Analysis of osteoclastogenesis and orthodontic tooth movement in an experimental hypertensive mouse model

• Project/Area Number: 19K10397
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 57070:Developmental dentistry-related
• Research Institution: Tohoku University
• Principal Investigator: Kitaura Hideki 東北大学, 歯学研究科, 准教授 (60295087)
• Co-Investigator(Kenkyū-buntansha): 溝口 到 東北大学, 歯学研究科, 教授 (20200032) ; 島 和弘 東北大学, 歯学研究科, 非常勤講師 (40792148) ; 石田 匡彦 東北大学, 歯学研究科, 大学院非常勤講師 (80770891)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2021: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 破骨細胞 / 高血圧 / 骨芽細胞 / 矯正歯科 / 骨吸収 / 歯の移動 / マウス

Outline of Research at the Start

近年、高齢化に伴い、歯科矯正領域においても様々な生活習慣病を有する患者が増加している。肥満、糖尿病にならび高血圧もその一つである。この高血圧は、骨吸収を増加が報告されている。矯正学的歯の移動では、破骨細胞が骨を吸収し歯が移動していく。これらのことから高血圧患者において、矯正学的歯の移動に影響が出ることが考えられる。しかしながら、高血圧マウスモデルでの矯正学的歯の移動に関する研究はない。そこで、高血圧マウスモデルでの矯正学的歯の移動の検討、破骨細胞形成に対する高血圧治療薬の影響およびそのメカニズムの解明、さらに高血圧治療薬の矯正学的歯の移動への影響を検討することである。

Outline of Final Research Achievements

We succussed to establish hypertensive mice by feeding LNAME. When hypertensive mice were injected with LPS, osteoclast formation and bone resorption were increased in hypertensive mice compared to normal mice. In addition, TNF-α in the serum of hypertensive mice was increased. Furthermore, the expression of AT1R was increased, and the expression of ATGR1 was found to increase when TNF-α acted on osteoblasts in vitro. Furthermore, femurs from hypertensive mice showed decreased bone mass and osteoporosis-like findings. These findings indicate that hypertension increases TNF-α and AGTR1 expression in osteoblasts, which in turn increases RANKL expression and osteoclastogenesis.

Academic Significance and Societal Importance of the Research Achievements

本研究では、高血圧が誘導されるマウスモデルを作成し、高血圧誘導時に骨粗鬆症が誘発されることを発見した。さらにそのメカニズムは、高血圧誘導時、炎症を増大させることが知られているTNF-αが増加し、TNF-αが骨を吸収する細胞である破骨細胞の形成に必要不可欠なRANKLを増加することで破骨細胞が増加し、骨の吸収が増加することを解明した。本研究成果により新しい治療薬、治療法などの医療の発展にもつながり、さらには矯正学的歯の移動のメカニズムの解明にも寄与する可能性のある、非常に意義のあることだと考えている。

Research Products

• [Journal Article] Salt-Sensitive Hypertension Induces Osteoclastogenesis and Bone Resorption via Upregulation of Angiotensin II Type 1 Receptor Expression in Osteoblasts (2022)
  • Author(s): Adya Pramusita, Hideki Kitaura, Fumitoshi Ohori, Takahiro Noguchi, Aseel Marahleh, Yasuhiko Nara, Ria Kinjo, Jinghan Ma, Kayoko Kanou, Yukinori Tanaka and Itaru Mizoguchi
  • Journal Title: Frontiers in Cell and Developmental Biology Volume: 10 Pages: 816764-816764
  • DOI: 10.3389/fcell.2022.816764
  • Peer Reviewed / Open Access
• [Journal Article] Micro-Osteoperforations Induce TNF-α Expression and Accelerate Orthodontic Tooth Movement via TNF-α-Responsive Stromal Cells (2022)
