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Epidemiology of Escherichia albertii

Research Project

Project/Area Number 19K10590
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 58020:Hygiene and public health-related: including laboratory approach
Research InstitutionJumonji University (2022-2023)
National Institute of Infectious Diseases (2019-2021)

Principal Investigator

Murakami Koichi  十文字学園女子大学, 人間生活学部, 教授 (70446839)

Co-Investigator(Kenkyū-buntansha) 重村 洋明  福岡県保健環境研究所, その他部局等, 研究員 (50761540)
Project Period (FY) 2019-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2021: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
KeywordsEscherichia albertii / Food pathogen / Epidemiology / 食中毒 / 菌の分離 / E. albertii / 薬剤耐性 / 人獣共通感染症原因菌 / 鞭毛 / 下痢原性細菌 / 食中毒細菌 / 培地
Outline of Research at the Start

Escherichia albertii(エシェリキア・アルベルティイ)(2003 年、種として認められる)はヒトに下痢、腹痛、発熱を惹起する食中毒原因細菌です。本菌の分離・同定は困難を伴います。本研究の目的は①本菌の最適な分離・同定手法を確立し、②ヒト糞便、食品及び動物試料の検査、あるいは感染事例の疫学的解析を通じて、本菌のヒトへの感染源、媒介食品、レゼルボア(動物等)等を明らかにし、③全ての E. albertii がヒトに病原性を有するか、菌株の分子疫学的解析にて明らかにし、④通常の培養法では観察されない鞭毛の発現条件を明らかにすることです。こ

Outline of Final Research Achievements

We propose that nonbiogroup 1 or 2 of E. albertii should be assigned to biogroup 3 to make screening of them easier in public health and clinical laboratory settings. Clearly, having group criteria for indole-negative/lysine-positive, indole-positive/lysine-negative, and indolepositive/lysine-positive E. albertii biogroups 1, 2, and 3 strains, respectively, should provide for more accurate identification of E. albertii isolates. According to our study, the most common symptom displayed by patients across the six episodes was watery diarrhea (>80%), followed by abdominal pain (50-84%) and fever (37-39.5°c) (26-44%). The estimated average incubation period of E. albertii infection was 12-24 h. Three of the six outbreak associated E. albertii isolates possessed intact ETT2 regions, while the remaining isolates contained disrupted ETT2-encoding genes.
We found that E. albertii expressed flagella under specific environmental conditions.

Academic Significance and Societal Importance of the Research Achievements

人獣共通感染症原因菌 Escherichia albertii の ①生物型分類の整理・提唱、②本菌食中毒の原因食品、潜伏期間等の疫学情報の提供、③本菌の鞭毛発現条件の発見、④本菌の薬剤耐性の状況の報告、⑤本菌の分離条件等を行い、本菌の疫学的な実態を多少なりとも明らかにしたと考える。

Report

(6 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (4 results)

All 2020 2019

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 3 results)

  • [Journal Article] Epidemiological Aspects of Escherichia albertii Outbreaks in Japan and Genetic Characteristics of the Causative Pathogen2020

    • Author(s)
      Masuda K、Ooka T、Akita H、Hiratsuka T、Takao S、Fukada M、Inoue K、Honda M、Toda J、Sugitani W、Narimatsu H、Ishioka T、Hirai S、Sekizuka T、Kuroda M、Morita Y、Hayashi Ta、Kimura H、Oishi K、Ohnishi M、Fujimoto S、Murakami K
    • Journal Title

      Foodborne Pathogens and Disease

      Volume: 17 Issue: 2 Pages: 144-150

    • DOI

      10.1089/fpd.2019.2654

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Truncated Class 1 Integron Gene Cassette Arrays Contribute to Antimicrobial Resistance of Diarrheagenic Escherichia coli2020

    • Author(s)
      Kubomura Akiko、Sekizuka Tsuyoshi、Onozuka Daisuke、Murakami Koichi、Kimura Hirokazu、Sakaguchi Masahiro、Oishi Kazunori、Hirai Shinichiro、Kuroda Makoto、Okabe Nobuhiko
    • Journal Title

      BioMed Research International

      Volume: 2020 Issue: 1 Pages: 1-9

    • DOI

      10.1155/2020/4908189

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Non-biogroup 1 or 2 strains of the emerging zoonotic pathogen escherichia albertii, their proposed assignment to biogroup 3, and their commonly detected characteristics2019

    • Author(s)
      Murakami Koichi、Maeda-Mitani Eriko、Kimura Hirokazu、Honda Mikiko、Ikeda Tetsuya、Sugitani Wakana、Konno Takayuki、Kawano Kimiko、Etoh Yoshiki、Sera Nobuyuki、Mizukoshi Fuminori、Saitoh Takehito、Kawamura Yoshiaki、Ishioka Taisei、Ohnishi Makoto、Oishi Kazunori、Fujimoto Shuji
    • Journal Title

      Frontiers in Microbiology

      Volume: 10 Issue: JULY Pages: 1-9

    • DOI

      10.3389/fmicb.2019.01543

    • URL

      https://localhost/en/publications/0ad6f9fa-a0e4-419b-921a-51710459b02c

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Flagellum expression and swimming activity by the zoonotic pathogen Escherichia albertii2019

    • Author(s)
      Murakami Koichi、Kimura Shinya、Nagafuchi Osamu、Sekizuka Tsuyoshi、Onozuka Daisuke、Mizukoshi Fuminori、Tsukagoshi Hiroyuki、Ishioka Taisei、Asai Tetsuo、Hirai Shinichiro、Musashi Manami、Suzuki Motoi、Ohnishi Makoto、Oishi Kazunori、Saruki Nobuhiro、Kimura Hirokazu、Iyoda Sunao、Kuroda Makoto、Fujimoto Shuji
    • Journal Title

      Environmental Microbiology Reports

      Volume: 12 Issue: 1 Pages: 92-96

    • DOI

      10.1111/1758-2229.12818

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access

URL: 

Published: 2019-04-18   Modified: 2025-01-30  

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