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Botulinum neurotoxin type B therapy for intractable orofacial pain

Research Project

Project/Area Number 19K10237
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 57050:Prosthodontics-related
Research InstitutionDepartment of Clinical Research, National Hospital Organization Kyoto Medical Center

Principal Investigator

Yoshida Kazuya  独立行政法人国立病院機構(京都医療センター臨床研究センター), 臨床研究企画運営部, 研究員 (90263087)

Project Period (FY) 2019-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2021: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords顎顔面痛 / 顎関節症 / 口腔顔面痛 / 慢性疼痛 / ボツリヌス毒素 / ボツリヌス治療 / 不随意運動 / 顎口腔ジストニア / ブラキシズム / 咀嚼筋 / ジストニア / 三叉神経痛 / ボツリヌス毒素製剤 / 翼口蓋神経節 / CAD/CAM / 口腔顎顔面痛
Outline of Research at the Start

従来の治療法で奏効しない口腔顔面痛の難症例は少なくない。最近、ボツリヌス毒素に鎮痛効果があり、中枢まで移行することが確認された。さらに、B型ボツリヌス毒素製剤が従来使用されてきたA型毒素製剤と比較して、疼痛に対してより効果的であると報告された。したがって、B型ボツリヌス毒素の難治性疼痛への有効性が推測される。申請者は顎口腔領域の筋過緊張に起因する様々な疾患をボツリヌス毒素によって治療してきた。本研究の目的は、世界に先がけて、B型ボツリヌス毒素製剤を口腔顎顔面領域の難治性疼痛に臨床応用し、トリプルマスク化した無作為化比較試験でその効果を実証することである。

Outline of Final Research Achievements

I was able to prove that botulinum toxin therapy is effective for various oral diseases (orofacial pain, oromandibular dystonia, trigeminal neuralgia, functional involuntary movements, temporomandibular joint disorder, habitual temporomandibular joint dislocation, and palatal tremor). Although it was impossible to objectively evaluate the effects of botulinum treatment in the oral region, in 2020, I developed and announced a scale (Oromandibular Dystonia Rating Scale) that can evaluate the effects of botulinum treatment, including QOL. This rating scale has made it possible to more accurately understand the effects of treatment and to conduct research with high evidence.

Academic Significance and Societal Importance of the Research Achievements

口腔領域の様々な疾患に対してボツリヌス治療が有効であることを証明できた。2020年にボツリヌス治療の効果をQOLも含めて評価できるスケール(Oromandibular Dystonia Rating Scale)を開発し、発表した。この評価表によってより正確に治療効果を把握できるようになり、エビデンスの高い研究が可能となった。今後、厚生労働省、製薬会社、患者の会とも連携して、わが国でのボツリヌス毒素製剤の適応拡大に向けて、治験を検討している。適応拡大ができれば、現在治療が困難な上記疾患の多くの患者にとって大きな福音となると考える。

Report

(5 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (45 results)

All 2022 2021 2020 2019 Other

All Journal Article (17 results) (of which Peer Reviewed: 14 results,  Open Access: 7 results) Presentation (18 results) (of which Invited: 3 results) Remarks (10 results)

  • [Journal Article] Botulinum toxin therapy for oromandibular dystonia and other movement disorders in the stomatognathic system2022

    • Author(s)
      Yoshida K
    • Journal Title

      Toxins

      Volume: 14 Issue: 4 Pages: 282-282

    • DOI

      10.3390/toxins14040282

    • Related Report
      2022 Annual Research Report 2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Botulinum toxin therapy for oromandibular dystonia2022

    • Author(s)
      Yoshida K
    • Journal Title

      Scholarly Community Encyclopedia

      Volume: 6 Pages: 23511-23511

    • Related Report
      2022 Annual Research Report
  • [Journal Article] Effects of botulinum toxin therapy on health-related quality of life evaluated by the Oromandibular Dystonia Rating Scale.2022

