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Based on DOHaD concept, associations between body composition among young women and their birth weight.

Research Project

Project/Area Number 19K11650
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 59040:Nutrition science and health science-related
Research InstitutionShowa Women's University

Principal Investigator

Konishi Kanae  昭和女子大学, 生活機構研究科, 准教授 (70238103)

Co-Investigator(Kenkyū-buntansha) 佐田 文宏  中央大学, 保健センター, 嘱託職員 (90187154)
山中 健太郎  昭和女子大学, 生活機構研究科, 教授 (90359662)
清水 史子  昭和女子大学, 生活機構研究科, 准教授 (40435269)
Project Period (FY) 2019-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2021: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
KeywordsDOHaD / 妊娠前BMI / 妊娠中体重増加量 / 栄養疫学 / 母子手帳 / 出生体重 / 体組成 / 母子健康手帳 / 若年成人女性
Outline of Research at the Start

わが国で増加する低出生体重児や20・30歳代女性の「やせ」の増加、若年成人女性の低栄養などの現状を背景に、DOHaDの観点から妊娠前から妊娠中の適切な栄養摂取および体重管理が、将来の生活習慣病予防の観点から重要視されている。
本研究では、①母子健康手帳データを用いて妊娠中の体重増加量軌跡パターンを低出生体重のリスク要因ごとに検討する。②胎児期から3歳時点の体格が若年成人期の体格・体組成にどのように関わっているかライフコース疫学の概念を用いて検討する。③妊娠前(若年成人)女性における、正常体重肥満(隠れ肥満)者へのランダム化比較試験を通じて、予防的な生活・食習慣改善法の確立を目指すものである。

Outline of Final Research Achievements

This study is based on the Developmental Origins of Health and Disease (DOHaD) concept, which states that various factors such as nutrition, environmental chemicals, and social environment from fetal life to early childhood affect the risk of developing lifestyle-related diseases in the future. This study aimed to examine factors from fetal life to early childhood that influence body size and body composition in young adulthood. We examined the relationship between the body mass index (BMI), lean body mass, and fat mass of young adult women and their mothers' pre-pregnancy and pregnancy status, their birth and early childhood physique, and development information, which were detailed in the maternal and child health handbook data. Regarding the relationship between birth weight and current BMI, lean mass, and fat mass, we found that lower birth weight was associated with a higher BMI and lower lean mass and fat mass.

Academic Significance and Societal Importance of the Research Achievements

近年、我が国では、胎児発育の指標である平均出生体重は減少傾向であり、低出生体重児割合(2020年;9.8%)がOECD加盟国の中でも高いことが問題となっている。この背景として、妊娠前の体格が「やせ」であることや妊娠前・妊娠中の低栄養が報告されており、DOHaDの観点からも妊娠前から妊娠中の適切な栄養摂取および体重管理が、将来の生活習慣病予防に繋がるとして重要視されている。本研究の結果は、出生体重が若年成人期の体組成に影響を与えること、特に筋肉量などを低下させることを示唆している。

Report

(5 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (36 results)

All 2023 2022 2021 2020 2019

All Journal Article (13 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 9 results,  Open Access: 8 results) Presentation (22 results) (of which Int'l Joint Research: 7 results) Book (1 results)

  • [Journal Article] Association Between Smoking and Hypertension in Pregnancy Among Japanese Women: A Meta-analysis of Birth Cohort Studies in the Japan Birth Cohort Consortium (JBiCC) and JECS2023

    • Author(s)
      Morisaki N, Obara T, Piedvache A, Kobayashi S, Miyashita C, Nishimura T, Ishikuro M, Sata F, Horikawa R, Mori C, Metoki H, Tsuchiya KJ, Kuriyama S, Kishi R.
    • Journal Title

      Journal of Epidemiology

      Volume: 33 Issue: 10 Pages: 498-507

    • DOI

      10.2188/jea.JE20220076

    • ISSN
      0917-5040, 1349-9092
    • Year and Date
      2023-10-05
    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] DOHaDとの出会いと10年間の歩み2023

