Can genetic profile predict response to resistance training?

• Project/Area Number: 19K11531
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 59020:Sports sciences-related
• Research Institution: Nippon Sport Science University
• Principal Investigator: Kikuchi Naoki 日本体育大学, 体育学部, 准教授 (10739478)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2021: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 筋力トレーニング / 遺伝子多型 / 筋力 / 筋肥大 / ゲノムワイド関連解析 / GWAS / ACTN3 / ALDH2 / トレーニング効果 / アスリート / パフォーマンス / MCT1 / CNTFR / 遺伝子発現

Outline of Research at the Start

本研究課題では筋力トレーニングの効果の個人差についての遺伝特性を明らかにすることを目的として、1)遺伝子多型、2)運動前後の遺伝子発現、さらには3)エピジェネティクスの観点から検討する。初年度には、レジスタンス運動直後の遺伝子プロファイルの検討を行う。次年度以降は、長期的なトレーニング反応を検討し、初年度に行った急性反応との関連性を解析する。さらに、同様のサンプルを用いて、網羅的なエピジェネティクスに関わる解析を行いトレーニング効果との関連性を検討する。

Outline of Final Research Achievements

The purpose of this study was to discover novel genetic polymorphisms associated with individual differences in the effects of strength training in the general population using genome-wide association analysis(GWAS). In this study, 56 men and women participated in a total of 16 sessions of strength training, twice a week for 8 weeks.Strength, muscle mass, and muscle function were measured before and after the training period. This study identified 95, 17, and 27 novel genetic polymorphisms associated with isometric knee extension muscle strength, thigh muscle cross-sectional area, and rate of change in the 30-second chair stand test, respectively, by GWAS. Further investigation of these polymorphisms is needed in the future.

Academic Significance and Societal Importance of the Research Achievements

本研究では、筋力トレーニングの効果に影響する遺伝子多型の検出を目指した。筋力トレーニングによる筋機能や筋量の上昇に対してトレーニング効果の個人差がある。遺伝子多型によってスクリーニングすることによって、個人対応型のトレーニングプログラムが期待できる。さらに、血圧上昇に対するリスクやサプリメント摂取による効果の違いなど、さまざまな個人差を把握することができる。