    • Author(s)
      Yoshida K
    • Journal Title

      Toxins

      Volume: 14 Issue: 11 Pages: 656-656

    • DOI

      10.3390/toxins14110751

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Etiolgy of pneumoparotid: A systematic review.2022

    • Author(s)
      Yoshida K
    • Journal Title

      Journal of Clinical Medicine

      Volume: 12 Issue: 1 Pages: 144-144

    • DOI

      10.3390/jcm12010144

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pneumoparotid related to obstructive sleep apnea syndrome treated by oral appliance with anterior opening to reduce intraoral pressure2022

    • Author(s)
      Yoshida K
    • Journal Title

      Clinical Case Reports

      Volume: 10 Issue: 5 Pages: 5816-5816

    • DOI

      10.1002/ccr3.5816

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] A CAD-CAM-derived needle guide for safe treatment of oromandibular dystonia2022

    • Author(s)
      Yoshida K
    • Journal Title

      Research Features

      Volume: -

    • Related Report
      2021 Research-status Report
  • [Journal Article] Behandlungsstrategien bei oromandibulaerer Dystonie2021

    • Author(s)
      Yoshida K
    • Journal Title

      Fortschritte der Neurologie Psychiatrie

      Volume: 89 Issue: 11 Pages: 562-572

    • DOI

      10.1055/a-1375-0669

    • Related Report
      2021 Research-status Report 2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effects of botulinum toxin type A on pain among trigeminal neuralgia, myofascial temporomandibular disorders, and oromandibular dystonia2021

    • Author(s)
      Yoshida Kazuya
    • Journal Title

      Toxins

      Volume: 13 Issue: 9 Pages: 605-605

    • DOI

      10.3390/toxins13090605

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Clinical Application of Botulinum Neurotoxin for Diseases in the Stomatognathic System2020

    • Author(s)
      吉田 和也
    • Journal Title

      Journal of Japanese Dental Society of Anesthesiology

      Volume: 48 Issue: 2 Pages: 33-40

    • DOI

      10.24569/jjdsa.48.2_33

    • NAID

      130007832247

    • ISSN
      2433-4480
    • Year and Date
      2020-04-15
    • Related Report
      2020 Research-status Report 2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Prevalence and incidence of oromandibular dystonia: an oral and maxillofacial surgery service-based study2020

    • Author(s)
      Yoshida K
    • Journal Title

      Clinical Oral Investigations

      Volume: 印刷中 Issue: 10 Pages: 5755-5764

    • DOI

      10.1007/s00784-021-03878-9

    • Related Report
      2021 Research-status Report 2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] 顎口腔ジストニア2020

    • Author(s)
      吉田和也
    • Journal Title

      Clinical Neuroscienc

      Volume: 38 Pages: 1118-1121

    • Related Report
      2020 Research-status Report
  • [Journal Article] がん治療における口腔ケア2020

    • Author(s)
      吉田和也、吉川 博政
    • Journal Title

      医療

      Volume: 74 Pages: 322-324

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Development and validation of a disease-specific oromandibular dystonia rating scale (OMDRS)2020

    • Author(s)
      Yoshida K
    • Journal Title

      Frontiers in Neurology

      Volume: 11 Pages: 583177-583177

    • DOI

      10.3389/fneur.2020.583177

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinical characteristics of functional movement disorders in the stomatognathic system2020

    • Author(s)
      Kazuya Yoshida
    • Journal Title

      Frontiers in Neurology

      Volume: 11 Pages: 123-123

    • DOI

      10.3389/fneur.2020.00123

    • Related Report
      2020 Research-status Report 2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Single-center analysis of antiresorptive agent-related osteonecrosis of the jaw in lung cancer patients2020

    • Author(s)
      Okamura M, Fujita K, Yamamoto Y, Kanai O, Nakatani K, Horimoto K, Hashimoto M, Sawai S, Shimosato M, Yoshida K, Mio T
    • Journal Title

