Comparative study on arteriosclerotic index CAVI and urinary sodium-potassium ratio in different regions of Japan.
| Project/Area Number |
19K10652
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Review Section |
Basic Section 58030:Hygiene and public health-related: excluding laboratory approach
|
|---|
| Research Institution | Keio University |
|---|
Principal Investigator |
KUWABARA Kazuyo 慶應義塾大学, 医学部(信濃町), 助教 (70627637)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
岡村 智教 慶應義塾大学, 医学部(信濃町), 教授 (00324567)
原田 成 慶應義塾大学, 医学部(信濃町), 講師 (10738090)
東山 綾 国立研究開発法人国立循環器病研究センター, 病院, 医長 (20533003)
|
|---|
| Project Period (FY) |
2019-04-01 – 2023-03-31
|
| Project Status |
Completed (Fiscal Year 2022)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2021: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Keywords | CAVI / 尿中ナトリウム・カリウム比 / 動脈硬化性疾患 / 高血圧 / 危険因子 / 喫煙 / コホート |
|---|
| Outline of Research at the Start |
先行研究では、尿中のナトリウム排泄量とカリウム排泄量の比（以下、尿中ナトカリ比）と脳卒中死亡や脳・心血管疾患の予後との関連が示されている。しかし、疾患の前段階と考えられる大動脈の動脈硬化の指標であるcardio-ankle vascular index （CAVI）との関連はこれまで報告されていない。そこで、研究１）生活習慣及び平均塩分摂取量の異なる関西（神戸研究）と東北（鶴岡メタボロームコホート研究）の男女でCAVIを比較し、尿中ナトカリ比との関連が両地域で異なるかどうかを比較・検証する。２）さらに、両地域におけるCAVIの上昇に寄与する危険因子の差異を明らかにする。
|
| Outline of Final Research Achievements |
Although the urinary Na/K ratio has been reported to be associated with cerebral and cardiovascular disease in patient populations, its association with the cardio-ankle vascular index (CAVI), a leading indicator of aortic arterial stiffness, has not been reported. It is also possible that differences in the contribution of the urinary Na/K ratio to arterial stiffness may be observed in populations with different lifestyles. Therefore, we compared and verified the association between CAVI and urinary Na/K ratio in the Kansai (Kobe Study) and Tohoku (Tsuruoka Metabolome Study) regions. The urinary Na/K ratio was significantly higher in the Tohoku region in both men and women, and the Na/K ratio tended to be higher in the group with high CAVI. The odds ratio was higher in the hypertensive/high urinary Na/K group.
|
| Academic Significance and Societal Importance of the Research Achievements |
異なる地域における動脈硬化の指標cardio-ankle vascular index ; CAVIと尿中ナトリウム・カリウム比（尿中Na/K比）に関する要因を検討することは、高血圧をはじめとした動脈硬化の進行に関わる要因を明らかにし、栄養介入による早期からの予防に繋がると考える。これらのことよりCAVIを一般住民や勤務者の健康管理に活用する可能性に加え、尿中ナトリウム・カリウム比を用いた保健指導に有用と考えられる。
|
Report
(5 results)
Research Products
(30 results)
-
[Journal Article] Determinants of Double Product: A Cross-Sectional Study of Urban Residents in Japan2023
Author(s)
Nakagoshi N, Kubo S, Nishida Y, Kuwabara K, Hirata A, Sata A, Higashiyama A, Kubota Y, Hirata T, Tatsumi Y, Kawamura K, Miyazaki J, Miyamatsu N, Sugiyama D, Miyamoto Y, Okamura T.
-
Journal Title
Related Report
Peer Reviewed
-
[Journal Article] Physique at Birth and Cardiovascular Disease Risk Factors in Japanese Urban Residents: the KOBE Study2022
Author(s)
Umemoto K, Kubo S, Nishida Y, Higashiyama A, Kawamura K, Kubota Y, Hirata T, Hirata A, Sata M, Kuwabara K, Miyazaki J, Kadota A, Iida M, Sugiyama D, Miyamatsu N, Miyamoto Y, Okamura T.
-
Journal Title
Journal of Atherosclerosis and Thrombosis
Volume: 29
Issue: 2
Pages: 188-199
DOI
NAID
ISSN
1340-3478, 1880-3873
Year and Date
2022-02-01
Related Report
Peer Reviewed / Open Access
-
[Journal Article] Metabolic profiling of charged metabolites in association with menopausal status in Japanese community-dwelling midlife women: Tsuruoka Metabolomic Cohort Study.2022
Author(s)
Watanabe K, Iida M, Harada S, Kato S, Kuwabara K, Kurihara A, Takeuchi A, Sugiyama D, Okamura T, Suzuki A, Amano K, Hirayama A, Sugimoto M, Soga T, Tomita M, Kobayashi Y, Banno K, Aoki D, Takebayashi T.
-
Journal Title
Maturitas
Volume: 155
Pages: 54-62
DOI
Related Report
Peer Reviewed / Open Access
-
-
[Journal Article] Erratum to “Validity Assessment of Self-reported Medication Use for Hypertension, Diabetes, and Dyslipidemia in a Pharmacoepidemiologic Study by Comparison With Health Insurance Claims” [J Epidemiol 31 (9) (2021) 495–502]2021
Author(s)
Matsumoto M, Harada S, Iida M, Kato S, Sata M, Hirata A, Kuwabara K, Takeuchi A, Sugiyama D, Okamura T, Takebayashi T.
-
Journal Title
Journal of Epidemiology
Volume: 31
Issue: 9
Pages: 520-521
DOI
NAID
ISSN
0917-5040, 1349-9092
Year and Date
2021-09-05
Related Report
Peer Reviewed
-
-
[Journal Article] Serum modified high-density lipoprotein and risk of atherosclerotic cardiovascular disease in a Japanese community-based nested case-control study2021
Author(s)
Sata M, Kakino A, Hirata A, Iida M, Usami Y, Harada S, Fujita Y, Kohsaka S, Izawa Y, Sawano M, Oki K, Sugiyama D, Takahashi S, Takebayashi T, Sawamura T, Okamura T.
-
Journal Title
Eur J Prev Cardiol .
Volume: online ahead of print.
Issue: 5
Pages: e193-e195
DOI
Related Report
Peer Reviewed
-
-
-
[Journal Article] Correction: Charged metabolite biomarkers of food intake assessed via plasma metabolomics in a population-based observational study in Japan.2021
Author(s)
Shibutami E, Ishii R, Harada S, Kurihara A, Kuwabara K, Kato S, Iida M, Akiyama M, Sugiyama D, Hirayama A, Sato A, Amano K, Sugimoto M, Soga T, Tomita M, Takebayashi T.
-
Journal Title
PLoS One.
Volume: 16
Issue: 4
Pages: e0250864-e0250864
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
