Effects of hybrid peripheral neuromuscle stimulation on motor recovery of upper extremity early after stroke
| Project/Area Number |
19K11355
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 59010:Rehabilitation science-related
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| Research Institution | Saitama Medical University (2021)
Dokkyo Medical University (2019-2020) |
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Principal Investigator |
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2021: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2020: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2019: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 脳卒中 / 上肢麻痺 / 脳可塑性 / ニューロモデュレーター / 急性期 / ニューロリハビリテーション / neuromodulation / neurorehabilitation / stroke / acute / upper extremity paresis / cortical plasticity / 神経筋肉電気刺激 / 脳再構成 / 上肢機能 |
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| Outline of Research at the Start |
慢性期脳卒中患者への随意運動介助型電気刺激(以下、IVES)と併用した作業療 法で上肢機能改善効果発現には長時間かつ長期間の介入を要し効果自体もまだ十分とは言えません。 本研究では、急性期脳卒中患者に、短い入院期間内でかつ短時間介入で最大の効果を発揮する ことが期待できる、IVESと反復末梢神経筋肉磁気刺激法をハイブリッドに組み合わせた作業療法が重度上肢麻痺の回復に有効であることを検証します。急性期脳卒中後の重度上肢運動障害に対して重度上肢麻痺へのlow dose(短時間介入) & short duration(短期間)による効率性と有効性を両立した新たな治療法の創出を目指します。
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| Outline of Final Research Achievements |
We aimed to investigate the effects of neuromodulators, such as neuromuscular stimulation (NMES) and repetitive peripheral magnetic stimulation (rPMS) on severe UE paresis during early acute phase of stroke. Outcome measures included UE motor section of the Fugl-Meyer Motor Assessment Scale (FMA-UE), Wolf motor function test (WMFT), and box and block test (BBT). To adjust the different treatment durations, we defined “progress rate” as the gains of UE function scores divided by treatment duration. The progress rate was significantly different in FMA-UE and WMFT, but not in BBT. We demonstrated the favorable effects of both neuromodulators (coupled EMG-triggered NMES and cyclic NMES or rPMS) on severe upper extremity (UE) function for early acute phase patients with stroke by showing a significant facilitation of UE motor recovery when applied neuromodulators to affected UE compared with standard care group.
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| Academic Significance and Societal Importance of the Research Achievements |
急性期病院では、短い期間で回復期病院や施設に転院するか自宅退院することになることから、その短期間で短時間介入でも効果が期待できる方法論の確立が待望されている。もし急性期において重度の上肢運動障害に有効な方法が開発されれば多くの患者の上肢機能回復に貢献できADL拡大と社会参加促進が実現できるであろう。
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Report
(4 results)
Research Products
(13 results)
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[Journal Article] Cognitive and linguistic dysfunction after thalamic stroke and recovery process: possible mechanism2021
Author(s)
Obayashi Shigeru、Department of Rehabilitation Medicine, Saitama Medical Center, Saitama Medical University, 1981 Kamoda, Kawagoe, Saitama 350-8550, Japan、Department of Rehabilitation Medicine, Chiba-Hokusoh hospital, Nippon Medical School, 1715 Kamagari, Inzai, Chiba 270-1694, Japan
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Journal Title
AIMS Neuroscience
Volume: 9
Issue: 1
Pages: 1-11
DOI
Related Report
Peer Reviewed
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