      Asia-Pacific Journal of Clinical Oncology

      Volume: 16 Issue: 6 Pages: 380-384

    • DOI

      10.1111/ajco.13395

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sphenopalatine ganglion block with botulinum neurotoxin for treating trigeminal neuralgia using CAD/CAM-derived injection guide2020

    • Author(s)
      Kazuya Yoshida
    • Journal Title

      Journal of oral & facial pain and haeadache

      Volume: 34 Issue: 2 Pages: 135-140

    • DOI

      10.11607/ofph.2510

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Kazuya Yoshida2020

    • Author(s)
      Mouth opening retaining appliance after coronoidotomy for the treatment of trismus: effects on pain during postoperative training and maximal extent of mouth opening.
    • Journal Title

      Clinics in Surgery

      Volume: 5 Pages: 2737-2737

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 顎関節症の難治性筋痛に対するボツリヌス治療2022

    • Author(s)
      吉田和也
    • Organizer
      第35回日本顎関節学会総会・学術大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 口腔内装置によって治療した睡眠時無呼吸症候群を伴う耳下腺気腫の1例2022

    • Author(s)
      吉田和也,河岡有美,兵 行忠
    • Organizer
      第67回日本口腔外科学会 総会・学術大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Three cases of minimally invasive surgery using surgical endoscope and navigation system2022

    • Author(s)
      Kizuka S, Kawaoka Y, Yoshida K, Hyo Y
    • Organizer
      第67回日本口腔外科学会 総会・学術大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Crouzon症候群男児に発生したセメント質骨形成線維腫の1例2022

    • Author(s)
      河岡有美,吉田和也,兵 行忠
    • Organizer
      第67回日本口腔外科学会 総会・学術大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 顎口腔ジストニアに対する感覚トリック を応用したスプリント療法2021

    • Author(s)
      吉田和也
    • Organizer
      公益社団法人日本補綴歯科学会 第130回記念学術大会
    • Related Report
      2021 Research-status Report
  • [Presentation] 顎口腔ジストニアの鑑別診断用問診表の有用性について2021

    • Author(s)
      吉田和也
    • Organizer
      第34回一般社団法人日本顎関節学会総会・学術大会
    • Related Report
      2021 Research-status Report
  • [Presentation] CAD/CAMによる注射針誘導ガイドを用いた 第二枝の三叉神経痛のボツリヌス治療2021

    • Author(s)
      吉田和也
    • Organizer
      第34回一般社団法人日本顎関節学会総会・学術大会
    • Related Report
      2021 Research-status Report
  • [Presentation] 顎口腔ジストニア(oromandibular dystonia)の有病率と年間発症率2021

    • Author(s)
      吉田和也
    • Organizer
      第8回日本ボツリヌス治療学会学術大会
    • Related Report
      2021 Research-status Report
  • [Presentation] 顎関節症に対するボツリヌス治療の効果と安全性について2021

    • Author(s)
      吉田和也
    • Organizer
      第8回日本ボツリヌス治療学会学術大会
    • Related Report
      2021 Research-status Report
  • [Presentation] 顎口腔ジストニア評価スケールの信頼性と妥当性2021

    • Author(s)
      吉田和也, 木塚慎弥, 河岡有美, 兵 行忠
    • Organizer
      日本口腔外科学会第66回学術大会
    • Related Report
      2021 Research-status Report
  • [Presentation] 顎口腔ジストニアの有病率と年間発症率2021

    • Author(s)
      吉田和也, 木塚慎弥, 河岡有美, 兵 行忠
    • Organizer
      日本口腔外科学会第66回学術大会
    • Related Report
      2021 Research-status Report
  • [Presentation] 口腔領域の疾患に対するボツリヌス治療2021

