Clinical epidemiological study on disease structure and quality assessment of healthcare for the older population by utilizing healthcare big data

• Project/Area Number: 19K10533
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 58010:Medical management and medical sociology-related
• Research Institution: Okayama University
• Principal Investigator: Koyama Toshihiro 岡山大学, 医歯薬学域, 准教授 (60595106)
• Co-Investigator(Kenkyū-buntansha): 萩谷 英大 岡山大学, 医歯薬学域, 准教授 (30718531) ; 座間味 義人 岡山大学, 大学病院, 教授 (70550250) ; 樋之津 史郎 札幌医科大学, 医学部, 教授 (80323567) ; 狩野 光伸 岡山大学, ヘルスシステム統合科学学域, 教授 (80447383)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2021: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2019: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 医療ビッグデータ / 臨床疫学 / 高齢者医療 / データサイエンス / 高齢者

Outline of Research at the Start

本研究では前述した高齢者医療の向上における問題点に対して，医療ビッグデータの解析技術を基盤と臨床疫学的な統計手法を融合した新規的な手法により，高齢者特有の重要疾患の変化を長期時系列分析により解明する。さらにこれら高齢者における重要疾患の変化に対し，現在の高齢者医療が適切であるか評価する。その上で，諸外国における高齢者医療の実態と比較し，今後の日本の高齢者医療の再構築の基盤となるエビデンス構築を目的とする。

Outline of Final Research Achievements

The purpose of this study was to analyze the actual situation of medical care for the elderly from a long-term perspective by utilizing medical big data covering the entire population and integrating clinical epidemiological methods. As studies utilizing medical big data of the entire population targeting the elderly, we have clarified diseases that could be targeted, and published clinical epidemiological studies on influenza, heptitis C, adverse reaction-related deaths, amyloidosis, and sarcoidosis in international journals, respectively.

Academic Significance and Societal Importance of the Research Achievements

研究成果の学術的意義は全国民を対象とする医療ビッグデータの活用と臨床疫学的な手法の統合により，高齢者医療の実態を長期的な視点で分析した点である。また、社会的意義として、本研究は医療ビッグデータ解析技術および臨床疫学的な高度統計手法，さらに高齢医学分野の融合した新規手法を高齢者医療に応用して、必要とされるエビデンスを創出したことである。