  • Author(s): Kinjo Ria、Kitaura Hideki、Ogawa Saika、Ohori Fumitoshi、Noguchi Takahiro、Marahleh Aseel、Nara Yasuhiko、Pramusita Adya、Ma Jinghan、Kanou Kayoko、Mizoguchi Itaru
  • Journal Title: International Journal of Molecular Sciences Volume: 23 Issue: 6 Pages: 2968-2968
  • DOI: 10.3390/ijms23062968
  • Peer Reviewed / Open Access
• [Journal Article] Role of the Interaction of Tumor Necrosis Factor-α and Tumor Necrosis Factor Receptors 1 and 2 in Bone-Related Cells (2022)
  • Author(s): Kitaura Hideki、Marahleh Aseel、Ohori Fumitoshi、Noguchi Takahiro、Nara Yasuhiko、Pramusita Adya、Kinjo Ria、Ma Jinghan、Kanou Kayoko、Mizoguchi Itaru
  • Journal Title: International Journal of Molecular Sciences Volume: 23 Issue: 3 Pages: 1481-1481
  • DOI: 10.3390/ijms23031481
  • Peer Reviewed / Open Access
• [Journal Article] Tumor necrosis factor-α enhances the expression of vascular endothelial growth factor in a mouse orthodontic tooth movement model (2022)
  • Author(s): Noguchi Takahiro、Kitaura Hideki、Marahleh Aseel、Ohori Fumitoshi、Nara Yasuhiko、Pramusita Adya、Kinjo Ria、Ma Jinghan、Kanou Kayoko、Mizoguchi Itaru
  • Journal Title: Journal of Dental Sciences Volume: 17 Issue: 1 Pages: 415-420
  • DOI: 10.1016/j.jds.2021.08.011
  • Peer Reviewed / Open Access
• [Journal Article] CXC receptor7 agonist acts as a CXC motif chemokine ligand12 inhibitor to ameliorate osteoclastogenesis and bone resorption (2022)
  • Author(s): Nugraha Alexander、Kitaura Hideki、Ohori Fumitoshi、Pramusita Adya、Ogawa Saika、Noguchi Takahiro、Marahleh Aseel、Nara Yasuhiko、Kinjo Ria、Mizoguchi Itaru
  • Journal Title: Molecular Medicine Reports Volume: 25 Issue: 3 Pages: 78-78
  • DOI: 10.3892/mmr.2022.12594
  • Peer Reviewed / Open Access
• [Journal Article] Effect of TNF-α on osteocyte RANKL expression during orthodontic tooth movement (2021)
  • Author(s): Marahleh Aseel、Kitaura Hideki、Ohori Fumitoshi、Noguchi Takahiro、Nara Yasuhiko、Pramusita Adya、Kinjo Ria、Ma Jinghan、Kanou Kayoko、Mizoguchi Itaru
  • Journal Title: Journal of Dental Sciences Volume: 16 Issue: 4 Pages: 1191-1197
  • DOI: 10.1016/j.jds.2021.03.006
  • Peer Reviewed / Open Access
• [Journal Article] Effects of Incretin-Related Diabetes Drugs on Bone Formation and Bone Resorption (2021)
  • Author(s): Kitaura Hideki、Ogawa Saika、Ohori Fumitoshi、Noguchi Takahiro、Marahleh Aseel、Nara Yasuhiko、Pramusita Adya、Kinjo Ria、Ma Jinghan、Kanou Kayoko、Mizoguchi Itaru
  • Journal Title: International Journal of Molecular Sciences Volume: 22 Issue: 12 Pages: 6578-6578
  • DOI: 10.3390/ijms22126578
  • Peer Reviewed / Open Access
• [Journal Article] The miR-155-5p inhibits osteoclast differentiation through targeting CXCR2 in orthodontic root resorption (2021)
  • Author(s): Jiang H, Kitaura H, Liu L, Mizoguchi I, Liu S.
