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A neural circuit controlling experience-dependent auditory preference behavior: Identification of relevant brain regions and its dynamics analysis

Research Project

Project/Area Number 19K12190
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 61060:Kansei informatics-related
Research InstitutionMeiji University

Principal Investigator

Kajiwara Riichi  明治大学, 理工学部, 専任准教授 (60356772)

Co-Investigator(Kenkyū-buntansha) 冨永 貴志  徳島文理大学, 神経科学研究所, 教授 (20344046)
高島 一郎  国立研究開発法人産業技術総合研究所, 情報・人間工学領域, 上級主任研究員 (90357351)
Project Period (FY) 2019-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2022: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2021: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2020: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2019: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords聴覚 / 嗜好性 / 選択行動 / 嗅周囲野 / 膜電位イメージング / ラット / 選択行動解析 / ラット・マウス / 嗅皮質 / 脳スライス / 動物行動実験 / 嗅周囲皮質 / 条件付け / 選択行動実験 / 嗜好性行動 / 学習・記憶 / 臨界期 / イメージング / 電気生理
Outline of Research at the Start

我々ヒトを含めた動物は日常において様々な選択を行っている.それは,天敵のニオイを先天的に嫌ったり,芳醇な香りを放つ果実を選択したり,といった生存に結びつく選択行動だけではない.好みの絵画や音楽鑑賞などといった,高い精神活動による選択行動もこれに相当する.本研究では,聴覚入力に対して生じる「嗜好」が,知覚・記憶のプロセスを経て形成される「親密度」と結びつく可能性に着目し,げっ歯類の行動・生理実験系を用いて聴覚嗜好性を司る神経回路機構の解明を目指す.

Outline of Final Research Achievements

The present study addresses whether our feelings of preference are formed by past experiences (memories) or innate. We investigated this issue by focusing on the auditory system of rats. First, we divided sound sources into two groups, the "reward-related" and the "reward-unrelated" groups, and presented them to the rats in a two-choice maze. The results showed that 1) the rats avoided the white noise used for comparison with the other sound stimuli even after the reward acquisition experience. However, 2) the sound stimulus with tone and melody was preferentially selected after the reward-acquisition experience. In addition, membrane potential imaging in ex vivo brain slices showed that the perirhinal cortex, which is thought to be involved in the familiarity evaluation of input information, is under the control of a robust inhibitory system, which may complicate the in vivo pharmacological analysis of the above results.

Academic Significance and Societal Importance of the Research Achievements

嗜好性・審美性にかかわる神経基盤については,既にヒトを対象とした研究で一定の知見が蓄積されるまでに至っている.その一方で,過去の体験に応じて嗜好に関する評価が変動するのか,という記憶処理との関連性を念頭においた調査は,十分に進んでいるとは言えない.本研究は,ラットの聴覚嗜好性行動を,生得的要因と後天的な要因を区別して調査する試みであり,得られた知見は,なぜ,我々が普段聞く曲に好き嫌いがあるのか,といった聴覚系嗜好性の問題にとどまらず,我々が好む音楽が人により異なるのは,生活環境での体験の違いによるものなのか?といった学習・記憶に依存した嗜好性の問題を解く手がかりを与える.

Report

(5 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (22 results)

All 2023 2022 2021 2020 2019

All Journal Article (7 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 5 results,  Open Access: 3 results) Presentation (15 results) (of which Int'l Joint Research: 4 results)

  • [Journal Article] Stable wide-field voltage imaging for observing neuronal plasticity at the neuronal network level2023

    • Author(s)
      Tominaga T, Kajiwara R, Tominaga Y
    • Journal Title

      Biophysics and Physicobiology

      Volume: 20 Issue: 1 Pages: n/a

    • DOI

      10.2142/biophysico.bppb-v20.0015

    • ISSN
      2189-4779
    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Novel Pneumatic Skin Sensory Stimulator and Its Application to a Two-Point Discrimination Test2022

    • Author(s)
      橋川 史崇, 水沼 将太, 大淵 さつき, 梶原 利一
    • Journal Title

      IEEJ Transactions on Sensors and Micromachines

      Volume: 142 Issue: 3 Pages: 32-37

    • DOI

      10.1541/ieejsmas.142.32

    • NAID

      130008165661

    • ISSN
      1341-8939, 1347-5525
    • Year and Date
      2022-03-01
    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] A novel pneumatic skin sensory stimulator and its application to a two‐point discrimination test2022

    • Author(s)
      Hashikawa F, Mizunuma S, Ofuchi S, Kajiwara R
    • Journal Title

      Electronics and Communications in Japan

      Volume: 105(3) Issue: 3

    • DOI

      10.1002/ecj.12362

    • NAID

      130008165661

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Voltage-Sensitive Dye versus Intrinsic Signal Optical Imaging: Comparison of Tactile Responses in Primary and Secondary Somatosensory Cortices of Rats2021

    • Author(s)
      Takashima Ichiro, Kajiwara Riichi
    • Journal Title

      Brain Sciences

      Volume: 11 Issue: 10 Pages: 1294-1294

    • DOI

      10.3390/brainsci11101294

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Perirhinal cortex area 35 controls the functional link between the perirhinal and entorhinal‐hippocampal circuitry.2021

    • Author(s)
      Kajiwara R, Tominaga T
    • Journal Title

      Bioessays

      Volume: 43 Issue: 3 Pages: 2000084-2000084

    • DOI

      10.1002/bies.202000084

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Involvement of GABAergic transmission in the nucleus accumbens related to cue-selection behavior with a waiting period2019

