Study for the mechanism of exercise-induced antidepressant effects and the development of novel therapeutic drug for depression
Project/Area Number |
19K11440
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 59020:Sports sciences-related
|
Research Institution | Osaka University |
Principal Investigator |
KONDO Makoto 大阪大学, 医学系研究科, 准教授 (50633012)
|
Co-Investigator(Kenkyū-buntansha) |
島田 昌一 大阪大学, 医学系研究科, 教授 (20216063)
中村 雪子 大阪大学, 医学系研究科, 特任講師 (90548083)
小山 佳久 大阪大学, 医学系研究科, 助教 (40397667)
臼井 紀好 大阪大学, 医学系研究科, 准教授 (00784076)
|
Project Period (FY) |
2019-04-01 – 2022-03-31
|
Project Status |
Completed (Fiscal Year 2021)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2021: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 運動 / 抗うつ効果 / うつ病治療薬 |
Outline of Research at the Start |
既存の抗うつ薬が効かない難治性のうつ病患者は大変多く、うつ病に対する新たな治療薬が求められている。近年我々は、運動がもたらす抗うつ効果について検討し、運動による抗うつ効果には、セロトニン3型受容体が必須の働きをしていることを見出した。本研究では、セロトニン3型受容体を介する抗うつ効果のメカニズムを明らかにし、さらに、うつ病モデルマウスを用いた検討により、運動による抗うつ効果の分子メカニズム解明から既存薬と異なる「運動の抗うつ機序」に基づいた新たなうつ病治療薬開発を目指す。
|
Outline of Final Research Achievements |
Current antidepressants have a limited efficacy: more than one-third of depressed patients fail to respond to multiple antidepressant treatments and are considered to experience treatment-resistant depression. Therefore, development of novel therapeutic drug for depression is highly desirable. We showed that the serotonin type 3 (5-hydroxytryptamine type 3: 5-HT3) receptor is essential for exercise-induced antidepressant effects. Furthermore, using depression model mice, we studied a novel 5-HT3 receptor-mediated antidepressant mechanism in detail, and revealed a new therapeutic target for depression. Our findings could provide significant benefits for treatment-resistant depressed patients.
|
Academic Significance and Societal Importance of the Research Achievements |
うつ病の患者数は世界で約3億人といわれ、深刻な社会経済的損失をもたらす。しかし、既存の抗うつ薬が効かない患者が多いことが問題となっており、新たな治療薬が望まれている。本研究では、運動がもたらす抗うつ効果の分子メカニズムに着目し、うつ病に対する新たな治療ターゲット候補となる分子を見出した。将来、うつ病の新たな治療薬の開発につながる研究成果であり、学術的意義や社会的意義は大きいと考えられる。
|
Report
(4 results)
Research Products
(66 results)
-
-
-
-
-
[Journal Article] Development of a new method for assessing otolith function in mice using three-dimensional binocular analysis of the otolith-ocular reflex2021
Author(s)
Harada S, Imai T, Takimoto Y, Ohta Y, Sato T, Kamakura T, Takeda N, Kitahara T, Kondo M, Ueno Y, Shimada S, Inohara H.
-
Journal Title
Scientific Reports
Volume: 11
Issue: 1
Pages: 17191
DOI
URL
Related Report
Peer Reviewed / Open Access
-
-
-
[Journal Article] Bladder urothelium converts bacterial lipopolysaccharide information into neural signaling via an ATP-mediated pathway to enhance the micturition reflex for rapid defense.2020
Author(s)
Ueda N, Kondo M, Takezawa K, Kiuchi H, Sekii Y, Inagaki Y, Soda T, Fukuhara S, Fujita K, Uemura M, Imamura R, Miyagawa Y, Nonomura N, Shimada S.
-
Journal Title
Scientific Reports
Volume: 10
Issue: 1
Pages: 21167-21167
DOI
Related Report
Peer Reviewed / Open Access
-
-
-
-
-
[Journal Article] Rat model of Meniere’s attack: intratympanic injection of potassium chloride produces direction-changing spontaneous nystagmus and hearing fluctuations.2019
Author(s)
Kamakura T, Kitahara T, Kondo M, Horii A, Hanada Y, Takimoto Y, Ishida Y, Nakamura Y, Imai T, Inohara H, Shimada S.
-
Journal Title
Audiology and Neurotology
Volume: 24
Issue: 5
Pages: 217-223
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] Rat model of acute attack of Meniere’s disease: direction-changing spontaneous nystagmus and hearing fluctuations induced by intratympanic injection of potassium chloride.2020
Author(s)
Kamakura T, Kitahara T, Kondo M, Horii A, Hanada Y, Takimoto Y, Ishida Y, Nakamura Y, Imai t, Inohara H, Shimada S.
Organizer
Association for Research in Otolaryngology(ARO)2020, 43rd Annual MidWinter Meeting
Related Report
Int'l Joint Research
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-