心不全リスク解明のための大規模コホートデータを用いた経時データ解析モデルの開発

• Project/Area Number: 19K11847
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 60030:Statistical science-related
• Research Institution: Teikyo University (2020-2022); Tohoku University (2019)
• Principal Investigator: 宮田 敏 帝京大学, 公私立大学の部局等, 教授 (60360343)
• Co-Investigator(Kenkyū-buntansha): 倉田 博史 東京大学, 大学院総合文化研究科, 教授 (50284237) ; 坂田 泰彦 国立研究開発法人国立循環器病研究センター, 病院, 部長 (90379206)
• Project Period (FY): 2019-04-01 – 2024-03-31
• Project Status: Granted (Fiscal Year 2022)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2021: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2019: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 統計数学 / コホート研究 / 関数データ解析 / 慢性心不全 / ネットワーク解析 / 機械学習 / 構造方程式モデル

Outline of Research at the Start

本コホートでは，毎年一回の臨床検査数値による疫学データの他、死亡あるいは心不全入院などのイベント情報を収集している。すでに登録時から5年次まで計6時点の経時データを確定済みであり、さらに継続してデータの登録を行う。リスク層別のための関数主成分分析は、生存時間イベントをアウトカムとした教師あり学習モデルとしてリスク層別のために最適化された新たな理論モデルを開発する。リスク因子探索のためのネットワーク解析には、打ち切りデータを応答変数とするベイズ構造方程式モデルを用い、混合効果として経時データを取り込む。開発したモデルの臨床的意義については、循環器内科専門医による医学的検討を行う。

Outline of Annual Research Achievements

本研究では，2006~2010年に東北大学を含む東北地区24基幹病院において登録された10,219名の慢性心不全及びその高リスク患者コホート（CHART-2研究）の登録
データを用い、予後リスクの層別化と心疾患イベントのリスク要因探索を行う。
今年度の研究実績として、心疾患イベントの登録と、年一回の調査による身体所見、生化学データ、心エコーデータ、投薬情報その他CHART-2研究のデータ登録作業を継続し、2023年3月末をもって登録時から10年次までの登録作業を完了した。
研究実績としては、１）CHART-2研究に基づく臨床、疫学研究を進め、1）機械学習（random　forest）を用いた慢性心不全患者の層別化について研究を行い学会、論文にて公表した。また、２）慢性心不全患者における心臓再同期療法の利用と有効性についての研究、３）慢性心不全に対する抗血栓療法における癌と心房細動の既往が予後に与える影響についての研究についても成果も論文発表した。
これらの臨床、疫学研究から得られた知見を統計学的にモデル化し予後リスクの層別化を行うため、生存データの判別に最適化された経時データの層別のための関数主成分分析の開発を行った。現在、理論面での検討とCHART-2研究のコホートデータを用いた検証のためのプログラム開発を行うとともに、コンピューターシミュレーションによる検討を行うためプログラム開発を行い、論文を作成中である。

Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

COVID-19の感染拡大に伴う研究遅延があったが、現在、遅れを取り戻すべく研究中である。2022年度末までに、本研究の基盤となるCHART-2研究の10年次までのデータ確定作業が完了した。
研究分担者である坂田の協力の下、臨床医学・循環器内科学的見地からの、データ解析の検討を行い、研究成果は論文、学会発表を通じて公表している。
また、研究協力者である倉田との共同研究のもと、関数主成分分析を元にした経時データの層別モデルの開発を進めている。
CHART-2研究のデータを用いた疫学研究について、人工知能（機械学習）を用いた層別化について論文発表を行ったが、さらに本研究の方法論的進捗をまとめ論文を準備中である。

Strategy for Future Research Activity

経時データの層別モデル構築のための，関数主成分解析については理論的な検討をさらに進め論文化を目指す。さらに、人工知能による層別化を、継時データに拡張する方策について検討中である。
解析データ管理のため，データベース管理システム（DBMS）の構築を行うとともに、シミュレーションスタディーのためのプログラム作成を進める。
シミュレーションによる理論モデルの検証と臨床医学・循環器内科学的見地からの検証を行う。

Research Products

• [Journal Article] Usefulness of cardiac magnetic resonance for early detection of cancer therapeutics-related cardiac dysfunction in breast cancer patients (2023)
  • Author(s): Terui Yosuke、Sugimura Koichiro、Miyata Satoshi、Shimokawa Hiroaki、et al.
