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Proposal of high precision multidimensional measurement of tongue mucosa under arbitrary environment based on time-domain correlation imaging method

Research Project

Project/Area Number 19K12817
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 90130:Medical systems-related
Research InstitutionChiba University

Principal Investigator

Nakaguchi Toshiya  千葉大学, フロンティア医工学センター, 教授 (20361412)

Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2021: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords舌診断支援 / 分光計測 / 形状計測 / 舌診断 / 時間相関イメージング / 分光画像
Outline of Research at the Start

舌粘膜の色・形は消化器系を主とする生体の状態変化を顕著に表すことが知られている.本研究は舌粘膜を非接触的かつ高精度多次元的に記録・解析する新しい手法を提案する.時間相関イメージング法の多重化により立体形状・分光特性・時系列変化の多種尺度を単一システムで同時的かつ瞬時に非接触計測する5次元イメージング法を構築する.また,光源変調化により周囲光源環境の影響を除外し,任意の位置・姿勢における舌粘膜記録の課題を解決する.本研究の成果は,医療機関における診断支援への応用だけでなく,一般家庭における健康モニタリングに貢献する舌状態の計測技術を確立する.

Outline of Final Research Achievements

This study proposed a "5D imaging method" that simultaneously realizes spectroscopic images of the tongue surface, three-dimensional shape, and measurement of time variation, and realized an imaging system that excludes the influence of the ambient light source environment by modulating the illumination source. The lighting arrangement was optimized to detect minute irregularities on the tongue surface using the photometric stereo method. A method to calculate the normal of the shape was developed considering the reliability of the measurement. A phantom model was created to evaluate the accuracy of tongue shape measurement, and it was confirmed that the tongue shape could be detected as small as 0.2mm. To record the spectral characteristics of the tongue surface, a multi-band imaging method was investigated. As a result of collecting and analyzing the tongue surface spectral images, we identified four main wavelengths that significantly reflect the color change of the tongue surface.

Academic Significance and Societal Importance of the Research Achievements

本研究は,体調の変化が顕著に現れる「舌」に注目している.消化器系疾患と舌色の直接的な関連は多数報告されていることや,疲労やストレス,体内水分量,代謝不全,脈管系の不良など疾患に至る前の健康状態も舌の状態変化に表れることが知られているため,本研究成果を活用して日常生活中の舌の色や形を継続的に記録することで,発病予防が期待できる.本技術は周囲環境の影響を除外した安定計測を目指しており,将来は家庭での健康モニタリングの実現に貢献できると考えている.

Report

(4 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (12 results)

All 2021 2020 2019

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (8 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results)

  • [Journal Article] Learning-based Tongue detection for automatic tongue color diagnosis system2020

    • Author(s)
      Qichao Tang, Tingxiao Yang, Yuichiro Yoshimura, Takao Namiki, Toshiya Nakaguchi
    • Journal Title

      Artificial Life and Robotics

      Volume: 25 Issue: 3 Pages: 363-369

    • DOI

      10.1007/s10015-020-00623-5

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Extraction of tongue coating area from tongue image for automated tongue diagnosis2020

    • Author(s)
      Gou Nambu, Takao Namiki, Toshiya Nakaguchi, Toshiyuki Tanaka
    • Journal Title

      Journal of Ergonomic Technology

      Volume: 20(1) Pages: 1-9

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Synergistic attention U-Net for sublingual vein segmentation2019

    • Author(s)
      Tingxiao Yang, Yuichiro Yoshimura, Akira Morita, Takao Namiki, Toshiya Nakaguchi
    • Journal Title

      Journal of the International Society of Artificial Life and Robotics

      Volume: - Issue: 4 Pages: 550-559

    • DOI

      10.1007/s10015-019-00547-9

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Pyramid Predictive Attention Network for Medical Image Segmentation2019

    • Author(s)
      Tingxiao Yang, Yuichiro Yoshimura, Akira Morita, Takao Namiki, Toshiya Nakaguchi
    • Journal Title

      IEICE Trans. on Fundamentals of Electronics, Communications and Computer Sciences

      Volume: E102-A Pages: 1225-1234

    • NAID

      130007699498

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Presentation] 照度差ステレオ法における撮影・法線算出条件の検討による舌の裂紋検出システムの構築2021

    • Author(s)
      石川堅也, 野口桂冴, 吉村裕一郎, 渡邊悠紀, 並木隆雄, 中口俊哉
    • Organizer
      第60回日本生体医工学会大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 舌の形状解析に基づく裂紋検出の基礎検討2021

    • Author(s)
      石川堅也,渡辺悠紀,吉村裕一郎,並木隆雄,中口俊哉
    • Organizer
      第4回舌診研究会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 舌画像解析によるシェーグレン症候群の診断支援2021

    • Author(s)
      野口桂冴,斎藤一郎,吉村裕一郎,並木隆雄,渡辺悠紀,中口俊哉
    • Organizer
      第4回舌診研究会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 口腔診断支援のための舌の色特徴に基づく機械学習を用いた疾患予測2021

    • Author(s)
      野口 桂冴,斎藤 一郎,吉村 裕一郎,並木 隆雄,渡辺 悠紀,中口 俊哉
    • Organizer
      第40回日本医用画像工学会大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Imaging and Analysis of Tongue Picture for Healthcare2019

    • Author(s)
      Toshiya Nakaguchi
    • Organizer
      2019 International Symposium on InfoComm and Media Technology in Bio-Medical and Healthcare Application
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 舌診断支援システムの自動化に向けた舌検出と領域抽出の検討2019

    • Author(s)
      唐啓超,Tingxiao Yang,吉村裕一郎,長谷川豊,森康久仁,須鎗弘樹,並木隆雄,中口俊哉
    • Organizer
      第38回日本医用画像工学会大会
    • Related Report
      2019 Research-status Report
  • [Presentation] 深層学習を用いた顔写真からの挺舌検出2019

    • Author(s)
      唐啓超,ヤン テイショウ,吉村裕一郎,並木隆雄,中口俊哉
    • Organizer
      電子情報通信学会技術報告
    • Related Report
      2019 Research-status Report
  • [Presentation] 舌の画像的解析による生体状態予測の取り組み2019

    • Author(s)
      中口俊哉
    • Organizer
      第6回デジタル生体医用画像の「色」シンポジウム
    • Related Report
      2019 Research-status Report
    • Invited

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Published: 2019-04-18   Modified: 2023-01-30  

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