    • Author(s)
      Okubo M, Matsuzaki K, Okada N, Komura Y, Kajiwara R
    • Journal Title

      Proc of Life Eng Symp 2019

      Volume: - Pages: 75-79

    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Journal Article] Time-lapse optical imaging system for monitoring the resting membrane potential change of neurons in a mouse brain slice.2019

    • Author(s)
      Machida Y, Yamada Y, Mizunuma S, Tominaga T, Kajiwara R
    • Journal Title

      Proc of Life Eng Symp 2019

      Volume: - Pages: 139-142

    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Novel object recognition behavior of juvenile and adult mice and the voltage-sensitive dye imaging of its rhinal cortical circuits in vitro2022

    • Author(s)
      Ide Y, Inoue T, Saito Y, Iwaoka M, Tominaga T, Kajiwara R
    • Organizer
      Neuro2022_Okinawa
    • Related Report
      2022 Annual Research Report
  • [Presentation] Air Pressure Control Device for Two-point Discrimination Test2021

    • Author(s)
      Hashikawa F, Mizunuma S, Ofuchi S, Kajiwara R
    • Organizer
      計測自動制御学会オンライン
    • Related Report
      2021 Research-status Report
  • [Presentation] Behavioral analysis of tone discrimination and auditory preference in rats2021

    • Author(s)
      noue T, Matsuzaki K, Kanemaki G, Komura Y, Kajiwara R
    • Organizer
      第44回 日本神経科学大会 第1回 CJK 国際会議
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Cortical oscillations in entorhinal and perirhinal cortices imaged with voltage-sensitive dye in slice preparations of mice2021

    • Author(s)
      Tominaga T, Tominaga Y, Kajiwara R
    • Organizer
      第59回生物物理学会年会
    • Related Report
      2021 Research-status Report
  • [Presentation] A behavioral assay system to analyze tone discrimination and auditory preference in rats.2021

    • Author(s)
      Matsuzaki K, Okubo M, Komura Y, Kajiwara R
    • Organizer
      第126回日本解剖学会・第98回日本生理学会大会・合同大会
    • Related Report
      2020 Research-status Report
  • [Presentation] Two-point discriminability and skin-rabbit illusion induced by the air pressure stimulation on a human forearm.2021

    • Author(s)
      Mizunuma S, Ohuchi S, Kajiwara R
    • Organizer
      JSKE 第16回日本感性工学会春季大会・ISASE2021
    • Related Report
      2020 Research-status Report
  • [Presentation] Optical membrane potential recordings with voltage-sensitive dye (VSD) enabling recordings of rare and unique neuronal activity patterns.2021

    • Author(s)
      Tominaga Y, Kajiwara R, Tominaga T
    • Organizer
      Neuroscience Meeting Planner. Chicago, IL: Society for Neuroscience, 2021. Online.
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] Contribution of the GABAergic and dopaminergic systems in the nucleus accumbens to patience for a future reward in rats.2020

    • Author(s)
      Okubo M, Matsuzaki K, Okada N, Komura Y, Kajiwara R
    • Organizer
      第43回日本神経科学大会
    • Related Report
      2020 Research-status Report
  • [Presentation] A voltage-sensitive dye imaging of neural propagation in rhinal cortices of immature and mature mouse.2020

    • Author(s)
      MachidaY, Yamada Y, Tominaga T, Kajiwara R
    • Organizer
      第43回日本神経科学大会
    • Related Report
      2020 Research-status Report
  • [Presentation] Single-shot repetitive wide-field voltage-sensitive dye (VSD) imaging allows for seeking unique network events and oscillations.2020

    • Author(s)
      Tominaga T, Kajiwara R, Tominaga Y
    • Organizer
      第43回日本神経科学大会
    • Related Report
      2020 Research-status Report
  • [Presentation] Involvement of GABAergic transmission in the nucleus accumbens related to cue-selection behavior with a waiting period.2019

    • Author(s)
      Okubo M, Matsuzaki K, Okada N, Komura Y, Kajiwara R.
    • Organizer
      計測自動制御学会ライフエンジニリングシンポジウム2019
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Time-lapse optical imaging system for monitoring the resting membrane potential change of neurons in a mouse brain slice.2019

    • Author(s)
      Machida Y, Yamada Y, Mizunuma S, Tominaga T, Kajiwara R
    • Organizer
      計測自動制御学会ライフエンジニリングシンポジウム2019
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] D-current related plasticity in the perirhinal-entorhinal network: a voltage-sensitive dye imaging in mouse brain slices.2019

    • Author(s)
      Kajwiara R, Tominaga Y, Tominaga T
    • Organizer
      Neuro2019第42回日本神経科学大会
    • Related Report
      2019 Research-status Report
  • [Presentation] GABAergic and dopaminergic systems in the nucleus accumbens affect a cue-selection task for assessing the waiting behavior.2019

    • Author(s)
      Okubo M, Matsuzaki K, Okada N, Komura Y, Kajiwara R
    • Organizer
      次世代脳プロジェクト冬のシンポジウム2019
    • Related Report
      2019 Research-status Report
  • [Presentation] The effects of muscimol injections into the nucleus accumbens on the waiting behavior and brain slice analysis of the network activity.2019

    • Author(s)
      Okada N, Okubo M, Machida Y, Komura Y, Tominaga T, Kajiwara R
    • Organizer
      第97回日本生理学会大会
    • Related Report
      2019 Research-status Report

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Published: 2019-04-18   Modified: 2024-01-30  

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