  • Journal Title: International Journal of Cardiology Volume: 371 Pages: 472-479
  • DOI: 10.1016/j.ijcard.2022.09.025
  • Peer Reviewed / Open Access
• [Journal Article] Regional variation of pediatric interhospital critical care transport in Japan (2023)
  • Author(s): Miura Shinya、Miyata Satoshi、Kawaguchi Atsushi、Yamaoka Kazue
  • Journal Title: Pediatrics International Volume: 65 Issue: 1
  • DOI: 10.1111/ped.15492
  • Peer Reviewed / Open Access
• [Journal Article] Machine learning approach to stratify complex heterogeneity of chronic heart failure: A report from the CHART‐2 study (2023)
  • Author(s): Nakano Kenji、Nochioka Kotaro、Yasuda Satoshi、Tamori Daito、Shiroto Takashi、Sato Yudai、Takaya Eichi、Miyata Satoshi、Kawakami Eiryo、Ishikawa Tetsuo、Ueda Takuya、Shimokawa Hiroaki
  • Journal Title: ESC Heart Failure Volume: 10 Issue: 3 Pages: 1597-1604
  • DOI: 10.1002/ehf2.14288
  • Peer Reviewed / Open Access
• [Journal Article] The safety of plasma apheresis from donors recovering from COVID-19 infection in Japan (2023)
  • Author(s): Kamo-Imai Ayumi、Togano Tomiteru、Sato Motohiko、Kawakami Yuiko、Inaba Kumi、Shimazu Hiroshi、Igarashi Saori、Tanaka Keiko、Terada Mari、Kinoshita-Iwamoto Noriko、Saito Sho、Kutsuna Satoshi、Hangaishi Akira、Morioka Shinichiro、Takahashi Kenzo、Miyata Satoshi、Ohmagari Norio
  • Journal Title: Transfusion and Apheresis Science Volume: in press Issue: 3 Pages: 103687-103687
  • DOI: 10.1016/j.transci.2023.103687
  • Peer Reviewed / Open Access
• [Journal Article] A Cohort Study of the Relationship between Active Collaboration and Operational Efficiency in Japanese Public Health Institutions (2022)
  • Author(s): Motoi Miura, Tetsuya Tanimoto, Satoshi Miyata, Masayasu Murakami, Yoshinori Nakata
  • Journal Title: JMA Journal Volume: 5 Issue: 4 Pages: 438-445
  • DOI: 10.31662/jmaj.2021-0195
  • ISSN: 2433-328X, 2433-3298
  • Year and Date: 2022-10-17
  • Peer Reviewed / Open Access
• [Journal Article] Utilization and Efficacy of Cardiac Resynchronization Therapy in Patients With Chronic Heart Failure ― A Report From the CHART-2 Study ― (2022)
  • Author(s): Hayashi Hideka、Yasuda Satoshi、Nakano Makoto、Sakata Yasuhiko、Nochioka Kotaro、Shiroto Takashi、Hasebe Yuhi、Noda Takashi、Miyata Satoshi、Shimokawa Hiroaki
  • Journal Title: Circulation Reports Volume: 4 Issue: 6 Pages: 264-273
  • DOI: 10.1253/circrep.CR-22-0036
  • ISSN: 2434-0790
  • Year and Date: 2022-06-10
  • Peer Reviewed / Open Access
• [Journal Article] Association of comorbidities and medications with risk of asthma exacerbation in pediatric patients: a retrospective study using Japanese claims data (2022)
  • Author(s): Maeda Shotaro、Kobayashi Shigetoshi、Takahashi Kenzo、Miyata Satoshi
  • Journal Title: Scientific Reports Volume: 12 Issue: 1 Pages: 5509-5509
  • DOI: 10.1038/s41598-022-08789-7
  • Peer Reviewed / Open Access
• [Journal Article] Natural history of Beh?et’s disease focusing on remission of oral ulcers (2022)
  • Author(s): Tomizuka Takafumi、Kikuchi Hirotoshi、Okubo Mai、Asako Kurumi、Miyata Satoshi、Kono Hajime
  • Journal Title: Modern Rheumatology Volume: 33 Issue: 3 Pages: 566-573
  • DOI: 10.1093/mr/roac035
  • Peer Reviewed / Open Access
• [Journal Article] Impact of statins in patients with vasospastic angina: A multicenter registry study of the Japanese Coronary Spasm Association (2022)
  • Author(s): Mori Hiroyoshi、Takahashi Jun、Sato Koichi、Miyata Satoshi、Takagi Yusuke、Tsunoda Ryusuke、Sumiyoshi Tetsuya、Matsui Motoyuki、Tanabe Yasuhiko、Sueda Shozo、Momomura Shin-ichi、Kaikita Koichi、Yasuda Satoshi、Ogawa Hisao、Shimokawa Hiroaki、Suzuki Hiroshi
  • Journal Title: Journal of Cardiology Volume: 80 Issue: 3 Pages: 226-231
  • DOI: 10.1016/j.jjcc.2022.03.009
  • Peer Reviewed / Open Access
• [Journal Article] Belt Electrode-Skeletal Muscle Electrical Stimulation in Older Hemodialysis Patients with Reduced Physical Activity: A Randomized Controlled Pilot Study (2022)