    • Author(s)
      佐田 文宏.
    • Journal Title

      Developmental Origins of Health and Disease Research

      Volume: 11 Issue: 1 Pages: 17-19

    • DOI

      10.51067/dohad.11.1_17

    • ISSN
      2187-2562, 2187-2597
    • Related Report
      2022 Annual Research Report
    • Open Access
  • [Journal Article] Gene-environment interactions related to maternal exposure to environmental and lifestyle-related chemicals during pregnancy and the resulting adverse fetal growth: a review2022

    • Author(s)
      Kobayashi S, Sata F, Kishi R.
    • Journal Title

      Environmental Health and Preventive Medicine

      Volume: 27 Issue: 0 Pages: 24-24

    • DOI

      10.1265/ehpm.21-00033

    • ISSN
      1342-078X, 1347-4715
    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association of exposure to prenatal per?uoroalkyl substances and estrogen receptor 1 polymorphisms with the second to fourth digit ratio in school-aged children: The Hokkaido study2022

    • Author(s)
      Nishimura Yoko、Moriya Kimihiko、Kobayashi Sumitaka、Ikeda- Araki Atsuko、Sata Fumihiro、Mitsui Takahiko、Itoh Sachiko、Miyashita Chihiro、Cho Kazutoshi、Kon Masafumi、Nakamura Michiko、Kitta Takeya、Murai Sachiyo、Kishi Reiko、Shinohara Nobuo
    • Journal Title

      Reproductive Toxicology

      Volume: 109 Pages: 10-18

    • DOI

      10.1016/j.reprotox.2022.02.002

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Foods Intakes and Their Influences on BMI(Body Mass Index) in Young and Middle Aged Women in Japan2022

    • Author(s)
      Akikazu Takada1, Fumiko Shimizu, Yukie Ishii, Mutsumi Ogawa, Tetsuya Takao
    • Journal Title

      Food and Nutrition Sciences

      Volume: 13 Issue: 04 Pages: 349-357

    • DOI

      10.4236/fns.2022.134026

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 大学教職員のやせに影響を及ぼす要因の検討2021

    • Author(s)
      佐田文宏,西條泰明,小西香苗,田中誠一,柳元伸太郎
    • Journal Title

      Campus Health

      Volume: 59(1) Pages: 71-73

    • Related Report
      2021 Research-status Report
  • [Journal Article] 若年者のやせに影響を及ぼす要因の検討2021

    • Author(s)
      佐田 文宏, 西條 泰明, 小西 香苗, 田中 誠一, 小町 裕志, 柳元 伸太郎.
    • Journal Title

      日本衛生学雑誌

      Volume: 76. Supp

    • Related Report
      2021 Research-status Report
  • [Journal Article] Associations between healthy Japanese dietary patterns and depression in Japanese women2020

    • Author(s)
      kanae Konishi
    • Journal Title

      Public Health Nutrition

      Volume: 24 Issue: 7 Pages: 1753-1765

    • DOI

      10.1017/s1368980020001548

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Association of exposure to prenatal phthalate esters and bisphenol A and polymorphisms in the ESR1 gene with the second to fourth digit ratio in school-aged children: Data from the Hokkaido study2020

    • Author(s)
      Nishimura Yoko、Moriya Kimihiko、Kobayashi Sumitaka、Araki Atsuko、Sata Fumihiro、Mitsui Takahiko、Itoh Sachiko、Miyashita Chihiro、Cho Kazutoshi、Kon Masafumi、Nakamura Michiko、Kitta Takeya、Murai Sachiyo、Kishi Reiko、Shinohara Nobuo
    • Journal Title

      Steroids

      Volume: 159 Pages: 108637-108637

    • DOI

      10.1016/j.steroids.2020.108637

    • Related Report
      2020 Research-status Report 2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] DOHaD学説:その成り立ちと学術分野としての発展2020

    • Author(s)
      佐田文宏
    • Journal Title

      医学のあゆみ

      Volume: 275 Pages: 939-946

    • Related Report
      2020 Research-status Report
  • [Journal Article] Effects of Gender, Age, and Clot Formation on the Measurements of Tryptophan Metabolites in Blood.2019