  • Journal Title: J Periodontal Res Volume: - Issue: 4 Pages: 761-773
  • DOI: 10.1111/jre.12875
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Inhibition of the CXCL9-CXCR3 axis suppresses the progression of experimental apical periodontitis by blocking macrophage migration and activation (2021)
  • Author(s): Hasegawa Tatsuya、Venkata Suresh V.、Yahata Yoshio、Nakano Masato、Suzuki Shigeto、Suzuki Shigeki、Yamada Satoru、Kitaura Hideki、Mizoguchi Itaru、Noiri Yuichiro、Handa Keisuke、Saito Masahiro
  • Journal Title: Scientific Reports Volume: 11 Issue: 1 Pages: 2613-2613
  • DOI: 10.1038/s41598-021-82167-7
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Local administration of high-dose diabetes medicine exendin-4 inhibits orthodontic tooth movement in mice (2020)
  • Author(s): Shen Wei-Ren、Kitaura Hideki、Qi Jiawei、Ogawa Saika、Ohori Fumitoshi、Noguchi Takahiro、Marahleh Aseel、Nara Yasuhiko、Adya Pramusita、Mizoguchi Itaru
  • Journal Title: The Angle Orthodontist Volume: 91 Issue: 1 Pages: 111-118
  • DOI: 10.2319/021320-103.1
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Anti-c-fms Antibody Prevents Osteoclast Formation and Bone Resorption in Co-Culture of Osteoblasts and Osteoclast Precursors In Vitro and in Ovariectomized Mice (2020)
  • Author(s): Nara Yasuhiko、Kitaura Hideki、Ogawa Saika、Shen Wei-Ren、Qi Jiawei、Ohori Fumitoshi、Noguchi Takahiro、Marahleh Aseel、Pramusita Adya、Kinjo Ria、Mizoguchi Itaru
  • Journal Title: International Journal of Molecular Sciences Volume: 21 Issue: 17 Pages: 6120-6120
  • DOI: 10.3390/ijms21176120
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Effect of a DPP-4 Inhibitor on Orthodontic Tooth Movement and Associated Root Resorption (2020)
  • Author(s): Qi Jiawei、Kitaura Hideki、Shen Wei-Ren、Ogawa Saika、Ohori Fumitoshi、Noguchi Takahiro、Marahleh Aseel、Nara Yasuhiko、Adya Pramusita、Mizoguchi Itaru
  • Journal Title: BioMed Research International Volume: 2020 Pages: 1-9
  • DOI: 10.1155/2020/7189084
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Osteocyte-Related Cytokines Regulate Osteoclast Formation and Bone Resorption (2020)
  • Author(s): Kitaura Hideki、Marahleh Aseel、Ohori Fumitoshi、Noguchi Takahiro、Shen Wei-Ren、Qi Jiawei、Nara Yasuhiko、Pramusita Adya、Kinjo Ria、Mizoguchi Itaru
  • Journal Title: International Journal of Molecular Sciences Volume: 21 Issue: 14 Pages: 5169-5169
  • DOI: 10.3390/ijms21145169
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] TNF-α stimulates the expression of RANK during orthodontic tooth movement (2020)
  • Author(s): Noguchi Takahiro、Kitaura Hideki、Ogawa Saika、Qi Jiawei、Shen Wei-Ren、Ohori Fumitoshi、Marahleh Aseel、Nara Yasuhiko、Pramusita Adya、Mizoguchi Itaru
  • Journal Title: Archives of Oral Biology Volume: 117 Pages: 104796-104796
  • DOI: 10.1016/j.archoralbio.2020.104796
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Obtaining Primary Osteocytes through Murine Calvarial Fractionation of GFP-Expressing Osteocytes (2020)
  • Author(s): Marahleh Aseel、Kitaura Hideki、Ogawa Saika、Shen Wei-Ren、Qi Jiawei、Ohori Fumitoshi、Noguchi Takahiro、Nara Yasuhiko、Pramusita Adya、Kinjo Ria、Mizoguchi Itaru
  • Journal Title: Journal of Visualized Experiments Volume: 160 Issue: 160
  • DOI: 10.3791/61513
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Effect of TNF-α-induced sclerostin on osteocytes during orthodontic tooth movement (2020)
  • Author(s): Ohori F, Kitaura H, Ogawa S, Shen WR, Qi J, Noguchi T, Marahleh A, Nara Y, Pramusita A, Mizoguchi I.