  • Author(s): Homma Midori、Miura Misa、Hirayama Yo、Takahashi Tamao、Miura Takahiro、Yoshida Naoki、Miyata Satoshi、Kohzuki Masahiro、Ebihara Satoru
  • Journal Title: Journal of Clinical Medicine Volume: 11 Issue: 20 Pages: 6170-6170
  • DOI: 10.3390/jcm11206170
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The A118G single-nucleotide polymorphism in <i>OPRM1</i> is a risk factor for asthma severity (2022)
  • Author(s): Kawakami Kaori、Miyasaka Tomomitsu、Nakamura Yutaka、Metoki Hirohito、Miyata Satoshi、Sato Miki、Sora Ichiro、Yamauchi Kohei、Kawakami Kazuyoshi、Blendy Julie A.、Kawano Tasuku、Shimokawa Hiroaki、Takayanagi Motoaki、Ohno Isao、Takahashi Tomoko
  • Journal Title: Allergology International Volume: 71 Issue: 1 Pages: 55-65
  • DOI: 10.1016/j.alit.2021.08.006
  • NAID: 130008145231
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Prognostic impact of a history of cancer and atrial fibrillation in antithrombotic therapy for chronic heart failure (2022)
  • Author(s): Nochioka Kotaro、Yasuda Satoshi、Sakata Yasuhiko、Shiroto Takashi、Hayashi Hideka、Takahashi Jun、Takahama Hiroyuki、Miyata Satoshi、Shimokawa Hiroaki
  • Journal Title: ESC Heart Failure Volume: 1 Issue: 4 Pages: 1-10
  • DOI: 10.1002/ehf2.13941
  • Peer Reviewed / Open Access
• [Journal Article] Characteristics of Inter-Arm Difference in Blood Pressure in Acute Aortic Dissection (2021)
  • Author(s): Sasamoto Nozomi、Akutsu Koichi、Yamamoto Takeshi、Otsuka Toshiaki、Sangen Hideto、Hayashi Hiroshi、Murata Hiroshige、Miyachi Hideki、Hosokawa Yusuke、Tara Shuhei、Tokita Yukichi、Miyata Satoshi、Morota Tetsuro、Nitta Takashi、Shimizu Wataru
  • Journal Title: Journal of Nippon Medical School Volume: 88 Issue: 5 Pages: 467-474
  • DOI: 10.1272/jnms.JNMS.2021_88-605
  • NAID: 130008117329
  • ISSN: 1345-4676, 1347-3409
  • Year and Date: 2021-10-25
  • Peer Reviewed
• [Journal Article] Prognostic significance of propofol-based intravenous anesthesia in early-stage lung cancer surgery (2021)
  • Author(s): Hayasaka Kazuki、Shiono Satoshi、Miyata Satoshi、Takaoka Seiji、Endoh Makoto、Okada Yoshinori
  • Journal Title: Surgery Today Volume: 51 Issue: 8 Pages: 1300-1308
  • DOI: 10.1007/s00595-020-02216-y
• [Journal Article] Prognostic model for patients with advanced cancer using a combination of routine blood test values (2021)
  • Author(s): Miyagi Taeko、Miyata Satoshi、Tagami Keita、Hiratsuka Yusuke、Sato Mamiko、Takeda Ikuo、Kohata Katsura、Satake Noriaki、Shimokawa Hiroaki、Inoue Akira
  • Journal Title: Supportive Care in Cancer Volume: - Issue: 8 Pages: 4431-4437
  • DOI: 10.1007/s00520-020-05937-5
  • Peer Reviewed
• [Journal Article] Risk prediction for new-onset atrial fibrillation using the Minnesota code electrocardiography classification system (2021)
  • Author(s): Igarashi Yu、Nochioka Kotaro、Sakata Yasuhiko、Tamai Tokiwa、Ohkouchi Shinya、Irokawa Toshiya、Ogawa Hiromasa、Hayashi Hideka、Fujihashi Takahide、Yamanaka Shinsuke、Shiroto Takashi、Miyata Satoshi、Hata Jun、Yamada Shogo、Ninomiya Toshiharu、Yasuda Satoshi、Kurosawa Hajime、Shimokawa Hiroaki
  • Journal Title: IJC Heart &amp; Vasculature Volume: 34 Pages: 100762-100762
  • DOI: 10.1016/j.ijcha.2021.100762
  • Peer Reviewed
• [Journal Article] Clinical impact of implementing humidified high-flow nasal cannula on interhospital transport among children admitted to a PICU with respiratory distress: a cohort study (2021)
  • Author(s): Miura Shinya、Yamaoka Kazue、Miyata Satoshi、Butt Warwick、Smith Sile
  • Journal Title: Critical Care Volume: 25 Issue: 1 Pages: 1-10
  • DOI: 10.1186/s13054-021-03620-7
• [Journal Article] Association between IDH mutational status and tumor-associated epilepsy or venous thromboembolism in patients with grade II and III astrocytoma (2021)
  • Author(s): Osada Yoshinari、Saito Ryuta、Miyata Satoshi、Shoji Takuhiro、Shibahara Ichiyo、Kanamori Masayuki、Sonoda Yukihiko、Kumabe Toshihiro、Watanabe Mika、Tominaga Teiji
