| Project/Area Number |
19K10601
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 58020:Hygiene and public health-related: including laboratory approach
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| Research Institution | Nagasaki University |
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Principal Investigator |
Mohammad Shah 長崎大学, 熱帯医学研究所, 助教 (40648086)
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| Co-Investigator(Kenkyū-buntansha) |
金子 聰 長崎大学, 熱帯医学研究所, 教授 (00342907)
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| Project Period (FY) |
2019-04-01 – 2023-03-31
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| Project Status |
Completed (Fiscal Year 2022)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2021: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | Cross-sectional study / Bacteremia / Malaria / Western Kenya / Hospitalized children / Septicemia / A cross-sectional study / Invasive bacteria / African children / A cross-sectional study, / Invasive bacteria, / Malaria, / Infection, / African children, / Western Kenya. / Bacterial infections / Children |
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| Outline of Research at the Start |
Studies have reported that bacteremia has been associated with high mortality in hospitalized children with severe malaria in Africa. But the challenges in the laboratory diagnosis of these organisms sometimes complicate a true understanding of its role in disease. Also, E. anophelis is an uncommon pathogen infrequently isolated from clinical specimens. This will be the first study in Western Kenya which could facilitate us to explore the prevalence of bacteremia caused by invasive bacteria including E. anophelis and their relationship with malaria in hospitalized children <5 years of age.
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| Outline of Final Research Achievements |
Malaria and Invasive bacterial infections (IBI) are leading causes of morbidity and mortality in all age groups, especially among children (aged <5 years) in sub-Saharan Africa. Several studies have shown that bacteremia is associated with high morbidity in children hospitalized with severe malaria in Western Kenya. This research aims to determine the prevalence of IBI in children <5 years hospitalized in rural and urban Western Kenya, clarify their clinical symptoms and antimicrobial susceptibility and investigate the relationship with malaria severity. The partial results of this study demonstrated that bacteremia is the leading cause of febrile illness. At the same time, 32.3% and 24.1% of patients were co-infected with malaria in urban and rural areas, respectively. Antimicrobial susceptibility data showed that tetracycline and gentamycin could be helpful for bacteremia treatment. The high frequency of IBI requires revision of current treatment guidelines.
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| Academic Significance and Societal Importance of the Research Achievements |
この研究は、菌血症が発熱性疾患の主な原因であり、ケニア西部ではマラリアが比較的一般的であることを示した。資源の少ない環境での死亡率と罹患率を減らすには、菌血症のリスクが高い子供に焦点を当てたガイドラインの管理を改善する必要がある。
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