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Sarcopenia and frailty on the older cancer patients after treatments

Research Project

Project/Area Number 19K11345
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 59010:Rehabilitation science-related
Research InstitutionKobe University

Principal Investigator

ONO Rei  神戸大学, 保健学研究科, 教授 (50346243)

Co-Investigator(Kenkyū-buntansha) 牧浦 大祐  神戸大学, 医学部附属病院, 理学療法士 (40813944)
井上 順一朗  神戸大学, 医学部附属病院, 理学療法士 (50437472)
酒井 良忠  神戸大学, 医学研究科, 特命教授 (90397802)
Project Period (FY) 2019-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2021: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords高齢がん / ロコモティブシンドローム / 健康寿命 / サルコペニア / フレイル / 要介護 / ロコモ / リハビリテーション
Outline of Research at the Start

本邦を含め先進各国では高齢がん患者が増加しており、治療成績の向上が喫緊の課題である。高齢がん患者の治療成績(アウトカム)は生存期間だけでなく、健康寿命の延伸も重要である。高齢がん患者において、がん治療によって治療後に健康寿命の延伸を阻害するサルコペニア、フレイルが誘発されていると考えられるが、頻度や要因は明らかになっていない。
本研究の目的は、根治療法後のサルコペニア、フレイルの有病率とがんを罹患していない同年代の高齢者の有病率を比較すること、根治療法後のサルコペニア、フレイル発生とがん治療や退院後の生活習慣との関係を明らかにすることである。

Outline of Final Research Achievements

The purpose of this study was to examine whether or not cancer incidence in old age increase the incidence of need for support and care. Residents enrolled in National Health Insurance claims data, Latter-Stage Older Persons Health Care System claims data were included in the study. During the follow-up period, 16,088 persons developed cancer. In the Cox proportional hazard model adjusted for sex, age, Charlson Comorbidity Index, and medical expenses in the 6 months before diagnosis, the older in the incedence of cancer in the old ages were significantly higher care needs than that in no incidence of cancer selected by propensity score matching (HR 1.49; 95%CI 1.36-1.62).
The results suggested that the older with cancer are a desirable population for intervention in terms of care prevention, even after treatment.

Academic Significance and Societal Importance of the Research Achievements

先進各国の高齢化に伴い、高齢期のがん罹患が増加し、それに伴い高齢がんサバイバーも増加している。
高齢がん患者における、がん治療成績向上に関する研究は散見されるが、高齢期のがん罹患が、健康寿命延伸に与える影響は明らかになっていなかった。
本研究により、高齢期のがん罹患は治療前後のみならず、治療後(退院後)も健康寿命延伸の観点から、積極的なリハビリテーションを展開する必要性があることを示唆できた。

Report

(5 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (16 results)

All 2024 2023 2021 2020 2019

All Journal Article (8 results) (of which Peer Reviewed: 8 results,  Open Access: 5 results) Presentation (7 results) (of which Int'l Joint Research: 2 results) Book (1 results)

  • [Journal Article] Claims-based Frailty Index in Japanese Older Adults: A Cohort Study Using LIFE Study Data2024

    • Author(s)
      Nakatsuka Kiyomasa、Ono Rei、Murata Shunsuke、Akisue Toshihiro、Fukuda Haruhisa
    • Journal Title

      Journal of Epidemiology

      Volume: 34 Issue: 3 Pages: 112-118

    • DOI

      10.2188/jea.JE20220310

    • ISSN
      0917-5040, 1349-9092
    • Year and Date
      2024-03-05
    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Impact of Preoperative Social Frailty on Overall Survival and Cancer-Specific Survival among Older Patients with Gastrointestinal Cancer2021

    • Author(s)
      Ono Rei、Makiura Daisuke、Nakamura Tetsu、Okumura Maho、Fukuta Akimasa、Saito Takashi、Inoue Junichiro、Oshikiri Taro、Kakeji Yoshihiro、Sakai Yoshitada
    • Journal Title

      Journal of the American Medical Directors Association

      Volume: 22 Issue: 9 Pages: 1825-1830.e1

    • DOI

      10.1016/j.jamda.2021.03.025

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] The effect of home-based preoperative pulmonary rehabilitation before lung resection: A retrospective cohort study2021

    • Author(s)
      Saito Takashi、Ono Rei、Tanaka Yugo、Tatebayashi Daisuke、Okumura Maho、Makiura Daisuke、Inoue Junichiro、Fujikawa Takashi、Kondo Shin、Inoue Tatsuro、Maniwa Yoshimasa、Sakai Yoshitada
    • Journal Title

      Lung Cancer

      Volume: 162 Pages: 135-139

    • DOI

      10.1016/j.lungcan.2021.10.012

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Allogeneic haematopoietic stem cell transplantation?clinical outcomes: impact of leg muscle strength2021

    • Author(s)
      Kondo Shin、Kagawa Kumiko、Saito Takashi、Oura Masahiro、Sogabe Kimiko、Harada Takeshi、Fujii Shiro、Nakamura Shingen、Miki Hirokazu、Sato Nori、Ono Rei、Abe Masahiro、Katoh Shinsuke
    • Journal Title