  • Journal Title: Brain Tumor Pathology Volume: 38 Issue: 3 Pages: 218-227
  • DOI: 10.1007/s10014-021-00406-1
• [Journal Article] Prevalence of Locomotive Organ Impairment and Associated Factors among Middle-Aged and Older People in Nan Province, Thailand (2021)
  • Author(s): Niwayama Marie、Sakisaka Kayako、Wongwatcharapaiboon Pongthep、Rattanachun Valika、Miyata Satoshi、Takahashi Kenzo
  • Journal Title: International Journal of Environmental Research and Public Health Volume: 18 Issue: 20 Pages: 10871-10871
  • DOI: 10.3390/ijerph182010871
  • Peer Reviewed / Open Access
• [Journal Article] Beneficial effects of exercise training on physical performance in patients with vasospastic angina (2021)
  • Author(s): Sugisawa Jun,Matsumoto Yasuharu,Takeuchi Masashi,Suda Akira,Tsuchiya Satoshi,Ohyama Kazuma,Nishimiya Kensuke,Akizuki Mina,Sato Koichi,Ohura Shoko,Ota Hideki,Ikeda Shohei,Shindo Tomohiko,Kikuchi Yoku,Hao Kiyotaka,Shiroto Takashi,Takahashi Jun,Miyata Satoshi,Sakata Yasuhiko,Takase Kei,Kohzuki Masahiro,Shimokawa Hiroaki
  • Journal Title: International Journal of Cardiology Volume: 328 Pages: 14-21
  • DOI: 10.1016/j.ijcard.2020.12.003
  • Peer Reviewed / Open Access
• [Journal Article] Important Roles of Endothelium-Dependent Hyperpolarization in Coronary Microcirculation and Cardiac Diastolic Function in Mice. (2020)
  • Author(s): Ikumi Y, Shiroto T, Godo S, Saito H, Tanaka S, Ito A, Kajitani S, Monma Y, Miyata S, Tsutsui M, Shimokawa H.
  • Journal Title: J Cardiovasc Pharmacol Volume: 75 Issue: 1 Pages: 31-40
  • DOI: 10.1097/fjc.0000000000000763
  • Peer Reviewed / Open Access
• [Journal Article] Transcatheter aortic valve implantation and cognitive function in elderly patients with severe aortic stenosis. (2020)
  • Author(s): Tsuchiya S, Matsumoto Y, Suzuki H, Takanami K, Kikuchi Y, Takahashi J, Miyata S, Tomita N, Kumagai K, Taki Y, Saiki Y, Arai H, Shimokawa H.
  • Journal Title: EuroIntervention Volume: 15 Issue: 18 Pages: e1580-e1587
  • DOI: 10.4244/eij-d-19-00489
  • Peer Reviewed / Open Access
• [Journal Article] Impacts of hippocampal blood flow on changes in left ventricular wall thickness in patients with chronic heart failure (2020)
  • Author(s): Suzuki Hideaki, Matsumoto Yasuharu, Sugimura Koichiro, Takahashi Jun, Miyata Satoshi, Fukumoto Yoshihiro, Taki Yasuyuki, Shimokawa Hiroaki
  • Journal Title: International Journal of Cardiology Volume: in press Pages: 103-107
  • DOI: 10.1016/j.ijcard.2020.01.019
  • Peer Reviewed / Open Access
• [Journal Article] Risk of de-novo heart failure and competing risk in asymptomatic patients with structural heart diseases. (2020)
  • Author(s): Takada T, Sakata Y, Nochioka K, Miura M, Abe R, Kasahara S, Sato M, Aoyanagi H, Fujihashi T, Yamanaka S, Suzuki K, Shiroto T, Sugimura K, Takahashi J, Miyata S, Shimokawa H; CHART-2 Investigators..
  • Journal Title: Int J Cardiol Volume: Int J Cardiol. 2020 Feb 6. pii Pages: 1-7
  • DOI: 10.1016/j.ijcard.2020.02.015
  • Peer Reviewed / Open Access
• [Journal Article] Temporal changes in left ventricular ejection fraction and their prognostic impacts in patients with Stage B heart failure. (2020)
  • Author(s): Aoyanagi H, Nochioka K, Sakata Y, Miura M, Shiroto T, Abe R, Kasahara S, Sato M, Fujihashi T, Yamanaka S, Hayashi H, Sugimura K, Takahashi J, Miyata S, Shimokawa H; CHART-2 Investigators..
  • Journal Title: Int J Cardiol Volume: 306 Pages: 123-132
  • DOI: 10.1016/j.ijcard.2020.02.040
  • Peer Reviewed / Open Access
• [Journal Article] Clinical characteristics and prognostic factors in elderly patients with chronic heart failure -A report from the CHART-2 study. (2020)
  • Author(s): Sato M, Sakata Y, Sato K, Nochioka K, Miura M, Abe R, Oikawa T, Kasahara S, Aoyanagi H, Yamanaka S, Fujihashi T, Hayashi H, Shiroto T, Sugimura K, Takahashi J, Miyata S, Shimokawa H; CHART-2 Investigator..