    • Author(s)
      吉田和也
    • Organizer
      ZUNAGERD会オンラインセミナー
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] CAD/CAMによる注射針誘導ガイドを用いた第二枝の三叉神経痛に対するボツリヌス治療2020

    • Author(s)
      吉田和也
    • Organizer
      第7回日本ボツリヌス治療学会学術大会
    • Related Report
      2020 Research-status Report
  • [Presentation] 歯科口腔外科疾患への臨床応用2019

    • Author(s)
      吉田和也
    • Organizer
      第6回日本ボツリヌス治療学会学術大会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] ボツリヌス毒素の口腔領域への臨床応用2019

    • Author(s)
      吉田和也
    • Organizer
      第47回日本歯科麻酔学会総会・学術集会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 骨吸収抑制薬関連顎骨壊死(ARONJ)Stage3の激痛に対して多職種連携し保存的療法で自宅退院後も良好な疼痛コントロールが得られた一例2019

    • Author(s)
      下郷麻衣子, 河鰭憲幸, 青木友和, 辰巳晃造, 上村直子, 青山佳代子, 吉田和也, 坂根直樹, 土屋宣之
    • Organizer
      第24回日本緩和医療学会学術大会
    • Related Report
      2019 Research-status Report
  • [Presentation] 下顎骨骨折術後に発症した壊死性筋膜炎の1例2019

    • Author(s)
      宮本絵里加, 吉田和也, 木塚慎弥, 藤井伸夫, 大野淳, 荒田順, 兵行忠
    • Organizer
      第64回日本口腔外科学会総会・学術大会
    • Related Report
      2019 Research-status Report
  • [Presentation] 下顎下縁部に発症した周辺性緻密骨種の1例2019

    • Author(s)
      木塚慎哉, 井上亮, 宮本絵里加, 吉田和也, 兵行忠
    • Organizer
      第64回日本口腔外科学会総会・学術大会
    • Related Report
      2019 Research-status Report
  • [Remarks] 顎口腔領域の不随意運動

    • URL

      https://sites.google.com/site/oromadibulardystonia/

    • Related Report
      2022 Annual Research Report 2021 Research-status Report 2020 Research-status Report 2019 Research-status Report
  • [Remarks] Involuntary movements

    • URL

      https://sites.google.com/site/oromandibulardystoniaenglish/

    • Related Report
      2022 Annual Research Report 2020 Research-status Report
  • [Remarks] Unwillkürliche Bewegungen

    • URL

      https://sites.google.com/site/oromandibulaeredystonie/

    • Related Report
      2022 Annual Research Report
  • [Remarks] Les mouvements involontaires

    • URL

      https://sites.google.com/site/dystonieoromandibulaire/

    • Related Report
      2022 Annual Research Report 2021 Research-status Report 2020 Research-status Report 2019 Research-status Report
  • [Remarks] 下颌口腔部位的不自主运动

    • URL

      https://sites.google.com/site/oromandibulardystoniachinese/

    • Related Report
      2022 Annual Research Report
  • [Remarks] Involuntary movements of the stomatognathic region

    • URL

      https://sites.google.com/site/oromandibulardystoniaenglish/

    • Related Report
      2021 Research-status Report 2019 Research-status Report
  • [Remarks] Unwillkuerliche Bewegungen

    • URL

      https://sites.google.com/site/oromandibulaeredystonie/

    • Related Report
      2021 Research-status Report 2020 Research-status Report
  • [Remarks] 口腔部位的不自主

    • URL

      https://sites.google.com/site/oromandibulardystoniachinese/

    • Related Report
      2021 Research-status Report 2019 Research-status Report
  • [Remarks] Movimientos involuntarios

    • Related Report
      2020 Research-status Report
  • [Remarks] Bewegungen der Mund- und Kieferregion

    • URL

      https://sites.google.com/site/oromandibulaeredystonie/

    • Related Report
      2019 Research-status Report

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Published: 2019-04-18   Modified: 2024-01-30  

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