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Effect of peripheral sensory input on swallowing reflex evoked by esophageal stimulation

Research Project

Project/Area Number 19K10428
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 57080:Social dentistry-related
Research InstitutionAsahi University

Principal Investigator

TANIGUCHI HIROSHIGE  朝日大学, 歯学部, 准教授 (80529636)

Co-Investigator(Kenkyū-buntansha) 青柳 陽一郎  日本医科大学, 大学院医学研究科, 大学院教授 (30286661)
Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2021: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords嚥下反射 / 食道刺激 / 摂食嚥下障害
Outline of Research at the Start

日本は,人口の高齢化に伴い摂食嚥下機能に障害を来たした要介護高齢者の問題が顕在化している.しかしながら,嚥下障害者に対する治療法は乏しく,特に,重度嚥下障害者に対しては有効な嚥下訓練法が確立されていないため,胃瘻などの非経口的栄養摂取を余儀なくされている.そこで申請者らは,重度嚥下障害を持つ患者であっても,誤嚥を回避し効果的に行う訓練として,食道の機械刺激によって誘発される嚥下反射が使用できないかと考えてきた..
本研究の目的は,食道刺激によって起こる嚥下反射を生理学的に解明し,最終的には食道刺激によって嚥下反射を誘発する方法を臨床応用し,新たな嚥下訓練法を確立することにある.

Outline of Final Research Achievements

Based on a physiological research approach, this study aimed to clarify the following: 1) Effects of different peripheral stimulation and the posture of subject on swallowing movement, 2) Effects of aging and diseases on swallowing movement caused by esophageal stimulation.
In the first year, the effects of the test food temperature and the posture of subject on swallowing movement were examined, and in the second year, the effects of different chemical stimulation on the induction of the swallowing reflex were examined. In the final year, this method was applied to dysphagia patients who had a history of cerebrovascular accidents. The results of this study clarified the conditions under which the swallowing reflex was induced more efficiently by esophageal stimulation, and suggested that esophageal stimulation induces the swallowing reflex even on dysphagia patients.

Academic Significance and Societal Importance of the Research Achievements

摂食嚥下障害の臨床においては,基礎データが構築されないまま,臨床的な経験値のみで実施されているものが多い。本研究によって,健常者における咽頭・食道内圧値が算出され,食道刺激と嚥下反射との定量的評価が明らかとなった。
結果によって摂食嚥下の障害解明や治療法確立の新たな手がかりを導くことが期待できる。本研究の手法が確立すれば,歯科領域のみならず摂食嚥下に関わる医科領域においても新たな訓練法の確立,障害の解明に有効なデータ収集が可能となる。

Report

(4 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (10 results)

All 2022 2021 2019

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (9 results) (of which Int'l Joint Research: 3 results)

  • [Journal Article] Elicitation of the Swallowing Reflex by Esophageal Stimulation in Healthy Subjects: An Evaluation Using High-Resolution Manometry.2019

    • Author(s)
      Hiroshige Taniguchi
    • Journal Title

      Dysphagia

      Volume: 45(3) Issue: 4 Pages: 211-215

    • DOI

      10.1007/s00455-019-10068-z

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 口腔機能,嚥下機能と 低栄養2022

    • Author(s)
      谷口裕重
    • Organizer
      第11回日本リハビリテーション栄養学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 義歯ケアと摂食嚥下リハビリテーション ー口腔と摂食嚥下・全身・栄養との繋がりー2022

    • Author(s)
      谷口裕重
    • Organizer
      第14回日本義歯ケア学会学術大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 食道刺激を利用したヒト嚥下運動を誘発する新たな手法の開発―脳梗塞患者を対象とした検討―2021

    • Author(s)
      谷口裕重,岡本美英子,中澤悠里,青柳陽一郎
    • Organizer
      日本老年歯科医学会第32回学術大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 食道内刺激によって嚥下運動を誘発する新たな手法~食道刺激温度の検討~2019

    • Author(s)
      谷口裕重,青柳陽一郎
    • Organizer
      日本顎口腔機能学会第62回学術大会
    • Related Report
      2019 Research-status Report
  • [Presentation] 高解像度マノメトリーを用いたDCIによる咽頭圧の評価2019

    • Author(s)
      棚橋幹基,谷口裕重,山田茂貴,金城 舞,太田恵未,安田順一,玄 景華,青柳陽一郎
    • Organizer
      第25回摂食嚥下リハビリテーション学会学術大会
    • Related Report
      2019 Research-status Report
  • [Presentation] 喉頭蓋谷残留と梨状窩残留に関連する因子の検討ー高解像度マノメトリーと嚥下造影検査を用いた評価ー2019

    • Author(s)
      蛭牟田誠,青柳陽一郎,稲本陽子,大橋美穂,谷口裕重,加賀谷斉,田矢理子,才藤栄一
    • Organizer
      第25回摂食嚥下リハビリテーション学会学術大会
    • Related Report
      2019 Research-status Report
  • [Presentation] An esophageal mechanical stimulation method for eliciting the swallowing reflex in patients with cerebrovascular disease.2019

    • Author(s)
      Hiroshige Taniguchi, Yoichiro Aoyagi, Yuri Yakazawa, Koichiro Matsuo, Eiichi Saitoh
    • Organizer
      9th European Society for Swallowing Disorders
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Effect of volume and viscosity on esophageal motility: A preliminary study using high-resolution manometry.2019

    • Author(s)
      Yoichiro Aoyagi, Sayuri Imaeda. Hiroshige Taniguchi, Makoto Hirumuta, Yuri Nakazawa, Eiichi Saitoh
    • Organizer
      9th European Society for Swallowing Disorders
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Elicitation of the swallowing reflex by esophageal stimulation: An evaluation using high-resolution manometry.2019

    • Author(s)
      Hiroshige Taniguchi
    • Organizer
      3rd International Dysphagia Symposium at FHUR
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research

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Published: 2019-04-18   Modified: 2023-01-30  

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