    • Author(s)
      Masuda, J. , Karayama, M. , Suda, T. , Maekawa, M. , Shimizu, F. and Takada, A.
    • Journal Title

      Food and Nutrition Sciences

      Volume: Vol.10 Issue: 07 Pages: 761-775

    • DOI

      10.4236/fns.2019.107056

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Gene-Environment Interactions to Detect Adverse Health Effects on the Next Generation.2019

    • Author(s)
      Sata F, Kobayashi S, Kishi R.
    • Journal Title

      Current Topics in Environmental Health and Preventive Medicine

      Volume: 13 Pages: 485-512

    • DOI

      10.1007/978-981-15-0520-1_19

    • ISBN
      9789811505195, 9789811505201
    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Dose-dependent associations between prenatal caffeine consumption and small for gestational age, preterm birth, and reduced birthweight in the Japan Environment and Children's Study.2019

    • Author(s)
      Kobayashi S, Sata F, Murata K, Saijo Y, Araki A, Miyashita C, Itoh S, Minatoya M, Yamazaki K, Ait Bamai Y, Kishi R; Japan Environment and Children's Study Group.
    • Journal Title

      Paediatric and Perinatal Epidemiology

      Volume: 33 Issue: 3 Pages: 185-194

    • DOI

      10.1111/ppe.12551

    • NAID

      120006842195

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Presentation] わが国のDOHaD研究の歩み2023

    • Author(s)
      佐田文宏
    • Organizer
      第93回日本衛生学会学術総会(東京)
    • Related Report
      2022 Annual Research Report
  • [Presentation] Relationship between iron supplementation during pregnancy and pre-pregnancy body mass index.2022

    • Author(s)
      Kanae Konishi
    • Organizer
      12th World Congress on Developmental Origins of Health and Disease, Vancouver, Canada.
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 若年成人女性における体組成と出生体重との関連2022

    • Author(s)
      倉田幸奈、小西香苗
    • Organizer
      第9回日本DOHaD学会(仙台)
    • Related Report
      2022 Annual Research Report
  • [Presentation] Dietary habits and metabolic syndrome among Japanese employees.2022

    • Author(s)
      Kanae Konishi, Kanako Nakagawa, Saki Mihara, Yasuaki Saijo, Shintaro Yanagimoto and Fumihiro Sata
    • Organizer
      22nd IUNS-ICN International Congress of Nutrition, Tokyo, Japan
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Establishment and management of a collaborative platform of birth cohorts in Japan,2022

    • Author(s)
      Sata F, Morisaki N, Shimizu A, Obara T, Metoki H, Tsuchiya KJ, Horikawa R, Mori C, Kishi R, Kuriyama S.
    • Organizer
      12th World Congress on Developmental Origins of Health and Disease, Vancouver, Canada.
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effects on energy intake and expenditure of ingesting low-calorie artificially-sweetened beverages in free-living healthy young women.2022

    • Author(s)
      Sawahara M. Yamanaka K.
    • Organizer
      22nd IUNS-ICN International Congress of Nutrition, Tokyo, Japan
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 国内出生コホート連携基盤の構築・維持・更新:日本の出生コホートの取り組み2022

    • Author(s)
      佐田文宏
    • Organizer
      第92回日本衛生学会学術総会シンポジウム3,2022/3/22,国内,口頭(オンライン)
    • Related Report
      2021 Research-status Report
  • [Presentation] 妊娠中の環境化学物質曝露と胎児発育:遺伝環境交互作用に関する疫学研究文献レビュー2022

    • Author(s)
      小林澄貴,佐田文宏,岸 玲子
    • Organizer
      第92回日本衛生学会学術総会,2022/3/21-23,国内,ポスター(オンライン)
    • Related Report
      2021 Research-status Report
  • [Presentation] Combined effects of sex hormone levels and genetic polymorphisms on digit ratio in school-aged children2021

    • Author(s)
      Sata F, Mitsui T, Araki A, Miyashita C, Ito S, Sasaki S, Kitta T, Moriya K, Kish R, Nonomura K
    • Organizer
      World Congress of Epidemology (WCE 2021), 2021/9/3-6, 国外,ポスター(オンライン)
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] 大学教職員のやせに影響を及ぼす要因の検討2021