  • Journal Title: Int J Cardiol Heart Vasc Volume: 27 Pages: 100497-100497
  • DOI: 10.1016/j.ijcha.2020.100497
  • Peer Reviewed / Open Access
• [Journal Article] Marked Impairment of Endothelium-Dependent Digital Vasodilatations in Patients with Microvascular Angina -Evidence for Systemic Small Artery Disease- (2020)
  • Author(s): Shoko Ohura-Kajitani, Takashi Shiroto, Shigeo Godo, Yosuke ikumi, Akiyo Ito, Shuhei Tanaka, Koichi Sato, Jun Sugisawa, Satoshi Tsuchiya, Akira Suda, Tomohiko Shindo, Shohei Ikeda, Kiyotaka Hao, Yoku Kikuchi, Kotaro Nochioka, Yasuharu Matsumoto, Jun Takahashi, Satoshi Miyata, Hiroaki Shimokawa.
  • Journal Title: Arteriosclerosis, Thrombosis, and Vascular Biology. Volume: - Issue: 5 Pages: 1400-1412
  • DOI: 10.1161/atvbaha.119.313704
  • Peer Reviewed / Open Access
• [Journal Article] The impact of antiplatelet therapy on patients with vasospastic angina: A multicenter registry study of the Japanese Coronary Spasm Association (2020)
  • Author(s): Mori Hiroyoshi、Takahashi Jun、Sato Koichi、Miyata Satoshi、Takagi Yusuke、Tsunoda Ryusuke、Sumiyoshi Tetsuya、Matsui Motoyuki、Tanabe Yasuhiko、Sueda Shozo、Momomura Shinichi、Kaikita Koichi、Yasuda Satoshi、Ogawa Hisao、Shimokawa Hiroaki、Suzuki Hiroshi
  • Journal Title: IJC Heart & Vasculature Volume: 29 Pages: 100561-100561
  • DOI: 10.1016/j.ijcha.2020.100561
  • Peer Reviewed / Open Access
• [Journal Article] Prognostic impacts of dynamic cardiac structural changes in heart failure patients with preserved left ventricular ejection fraction (2020)
  • Author(s): Yamanaka Shinsuke、Sakata Yasuhiko、Nochioka Kotaro、Miura Masanobu、Kasahara Shintaro、Sato Masayuki、Aoyanagi Hajime、Fujihashi Takahide、Hayashi Hideka、Shiroto Takashi、Sugimura Koichiro、Takahashi Jun、Miyata Satoshi、Shimokawa Hiroaki、CHART‐2 Investigators
  • Journal Title: European Journal of Heart Failure Volume: 22 Issue: 12 Pages: 2258-2268
  • DOI: 10.1002/ejhf.1945
  • Peer Reviewed / Open Access
• [Journal Article] Low-intensity pulsed ultrasound ameliorates cardiac diastolic dysfunction in mice-A possible novel therapy for HFpEF (2020)
  • Author(s): Monma Y, Shindo T, Eguchi K, Kurosawa R, Kagaya Y, Ikumi Y, Ichijo S, Nakata T, Miyata S, Matsumoto A, Sato H, Miura M, Kanai H, Shimokawa H
  • Journal Title: Cardiovasc Res Volume: Jul 19 Issue: 5 Pages: 1325-1338
  • DOI: 10.1093/cvr/cvaa221
  • Peer Reviewed / Open Access
• [Journal Article] Beneficial effects of riociguat on hemodynamic responses to exercise in CTEPH patients after balloon pulmonary angioplasty - A randomized controlled study (2020)
  • Author(s): Aoki T, Tatebe S, Shimokawa H et al.
  • Journal Title: Int J Cardiol Heart Vasc . Volume: 29 Pages: 100579-100579
  • DOI: 10.1016/j.ijcha.2020.100579
  • Peer Reviewed / Open Access
• [Journal Article] Identification of the Novel Variants in Patients With Chronic Thromboembolic Pulmonary Hypertension (2020)
  • Author(s): Yaoita N, Satoh K, Tatebe S, Yasuda S, Shimokawa H et al.
  • Journal Title: J Am Heart Assoc . Volume: 9 Issue: 21 Pages: 1-12
  • DOI: 10.1161/jaha.120.015902
  • Peer Reviewed / Open Access
• [Journal Article] Temporal trends in the prevalence and outcomes of geriatric patients with acute myocardial infarction in Japan-A report from the Miyagi AMI Registry Study. (2020)
  • Author(s): Sato K, Takahashi J, Hao K, Miyata S, Suda A, Shindo T, Ikeda S, Kikuchi Y, Shiroto T, Matsumoto Y, Sakata Y, Shimokawa H.