Research Products

• [Int'l Joint Research] University of Hawaii/Mount Sinai Beth Israel(米国)
• [Journal Article] Trends in sarcoidosis mortality rate in Japan from 2001 to 2020: A population-based study (2022)
  • Author(s): Harada Ko、Hagiya Hideharu、Koyama Toshihiro、Otsuka Fumio
  • Journal Title: Respiratory Medicine Volume: 196 Pages: 106828-106828
  • DOI: 10.1016/j.rmed.2022.106828
  • Peer Reviewed / Open Access
• [Journal Article] Identification of prophylactic drugs for oxaliplatin-induced peripheral neuropathy using big data. (2022)
  • Author(s): Zamami Y, Niimura T, Kawashiri T, Goda M, Naito Y, Fukushima K, Ushio S, Aizawa F, Hamano H, Okada N, Yagi K, Miyata K, Takechi K, Chuma M, Koyama T, Kobayashi D, Shimazoe T, Fujino H, Izawa-Ishizawa Y, Ishizawa K.
  • Journal Title: Biomed Pharmacother. Volume: 148 Pages: 112744-112744
  • DOI: 10.1016/j.biopha.2022.112744
  • Peer Reviewed / Open Access
• [Journal Article] Trends in the amyloidosis mortality rate in Japan: A nationwide observational study from 1998 to 2019 (2022)
  • Author(s): Harada Ko、Hagiya Hideharu、Koyama Toshihiro、Otsuka Fumio
  • Journal Title: Geriatrics and Gerontology International Volume: 22 Issue: 3 Pages: 246-250
  • DOI: 10.1111/ggi.14348
• [Journal Article] Impact of the world hand hygiene and global handwashing days on public awareness between 2016 and 2020: Google trends analysis (2022)
  • Author(s): Nishimura Yoshito、Hagiya Hideharu、Keitoku Koichi、Koyama Toshihiro、Otsuka Fumio
  • Journal Title: American Journal of Infection Control Volume: 50 Issue: 2 Pages: 141-147
  • DOI: 10.1016/j.ajic.2021.08.033
• [Journal Article] Impact of the World Antimicrobial Awareness Week on public interest between 2015 and 2020: A Google Trends analysis (2021)
  • Author(s): Keitoku Koichi、Nishimura Yoshito、Hagiya Hideharu、Koyama Toshihiro、Otsuka Fumio
  • Journal Title: International Journal of Infectious Diseases Volume: 111 Pages: 12-20
  • DOI: 10.1016/j.ijid.2021.08.018
• [Journal Article] Relevance of CYP3A5 Expression on the Clinical Outcome of Patients With Renal Cell Carcinoma (2021)
  • Author(s): MATSUMOTO JUN、KOTERA YUMI、WATARI SHOGO、TAKEUCHI KOICHI、UEKI HIDEO、KOYAMA TOSHIHIRO、WADA KOICHIRO、FUJIYOSHI MASACHIKA、NASU YASUTOMO、ARIYOSHI NORITAKA
  • Journal Title: Anticancer Research Volume: 41 Issue: 5 Pages: 2511-2521
  • DOI: 10.21873/anticanres.15029
  • NAID: 120007144319
• [Journal Article] Trends in hepatitis C virus‐associated mortality rates in Japan, 1998-2017 (2021)
  • Author(s): Hagiya Hideharu、Koyama Toshihiro、Deguchi Matsuo、Minato Yusuke、Miura Satomi、Funahashi Tomoko、Teratani Yusuke、Zamami Yoshito、Shinomiya Kazuaki、Kitamura Yoshihisa、Sendo Toshiaki、Hinotsu Shiro、Kano Mitsunobu
  • Journal Title: Journal of Gastroenterology and Hepatology Volume: - Issue: 9 Pages: 2486-2492
  • DOI: 10.1111/jgh.15517
  • Peer Reviewed
• [Journal Article] Population-Based Observational Study of Adverse Drug Event-Related Mortality in the Super-Aged Society of Japan (2021)
  • Author(s): Funahashi Tomoko、Koyama Toshihiro、Hagiya Hideharu、Harada Ko、Iinuma Syunya、Ushio Soichiro、Zamami Yoshito、Niimura Takahiro、Shinomiya Kazuaki、Ishizawa Keisuke、Sendo Toshiaki、Hinotsu Shiro、Kano Mitsunobu R.
  • Journal Title: Drug Safety Volume: - Issue: 5 Pages: 531-539
  • DOI: 10.1007/s40264-020-01037-9
  • Peer Reviewed
• [Journal Article] Place of death trends among patients with dementia in Japan: a population-based observational study (2019)
  • Author(s): Koyama Toshihiro、Sasaki Misato、Hagiya Hideharu、Zamami Yoshito、Funahashi Tomoko、Ohshima Ayako、Tatebe Yasuhisa、Mikami Naoko、Shinomiya Kazuaki、Kitamura Yoshihisa、Sendo Toshiaki、Hinotsu Shiro、Kano Mitsunobu R.
  • Journal Title: Scientific Reports Volume: 9 Issue: 1 Pages: 41598-56388
  • DOI: 10.1038/s41598-019-56388-w
  • NAID: 120006875660
  • Peer Reviewed
• [Journal Article] Fall-related mortality trends in older Japanese adults aged ?65 years: a nationwide observational study (2019)
  • Author(s): Hagiya Hideharu、Koyama Toshihiro、Zamami Yoshito、Tatebe Yasuhisa、Funahashi Tomoko、Shinomiya Kazuaki、Kitamura Yoshihisa、Hinotsu Shiro、Sendo Toshiaki、Rakugi Hiromi、Kano Mitsunobu R
  • Journal Title: BMJ Open Volume: 9 Issue: 12 Pages: e033462-e033462
  • DOI: 10.1136/bmjopen-2019-033462
  • NAID: 120006816628
  • Peer Reviewed / Open Access
• [Journal Article] Oral anticoagulants usage in Japanese patients aged 18ー74 years with non-valvular atrial fibrillation: a retrospective analysis based on insurance claims data (2019)
  • Author(s): Ohshima Ayako、Koyama Toshihiro、Ogawa Aiko、Zamami Yoshito、Tanaka Hiroyoshi Y、Kitamura Yoshihisa、Sendo Toshiaki、Hinotsu Shiro、Miller Michael W、Kano Mitsunobu R
  • Journal Title: Family Practice Volume: in press Issue: 6 Pages: 685-692
  • DOI: 10.1093/fampra/cmz016
  • Peer Reviewed
• [Presentation] 日本語)日本における副作用に起因した死亡率の傾向に関する全国規模の観察研究 (2020)
  • Author(s): 舩橋智子、小山敏広、狩野光伸
  • Organizer: 日本薬学会