  • Journal Title: J Immunol Res Volume: 2019 Pages: 1-10
  • DOI: 10.1155/2019/9716758
  • Peer Reviewed / Open Access
• [Journal Article] TNF-α directly enhances osteocyte RANKL expression and promotes osteoclast formation. (2019)
  • Author(s): Marahleh A, Kitaura H, Ohori F, Kishikawa A, Ogawa S, Shen WR, Qi J, Noguchi T, Nara Y, Mizoguchi I.
  • Journal Title: Front Immunol Volume: 10 Issue: 3 Pages: 2925-2925
  • DOI: 10.3390/ijms21031130
  • Peer Reviewed / Open Access
• [Journal Article] Establishment of an orthodontic retention mouse model and the effect of anti-c-Fms antibody on orthodontic relapse (2019)
  • Author(s): Qi J, Kitaura H, Shen WR, Kishikawa A, Ogawa S, Ohori F, Noguchi T, Marahleh A, Nara Y, Mizoguchi I.
  • Journal Title: PLos One Volume: 14 Issue: 6 Pages: e0214260-e0214260
  • DOI: 10.1371/journal.pone.0214260
  • Peer Reviewed / Open Access
• [Journal Article] TNF-α is responsible for the contribution of stromal cells to osteoclast and odontoclast formation during orthodontic tooth movement (2019)
  • Author(s): Ogawa S, Kitaura H, Kishikawa A, Qi J, Shen WR, Ohori F, Noguchi T, Marahleh A, Nara Y, Ochi Y, Mizoguchi I.
  • Journal Title: PLos One Volume: 14 Issue: 10 Pages: e0223989-e0223989
  • DOI: 10.1371/journal.pone.0223989
  • Peer Reviewed / Open Access
• [Journal Article] TNF-α Directly Enhances Osteocyte RANKL Expression and Promotes Osteoclast Formation (2019)
  • Author(s): Marahleh Aseel、Kitaura Hideki、Ohori Fumitoshi、Kishikawa Akiko、Ogawa Saika、Shen Wei-Ren、Qi Jiawei、Noguchi Takahiro、Nara Yasuhiko、Mizoguchi Itaru
  • Journal Title: Frontiers in Immunology Volume: 10 Pages: 2925-2925
  • DOI: 10.3389/fimmu.2019.02925
  • Peer Reviewed / Open Access
• [Presentation] Salt-Sensitive Hypertension Induces Osteoclastogenesis and Bone Resorption via Upregulation of AGTR1 Expression in Osteoblast (2021)
  • Author(s): Pramusita A, Kitaura H, Ogawa S, Ohori F, Noguchi T, Marahleh A, Nara Y, Kinjo R, Ma J, Kanou K, Mizoguchi I
  • Organizer: The 16th International Workshop on Biomaterials in Interface Science
  • Int'l Joint Research
• [Presentation] TNF-α Enhances Osteocytic-driven Osteoclastogenesis by promoting RANKL Expression in vivo and in vitro (2021)
  • Author(s): Marahleh A, Kitaura H, Kishikawa A, Ogawa S, Shen WR, Qi J, Ohori F, Noguchi T, Nara Y, Pramusita A, Mizoguchi I
  • Organizer: Interface Summer Seminar 2021 The 16th International Workshop on Biomaterials in Interface Science
  • Int'l Joint Research
• [Presentation] Investigation of the Effect of Anti-c-fms Antibody on Osteoclast formation in Ovariectomized Mice (2021)
  • Author(s): Nara Y, Kitaura H, Ogawa S, Shen WR, Qi J, Ohori F, Noguchi T, Marahleh A, Pramusita A, Kinjo R, Mizoguchi I
  • Organizer: American Society for Bone and Mineral Research 2021 Annual Meeting
  • Int'l Joint Research
• [Presentation] Salt-Sensitive Hypertension Induces Systemic Bone Resorption Via Upregulation of Angiotensin II Type 1 Receptor in Osteoblast (2021)
  • Author(s): Pramusita A, Kitaura H, Ogawa S, Ohori F, Noguchi T, Marahleh A, Nara Y, Kinjo R, Mizoguchi I
  • Organizer: American Society for Bone and Mineral Research 2021 Annual Meeting