  • Journal Title: J Cardiol Volume: 75 Issue: 5 Pages: 465-472
  • DOI: 10.1016/j.jjcc.2019.10.006
  • Peer Reviewed
• [Journal Article] Factors limiting habitual exercise in patients with chronic heart failure: a multicenter prospective cohort study. (2020)
  • Author(s): Tadaki S, Sakata Y, Miura Y, Nochioka K, Miura M, Miyata S, Asakura M, Shimada K, Yamamoto T, Fukumoto Y, Kadokami T, Yasuda S, Miura T, Ando SI, Yano M, Kitakaze M, Daida H, Shimokawa H.
  • Journal Title: Heart Vessels Volume: 35 Issue: 5 Pages: 655-664
  • DOI: 10.1007/s00380-019-01529-4
  • Peer Reviewed / Open Access
• [Journal Article] Cyclophilin A as a biomarker for the therapeutic effect of balloon angioplasty in chronic thromboembolic pulmonary hypertension. (2020)
  • Author(s): Kozu K, Satoh K, Aoki T, Tatebe S, Miura M, Yamamoto S, Yaoita N, Suzuki H, Shimizu T, Sato H, Konno R, Terui Y, Nochioka K, Kikuchi N, Satoh T, Sugimura K, Miyata S, Shimokawa H.
  • Journal Title: J Cardiol Volume: 75 Issue: 4 Pages: 415-423
  • DOI: 10.1016/j.jjcc.2019.09.010
  • Peer Reviewed / Open Access
• [Journal Article] Clinical benefits and risks of antithrombotic therapy in patients with atrial fibrillation with comorbidities - A report from the CHART-2 Study. (2020)
  • Author(s): Shiroto T, Sakata Y, Nochioka K, Abe R, Kasahara S, Sato M, Aoyanagi H, Fujihashi T, Yamanaka S, Hayashi H, Miura M, Takahashi J, Miyata S, Shimokawa H.
  • Journal Title: Int J Cardiol Volume: 299 Pages: 160-168
  • DOI: 10.1016/j.ijcard.2019.09.022
  • Peer Reviewed
• [Journal Article] Identification of Adipsin as a Novel Prognostic Biomarker in Patients With Coronary Artery Disease. (2019)
  • Author(s): Ohtsuki T, Satoh K, Shimizu T, Ikeda S, Kikuchi N, Satoh T, Kurosawa R, Nogi M, Sunamura S, Yaoita N, Omura J, Aoki T, Tatebe S, Sugimura K, Takahashi J, Miyata S, Shimokawa H.
  • Journal Title: J Am Heart Assoc Volume: 8 Issue: 23
  • DOI: 10.1161/jaha.119.013716
  • Peer Reviewed / Open Access
• [Journal Article] Prognostic value of the model for end-stage liver disease excluding INR score (MELD-XI) in patients with adult congenital heart disease. (2019)
  • Author(s): Konno R, Tatebe S, Sugimura K, Satoh K, Aoki T, Miura M, Suzuki H, Yamamoto S, Sato H, Terui Y, Miyata S, Adachi O, Kimura M, Saiki Y, Shimokawa H.
  • Journal Title: PLoS One Volume: 14 Issue: 11 Pages: 0225403-0225403
  • DOI: 10.1371/journal.pone.0225403
  • Peer Reviewed / Open Access
• [Journal Article] Coronary functional abnormalities in patients with angina and non-obstructive coronary artery disease. (2019)
  • Author(s): Suda A, Takahashi J, Hao K, Kikuchi Y, Shindo T, Ikeda S, Sato K, Sugisawa J, Matsumoto Y, Miyata S, Sakata Y, Shimokawa H.
  • Journal Title: J Am Coll Cardiol Volume: 74 Issue: 19 Pages: 2350-2360
  • DOI: 10.1016/j.jacc.2019.08.1056
  • Peer Reviewed
• [Journal Article] Diagnostic and Prognostic Significance of Serum Levels of SeP (Selenoprotein P) in Patients With Pulmonary Hypertension (2019)
  • Author(s): Nobuhiro Kikuchi, Kimio Satoh, Taijyu Satoh, Nobuhiro Yaoita, Mohammad Abdul Hai Siddique, Junichi Omura, Ryo Kurosawa, Masamichi Nogi, Shinichiro Sunamura, Satoshi Miyata, Hirofumi Misu, Yoshiro Saito, Hiroaki Shimokawa
  • Journal Title: Arterioscler Thromb Vasc Biol. Volume: 39 Issue: 12 Pages: 2553-2562
  • DOI: 10.1161/atvbaha.119.313267
  • Peer Reviewed / Open Access
• [Journal Article] Usefulness of intracoronary administration of fasudil, a selective Rho-kinase inhibitor, for PCI-related refractory myocardial ischemia. (2019)
  • Author(s): Kikuchi Y, Takahashi J, Hao K, Sato K, Sugisawa J, Tsuchiya S, Suda A, Shindo T, Ikeda S, Shiroto T, Matsumoto Y, Miyata S, Sakata Y, Shimokawa H.