      BMJ Supportive & Palliative Care

      Volume: 1 Pages: 003256-003256

    • DOI

      10.1136/bmjspcare-2021-003256

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comparison between quantitative and subjective assessments of chemotherapy-induced peripheral neuropathy in cancer patients: A prospective cohort study2020

    • Author(s)
      SAITO Takashi、MAKIURA Daisuke、INOUE Junichiro、DOI Hisayo、YAKUSHIJIN Kimikazu、OKAMURA Atsuo、MATSUOKA Hiroshi、MUKOHARA Toru、SAURA Ryuichi、SAKAI Yoshitada、ONO Rei
    • Journal Title

      Physical Therapy Research

      Volume: 23 Issue: 2 Pages: 166-171

    • DOI

      10.1298/ptr.E10027

    • NAID

      130007958543

    • ISSN
      2189-8448
    • Year and Date
      2020-12-20
    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Physical activity among patients with breast cancer receiving aromatase inhibitors is associated with bone health: a cross-sectional observational study2020

    • Author(s)
      Saito Takashi、Ono Rei、Kono Seishi、Asano Mika、Fukuta Akimasa、Tanaka Yuko、Takao Shintaro、Sakai Yoshitada
    • Journal Title

      Breast Cancer Research and Treatment

      Volume: 182 Issue: 1 Pages: 187-193

    • DOI

      10.1007/s10549-020-05668-5

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Social frailty as a risk factor for new-onset depressive symptoms at one year post-surgery in older patients with gastrointestinal cancer2020

    • Author(s)
      Okumura Maho、Inoue Tatsuro、Melinda Gea、Saito Takashi、Fukuta Akimasa、Makiura Daisuke、Inoue Junichiro、Sakai Yoshitada、Ono Rei
    • Journal Title

      Journal of Geriatric Oncology

      Volume: 11 Issue: 5 Pages: 904-907

    • DOI

      10.1016/j.jgo.2020.01.012

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association between preoperative sleep disturbance and low muscle mass in patients with gastrointestinal cancer2020

    • Author(s)
      Okumura M, Saito T, Fukuta A, Makiura D, Inoue J, Sakai Y, Ono R
    • Journal Title

      Journal of Physical Therapy Science

      Volume: 32 Issue: 1 Pages: 59-64

    • DOI

      10.1589/jpts.32.59

    • NAID

      130007789037

    • ISSN
      0915-5287, 2187-5626
    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] レセプトデータを使用した要介護発生における高齢期がんのインパクト LIFE Study2021

    • Author(s)
      小野 玲, 中塚 清将, 福田 治久
    • Organizer
      第63回日本老年医学会学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] Prevalence of geriatric syndromes in community-dwelling elderly cancer survivors2020

    • Author(s)
      Rei Ono, Daisuke Makiura, Kazuaki Uchida, Rika Kawaharada, Yoshiaki Kido, Hisafumi Yasuda, Hisatomo Kowa
    • Organizer
      SIOG 2020 Annual Meeting
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] 地域在住高齢がんサバイバーにおける運動機能と精神機能、生化学データの特徴2020

    • Author(s)
      小野 玲, 牧浦 大祐, 内田 一彰, 河原田 里果, 木戸 良明, 安田 尚史, 古和 久朋
    • Organizer
      第26回日本緩和医療学会学術大会
    • Related Report
      2020 Research-status Report
  • [Presentation] 高齢がんサバイバーにおけるがん腫別の要支援・要介護認定~レセプトデータ分析~2020

    • Author(s)
      小野 玲, 福田 治久
    • Organizer
      第3回がん理学療法部門研究会
    • Related Report
      2020 Research-status Report
  • [Presentation] The high impact of preoperative social frailty on overall survival in elderly gastrointestinal cancer patients2019

    • Author(s)
      Ono R, Makiura D, Okumura M, Fukuta A, Saito T, Inoue J, Yamamoto M, Nakamura T, Kakeji Y, Sakai Y
    • Organizer
      19th Congress of the International Society of Geriatric Oncology
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 高齢消化器がん患者における術前の認知機能低下の有病率と関連要因2019

    • Author(s)
      小野玲, 牧浦大祐, 奥村真帆, 福田章真, 斎藤貴, 井上順一朗, 酒井良忠
    • Organizer
      第4回日本がんサポーティブケア学会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] 高齢消化器がん患者における術前の社会的つながりと術後1年のうつ症状の新規発生との関連2019

    • Author(s)
      奥村真帆,井上達郎, Melinda Gea, 斎藤貴, 福田章真, 牧浦大祐, 井上順一朗, 酒井良忠, 小野玲
    • Organizer
      第4回日本がんサポーティブケア学会学術集会
    • Related Report
      2019 Research-status Report
  • [Book] Physical Therapy and Research in Patients with Cancer2023

    • Author(s)
      Morishita S, Inoue J, Nakano J
    • Total Pages
      578
    • Publisher
      Springer Singapore
    • ISBN
      9789811967092
    • Related Report
      2022 Annual Research Report

URL: 

Published: 2019-04-18   Modified: 2024-01-30  

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