  • Int'l Joint Research
• [Presentation] Increased osteoclastogenesis and bone resorption in salt-sensitive hypertension via upregulation of AGTR1 Expression in Osteoblast (2021)
  • Author(s): Pramusita A, Kitaura H, Ogawa S, Ohori F, Noguchi T, Marahleh A, Nara Y, Kinjo R, Jingham M, Kano K, Mizoguchi I
  • Organizer: The 80th Annual Meeting of the Japanese Orthodontic Society & The 5th International Congress
  • Int'l Joint Research
• [Presentation] Docosahexaenoic Acid inhibit TNF-α-induced osteoclast formation, bone resorption and orthodontic tooth movement through GPR120 (2021)
  • Author(s): Jingham M, Kitaura H, Ogawa S, Ohori F, Noguchi T, Marahleh A, Nara Y, Pramusita A, Kinjo R, Mizoguchi I
  • Organizer: The 80th Annual Meeting of the Japanese Orthodontic Society & The 5th International Congress
  • Int'l Joint Research
• [Presentation] Micro-osteoperforations induce accelerate orthodontic tooth movement via TNF-α expression (2021)
  • Author(s): Kinjo R, Kitaura H, Ogawa S, Ohori F, Noguchi T, Marahleh A, Nara Y, Pramusita A, Jingham M, Kano K, Mizoguchi I
  • Organizer: FJMU-HKU-TU International Symposioum on Oral Health Science 2021
  • Int'l Joint Research
• [Presentation] Docosahexaenoic acid inhibits osteoclast formation and orthodontic tooth movement through GPR120 (2021)
  • Author(s): Jingham M, Kitaura H, Kishikawa A, Ogawa S, Ohori F, Noguchi T, Marahleh A, Nara Y, Pramusita A, Kinjo R, Kano K, Mizoguchi I
  • Organizer: Tohoku and Airlangga Dental Seminar (TADS)
  • Int'l Joint Research
• [Presentation] Enhancement of orthodontic tooth movement and root resorption in ovariectomized mice (2021)
  • Author(s): Nara Y, Kitaura H, Marahleh A, Ohori F, Noguchi T, Pramusita A, Kinjo R, Jingham M, Kano K, Mizoguchi I
  • Organizer: International Symposium for Interface Oral Health Science 2022
  • Int'l Joint Research
• [Presentation] Development of orthodontic wires for metal allergy patient using titanium nitride plating (2021)
  • Author(s): Ito A, Kitaura H, Sugisawa H, Noguchi T, Ohori F, Mizoguchi I
  • Organizer: International Symposium for Interface Oral Health Science 2022
  • Int'l Joint Research
• [Presentation] TNF-α Directly and Indirectly Induces RANKL Expression on Osteocytes during Orthodontic Tooth Movement. (2020)
  • Author(s): Ohori F, Kitaura H, Marahleh A, Kishikawa A, Ogawa S, Noguchi T, Nara Y, Pramusita A, Kinjo R, Ma J, Mizoguchi I.
  • Organizer: International JointSymposium 2020, The 15th International Workshop on Biomaterials in Interface ScienceThe 11th Symposium on Innovative Dental-Engineering Alliance,
  • Int'l Joint Research
• [Presentation] TNF-α induces orthodontic tooth movement and enhances osteocyte RANKL expression by activating MAPKs and NFκB pathway. (2020)
  • Author(s): Marahleh A, Kitaura H, Ohori F, Ogawa S, Noguchi T, Nara Y, Pramusita A, Kinjo R, Mizoguchi I.
  • Organizer: The 9th International Orthodontic Congress
  • Int'l Joint Research
• [Presentation] Solt-sensitive hypertension exacerbates osteoclastogenesis and bone resorption in vivo. (2020)
  • Author(s): Pramusita A, Kitaura H, Ogawa S, Ohori F, Noguchi T, Marahleh A, Nara Y, Kinjo R, Mizoguchi I.