  • Journal Title: Int J Cardiol Volume: 297 Pages: 8-13
  • DOI: 10.1016/j.ijcard.2019.09.057
  • Peer Reviewed
• [Journal Article] ADAMTS8 promotes the development of pulmonary arterial hypertension and right ventricular failure: a possible novel therapeutic target (2019)
  • Author(s): Omura J, Satoh K, Kikuchi N, Satoh T, Kurosawa R, Nogi M, Ohtsuki T, Elias-Al-Mamun M, Siddique MAH, Yaoita N, Sunamura S, Miyata S, Hoshikawa Y, Okada Y, Shimokawa H
  • Journal Title: Circ Res Volume: 125 Issue: 10 Pages: 884-906
  • DOI: 10.1161/circresaha.119.315398
  • Peer Reviewed / Open Access
• [Journal Article] Identification of Emetine as a Therapeutic Agent for Pulmonary Arterial Hypertension: Novel Effects of an Old Drug. (2019)
  • Author(s): Siddique MAH, Satoh K, Kurosawa R, Kikuchi N, Elias-Al-Mamun M, Omura J, Satoh T, Nogi M, Sunamura S, Miyata S, Ueda H, Tokuyama H, Shimokawa H.
  • Journal Title: Arterioscler Thromb Vasc Biol Volume: 39 Issue: 11 Pages: 2367-2385
  • DOI: 10.1161/atvbaha.119.313309
  • Peer Reviewed / Open Access
• [Journal Article] Association between temporal changes in C-reactive protein levels and prognosis in patients with previous myocardial infarction - A report from the CHART-2 Study. (2019)
  • Author(s): Oikawa T, Sakata Y, Nochioka K, Miura M, Abe R, Kasahara S, Sato M, Aoyanagi H, Saga C, Ikeno Y, Shiroto T, Sugimura K, Takahashi J, Miyata S, Shimokawa H; CHART-2 Investigators..
  • Journal Title: Int J Cardiol Volume: 293 Pages: 17-24
  • DOI: 10.1016/j.ijcard.2019.07.022
  • Peer Reviewed
• [Journal Article] Identification of celastramycin as a novel therapeutic agent for pulmonary arterial hypertension: high-throughput screening of 5,562 compounds (2019)
  • Author(s): Kurosawa R, Satoh K, Kikuchi N, Kikuchi H, Saigusa D, Elias-Al-Mamun M, Siddique MAH, Omura J, Satoh T, Sunamura S, Nogi M, Numano K, Miyata S, Uruno A, Kano K, Matsumoto Y, Doi T, Aoki J, Oshima Y, Yamamoto M, Shimokawa H
  • Journal Title: Circ Res Volume: 125 Issue: 3 Pages: 309-327
  • DOI: 10.1161/circresaha.119.315229
  • Peer Reviewed / Open Access
• [Journal Article] Increased risk of cancer death in patients with chronic heart failure with a special reference to inflammation-A report from the CHART-2 Study. (2019)
  • Author(s): Oikawa T, Sakata Y, Nochioka K, Miura M, Abe R, Kasahara S, Sato M, Aoyanagi H, Shiroto T, Sugimura K, Takahashi J, Miyata S, Shimokawa H; CHART-2 Investigators..
  • Journal Title: Int J Cardiol Volume: 290 Pages: 106-112
  • DOI: 10.1016/j.ijcard.2019.04.078
  • Peer Reviewed
• [Presentation] Elevated Serum Non-High Density Lipoprotein Cholesterol as Residual Risks for Myocardial Infarction Recurrence Under Statin Treatment (2021)
  • Author(s): 白戸 崇、鈴木 康太、及川 卓也、後岡 広太郎、高橋 潤、宮田 敏、坂田 泰彦、下川 宏明、安田 聡
  • Organizer: 第85回 日本循環器学会学術集会
  • Int'l Joint Research
• [Presentation] A prognostic impact of brain structural abnormalities in patients with chronic heart failure (B-HeFT2) (2021)
