Project/Area Number |
19K10250
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 57050:Prosthodontics-related
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Research Institution | Nagasaki University |
Principal Investigator |
バラネザハド 有礼左 (バラネザハド アリレザ) 長崎大学, 医歯薬学総合研究科(歯学系), 助教 (00608870)
|
Co-Investigator(Kenkyū-buntansha) |
渡邊 郁哉 長崎大学, 医歯薬学総合研究科(歯学系), 教授 (00274671)
尾立 哲郎 長崎大学, 病院(歯学系), 講師 (70513167)
|
Project Period (FY) |
2019-04-01 – 2024-03-31
|
Project Status |
Granted (Fiscal Year 2022)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2021: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | implant / zirconia / vioactivity / Implant / Zirconia / Bioactivity / インプラント / ジルコニア / 生体活性 / 生体材料 / 骨形成 |
Outline of Research at the Start |
インプラント治療の成功の鍵は、早期にオッセオインテグレーションを達成することである。これまで主流のチタンインプラントに比べ、欧州で認可を受けているイットリア系部分安定化ZrO2 (ジルコニア)インプラントは破壊靭性に優れるが、水熱劣化や骨伝導性がないという欠点がある。そこで、本研究の目的は水熱劣化を起こさないセリア系ZrO2/アルミナ複合体表面に強固なジルコニア融合コーティングビーズを埋め込むことで表面を粗造化し、粗造化した表面に成分徐放性のあるバイオガラス(BG)膜を生成させることで、生体活性のあるジルコニアインプラントを創出することである。
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Outline of Annual Research Achievements |
Ceramic 45S5 BG (45%SiO2, 24.5%Na2O, 24.5%CaO, and 6%P2O5 by weight) have gained researchers attention as a functional biomaterial due to its bioactive surface and osseointegration ability. It has been approved that BG 45S5 can heal and repair bone damages. Therefore, The sol-gel technique preparation protocol followed to prepare 45S5 BG, by mixing the tetraethylorthosilicate (TEOS, Wako, Tokyo, Japan), nitric acid, triethylphosphate (TEP, Wako, Japan), calcium nitrate tetrahydrate (Wako), sodium nitrate (Wako). The zirconia substrates coated by one-time vacuum sol-dipping method under 0.1 bar pressure dipped for 60 s and dried at 60°C for 1 hour followed by sintering at 1200°C for 1 hour to melt the BG on the surface in a programmable furnace with a heating rate of 10°C/min. The characterizations such as morphology, adhesion test and roughness investigated after BG coating. The SEM images confirmed that 900°C is not enough to melt and cover entire surface therefore 1200°C was applied. Also the Fractography result showed that the thickness of the coating layer is controllable between 5 um to 45 um. The XRD result mentioned the non-crystallin and crystalline BG phase structures.
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Current Status of Research Progress |
Current Status of Research Progress
3: Progress in research has been slightly delayed.
Reason
The BG coating was fully covered the zirconia substrate also the BG coating firmly adhered to the surface and the thickness of coating was controllable.
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Strategy for Future Research Activity |
The BG coating, prepared by sol-gel technique, on the rough bead-fused zirconia substrates coated by one-time vacuum sol-dipping method under 0.1 bar pressure and dipped for 60s and sintered at 1200°C for 1 hour will be characterized more. The characterizations such as TEM and adhesion test and roughness will be investigated. Later cell study will be investigated for biological properties.
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