Research Products

• [Int'l Joint Research] Liverpool John Moores University(英国)
• [Int'l Joint Research] Medical University of Lublin(ポーランド)
• [Int'l Joint Research] Cagliari University,(イタリア)
• [Int'l Joint Research] Medical University of Lublin/Gdansk University(ポーランド)
• [Int'l Joint Research] University of Cagliari(イタリア)
• [Int'l Joint Research] Medical university of Lublin(ポーランド)
• [Journal Article] Is COL1A1 gene rs1107946 polymorphism associated with sport climbing status and flexibility? (2022)
  • Author(s): Mika Saito, Michal Ginszt, Ekaterina A. Semenova, Myosotis Massidda, Kinga Huminska-Lisowska, Monika Michałowska-Sawczyn, Hiroki Homma, Pawel; Cszczyk, Takanobu Okamoto, Andrey K. Larin, Edward V. Generozov, Piotr Majcher, Koichi Nakazato, Ildus I. Ahmetov, and Naoki Kikuchi.
  • Journal Title: Genes Volume: 13 Issue: 3 Pages: 403-403
  • DOI: 10.3390/genes13030403
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Genetic profile of sports climbing athletes from three different ethnicities. (2022)
  • Author(s): Mika Saito, Michal Ginszt, Ekaterina A. Semenova, Myosotis Massidda, Kinga Huminska-Lisowska, Monika Michałowska-Sawczyn, Hiroki Homma, Pawel; Ciszczyk, Takanobu Okamoto, Andrey K. Larin, Edward V. Generozov, Piotr Majcher, Koichi Nakazato, Ildus I.Ahmetov, Naoki Kikuchi.
  • Journal Title: Biology of Sport. Volume: 39 Issue: 4 Pages: 913-919
  • DOI: 10.5114/biolsport.2022.109958
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Effect of online low-intensity exercise training on fitness and cardiovascular parameters. (2022)
  • Author(s): Naoki Kikuchi, Yukina Mochizuki, Ayumu Kozuma, Takamichi Inoguchi, Mika Saito, Minoru Deguchi, Hiroki Homma, Madoka Ogawa, Yuto Hashimoto, Koichi Nakazato, Takanobu Okamoto.
  • Journal Title: International Journal of Sports Medicine Volume: 43 Issue: 05 Pages: 418-426
  • DOI: 10.1055/a-1582-2874
  • Peer Reviewed
• [Journal Article] Genes and weightlifting performance (2021)
  • Author(s): Naoki Kikuchi, Ethan Moreland, Hiroki Homma, Ekaterina A. Semenova, Mika Saito, Andrey K. Larin, Naoyuki Kobatake, Rinat A. Yusupov, Takanobu Okamoto, Koichi Nakazato, Alun G. Williams, Edward V. Generozov, Ildus I. Ahmetov.
  • Journal Title: Genes Volume: 13 Issue: 1 Pages: 25-25
  • DOI: 10.3390/genes13010025
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Association between MCT1 T1470A polymorphism and climbing status in Polish and Japanese climbers (2021)
  • Author(s): Saito Mika、Ginszt Michal、Massidda Myosotis、Cieszczyk Pawel、Okamoto Takanobu、Majcher Piotr、Nakazato Koichi、Kikuchi Naoki
  • Journal Title: Biology of Sport Volume: 38 Issue: 2 Pages: 229-234
  • DOI: 10.5114/biolsport.2020.98624
  • NAID: 120007191101
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Association between the ACE I/D polymorphism and muscle injuries in Italian and Japanese elite football players (2020)
  • Author(s): Massidda Myosotis、Miyamoto-Mikami Eri、Kumagai Hiroshi、Ikeda Hayato、Shimasaki Yu、Yoshimura Masafumi、Cugia Paolo、Piras Francesco、Scorcu Marco、Kikuchi Naoki、Cal? Carla Maria、Fuku Noriyuki
  • Journal Title: Journal of Sports Sciences Volume: 38 Issue: 21 Pages: 2423-2429
  • DOI: 10.1080/02640414.2020.1787683
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Ciliary Neurotrophic Factor Receptor rs41274853 Polymorphism Is Associated With Weightlifting Performance in Japanese Weightlifters (2020)
  • Author(s): Homma Hiroki、Kobatake Naoyuki、Sekimoto Yusuke、Saito Mika、Mochizuki Yukina、Okamoto Takanobu、Nakazato Koichi、Nishiyama Tetsunari、Kikuchi Naoki
  • Journal Title: Journal of Strength and Conditioning Research Volume: 34 Issue: 11 Pages: 3037-3041
  • DOI: 10.1519/jsc.0000000000003750
  • NAID: 120007096948
  • Peer Reviewed
• [Journal Article] eQTL variants in COL22A1 are associated with muscle injury in athletes (2020)
  • Author(s): Miyamoto-Mikami Eri、Kumagai Hiroshi、Kikuchi Naoki、Kamiya Nobuhiro、Miyamoto Naokazu、Fuku Noriyuki
  • Journal Title: Physiological Genomics Volume: 52 Issue: 12 Pages: 588-589
  • DOI: 10.1152/physiolgenomics.00115.2020
  • Peer Reviewed / Open Access
• [Journal Article] COL5A1 rs12722 polymorphism is not associated with passive muscle stiffness and sports-related muscle injury in Japanese athletes. (2019)
  • Author(s): Miyamoto-Mikami E, Miyamoto N, Kumagai H, Hirata K, Kikuchi N, Zempo H, Kimura N, Kamiya N, Kanehisa H, Naito H, Fuku N.
  • Journal Title: BMC Medical Genetics. Volume: 20 Issue: 1 Pages: 192-192
  • DOI: 10.1186/s12881-019-0928-2
  • Peer Reviewed / Open Access
• [Journal Article] ESR1 rs2234693 Polymorphism Is Associated with Muscle Injury and Muscle Stiffness (2018)
  • Author(s): Hiroshi Kumagai、Eri Miyamoto-Mikami、Kosuke Hirata、Naoki Kikuchi、Nobuhiro Kamiya、Seigo Hoshikawa、Hirofumi Zempo、Hisashi Naito、Naokazu Miyamoto、Noriyuki Fuku
  • Journal Title: Medicine & Science in Sports & Exercise Volume: 1 Issue: 1 Pages: 19-26
  • DOI: 10.1249/mss.0000000000001750
  • Peer Reviewed / Open Access
• [Presentation] クライミング競技者における競技パフォーマンスとACE遺伝子I/D多型との関連性 (2021)
  • Author(s): 齋藤未花、本間洋樹、望月佑季奈、岡本孝信、中里浩一、菊池直樹.
  • Organizer: 第28回日本運動生理学会
• [Presentation] ウエイトリフティング選手の競技実績とMCT1遺伝子T1470A多型との関連性. (2021)
  • Author(s): 本間洋樹、小畑直之、齋藤未花、望月佑季奈、岡本孝信、中里浩一、菊池直樹
  • Organizer: 第28回日本運動生理学会
• [Presentation] 握力および30秒間椅子立ち上がりテストとMCT1遺伝子T1470A多型との関連性 世田谷-青葉研究 (2020)
  • Author(s): 齋藤未花、本間洋樹、望月佑季奈 、上妻歩夢、矢部まどか、岡本孝信、中里浩一、菊池直樹
  • Organizer: 第75回日本体力医学会
• [Presentation] ウエイトリフティングパフォーマンスとCNTFR遺伝子rs41274853多型およびACTN3遺伝子R577X多型の関連性. (2020)
  • Author(s): 本間洋樹、小畑直之、齋藤未花、望月佑季奈、岡本孝信、中里浩一、西山哲成、菊池直樹
  • Organizer: 第75回日本体力医学会
• [Presentation] The Association Between Mct1 T1470a And Ace I/d Polymorphisms And Athletic Status In Climbing Athletes (2019)
  • Author(s): Mika Saito, Jou Takahira, Sakura Daiku, Souichiro Miyauchi,Naoki Kikuchi
  • Organizer: 66th ACSM annual meeting.
  • Int'l Joint Research
• [Remarks] KIKULAB S&C Research Team
  • URL: https://kikulab-nssu.com
• [Remarks] KIKULAB S&C Research Team ホームページ
  • URL: https://kikulab-nssu.com
• [Remarks] KIKULAB S&C Research Team ホームページ
  • URL: http://kikulab-nssu.com