  • Organizer: The 9th International Orthodontic Congress
  • Int'l Joint Research
• [Presentation] Micro-osteoperforations induce TNF-α expression and accelerate orthodontic tooth movement in mice. (2020)
  • Author(s): Kinjo R, Kitaura H, Ogawa S, Ohori F, Noguchi T, Marahleh A, Nara Y, Pramusita A, Mizoguchi I.
  • Organizer: The 9th International Orthodontic Congress
  • Int'l Joint Research
• [Presentation] Craniofacial characteristics, malocclusions and successful orthodontic treatment results in 3 Diamond Blackfan Syndrome patients. (2020)
  • Author(s): Sasaki S, Kitaura H, Yoshida M, Mayama A, Mizoguchi I.
  • Organizer: The 9th International Orthodontic Congress
  • Int'l Joint Research
• [Presentation] Statistical and clinical survey of congenital disease patients in the past 10-year period in Tohoku University Hospital Department of orthodontics. (2020)
  • Author(s): Sasaki S, Kitaura H, Maeda T, Ogawa S, Ogura H, Kameda M, Kinjo R, Shigemi S, Numazaki K, Mizoguchi I.
  • Organizer: The 9th International Orthodontic Congress
  • Int'l Joint Research
• [Presentation] Role of TNF-α-responsible stromal clls to osteoclast and odontoclast formation during orthodontic tooth movement. (2020)
  • Author(s): Ogawa S, Kitaura H, Ohori F, Noguchi T, Marahleh A, Nara Y, Pramusita A, Mizoguchi I.
  • Organizer: The 9th International Orthodontic Congress
  • Int'l Joint Research
• [Presentation] TNF-α stimulates the expression of RANK during orthodontic tooth movement. (2020)
  • Author(s): Noguchi T, Kitaura H, Ogawa S, Ohori F, Marahleh A, Nara Y, Pramusita A, Kinjo R, Mizoguchi I.
  • Organizer: The 9th International Orthodontic Congress
  • Int'l Joint Research
• [Presentation] Diabetes medicine DPP-4 inhibitor inhibits orthodontic tooth movement and associated root resorption in mouse tooth movement model. (2020)
  • Author(s): Noguchi T, Kitaura H, Qi J, Ogawa S, Ohori F, Marahleh A, Nara Y, Pramusita A, Kinjo R, Mizoguchi I.
  • Organizer: The 9th International Orthodontic Congress
  • Int'l Joint Research
• [Presentation] Diabetes Medicine Glucagon-Like Peptode-1 Receptor Agonist Inhibits Orthodontic Tooth Movement and Root Resorption. (2020)
  • Author(s): Ohori F, Kitaura H, Shen WR, Ogawa S, Noguchi T, Marahleh A, Nara Y, Pramusita A, Kinjo R, Mizoguchi I
  • Organizer: The 9th International Orthodontic Congress
  • Int'l Joint Research
• [Presentation] Inhibitory Effect of IL-33 on TNF-α-Induced Osteoclastogenesis and Orthodontic Tooth Movement. (2020)
  • Author(s): Ohori F, Kitaura H, Ogawa S, Noguchi T, Marahleh A, Nara Y, Pramusita A, Kinjo R, Mizoguchi I.
  • Organizer: The 9th International Orthodontic Congress
  • Int'l Joint Research
• [Presentation] Investigation of the Molecular Mechanism of TNF-α-Induced RANK on Osteoclast Precursors in Orthodontic Tooth Movement. (2020)
  • Author(s): Noguchi T, Kitaura H, Ogawa S, Ohori F, Marahleh A, Nara Y, Pramusita A, Kinjo R, Mizoguchi I.
  • Organizer: American Society for Bone and Mineral Research 2020 Annual Meeting.
  • Int'l Joint Research
• [Presentation] Investigation of Effect of IL-33 on TNF-α-Induced Osteoclast Formation and Orthodontic Tooth Movement. (2020)
  • Author(s): Ohori F, Kitaura H, Ogawa S, Noguchi T, Marahleh A, Nara Y, Pramusita A, Kinjo R, Mizoguchi I.