    • Author(s)
      佐田文宏,西條泰明,小西香苗,田中誠一,柳元伸太郎,
    • Organizer
      第59回全国大学保健管理研究集会,2021/10/7,国内,口頭(オンライン)
    • Related Report
      2021 Research-status Report
  • [Presentation] 妊娠中の母親の食事パターンと栄養素摂取2021

    • Author(s)
      倉田幸奈、小西香苗
    • Organizer
      第68回日本栄養改善学会学術総会(オンライン開催)
    • Related Report
      2021 Research-status Report
  • [Presentation] 食事摂取基準スコアを用いた妊娠中の栄養素摂取状況評価および食品摂取につい て2021

    • Author(s)
      小西香苗
    • Organizer
      第68回日本栄養改善学会学術総会(オンライン開催)
    • Related Report
      2021 Research-status Report
  • [Presentation] Maternal nutrition - Starting from 'Before Pregnancy’2021

    • Author(s)
      Kanae KONISHI
    • Organizer
      IUNS International Workshop on Capacity and Leadership Development in Nutritional Sciences(Online)
    • Related Report
      2021 Research-status Report
  • [Presentation] 妊娠中の鉄剤処方と妊娠前体格との関連2021

    • Author(s)
      小西香苗
    • Organizer
      第31回日本疫学会学術総会
    • Related Report
      2020 Research-status Report
  • [Presentation] 若年者のやせに影響を及ぼす要因の検討2021

    • Author(s)
      佐田文宏 、西條泰明 、小西香苗、田中誠一、小町裕志、柳本伸太郎
    • Organizer
      第91回日本衛生学会
    • Related Report
      2020 Research-status Report
  • [Presentation] 中高年男女における、社会経済学的要因と食事パターンとの関連2020

    • Author(s)
      小西香苗、武藤杏子、広田直子、百武愛子、村松宰
    • Organizer
      第74回日本栄養・食糧学会大会
    • Related Report
      2020 Research-status Report
  • [Presentation] 女子大学生における時間栄養学を取り入れた生活習慣・食生活改善の介入研究2020

    • Author(s)
      小西香苗
    • Organizer
      第67回日本栄養改善学会
    • Related Report
      2020 Research-status Report
  • [Presentation] 妊娠前体格および妊娠中体重増加量と出生体重との関連2019

    • Author(s)
      小西香苗
    • Organizer
      第73回 日本栄養・食糧学会
    • Related Report
      2019 Research-status Report
  • [Presentation] Association of pre-pregnancy body mass index and gestational weight gain with infant birth weight.2019

    • Author(s)
      Kanae Konishi
    • Organizer
      11th World Congress on Developmental Origins of Health and Disease
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] An attempt of holding a workshop of birth cohort collaboration toward establishing consortia in Japan.2019

    • Author(s)
      Fumihiro Sata
    • Organizer
      11th World Congress on Developmental Origins of Health and Disease
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 妊婦面接と乳児健診からみた母子の現状 ~品川区の健診アンケート項目から~2019

    • Author(s)
      中島圭子、永井靖子、今井美香子、北澤幸子、三浦由紀子、榎本芳美、 福内恵子、小西香苗
    • Organizer
      第78回日本公衆衛生学会
    • Related Report
      2019 Research-status Report
  • [Presentation] 第1回出生コホート研究連携ワークショップ~コンソーシアム設立に向けた試み~.2019

    • Author(s)
      佐田 文宏
    • Organizer
      第8回日本DOHaD学会学術集会 シンポジウム1「コホート連携」
    • Related Report
      2019 Research-status Report
  • [Book] DOHaD 先制医療への展開2023

    • Author(s)
      一般社団法人 日本DOHaD学会
    • Total Pages
      316
    • Publisher
      金原出版
    • ISBN
      9784307170796
    • Related Report
      2022 Annual Research Report

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Published: 2019-04-18   Modified: 2024-01-30  

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