  • Author(s): 鈴木 秀明、建部 俊介、高橋 潤、松本 泰治、杉村 宏一郎、宮田 敏、福本 義弘、瀧 靖之、下川 宏明、安田 聡
  • Organizer: 第85回 日本循環器学会学術集会
  • Int'l Joint Research
• [Presentation] Clinical Characteristics and Outcomes of Young Patients with Heart Failure with Preserved Ejection Fraction (2021)
  • Author(s): 山中 信介、坂田 泰彦、後岡 広太郎、藤橋 敬英、林 秀華、白戸 崇、髙橋 潤、宮田 敏、下川 宏明、安田 聡
  • Organizer: 第85回 日本循環器学会学術集会
  • Int'l Joint Research
• [Presentation] Usefulness of Native T1 Mapping for Prediction of Chemotherapeutics-related Cardiac Dysfunction in Breast Cancer Patients (2021)
  • Author(s): 照井 洋輔、杉村 宏一郎、大田 英揮、多田 寛、勝田 祐子、佐藤 遥、後岡 広太郎、建部 俊介、宮田 敏、坂田 泰彦、石田 孝宜、高瀬 圭、安田 聡
  • Organizer: 第85回 日本循環器学会学術集会
  • Int'l Joint Research
• [Presentation] Prognostic Impacts of Polypharmacy in Patients with Chronic Heart Failure: -A Report from the CHART-2 Study- (2021)
  • Author(s): 藤橋 敬英、後岡 広太郎、坂田 泰彦、山中 信介、林 秀華、白戸 崇、高橋 潤、宮田 敏、下川 宏明、安田 聡
  • Organizer: 第85回 日本循環器学会学術集会
  • Int'l Joint Research
• [Presentation] Sex Differences in the Incidence and Predictors of Sudden Cardiac Death in Patients with Chronic Heart Failure: Report from the CHART2 Study (2021)
  • Author(s): 林 秀華、後岡 広太郎、坂田 泰彦、山中 信介、藤橋 敬英、白戸 崇、中野 誠、杉村 宏一郎、高橋 潤、宮田 敏、下川 宏明、安田 聡
  • Organizer: 第85回 日本循環器学会学術集会
  • Int'l Joint Research
• [Presentation] 微小血管狭心症患者における抵抗血管内皮依存性拡張反応の著明な障害 ―全身性小血管病のエビデンス― (2020)
  • Author(s): 大浦 翔子、白戸 崇、神戸 茂雄、井汲 陽祐、伊藤 秋代、田中 修平、須田 彬、進藤 智彦、池田 尚平、羽尾 清貴、菊地 翼、松本 泰治、高橋 潤、宮田 敏、下川 宏明
  • Organizer: 第73回日本酸化ストレス学会 / 第20回日本NO学会合同学術集会
• [Presentation] Prognostic Impacts of Atrial Fibrillation in Patients with Chronic Heart Failure Insights from the CHART-2 Study (2020)
  • Author(s): 中野 誠, 相澤 健太郎, 長谷部 雄飛, 後岡 広太郎, 白戸 崇, 宮田 敏, 坂田 泰彦, 下川 宏明
  • Organizer: 第84回日本循環器学会学術集会 (2020年7月27日～8月2日 WEB開催)
  • Int'l Joint Research
• [Presentation] Incidence and Predictors of Sudden Cardiac Death in Stage B vs. Stage C/D Heart Failure -Insights from the CHART-2 Study- (2020)
  • Author(s): 林 秀華, 坂田 泰彦, 後岡 広太郎, 青柳 肇, 山中 信介, 藤橋 敬英, 白戸 崇, 杉村 宏一郎, 髙橋 潤, 宮田 敏, 下川 宏明
  • Organizer: 第84回日本循環器学会学術集会 (2020年7月27日～8月2日 WEB開催)
  • Int'l Joint Research
• [Presentation] 乳がん患者における抗がん剤に関連した心筋障害の心臓MRIによる評価 (2020)
  • Author(s): 照井 洋輔、杉村 宏一郎、大田 英揮、多田 寛、佐藤 遥、後岡 広太郎、 建部 俊介、宮田 敏、坂田 泰彦、石田 孝宜、高瀬 圭、下川 宏明
  • Organizer: 第30回日本心血管画像動態学会
• [Presentation] 左室駆出率が保たれた心不全患者におけるBMIの関与と性差 -CHART-2研究からの報告 (2020)
  • Author(s): 山中信介、坂田泰彦、後岡広太郎、青柳 肇、藤橋敬英、林 秀華、白戸 崇、杉村宏一郎、高橋 潤、宮田 敏、下川宏明
  • Organizer: 第13回日本性差医学・医療学会学術集会
• [Presentation] 慢性心不全患者における尿酸値と予後の性差 -CHART-2 研究- (2020)
  • Author(s): 藤橋敬英、坂田泰彦、後岡広太郎、青柳 肇、山中信介、林 秀華、白戸 崇、杉村宏一郎、高橋 潤、宮田 敏、下川宏明
  • Organizer: 第13回日本性差医学・医療学会学術集会
• [Presentation] 慢性心不全患者における突然死発症と予後規定因子の性差についての検討 (2020)
  • Author(s): 林 秀華、坂田泰彦、後岡広太郎、青柳 肇、山中信介、藤橋敬英、白戸 崇、中野 誠、杉村宏一郎、高橋 潤、宮田 敏、下川宏明
  • Organizer: 第13回日本性差医学・医療学会学術集会
• [Presentation] 心房細動患者における抗凝固薬・抗血小板薬併用の有効性と安全性に関する性差の検討 (2020)
  • Author(s): 白戸 崇、坂田泰彦、後岡広太郎、青柳 肇、山中信介、藤橋敬英、林 秀華、杉村宏一郎、高橋 潤、宮田 敏、下川宏明
  • Organizer: 第13回日本性差医学・医療学会学術集会