  • Organizer: American Society for Bone and Mineral Research 2020 Annual Meeting.
  • Int'l Joint Research
• [Presentation] TNF-α increases sclerostin expression in osteocyte during orthodontic tooth movement. (2019)
  • Author(s): Ohori F, Kitaura H, Marahleh A, Kishikawa A, Ogawa S, Qi J, Shen WR, Noguchi T, Nara Y, Mizoguchi I.
  • Organizer: American Society for Bone and Mineral Research 2019 Annual Meeting.
  • Int'l Joint Research
• [Presentation] TNF-α directly enhances osteocyte RANKL expression and promotes osteoclast formation. (2019)
  • Author(s): Marahleh A, Kitaura H, Ohori F, Kishikawa A, Ogawa S, Shen WR, Qi J, Noguchi T, Nara Y, Mizoguchi I.
  • Organizer: American Society for Bone and Mineral Research 2019 Annual Meeting.
  • Int'l Joint Research
• [Presentation] TNF-α is responsible for stromal cell contribution to osteoclast and odontoclast formation during orthodontic tooth movement. (2019)
  • Author(s): Ogawa S, Kitaura H, Marahleh A, Kishikawa A, Qi J, Shen WR, Ohori F, Noguchi T, Nara Y, Mizoguchi I.
  • Organizer: American Society for Bone and Mineral Research 2019 Annual Meeting.
  • Int'l Joint Research
• [Presentation] TNF-α stimulates the expression of RANK during orthodontic tooth movement. (2019)
  • Author(s): Noguchi T, Kitaura H, Marahleh A, Kishikawa A, Ogawa S, Qi J, Shen WR, Ohori F, Nara Y, Mizoguchi I.
  • Organizer: American Society for Bone and Mineral Research 2019 Annual Meeting.
  • Int'l Joint Research
• [Presentation] TNF-α Induced Sclerostin Expression on Osteocytes during Orthodontic Tooth Movement. (2019)
  • Author(s): Ohori F, Kitaura H, Marahleh A, Kishikawa A, Ogawa S, Qi J, Shen WR, Noguchi T, Nara Y, Mizoguchi I.
  • Organizer: American Society for Bone and Mineral Research 2019 Annual Meeting.
  • Int'l Joint Research
• [Presentation] NF-α directly enhances osteocyte RANKL expression and promotes osteoclast formation. (2019)
  • Author(s): Marahleh A, Kitaura H, Ohori F, Kishikawa A, Ogawa S, Shen WR, Qi J, Noguchi T, Nara Y, Mizoguchi I
  • Organizer: 2019 NIH-Japan-JSPS Symposium.
  • Int'l Joint Research
• [Presentation] Local injections of high-dose diabetic medicine exendin-4 inhibit orthodontic tooth movement of mice. (2019)
  • Author(s): Shen WR, Kitaura H, Qi J, Kishikawa A, Ogawa S, Ohori F, Noguchi T, Marahleh A, Nara Y, Mizoguchi I.
  • Organizer: The 78th Annual Meeting of the Japanese Orthodontic Society.
• [Presentation] NF-α enhances osteocyte RANKL expression and promotes osteoclast formation during orthodontic tooth movement. (2019)
  • Author(s): Marahleh A, Kitaura H, Ohori F, Kishikawa A, Ogawa S, Shen WR, Qi J, Noguchi T, Nara Y, Mizoguchi I.
  • Organizer: The 78th Annual Meeting of the Japanese Orthodontic Society.
• [Presentation] C-X-C Receptor 7 Agonist as C-X-C Ligand 12 Inhibitor Ameliorates Osteoclastogenesis and Bone Resorption. (2019)
  • Author(s): Nugraha AP, Kitaura H, Kishikawa A, Ogawa S, Shen WR, Qi J, Ohori F, Noguchi T, Marahleh A, Nara Y, Pramusita A, Mizoguchi I.
  • Organizer: The 78th Annual Meeting of the Japanese Orthodontic Society.