谷昌広
    • Organizer
      東北福祉大学公開講座
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 在宅療養歯科支援診療所 及びかかりつけ強化型歯科診療所 届出に関する心得2019

    • Author(s)
      土谷昌広
    • Organizer
      仙台歯科医師会 施設基準届出に係る講習会
    • Related Report
      2019 Research-status Report
  • [Presentation] 東日本大震災後のプレハブ仮設居住者における歯痛罹患に関する検討2019

    • Author(s)
      土谷昌広,渡部芳彦,渡邉 誠,佐々木啓一
    • Organizer
      日本補綴歯科学会第128回学術大会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] スポーツ関連外傷歯既往の関連因子に関するの検討:宮城県スポーツ少年団団員の横断調査2019

    • Author(s)
      土谷昌広,土谷忍
    • Organizer
      日本口腔科学会第73会学術集会
    • Related Report
      2019 Research-status Report
  • [Book] 福祉・保健・医療のための栄養ケア入門2019

    • Author(s)
      渡邉 早苗、寺本 房子、石山 麗子
    • Total Pages
      168
    • Publisher
      建帛社
    • ISBN
      9784767933863
    • Related Report
      2019 Research-status Report

URL: 

Published: 2019-04-18   Modified: 2025-01-30  

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