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Elucidation of human genome gene related to three-dimensional mandible morphology acquired from cone-beam CT images

Research Project

Project/Area Number 19K10412
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 57070:Developmental dentistry-related
Research InstitutionShowa University

Principal Investigator

Haga Shugo  昭和大学, 歯学部, 准教授 (00736655)

Co-Investigator(Kenkyū-buntansha) 山口 徹太郎  神奈川歯科大学, 大学院歯学研究科, 教授 (40384193)
冨田 大介  昭和大学, 歯学部, 助教 (40805842)
中脇 貴俊  昭和大学, 歯学部, 普通研究生 (90783522)
長濱 諒  昭和大学, 歯学部, 助教 (90783530)
Project Period (FY) 2019-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2021: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
KeywordsコーンビームCT / CBCT / 顎骨形態計測 / 顎骨形態
Outline of Research at the Start

不正咬合(咬合の異常)とは顎骨や歯列、個々の歯の形態が複雑に関与し発症する疾患である。歯科矯正臨床においては、不正咬合の発生リスクを予測し、その予防や誘因の制御、口腔顎顔面ならびに歯列・咬合を正常な状態へと誘導する事が重要であり解明が急がれる。不正咬合の原因解明には形態学的バランスや成長発育、環境的・遺伝的要因など多様な因子の相互作用の理解が必要であり、申請者らはこれまで頭蓋顎顔面形態と遺伝要因との関連性を明らかにしてきた。これらの研究体制継続のもと本研究では、コーンビームCT画像から取得した3次元的下顎骨形態に注目し、これに関連するヒトゲノム遺伝子探索を行う。

Outline of Final Research Achievements

In this study, we used cone-beam CT data at the time of orthodontic treatment planning and at the completion of preoperative orthodontic treatment to quantify the changes in the morphology of the mandibular symphysis and elucidate the relevant factors. Additionally, using three-dimensional finite element analysis model (3D-FEM), we aimed to verify the mechanical behavior of the mandible. Statistical analysis suggested that four factors, FMA, IMPA change, treatment period, and ANB angle affected the morphological changes. In addition, changes in the bone morphology associated with orthodontic force did not extend to the area near the base of mandibular symphysis and the 3D-FEM yielded the similar results.
Therefore, changes in the bone morphology caused by surgical orthodontic treatment are limited to the area surrounding the roots of the teeth, not to the entire mandibular symphysis.

Academic Significance and Societal Importance of the Research Achievements

顎矯正手術を伴う骨格性下顎前突症患者は、術前矯正治療時にdental compensation改善のため下顎前歯を唇側傾斜させる事が多い。しかしながら、これらの症例の下顎symphysisは菲薄な場合が多々あり、下顎前歯の移動に制約が生じる。外科的矯正治療における骨形態変化が、どの範囲まで及ぶのかを把握することは治療方針や予後を検討する上で重要である。本研究内容は、今後の外科的矯正歯科臨床を進める上で有益なデータである。

Report

(5 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (5 results)

All 2022 2021

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (1 results)

  • [Journal Article] Elucidation of Factors Affecting Morphological Changes in the Alveolar Region of the Mandible Associated with Surgical Orthodontic Treatment2022

    • Author(s)
      Taira MIYAZAWA, Shugo HAGA, Yukio ASO, Aya SATO, Masayuki YOSHIDA, Koutaro MAKI
    • Journal Title

      Journal of the Japan Society of Cranio-Maxillo-Facial Surgery

      Volume: 38 Pages: 19-34

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationship Between Zygomaticomaxillary Sutures and Maxillofacial Morphology in a Three-Dimensional Plane2022

    • Author(s)
      Maiko KOMATSU, Shugo HAGA, Ryo NAGAHAMA, Koutaro MAKI
    • Journal Title

      Journal of the Japan Society of Cranio-Maxillo-Facial Surgery

      Volume: 38 Pages: 11-18

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Elucidation of Factors Affecting Morphological Changes in the Alveolar Region of the Mandible Associated with Surgical Orthodontic Treatment2022

    • Author(s)
      Taira MIYAZAWA , Shugo HAGA , Yukio ASO , Aya SATO , Masayuki YOSHIDA , Koutaro MAKI
    • Journal Title

      Journal of the Japan Society of Cranio-Maxillo-Facial Surgery

      Volume: 38(1) Pages: 19-34

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Relationship Between Zygomaticomaxillary Sutures and Maxillofacial Morphology in a Three-Dimensional Plane2022

    • Author(s)
      Maiko KOMATSU , Shugo HAGA , Ryo NAGAHAMA , Koutaro MAKI
    • Journal Title

      Journal of the Japan Society of Cranio-Maxillo-Facial Surgery

      Volume: 38(1) Pages: 11-18

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Presentation] 外科的矯正治療における下顎前歯歯槽骨形態の変化について2021

    • Author(s)
      宮澤 平 , 芳賀 秀郷 , 槇 宏太郎
    • Organizer
      第80回日本矯正歯科学会学術大会&第5回国際会議
    • Related Report
      2021 Research-status Report

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Published: 2019-04-18   Modified: 2024-01-30  

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