Functional and anatomical assessment of coronary artery disease based on intravascular optical coherence tomography
Project/Area Number |
19K12846
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 90130:Medical systems-related
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Research Institution | Wakayama Medical University |
Principal Investigator |
Kubo Takashi 和歌山県立医科大学, 医学部, 博士研究員 (30316096)
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Project Period (FY) |
2019-04-01 – 2022-03-31
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Project Status |
Completed (Fiscal Year 2021)
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Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2021: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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Keywords | 画像診断 / 光干渉断層法 |
Outline of Research at the Start |
我々は、血管内光干渉断層法の技術を基礎にした、心臓冠動脈の血流循環・壁ストレス情報の獲得を可能にする、新しい画像診断装置を開発する。病理解剖例の摘出心臓の冠動脈で実験を行い、(1)心筋血流予備量比・壁ストレス測定の実行可能性を検証する。(2)急性心筋梗塞の発症予知の可能性を探る。(3)医療における有用性の検証と今後の臨床使用に向けての課題抽出を行う。
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Outline of Final Research Achievements |
This study has developed a technique for calculating the physiological severity of coronary artery disease based on the anatomical information of the coronary artery obtained from the intravascular optical coherence tomography (OCT). OCT was able to estimate changes in blood flow in coronary artery lesions by the ability to automatically measure the area of the lumen. In addition, OCT was able to evaluate in detail the histopathological characteristics of arteriosclerotic plaques at high risk of developing acute myocardial infarction. The results of this study suggest that OCT can accurately diagnose myocardial ischemia in angina pectoris and improve the prediction accuracy of acute myocardial infarction.
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Academic Significance and Societal Importance of the Research Achievements |
本研究が発展させた血管内画像診断の新たな解析手法により、胸痛の強度や性情などの主観的判定にたよってきた狭心症診断の客観的判定が可能になる。客観的で正確な狭心症の診断は、真に治療介入を必要とする症例の同定につながり、適正な医療を導くことができる。また、急性心筋梗塞の発症を高い精度で予知できれば、治療介入することによる発症の予防・人々の生活の質や生命予後の改善・医療経済負担の軽減に貢献できると期待される。
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Report
(4 results)
Research Products
(92 results)
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[Journal Article] NIRS-IVUS for Differentiating Coronary Plaque Rupture, Erosion and Calcified Nodule in Acute Myocardial Infarction2020
Author(s)
Kosei Terada, Takashi Kubo, Takeyoshi Kameyama, Yoshiki Matsuo, Yasushi Ino, Hiroki Emori, Daisuke Higashioka, Yosuke Katayama, Amir Kh.M. Khalifa, Masahiro Takahata, Kunihiro Shimamura, Yasutsugu Shiono, Atsushi Tanaka, Takeshi Hozumi, Ryan D. Madder, Takashi Akasaka
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Journal Title
JACC: Cardiovascular Imaging
Volume: -
Issue: 7
Pages: 30827-5
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Feasibility and Clinical Significance of In Vivo Cholesterol Crystal Detection Using Optical Coherence Tomography.2020
Author(s)
Katayama Y, Tanaka A, Taruya A, Kashiwagi M, Nishiguchi T, Ozaki Y, Matsuo Y, Kitabata H, Kubo T, Shimada E, Kondo T, Akasaka T.
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Journal Title
Arterioscler Thromb Vasc Biol
Volume: 40(1)
Issue: 1
Pages: 220-229
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Very late phase vascular response after everolimus eluting stent implantation assessed by optical coherence tomography2020
Author(s)
Khalifa AKM, Ino Y, Kubo T, Tanimoto T, Shimamura K, Shiono Y, Takahata M, Terada K, Higashioka D, Wada T, Taruya A, Emori H, Katayama Y, Kashiwagi M, Kuroi A, Matsuo Y, Fujita S, Tanaka A, Hozumi T, Akasaka T
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Journal Title
The International Journal of Cardiovascular Imaging
Volume: 36
Issue: 9
Pages: 1627-1635
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Comparison of Diagnostic Performance of Intracoronary Optical Coherence Tomography-based and Angiography-based Fractional Flow Reserve for Evaluation of Coronary Stenosis.2020
Author(s)
Huang J, Emori H, Ding D, Kubo T, Yu W, Huang P, Zhang S, Gutierrez-Chico JL, Akasaka T, Wijns W, Tu S.
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Journal Title
EuroIntervention
Volume: 16
Issue: 7
Pages: 568-576
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] 冠動脈インターベンションの現状と未来:OCT/OFDI2020
Author(s)
久保隆史, 寺田幸誠, 江守裕紀, 東岡大輔, 片山陽介, 高畑昌弘, 塩野泰紹, 嶋村邦宏, 松尾好記, 猪野 靖, 赤阪隆史
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Journal Title
循環器内科
Volume: 87
Pages: 173-180
Related Report
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[Journal Article] Stabilization of High Risk Coronary Plaque on Optical Coherence Tomography and Near-Infrared Spectroscopy by Intensive Lipid-Lowering Therapy With Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Inhibitor2019
Author(s)
Ino Y, Kubo T, Shimamura K, Takahata M, Matsuo Y, Kitabata H, Shiono Y, Wada T, Terada K, Katayama Y, Emori H, Higashioka D, Tanaka A, Hozumi T, Akasaka T
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Journal Title
Circulation Journal
Volume: 83
Issue: 8
Pages: 1765
DOI
NAID
ISSN
1346-9843, 1347-4820
Year and Date
2019-07-25
Related Report
Peer Reviewed / Open Access
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[Journal Article] Imaging assessment and accuracy in coronary artery autopsy: comparison of frequency-domain optical coherence tomography with intravascular ultrasound and histology.2019
Author(s)
Shimokado A, Kubo T, Matsuo Y, Ino Y, Shiono Y, Shimamura K, Katayama Y, Taruya A, Nishiguchi T, Kashiwagi M, Kitabata H, Hozumi T, Tanaka A, Akasaka T.
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Journal Title
Int J Cardiovasc Imaging
Volume: 35
Issue: 10
Pages: 1785-1790
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Role of optical coherence tomography in optimizing percutaneous coronary intervention2019
Author(s)
Khalifa A, Kubo T, Ino Y, Takahata M, Shimamura K, Shiono S, Terada K, Emori H, Higashioka D, Katayama Y, Akasaka T
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Journal Title
J Coron Art Dis
Volume: 25
Pages: 52-59
NAID
Related Report
Peer Reviewed
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[Presentation] Diagnosis of Coronary Plaque Rupture, Plaque Erosion and Calcified Nodule by Using Near-Infrared Spectroscopy Intravascular Ultrasound2019
Author(s)
Terada K, Kubo T, Matsuo Y, Ino Y, Kitabata H, Emori H, Katayama Y, Khalifa AK, Shimamura K, Shiono Y, Tanaka A, Hozumi T, Akasaka T
Organizer
European Society of Cardiology: ESC Congress
Related Report
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[Presentation] Quantitative Assessment of Lipid Composition by NIRS IVUS Is Helpful for Differentiating among Plaque Rupture Plaque Erosion and Calcified Nodule in the Culprit Lesion of ACS2019
Author(s)
Terada K, Kubo T, Matsuo Y, Ino Y, Kitabata H, Emori H, Katayama Y, Khalifa AK, Shimamura K, Shiono Y, Tanaka A, Hozumi T, Akasaka T
Organizer
The 31th Transcatheter Cardiovascular Therapeutics
Related Report
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